Cell transplantation and genetic engineering: New approaches to cardiac pathology

Expert Opinion on Biological Therapy

Volumn 3, Issue 7, 2003, Pages 1023-1039

  Leo, Jonathan ^a   Barbash, Israel M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cell; Gene; Heart failure; Myocardial infarction; Transplantation

Indexed keywords

CELL GROWTH; CELL NUCLEUS TRANSPLANTATION; CELL SELECTION; CELL SURVIVAL; EMBRYO CELL; ENDOTHELIUM CELL; FETUS CELL; FIBROBLAST; GENETIC ENGINEERING; HEART FAILURE; HEART GRAFT; HEART MUSCLE CELL; HEMATOPOIETIC STEM CELL; HUMAN; MYOBLAST; NONHUMAN; REVIEW; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING; UMBILICAL CORD BLOOD;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL TRANSPLANTATION; FETAL BLOOD; GENETIC ENGINEERING; HEART DISEASES; HEART FAILURE, CONGESTIVE; HUMANS; MYOCYTES, CARDIAC; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING;

EID: 0142119212     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.3.7.1023     Document Type: Review

References (173)

1. REINLIB L, FIELD L: Cell transplantation as future therapy for cardiovascular disease?: a workshop of the National Heart, Lung, and Blood Institute. Circulation (2000) 101:E182-E187.
2. JESSUP M, BROZENA S: Heart failure. N. Engl. J. Med. (2003) 348:2007-2018.
3. REDFIELD MM: Heart failure - an epidemic of uncertain proportions. N. Engl. J. Med. (2002) 347:1442-1444.
4. NO AUTHORS LISTED: Heart and stroke statistical update. Dallas, Texas American Heart Association (1999).
5. CLELAND JG, KHAND A, CLARK A: The heart failure epidemic: exactly how big is it? Eur. Heart J. (2001) 22:623-626.
6. PASUMARTHI KB, FIELD LJ: Cardiomyocyte cell cycle regulation. Circ. Res. (2002) 90:1044-1054.
7. NADAL-GINARD B, KAJSTURA J, LERI A, ANVERSA P: Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ. Res. (2003) 92:139-150. Review on original, provocative and debated concepts of myocardial regeneration from leaders in the field.
8. MANN DL: Mechanisms and models in heart failure: a combinatorial approach. Circulation (1999) 100:999-1008.
9. KHAND A, GEMMEL I, CLARK AL, CLELAND JG: Is the prognosis of heart failure improving? J. Am. Coll. Cardiol. (2000) 36:2284-2286.
10. VERFAILLIE CM: Adult stem cells: assessing the case for pluripotency. Trends Cell Biol. (2002) 12:502-508. Excellent critical review on pluripotency and plasticity of adult stem cells.
11. LI RK, MICKLE DA, WEISEL RD, ZHANG J, MOHABEER MK: In vivo survival and function of transplanted rat cardiomyocytes. Circ. Res. (1996) 78:283-288.
12. SOONPAA MH, KOH GY, KLUG MG, FIELD LJ: Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium. Science (1994) 264:98-101. Landmark classic paper on cardiac cell transplantation.
13. LEOR J, PATTERSON M, QUINONES MJ, KEDES LH, KLONER RA: Transplantation of fetal myocardial tissue into the infarcted myocardium of rat. A potential method for repair of infarcted myocardium? Circulation (1996) 94:II332-II336.
14. SCORSIN M, HAGEGE AA, MAROTTE F et al.: Does transplantation of cardiomyocytes improve function of infarcted myocardium? Circulation (1997) 96:II-188-193.
15. SCORSIN M, MAROTTE F, SABRI A et al.: Can grafted cardiomyocytes colonize peri-infarct myocardial-areas? Circulation (1996) 94:II337-II340.
16. YAO M, DIETERLE T, HALE S et al.: Long term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function. J. Mol. Cell. Cardiol. (2003) 35(6):661-670.
17. LI RK, JIA ZQ, WEISEL RD et al.: Cardiomyocyte transplantation improves heart function. Ann. Thorac. Surg. (1996) 62:654-660; discussion 660-661.
18. KOH GY, KIM SJ, KLUG MG, PARK K, SOONPAA MH, FIELD LJ: Targeted expression of transforming growth factor-beta 1 in intracardiac grafts promotes vascular endothelial cell DNA synthesis. J. Clin. Invest. (1995) 95:114-121.
19. LI RK, MICKLE DA, WEISEL RD et al.: Natural history of fetal rat cardiomyocytes transplanted into adult rat myocardial scar tissue. Circulation (1997) 96:II-179-186; discussion 186-187.
20. SCORSIN M, HAGEGE AA, DOLIZY I et al.: Can cellular transplantation improve function in doxorubicin-induced heart failure? Circulation (1998) 98:II151-II155; discussion II155-II156.
21. REINECKE H, ZHANG M, BARTOSEK T, MURRY CE: Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts [In Process Citation]. Circulation (1999) 100:193-202.
22. ETZION S, BATTLER A, BARBASH IM et al.: Influence of embryonic cardiomyocyte transplantation on the progression of heart failure in a rat model of extensive myocardial infarction. J. Mol. Cell. Cardiol. (2001) 33:1321-1330.
23. MULLER-EHMSEN J, PETERSON KL, KEDES L et al.: Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation (2002) 105:1720-1726.
24. YOO KJ, LI RK, WEISEL RD et al.: Heart cell transplantation improves heart function in dilated cardiomyopathic hamsters [In Process Citation]. Circulation (2000) 102:III204-III209.
25. SAKAKIBARA Y, NISHIMURA K, TAMBARA K et al.: Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation. J. Thorac. Cardiovasc. Surg. (2002) 124:50-56.
26. MULLER-EHMSEN J, WHITTAKER P, KLONER RA et al.: Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J. Mol. Cell. Cardiol. (2002) 34:107-116.
27. LEOR J, PRENTICE H, SARTORELLI V et al.: Gene transfer and cell transplant: an experimental approach to repair a 'broken heart'. Cardiovasc. Res. (1997) 35:431-441.
28. SOLTER D, GEARHART J: Putting stem cells to work. Science (1999) 283:1468-1470.
29. LANZA R.P, CIBELLI JB, WEST MD: Prospects for the use of nuclear transfer in human transplantation. Nat. Biotechnol. (1999) 17:1171-1174.
30. JIANG Y, JAHAGIRDAR BN, REINHARDT RL et al.: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature (2002) 418:41-49.
31. THOMSON JA, ITSKOVITZ-ELDOR J, SHAPIRO SS et al.: ES cell lines derived from human blastocysts. Science (1998) 282:1145-1147. Classic, first paper on creation of human ES cell line.
32. ORLIC D, HILL JM, ARAI AE: Stem cells for myocardial regeneration. Circ. Res. (2002) 91:1092-1102. One of the best reviews on this topic.
33. BLAU HM, BRAZELTON TR, WEIMANN JM: The evolving concept of a stem cell: entity or function? Cell (2001) 105:829-841. Comprehensive review on adult stem cell plasticity and pluripotency.
34. MARTIN GR: Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by terarocarcinoma stem cells. Proc. Natl. Acad. Sci. USA (1981) 78:7634-7638.
35. EVANS MJ, KAUFMAN MH: Establishment in culture of pluripotential cells from mouse embryos. Nature (1981) 292:154-156.
36. SHAMBLOTT MJ, AXELMAN J, WANG S et al.: Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc. Natl. Acad. Sci. USA (1998) 95:13726-13731.
37. KEHAT I, KENYAGIN-KARSENTI D, SNIR M et al.: Human ES cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J. Clin. Invest. (2001) 108:407-414.
38. XU C, POLICE S, RAO N, CARPENTER MK: Characterization and enrichment of cardiomyocytes derived from human ES cells. Circ. Res. (2002) 91:501-508.
39. MUMMERY C, WARD-VAN OOSTWAARD D, DOEVENDANS P et al.: Differentiation of human ES cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation (2003) 107:2733-2740.
40. KEHAT I, GEPSTEIN A, SPIRA A, ITSKOVITZ-ELDOR J, GEPSTEIN L: High-resolution electrophysiological assessment of human ES cell-derived cardiomyocytes: a novel in vitro model for the study of conduction. Circ. Res. (2002) 91:659-661.
41. KLUG MG, SOONPAA MH, KOH GY, FIELD LJ: Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts. J. Clin. Invest. (1996) 98:216-224.
42. MULLER M, FLEISCHMANN BK, SELBERT S et al.: Selection of ventricular-like cardiomyocytes from ES cells in vitro. FASEB J. (2000) 14:2540-2548.
43. MIN JY, YANG Y, CONVERSO KL et al.: Transplantation of ES cells improves cardiac function in postinfarcted rats. J. Appl. Physiol. (2002) 92:288-296.
44. YANG Y, MIN JY, RANA JS et al.: VEGF enhances functional improvement of postinfarcted hearts by transplantation of ESC-differentiated cells. J. Appl. Physiol. (2002) 93:1140-1151.
45. TAKAHASHI T, LORD B, SCHULZE PC et al.: Ascorbic acid enhances differentiation of ES cells into cardiac myocytes. Circulation (2003) 107:1912-1916.
46. CONDORELLI G, BORELLO U, DE ANGELIS L et al.: Cardiomyocytes induce endothelial cells to transdifferentiate into cardiac muscle: implications for myocardium regeneration. Proc. Natl. Acad. Sci. USA (2001) 98:10733-10738.
47. BADORFF C, BRANDES RP, POPP R et al.: Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation (2003) 107:1024-1032.
48. HOLDEN C, VOGEL G: Stem cells. Plasticity: time for a reappraisal? Science (2002) 296:2126-2129.
49. WURMSER AE, GAGE FH: Stem cells: cell fusion causes confusion. Nature (2002) 416:485-487.
50. HAWKE TJ, GARRY DJ: Myogenic satellite cells: physiology to molecular biology. J. Appl. Physiol. (2001) 91:534-551.
51. MURRY CE, WISEMAN RW, SCHWARTZ SM, HAUSCHKA SD: Skeletal myoblast transplantation for repair of myocardial necrosis. J. Clin. Invest. (1996) 98:2512-2523.
52. CHIU RC, ZIBAITIS A, KAO RL: Cellular cardiomyoplasty: myocardial regeneration with satellite cell implantation. Ann. Thorac. Surg. (1995) 60:12-18.
53. ZIBAITIS A, GREENTREE D, MA F, MARELLI D, DUONG M, CHIU RC: Myocardial regeneration with satellite cell implantation. Transplant. Proc. (1994) 26:3294.
54. REINECKE H, MACDONALD GH, HAUSCHKA SD, MURRY CE: Electromechanical coupling between skeletal and cardiac muscle. Implications for infarct repair. J. Cell Biol. (2000) 149:731-740.
55. ROBINSON SW, CHO PW, LEVITSKY HI et al.: Arterial delivery of genetically labelled skeletal myoblasts to the murine heart: long-term survival and phenotypic modification of implanted myoblasts. Cell Transplant. (1996) 5:77-91.
56. TAYLOR DA, ATKINS BZ, HUNGSPREUGS P et al.: Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat. Med. (1998) 4:929-933. Classic paper on the use of skeletal myoblasts for myocardial repair.
57. HUTCHESON KA, ATKINS BZ, HUEMAN MT, HOPKINS MB, GLOWER DD, TAYLOR DA.: Comparison of benefits on myocardial performance of cellular cardiomyoplasty with skeletal myoblasts and fibroblasts. Cell Transplant. (2000) 9:359-368.
58. SCORSIN M, HAGEGE A, VILQUIN JT et al.: Comparison of the effects of fetal cardiomyocyte and skeletal myoblast transplantation on postinfarction left ventricular function. J. Thorac. Cardiovasc. Surg. (2000) 119:1169-1175.
59. JAIN M, DERSIMONIAN H, BRENNER DA et al.: Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Circulation (2001) 103:1920-1927.
60. MENASCHE P, HAGEGE AA, SCORSIN M et al.: Myoblast transplantation for heart failure. Lancet (2001) 357:279-280.
61. SIMINIAK T, KALAWSKI R, FISZER D et al.: Autologous skeletal myoblast transplantation in treatment of postinfarction heart failure - Phase I clinical trial feasibility study. Eur. Heart J. (2002) 4:30.
62. MENASCHE P, HAGEGE AA, VILQUIN JT et al.: Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J. Am. Coll. Cardiol. (2003) 41:1078-1083.
63. COATS AJ: What causes the symptoms of heart failure? Heart (2001) 86:574-578.
64. GROUNDS MD: Age-associated changes in the response of skeletal muscle cells to exercise and regeneration. Ann. NY Acad. Sci. (1998) 854:78-91.
65. SUZUKI K, BRAND NJ, ALLEN S et al.: Overexpression of connexin 43 in skeletal myoblasts: Relevance to cell transplantation to the heart. J. Thorac. Cardiovasc. Surg. (2001) 122:759-766.
66. ORLIC D, KAJSTURA J, CHIMENTI S et al.: Bone marrow cells regenerate infarcted myocardium. Nature (2001) 410:701-705. Classic, pioneering paper on cardiac repair potential of BM HSCs.
67. TOMA C, PITTENGER MF, CAHILL KS, BYRNE BJ, KESSLER PD: Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation (2002) 105:93-98.
68. JACKSON KA, MAJKA SM, WANG H et al.: Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J. Clin. Invest. (2001) 107:1395-1402.
69. ORLIC D, KAJSTURA J, CHIMENTI S, BODINE DM, LERI A, ANVERSA P: Transplanted adult bone marrow cells repair myocardial infarcts in mice. Ann. NY Acad. Sci. (2001) 938:221-229; discussion 229-230.
70. FERRARI G, CUSELLA-DE ANGELIS G, COLETTA M et al.: Muscle regeneration by bone marrow-derived myogenic progenitors. Science (1998) 279:1528-1530.
71. BITTNER RE, SCHOFER C, WEIPOLTSHAMMER K et al.: Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice. Anat. Embryol. (Berl.) (1999) 199:391-396.
72. PITTENGER MF, MACKAY AM, BECK SC et al.: Multilineage potential of adult human mesenchymal stem cells. Science (1999) 284:143-147.
73. WAKITANI S, SAITO T, CAPLAN AI: Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve (1995) 18:1417-1426.
74. GAO J, DENNIS JE, MUZIC RF, LUNDBERG M, CAPLAN AI: The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion. Cells Tissues Organs (2001) 169:12-20.
75. LIECHTY KW, MACKENZIE TC, SHAABAN AF et al.: Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat. Med. (2000) 6:1282-1286.
76. GRONTHOS S, FRANKLIN DM, LEDDY HA, ROBEY PG, STORMS RW, GIMBLE JM: Surface protein characterization of human adipose tissue-derived stromal cells. J. Cell. Physiol. (2001) 189:54-63.
77. KUZNETSOV SA, MANKANI MH, GRONTHOS S, SATOMURA K, BIANCO P, ROBEY PG: Circulating skeletal stem cells. J. Cell. Biol. (2001) 153:1133-1140.
78. ERICES A, CONGET P, MINGUELL JJ: Mesenchymal progenitor cells in human umbilical cord blood. Br. J. Haematol. (2000) 109:235-242.
79. RANGAPPA S, FEN C, LEE EH, BONGSO A, WEI ES: Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. Ann. Thorac. Surg. (2003) 75:775-779.
80. COSSU G, MAVILIO F: Myogenic stem cells for the therapy of primary myopathies: wishful thinking or therapeutic perspective? J. Clin. Invest. (2000) 105:1669-1674.
81. WANG JS, SHUM-TIM D, CHEDRAWY E, CHIU RC: The coronary delivery of marrow stromal cells for myocardial regeneration: pathophysiologic and therapeutic implications. J. Thorac. Cardiovasc. Surg. (2001) 122:699-705.
82. MAKINO S, FUKUDA K, MIYOSHI S et al.: Cardiomyocytes can be generated from marrow stromal cells in vitro. J. Clin. Invest. (1999) 103:697-705.
83. TOMITA S, MICKLE DA, WEISEL RD et al.: Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J. Thorac. Cardiovasc. Surg. (2002) 123:1132-1140.
84. TOMITA S, LI RK, WEISEL RD et al.: Autologous transplantation of bone marrow cells improves damaged heart function. Circulation (1999) 100:II247-II256.
85. BARBASH IM, CHOURAQUI P, BARON J et al.: Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration and body distribution. Circulation (2003) (In Press).
86. YAU TM, TOMITA S, WEISEL RD et al.: Beneficial effect of autologous cell transplantation on infarcted heart function: comparison between bone marrow stromal cells and heart cells. Ann. Thorac. Surg. (2003) 75:169-176; discussion 176-177.
87. CAPLICE NM, GERSH BJ: Stem cell to repair the heart. Circ. Res. (2003) 92:6-8. Excellent critical editorial on the clinical future of stem cell-based therapy.
88. PITTENGER MF, MACKAY AM, BECK SC et al.: Multilineage potential of adult human mesenchymal stem cells. Science (1999) 294:143-147.
89. BREHM M, ZEUST, STRAUER BE: Stem cells - clinical application and perspectives. Herz (2002) 27:611-620. Comprehensive, clinically oriented review.
90. ORLIC D, KAJSTURA J, CHIMENTI S et al.: Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl. Acad. Sci. USA (2001) 98:10344-10349.
91. WAGERS AJ, SHERWOOD RI, CHRISTENSEN JL, WEISSMAN IL: Little evidence for developmental plasticity of adult hematopoietic stem cells. Science (2002) 297:2256-2259.
92. YING QL, NICHOLS J, EVANS EP, SMITH AG: Changing potency by spontaneous fusion. Nature (2002) 416:545-548.
93. TERADA N, HAMAZAKI T, OKA M et al.: Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature (2002) 416:542-545.
94. VOGEL G: Stem cell research. Studies cast doubt on plasticity of adult cells. Science (2002) 295:1989-1991.
95. ASAHARA T, MASUDA H, TAKAHASHI T et al.: Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ. Res. (1999) 85:221-228. Original report on the angiogenic and myogenic potential of bone marrow endothelial progenitor cells.
96. ASAHARA T, MUROHARA T, SULLIVAN A et al.: Isolation of putative progenitor endothelial cells for angiogenesis. Science (1997) 275:964-967.
97. REHMAN J, LI J, ORSCHELL CM, MARCH KL: Peripheral blood 'endothelial progenitor cells' are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation (2003) 107:1164-1169.
98. KALKA C, MASUDA H, TAKAHASHI T et al.: Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc. Natl. Acad. Sci. USA (2000) 97:3422-3427.
99. MUROHARA T, IKEDA H, DUAN J et al.: Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization. J. Clin. Invest. (2000) 105:1527-1536.
100. KAWAMOTO A, TKEBUCHAVA T, YAMAGUCHI J et al.: Intramyomcardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia. Circulation (2003) 107:461-468.
101. ASSMUS B, SCHACHINGER V, TEUPE C et al.: Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation (2002) 106:3009-3017.
102. KOCHER AA, SCHUSTER MD, SZABOLCS MJ et al.: Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat. Med. (2001) 7:430-436. Original paper suggesting myogenic potential of angioblasts delivered intravenously.
103. EDELBERG JM, TANG L, HATTORI K, LYDEN D, RAFII S: Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ. Res. (2002) 90:E89-E93.
104. ASAHARA T, TAKAHASHI T, MASUDA H et al.: VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J. (1999) 18:3964-3972.
105. TAKAHASHI T, KALKA C, MASUDA H et al.: Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat. Med. (1999) 5:434-438.
106. STRAUER BE, BREHM M, ZEUS T et al.: Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation (2002) 106:1913-1918.
107. TEPPER OM, GALIANO RD, CAPLA JM et al.: Human endothelial progenitor cells from Type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation (2002) 106:2781-2786.
108. HILL JM, ZALOS G, HALCOX JP et al.: Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N. Engl. J. Med. (2003) 348:593-600.
109. QUAINI F, URBANEK K, BELTRAMI AP et al.: Chimerism of the transplanted heart. N. Engl. J. Med. (2002) 346:5-15.
110. LAFLAMME MA, MYERSON D, SAFFITZ JE, MURRY CE: Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts. Circ. Res. (2002) 90:634-640.
111. SAUER H, HESCHELER J, WARTENBERG M: Cardiac differentiation of mesenchymal stem cells in sex mis-matched transplanted hearts: self-repair or just a visit? Cardiovasc. Res. (2002) 56:357-358.
112. DEB A, WANG S, SKELDING KA, MILLER D, SIMPER D, CAPLICE NM: Bone marrow-derived cardiomyocytes are present in adult human heart: a study of gender-mismatched bone marrow transplantation patients. Circulation (2003) 107:1247-1249.
113. FUCHS S, BAFFOUR R, ZHOU YF et al.: Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia. J. Am. Coll. Cardiol. (2001) 37:1726-1732.
114. STAMM C, WESTPHAL B, KLEINE HD et al.: Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet (2003) 361:45-46.
115. TSE HF, KWONG YL, CHAN JK, LO G, HO CL, LAU CP: Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet (2003) 361:47-49.
116. TATEISHI-YUYAMA E, MATSUBARA H, MUROHARA T et al.: Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet (2002) 360:427-435.
117. FUCHS S, SATLER LF, KORNOWSKI R et al.: Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease. A feasibility study. J. Am. Coll. Cardiol. (2003) 41:1721-1724.
118. PERIN EC, DOHMANN HF, BOROJEVIC R et al.: Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation (2003) 107:2294-2302. Original, positive clinical report on autologous bone marrow transplantation in patients with ischaemic cardiomyopathy.
119. WAGNER JE, KURTZBERG J: Cord blood stem cells. Curr. Opin. Hematol. (1997) 4:413-418.
120. CHEN J, SANBERG PR, LI Y et al.: Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke (2001) 32:2682-2688.
121. LU D, SANBERG PR, MAHMOOD A et al.: Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury. Cell Transplant. (2002) 11:275-281.
122. PLUCHINO S, QUATTRINI A, BRAMBILLA E et al.: Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature (2003) 422:688-694.
123. GAROT J, UNTERSEEH T, TEIGER E et al.: Magnetic resonance imaging of targeted catherer-based implantation of myogenic precursor cells into infarcted left ventricular myocardium. J. Am. Coll. Cardiol. (2003) 41:1841-1846.
124. THOMPSON CA, NASSERI BA, MAKOWER J et al.: Percutaneous transvenous cellular cardiomyoplasty: A novel nonsurgical approach for myocardial cell transplantation. J. Am. Coll. Cardiol. (2003) 41:1964-1971.
125. CHEN J, LI Y, WANG L et al.: Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke (2001) 32:1005-1011.
126. CHEN J, ZHANG ZG, LI Y et al.: Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ. Res. (2003) 92:692-699.
127. SHINTANI S, MUROHARA T, IKEDA H et al.: Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation (2001) 103:2776-2779.
128. AICHER A, BRENNER W, ZUHAYRA M et al.: Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation (2003) 107:2134-2139.
129. YAMAGUCHI J-I, KUSANO KF, MASUO O et al.: Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation (2003) 107:1322-1328.
130. ZHANG M, METHOT D, POPPA V, FUJIO Y, WALSH K, MURRY CE: Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies. J. Mol. Cell. Cardiol. (2001) 33:907-921.
131. LI RK, MICKLE DA, WEISEL RD, RAO V, JIA ZQ: Optimal time for cardiomyocyte transplantation to maximize myocardial function after left ventricular injury. Ann. Thorac. Surg. (2001) 72:1957-1963.
132. VACANTI JP, LANGER R. Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation. Lancet (1999) 354(Suppl. 1):S132-S134.
133. NUGENT HM, EDELMAN ER: Tissue engineering therapy for cardiovascular disease. Circ. Res. (2003) 92:1068-1078.
134. RABKIN E, SCHOEN FJ: Cardiovascular tissue engineering. Cardiovasc. Pathol. (2002) 11:305-317.
135. ZIMMERMANN WH, DIDIE M, WASMEIER GH et al.: Cardiac grafting of engineered heart tissue in syngenic rats. Circulation (2002) 106:I151-I157.
136. ZIMMERMANN WH, SCHNEIDERBANGER K, SCHUBERT P et al.: Tissue engineering of a differentiated cardiac muscle construct. Circ. Res. (2002) 90:223-230.
137. SHIMIZU T, YAMATO M, ISOI Y et al.: Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces. Circ. Res. (2002) 90:e40.
138. SHIMIZU T, YAMATO M, AKUTSU T et al.: Electrically communicating three-dimensional cardiac tissue mimic fabricated by layered cultured cardiomyocyte sheets. J. Biomed. Mater. Res. (2002) 60:110-117.
139. DAR A, SHACHAR M, LEOR J, COHEN S: Optimization of cardiac cell seeding and distribution in 3D porous alginate scaffolds. Biotechnol. Bioeng. (2002) 80:305-312.
140. MIRONOV V, BOLAND T, TRUSK T, FORGACS G, NIARKWALD RR: Organ printing: computer-aided jet-based 3D tissue engineering. Trends Biotech. (2003) 21:157-161.
141. LEOR J, ABOULAFIA-ETZION S, DAR A et al.: Bioengineered cardiac grafts: A new approach to repair the infarcted myocardium? Circulation (2000) 102:III56-III61.
142. ISNER JM: Myocardial gene therapy. Nature (2002) 415:234-239.
143. DI DONNA S, RENAULT V, FORESTIER C et al.: Regenerative capacity of human satellite cells: the mitotic clock in cell transplantation. Neurol. Sci. (2000) 21:S943-S951.
144. ETZION S, BARBASH IM, FEINBERG MS et al.: Cellular cardiomyoplasty of cardiac fibroblasts by adenoviral delivery of MyoD ex vivo: an unlimited source of cells for myocardial repair. Circulation (2002) 106:II25-II30.
145. WEINTRAUB H, DWARKI VJ, VERMA I et al.: Muscle-specific transcriptional activation by MyoD. Genes Dev. (1991) 5:1377-1386.
146. MURRY CE, KAY MA, BARTOSEK T, HAUSCHKA SD, SCHWARTZ SM: Muscle differentiation during repair of myocardial necrosis in rats via gene transfer with MyoD. J. Clin. Invest. (1996) 98:2209-2217.
147. LATTANZI L, SALVATORI G, COLETTA M et al.: High efficiency myogenic conversion of human fibroblasts by adenoviral vecror-mediated MyoD gene transfer. An alternative strategy for ex vivo gene therapy of primary myopathies. J. Clin. Invest. (1998) 101:2119-2128.
148. TAM SK, GU W, NADAL-GINARD B: Molecular cardiomyoplasty: potential cardiac gene therapy for chronic heart failure. J. Thorac. Cardiovasc. Surg. (1995) 109:918-923; discussion 923-924.
149. EDELBERG JM, AIRD WC, ROSENBERG RD: Enhancement of murine cardiac chronotropy by the molecular transfer of the human beta2 adrenergic receptor cDNA. J. Clin. Invest. (1998) 101:337-343.
150. EDELBERG JM, HUANG DT, JOSEPHSON ME, ROSENBERG RD: Molecular enhancement of porcine cardiac chronotropy. Heart (2001) 86:559-562.
151. RUHPARWAR A, TEBBENJOHANNS J, NIEHAUS M et al.: Transplanted fetal cardiomyocytes as cardiac pacemaker. Eur. J. Cardiothorac. Surg. (2002) 21:853-857.
152. MIAKE J, MARBAN E, NUSS HB: Biological pacemaker created by gene transfer. Nature (2002) 419:132-133.
153. DONAHUE JK, HELDMAN AW, FRASER H et al.: Focal modification of electrical conduction in the heart by viral gene transfer. Nat. Med. (2000) 6:1395-1398.
154. FELD Y, MELAMED-FRANK M, KEHAT I, TAL D, MAROM S, GEPSTEIN L: Electrophysiological modulation of cardiomyocytic tissue by transfected fibroblasts expressing potassium channels: a novel strategy to manipulate excitability. Circulation (2002) 105:522-529.
155. CAMPBELL KH, MCWHIR J, RITCHIE WA, WILMUT I: Sheep cloned by nuclear transfer from a cultured cell line. Nature (1996) 380:64-66.
156. LANZA RP, CHUNG HY, YOO JJ et al.: Generation of histocompatible tissues using nuclear transplantation. Nat. Biotechnol. (2002) 20:689-696.
157. YAU TM, FUNG K, WEISEL RD, FUJII T, MICKLE DA, LI RK: Enhanced myocardial angiogenesis by gene transfer with transplanted cells. Circulation (2001) 104:I218-I222.
158. LEE RJ, SPRINGER ML, BLANCO-BOSE WE, SHAW R, URSELL PC, BLAU HM: VEGF gene delivery to myocardium: deleterious effects of unregulated expression. Circulation (2000) 102:898-901.
159. SUZUKI K, MURTUZA B, SAMMUT IA et al.: Heat shock prorein 72 enhances manganese superoxide dismurase activity during myocardial ischemia-reperfusion injury, associated with mitochondrial protection and apoptosis reduction. Circulation (2002) 106:I270-I276.
160. SUZUKI K, MURTUZA B, SMOLENSKI RT et al.: Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptosis. Circulation (2001) 104:I308-I3.
161. BLASCO MA: Telomerase beyond telomeres. Nat. Rev. Cancer (2002) 2:627-633.
162. OUELLETTE MM, LEE K: Telomerase: diagnostics, cancer therapeutics and tissue engineering. Drug Discov. Today (2001) 6:1231-1237.
163. SHAY JW, WRIGHT WE: The use of telomerized cells for tissue engineering. Nat. Biotechnol. (2000) 18:22-23.
164. MURASAWA S, LLEVADOT J, SILVER M, ISNER J M, LOS ORDO DW, ASAHARA T: Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells. Circulatian (2002) 106:1133-1139.
165. OH H, SCHNEIDER MD: The emerging role of telomerase in cardiac muscle cell growth and survival. J. Mol. Cell. Cardiol. (2002) 34:717-724. Review on new perspective in myocardial biology with therapeutic implications.
166. SOONPAA MH, KOH GY, PAJAK L et al.: Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J. Clin. Invest. (1997) 99:2644-2654.
167. NISHIDA M, LI TS, FURATA K, YANO M, MATSUZAKI M, HAMANO K: Improvement of cardiac function by bone marrow cell implantation in a rat hypoperfusion heart model. Ann. Thorac. Surg. (2003) 75:768-773; discussion 773-774.
168. FUKUDA K: Reprogramming of bone marrow mesenchymal stem cells into cardiomyocytes. C. R. Biol (2002) 325:1027-1038.
169. SAKAI T, LI RK, WEISEL RD et al.: Fetal cell transplantation: a comparison of three cell types. J. Thorac. Cardiovasc. Surg. (1999) 118:715-724.
170. YOO KJ, LI RK, WEISEL RD, MICKLE DA, LI G, YAU TM: Autologous smooth muscle cell transplantation improved heart function in dilated cardiomyopathy. Ann. Thorac. Surg. (2000) 70:859-865.
171. YOO KJ, LI RK, WEISEL RD et al.: Smooth muscle cells transplantation is better than heart cells transplantation for improvement of heart function in dilated cardiomyopathy. Yonsei Med. J. (2002) 43:296-303.
172. HAJJAR RJ, DEL MONTE F, MATSUI T, ROSENZWEIG A: Prospects for gene therapy for heart failure. Circ. Res. (2000) 86:616-621.
173. http://clinicaltrials.gov/ct/show/NCT00043628?order = 2 NIH clinical trials page.