AIDS pathogenesis: What have two decades of HIV research taught us?

Nature Reviews Immunology

Volumn 3, Issue 4, 2003, Pages 343-348

  Rowland Jones, Sarah L ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CLINICAL RESEARCH; EPIDEMIC; HIGH RISK POPULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; PRIORITY JOURNAL; REVIEW; SIMIAN VIRUS; T LYMPHOCYTE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; FEMALE; HISTORY; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; ISOLATION AND PURIFICATION; MALE; MEDICAL RESEARCH; PATHOGENICITY; TIME;

ACQUIRED IMMUNODEFICIENCY SYNDROME; BIOMEDICAL RESEARCH; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISEASE OUTBREAKS; FEMALE; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HIV-1; HUMANS; MALE; TIME FACTORS;

EID: 0142259696     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1058     Document Type: Review

References (76)

1. Gottlieb, M. S. et al. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. N. Engl. J. Med. 305, 1425-1431 (1981).
2. Masur, H. et al. An outbreak of community-acquired Pneumocystis carinii pneumonia. N. Engl. J. Med. 305, 1431-1438 (1981).
3. Barre-Sinoussi, F. et al. Isolation of a T-lymphotropic retrovirus from a patient at risk of acquired immune deficiency syndrome (AIDS). Science 220, 868-871 (1983).
4. Popovic, M., Sarngadharan, M. G., Read, E. & Gallo, R. C. Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 224, 497-500 (1984).
5. Levy, J. A. et al. Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. 225, 840-842 (1984).
6. Kreiss, J. K. et al. AIDS virus infection in Nairobi prostitutes. Spread of the epidemic to East Africa N. Engl. J. Med. 314, 414-418 (1986).
7. Weiss, R. A. & Jaffe, H. W. Duesberg, HIV and AIDS. Nature 345, 659-660 (1990).
8. Sipsas, N. V. et al. Identification of type-specific cytotoxic T lymphocyte responses to homologous viral proteins in laboratory workers accidentally infected with HIV-1. J. Clin. Invest. 99, 752-762 (1997).
9. Zhu, T. et al. An African HIV-1 sequence from 1959 and implications for the origin of the epidemic. Nature 391, 594-597 (1998).
10. Roberts, J. D., Bebenek, K. & Kunkel, T. A. The accuracy of reverse transcriptase from HIV-1. Science 242, 1171-1173 (1988).
11. Perelson, A. S. et al. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387, 188-191 (1997)
12. Korber, B. et al. Timing the ancestor of the HIV-1 pandemic strains. Science 298, 1789-1796 (2000).
13. Korber, B. et al. Evolutionary and immunological implications of contemporary HIV-1 variation. Br. Med. Bull. 58, 19-42 (2001).
14. Clavel, F. et al. Molecular cloning and polymorphism of the human immune deficiency virus type 2. Nature 324, 691-695 (1986).
15. Guyader, M. et al. Genome organisation and transactivation of the human immunodeficiency virus type 2. Nature 326, 662-669 (1987).
16. Gao, F. et al. Human infection by genetically diverse SIVSM-related HIV-2 in west Africa. Nature 358, 495-499 (1992).
17. Gao, F. et al. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature 397, 436-441 (1999).
18. Rey-Cuille, M. A. et al. Simian immunodeficiency virus replicates to high levels in sooty mangabeys without inducing disease. J. Virol. 72, 3872-3886 (1998).
19. Broussard, S. R. et al. Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease. J. Virol. 75, 2262-2275 (2001).
20. Kaur, A. et al. Diverse host responses and outcomes following simian immunodeficiency virus SIVmac239 infection in sooty mangabeys and rhesus macaques. J. Virol. 72, 9597-9611 (1998).
21. Daniel, M. D. et al. Long-term persistent infection of macaque monkeys with the simian immunodeficiency virus. J. Gen. Virol. 68, 3183-3189 (1987).
22. Whittle, H. C., Ariyoshi, K. & Rowland-Jones, S. HIV-2 and T-cell recognition. Curr. Opin. Immunol. 10, 382-387 (1998).
23. Dalgleish, A. et al. The CD4 antigen is an essential component of the receptor for the AIDS retrovirus. 312, 763-767 (1984).
24. Klatzmann, D. et al. T-lymphocyte T4 molecule behaves as the receptor for human retroviral LAV. Nature 312, 767-768 (1984).
25. + T-helper cells. Am. J. Pathol. 140, 15-22 (1992).
26. Pantaleo, G. et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. 362, 355-358 (1993).
27. Embretson, J. et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. 362, 359-362 (1993).
28. + T cells is markedly enhanced in the setting of antigen-specific immune activation. J. Exp. Med. 183, 687-692 (1996).
29. + cell numbers and clinical staging. J. Clin. Invest. 84, 1892-1899 (1989).
30. Gruters, R. A. et al. Immunological and virological markers in individuals progressing from seroconversion to AIDS. AIDS 5, 837-844 (1991).
31. Musey, L. K. et al. Early and persistent human immunodeficiency virus type 1 (HIV-1)-specific T helper dysfunction in blood and lymph nodes following acute HIV-1 infection. J. Infect. Dis. 180, 278-284 (1999).
32. + T cells. Nature 417, 95-98 (2002).
33. Kalams, S. A. & Walker, B. D. The critical need for CD4 help in maintaining effective cytotoxic T-lymphocyte responses. J. Exp. Med. 188, 2199-2204 (1998).
34. Feng, Y., Broder, C. C., Kennedy, P. E. & Berger, E. A. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane G protein-coupled receptor. Science 272, 872-877 (1996).
35. + T cells. Science 270, 1811-1815 (1995).
36. Alkhatib, G. et al. CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272, 1955-1958 (1996).
37. Deng, H. et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381, 661-666 (1996).
38. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 381, 667-673 (1996).
39. H1 lymphocytes. Nature 391, 344-345 (1998).
40. Bleul, C. C., Wu, L., Hoxie, J. A., Springer, T. A. & Mackay, C. R. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. 94, 1925-1930 (1997).
41. Connor, R. I., Sheridan, K. E., Ceradini, D., Choe, S. & Landau, N. R. Change in coreceptor use correlates with disease progression in HIV-1-infected individuals. J. Exp. Med. 185, 621-628 (1997).
42. Daar, E. S., Moudgil, T., Meyer, R. D. & Ho, D. D. Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N. Engl. J. Med. 324, 961-964 (1991).
43. Mellors, J. W. et al. Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann. Intern. Med. 122, 573-579 (1995).
44. Piatak, M., Saag, M. & Yang, L. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 259, 1749-1754 (1993).
45. Margolick, J. B. et al. Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. The Multicenter AIDS Cohort Study. Nature Med. 1, 674-680 (1995).
46. Ho, D. D. et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373, 123-126 (1995).
47. Wei, X. et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373, 117-122 (1995).
48. Pakker, N. G. et al. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nature Med. 4, 208-214 (1998).
49. + subset in HIV disease implicate replicative sensecence in HIV pathogenesis. AIDS 10, F17-F22 (1996).
50. + T-cell turnover. Science 274, 1543-1547 (1996).
51. Hellerstein, M. et al. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nature Med. 5, 83-89 (1999).
52. Kovacs, J. A. et al. Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV. J. Exp. Med. 194, 1731-1741 (2001).
53. Sopper, S. et al. Impact of simian immunodeficiency virus (SIV) infection on lymphocyte numbers and T-cell turnover in different organs of rhesus monkeys. Blood 101, 1213-1219 (2003).
54. De Boer, R. J., Mohri, H., Ho, D. D. & Perelson, A. S. Turnover rates of B cells. T cells and NK cells in simian immunodeficiency virus-infected and uninfected rhesus macaques. J. Immunol. 170, 2479-2487 (2003).
55. Douek, D. C. et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 396, 690-695 (1998).
56. Hazenberg, M. D. et al. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T-cell population in HIV-1 infection. Nature Med. 6, 1036-1042 (2000).
57. Hazenberg, M. D. et al. T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood 95, 249-255 (2000).
58. Douek, D. C. et al. Evidence for increased T-cell turnover and decreased thymic output in HIV infection. J. Immunol. 167, 6663-6668 (2001).
59. Grossman, Z., Meier-Schellersheim, M., Sousa, A. E., Victorino, R. M. & Paul, W. E. CD4-T-cell depletion in HIV infection: are we closer to understanding the cause? Nature Med. 8, 319-323 (2002).
60. Sousa, A. E., Carneiro, J., Meier-Schellersheim, M., Grossman, Z. & Victorino, R. M. CD4 T-cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load. J. Immunol. 169, 3400-3406 (2002).
61. Chakrabarti, L. A. et al. Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection. J. Virol. 74, 1209-1223 (2000).
62. Walker, B. D. et al. HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature 328, 345-348 (1987).
63. Plata, F. et al. AIDS virus-specific cytotoxic T lymphocytes in lung disorders. Nature 328, 348-351 (1987).
64. Altman, J. et al. Direct visualization and phenotypic analysis of virus-specific T lymphocytes in HIV-infected individuals. Science 274, 94-96 (1996).
65. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68, 6103-6110 (1994).
66. Wilson, J. D. et al. Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection. AIDS 14, 225-233 (2000).
67. Ogg, G. S. et al. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma viral RNA load. Science 279, 2103-2106 (1998).
68. Addo, M. M. et al. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol. 77, 2081-2092 (2003).
69. Phillips, R. E. et al. Human immunodeficiency virus genetic variation that can escape cytotoxic T-cell recognition. Nature 354, 453-459 (1991).
70. Price, D. A. et al. Positive selection of HIV-1 cytotoxic T-lymphocyte escape variants during primary infection. Proc. Natl Acad. Sci. USA 94, 1890-1895 (1997).
71. Allen, T. M. et al. Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia. Nature 407, 386-390 (2000).
72. Moore, C. B. et al. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science 296, 1439-1443 (2002).
73. Poignard, P. et al. Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo. Immunity 10, 431-438 (1999).
74. O'Brien, S. J., Nelson, G. W., Winkler, C. A. & Smith, M. W. Polygenic and multifactorial disease gene association in man: lessons from AIDS. Annu. Rev. Genet. 34, 563-591 (2000).
75. Liu, R. et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 88, 7-20 (1996).
76. Carrington, M. et al. HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage. Science 283, 1748-1752 (1999).