Impact of simian immunodeficiency virus (SIV) infection on lymphocyte numbers and T-cell turnover in different organs of rhesus monkeys

Blood

Volumn 101, Issue 4, 2003, Pages 1213-1219

  Sopper, Sieghart ^a   Nierwetberg, Dagmar ^b   Halbach, Astrid ^b   Sauer, Ursula ^b   Scheller, Carsten ^b   Stahl Hennig, Christiane ^b   Mätz Rensing, Kerstin ^b   Schäfer, Frank ^b   Schneider, Thomas ^b   Ter Meulen, Volker ^b   Müller, Justus G ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CD4 ANTIGEN; CD8 ANTIGEN; KI 67 ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPH NODE CELL; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION; TISSUE DISTRIBUTION; VIRUS REPLICATION;

EID: 0037441882     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-06-1644     Document Type: Article

References (46)

1. + T-cell depletion in HIV disease. Nature. 2001;410:974-979.
2. Sopper S, Hemm S, Meixensberger J, et al. Dynamics of the immune system response in cerebrospinal fluid and blood of SIVmac-infected rhesus monkeys. J Med Primatol. 1993;22:138-146.
3. Schneider T, Jahn H, Schmidt W, Riecken E, Zeitz M, Ullrich R. Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood. Berlin Diarrhea/Wasting Syndrome Study Group. Gut. 1995;37:524-529.
4. + T cell depletion and viral replication in SIV infection. Science. 1998;280:427-431.
5. + lymphocyte population in the blood of SIV-infected macaques is not reflected in lymph nodes. AIDS Res Hum Retroviruses. 1993;9:639-646.
6. Rosok BI, Bostad L, Voltersvik P, et al. Reduced CD4 cell counts in blood do not reflect CD4 cell depletion in tonsillar tissue in asymptomatic HIV-1 infection. AIDS. 1996;10:F35-F38.
7. Elovaara I, Müller K. Cytoimmunological abnormalities in cerebrospinal fluid in early stages of HIV-1 infection often precede changes in blood. J Neuroimmunol. 1993;44:199-204.
8. Wei X, Ghosh SK, Taylor ME, et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature. 1995;373:117-122.
9. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature. 1995;373:123-126.
10. Mohri H, Bonhoeffer S, Monard S, Perelson A, Ho D. Rapid turnover of T lymphocytes in SIV-infected rhesus macaques. Science. 1998;279:1223-1227.
11. - T lymphocyte turnover in simian immunodeficiency virus-infected macaques. Proc Natl Acad Sci U S A. 1998;95:6388-6393.
12. Hellerstein M, Hanley M, Cesar D, et al. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nat Med. 1999;5:83-89.
13. + T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy. Nat Med. 1998;4:794-801.
14. Hazenberg M, Stuart JC, Otto S, et al. T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood. 2000;95:249-255.
15. - T cell turnover in HIV-infected patients. Proc Natl Acad Sci U S A. 2000;97:13778-13783.
16. + T lymphocytes in HIV-1 infection as measured by Ki-67 antigen. J Exp Med. 1998;187:1295-1303.
17. Mohri H, Perelson AS, Tung K, et al. Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy. J Exp Med. 2001;194:1277-1287.
18. Kovacs JA, Lempicki RA, Sidorov IA, et al. Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV. J Exp Med. 2001;194:1731-1741.
19. + T-cell turnover in HIV-1 infection: a paradigm revisited. Immunol Today. 1998;19:44-48.
20. Johnson R. The dynamics of T-lymphocyte turnover in AIDS. AIDS. 2000;14:S3-S9.
21. + T-cell depletion in HIV infection: are we closer to understanding the cause? Nat Med. 2002;8:319-323.
22. Hellerstein MK, McCune JM. T cell turnover in HIV-1 disease. Immunity. 1997;7:583-589.
23. Westermann J, Pabst R. Distribution of lymphocyte subsets and natural killer cells in the human body. Clin Invest. 1992;70:539-544.
24. Rosenberg Y, Anderson A, Pabst R. HIV-induced decline in blood CD4/CD8 ratios: viral killing or altered lymphocyte trafficking? Immunol Today. 1998;19:10-17.
25. + T cell repopulation of lymphoid tissues after treatment of HIV-1 infection. Proc Natl Acad Sci U S A. 1998;95:1154-1159.
26. Pakker N, Notermans D, deBoer R, et al. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nat Med. 1998;4:208-214.
27. Halbach A, Nierwetberg D, Muller JG, et al. Total numbers of lymphocyte subsets in different lymph node regions of uninfected and SIV-infected macaques. J Med Primatol. 2000;29:148-157.
28. Sopper S, Sauer U, Hemm S, et al. Protective role of the virus-specific immune response for development of severe neurologic signs in simian immunodeficiency virus-infected macaques. J Virol. 1998;72:9940-9947.
29. Sopper S, Sauer U, Muller JG, Stahl-Hennig C, ter Meulen V. Early activation and proliferation of T cells in simian immunodeficiency virus-infected rhesus monkeys. AIDS Res Hum Retroviruses. 2000;16:689-697.
30. Lewis MG, Bellah S, McKinnon K, et al. Titration and characterization of two rhesus-derived SIV-mac challenge stocks. AIDS Res Hum Retroviruses. 1994;10:213-220.
31. Hazenberg MD, Otto SA, Cohen Stuart JW, et al. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nat Med. 2000;6:1036-1042.
32. Wykrzykowska J, Rosenzweig M, Veazey R, et al. Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus. J Exp Med. 1998;187:1767-1778.
33. McCune JM, Loftus R, Schmidt DK, et al. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J Clin Invest. 1998;101:2301-2308.
34. + lymphocytes that includes memory cells. J Immunol. 1990;144:3779-3783.
35. + memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals. Proc Natl Acad Sci U S A. 1990;87:6058-6062.
36. Burke A, Anderson D, Mannan P, et al. Systematic lymphadenopathic histology in human immunodeficiency virus-1-seropositive drug addicts without apparent acquired immunodeficiency syndrome. Hum Pathol. 1994;25:248-256.
37. Furrer H. Prevalence and clinical significance of splenomegaly in asymptomatic human immunodeficiency virus type 1-infected adults. Swiss HIV cohort study. Clin Infect Dis. 2000;30:943-945.
38. Grossman Z, Heberman RB, Dimitrov DS. T cell turnover in SIV infection [technical comment]. Science. 1999;284:555a.
39. + T cells go out of stock. Nat Immunol. 2000;1:285-289.
40. + T-cell activation in HIV infection is antigenic stimulation. J Acquir Immune Defic Syndr. 2000;25:203-211.
41. + T cells correlate with plasma human immunodeficiency virus (HIV-1) RNA level in HIV-1 infection. J Infect Dis. 1998;178:1279-1287.
42. + cell turnover [letter]. Nature. 1995;375:194.
43. + T cell responses associated with control of viremia. Science. 1997;278:1447-1450.
44. +Ki67+ lymphocytes in HIV-infected patients are effector T cells accumulated in the G 1 phase of the cell cycle. Eur J Immunol. 2000;30:3598-3603.
45. + T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nat Med. 1999;5:518-525.
46. Tough DF, Borrow P, Sprent J. Induction of byslander T cell proliferation by viruses and type I interferon in vivo. Science. 1996;272:1947-1950.