Role of the serotonin 5-HT2A receptor learning

Learning and Memory

Volumn 10, Issue 5, 2003, Pages 355-362

  Harvey, John A ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 AMINO 5 CHLORO 2 METHOXYPHENYL) 3 (1 BUTYL 4 PIPERIDINYL) 1 PROPANONE; 1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; 2 CYCLOPROPYLMETHOXY N (8 METHYL 8 AZABICYCLO[3.2.1]OCTAN 3 YLCARBAMOYL)BENZAMIDE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 2 (DIETHYLAMINO)ETHYL ESTER; BEMESETRON; BROMOLYSERGIDE; CINANSERIN; CYPROHEPTADINE; ITASETRON; KETANSERIN; METERGOLINE; MIANSERIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; ONDANSETRON; PINDOLOL; RS 6733; SEROTONIN 2A RECEPTOR; SPIPERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AWARENESS; COGNITION; CONTROLLED STUDY; DRUG EFFECT; ELECTROPHYSIOLOGY; EYELID REFLEX; FRONTAL CORTEX; LEARNING; NICTITATING MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; REVIEW; SEROTONINERGIC SYSTEM; STIMULUS RESPONSE;

ANIMALS; ASSOCIATION LEARNING; BRAIN; COGNITION; CONDITIONING, CLASSICAL; ERGOLINES; FRONTAL LOBE; HALLUCINOGENS; HIPPOCAMPUS; KETANSERIN; LYSERGIC ACID DIETHYLAMIDE; MIANSERIN; NICTITATING MEMBRANE; PIPERIDINES; RABBITS; RECEPTOR, SEROTONIN, 5-HT2A; RITANSERIN; SCHIZOPHRENIA; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0142089973     PISSN: 10720502     EISSN: None     Source Type: Journal    
DOI: 10.1101/lm.60803     Document Type: Review

References (98)

1. Abramson, H.A., Jarvik, M.E., Kaufman, M.R., Kornetsky, C., Levine, A., and Wagner, M. 1955. Lysergic acid diethylamide (LSD-25). I. Physiological and perceptual responses. J. Psychol. 39: 3-60.
2. Aghajanian, G.K. and Marek, G.J. 1997. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology 36: 589-599.
3. -. 2000. Serotonin model of schizophrenia: Emerging role of glutamate mechanisms. Brain Res. Brain Res. Rev. 31: 302-312.
4. 2 receptors. Neuropharmacology 32: 1427-1432.
5. 2C receptors in the rabbit: High correlation with the profile for the human receptors. Eur. J. Pharmacol. 406: 163-169.
6. 2A receptors in the rabbit. J. Pharmacol. Exp. Ther. 299: 1066-1072.
7. 2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients. J. Neural. Transm. 85: 19-29.
8. 2C) receptors reveal novel inverse agonist activity of receptor ligands. J. Biol. Chem. 269: 11687-11690.
9. Barnes, J.M., Costall, B., Coughlan, J., Domeney, A.M., Gerrard, P.A., Kelly, M.E., Naylor, R.J., Onaivi, E.S., Tomkins, D.M., and Tyers, M.B. 1990. The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates. Pharmacol. Biochem. Behav. 35: 955-962.
10. Barnes, N.M. and Sharp, T. 1999. A review of central 5-HT receptors and their function. Neuropharmacology 38: 1083-1152.
11. Beylin, A.V., Gandhi, C.C., Wood, G.E., Talk, A.C., Matzel, L.D., and Shors, T.J. 2001. The role of the hippocampus in trace conditioning: Temporal discontinuity or task difficulty? Neurobiol. Learn. Mem. 76: 447-461.
12. Braun, U., Shulgin, A.T., and Braun, G. 1980. Centrally active n-substituted analogs of 3,4-methylenedioxyphenylisopropylamine (3,4-methylenedioxyamphetamine). J. Pharmaceut. Sci. 69: 192-195.
13. Brawley, P. and Duffield, J.C. 1972. The pharmacology of hallucinogens. Pharmacol. Rev. 24: 31-66.
14. Buchanan, S.L. and Powell, D.A. 1982. Cingulate cortex: Its role in Pavlovian conditioning. J. Comp. Physiol. Psychol. 96: 755-774.
15. Burnet, P.W.J., Eastwood, S.L., and Harrison, P.J. 1996. 5-HT1A and 5-HT2A receptor mRNAs and binding sites are differentially altered in schizophrenia. Neuropsychopharmacology 15: 442-455.
16. 1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine. Eur. J. Pharmacol. 283: 133-139.
17. 1A antagonist, prevents the impairment of spatial learning caused by intrahippocampal administration of scopolamine or 7-chlorokynurenic acid. Brain Res. 774: 167-174.
18. 3 receptor antagonist. Behav. Brain Res. 82: 185-194.
19. Clark, R.E. and Squire, L.R. 1998. Classical conditioning and brain systems: The role of awareness. Science 280: 77-81.
20. Cole, J.C. and Sumnall, H.R. 2003. Altered states: The clinical effects of ecstasy. Pharmacol. Ther. 98: 35-58.
21. Egan, C.T., Herrick-Davis, K., and Teitler, M. 1998. Creation of a constitutively activated state of the 5-hydroxytryptamine2A receptor by site-directed mutagenesis: Inverse agonist activity of antipsychotic drugs. J. Pharmacol. Exp. Ther. 286: 85-90.
22. Fontana, D.J., Daniels, S.E., Wong, E.H., Clark, R.D., and Eglen, R.M. 1997. The effects of novel, selective 5-hydroxytryptamine (5-HT)4 receptor ligands in rat spatial navigation. Neuropharmacology 36: 689-696.
23. Geinisman, Y., Berry, R.W., Disterhoft, J.F., Power, J.M., and Van der Zee, E.A. 2001. Associative learning elicits the formation of multiple-synapse boutons. J. Neurosci. 21: 5568-5573.
24. Gibbs, C.M. and Powell, D.A. 1991. Single-unit activity in the dorsomedial prefrontal cortex during the expression of discriminative bradycardia in rabbits. Behav. Brain Res. 43: 79-92.
25. Gimpl, M.P., Gormezano, I., and Harvey, J.A. 1979. Effects of LSD on learning as measured by classical conditioning of the rabbit nictitating membrane response. J. Pharmacol. Exp. Ther. 208: 330-334.
26. Ginn, S.R. and Powell, D.A. 1986. Pizotifen attenutates classical eyeblink and heart rate conditioning in rabbits. Physiol. Psychol. 14: 36-41.
27. Gormezano, I., Harvey, J.A., and Aycock, E. 1980. Sensory and associative effects of LSD on classical appetitive conditioning of the rabbit jaw movement response. Psychopharmacology 70: 137-143.
28. Gormezano, I., Kehoe, E.J., and Marshall, B. 1983. Twenty years of classical conditioning research with the rabbit. In Progress in psychobiology and physiological psychology (ed. J.M. Sprague and A.N. Epstein), Vol. 10, pp. 197-275. Academic Press, New York.
29. Harder, J.A., Maclean, C.J., Alder, J.T., Francis, P.T., and Ridley, R.M. 1996. The 5-HT1A antagonist, Way100635, ameliorates the cognitive impairment induced by fornix transaction in the marmoset. Psychopharmacology 127: 245-254.
30. Harvey, J.A. 1987. Effects of drugs on associative learning. In Psychopharmacology, the third generation of progress. (ed. H. Meltzer), pp. 1485-1491. Raven Press, New York.
31. -. 1996. Serotonergic regulation of associative learning. Behav. Brain Res. 73: 47-50.
32. Harvey, J.A. and Welsh, J.P. 1996. Learning and performance: A critical review of the role of the cerebellum in instrumental and classical conditioning. In The acquisition of motor behavior in vertebrates. (eds. J.R. Bloedel, T.J. Ebner, and S.P. Wise), pp. 115-141. MIT press, Cambridge, MA.
33. Harvey, J.A., Gormezano, I., and Cool V.A. 1982. Effects of d-lysergic acid diethylamide, d-2-bromolysergic acid diethylamide, dl-2,5-dimethoxy-4-methylamphetamine and d-amphetamine on classical conditioning of the rabbit nictitating membrane response. J. Pharmacol. Exp. Ther. 221: 289-294.
34. Harvey, J.A., Gormezano, I., Cool-Hauser, V.A., and Schindler, C.W. 1988. Effects of LSD on classical conditioning as a function of CS-UCS interval: Relationship to reflex facilitation. Pharmacol. Biochem. Behav. 30: 433-441.
35. 2 receptor antagonists on a cranial nerve reflex in the rabbit: Evidence for inverse agonism. Psychopharmacology 141: 162-168.
36. Hasuo, H., Matsuoka, T., and Akasu, T. 2002. Activation of presynaptic 5-hydroxytryptamine 2A receptors facilitates excitatory synaptic transmission via protein kinase C in the dorsolateral septal nucleus. J. Neurosci. 22: 7509-7517.
37. Hensman, R., Guimaraes, F.S., Wang, M., and Deakin, J.F. 1991. Effects of ritanserin on aversive classical conditioning in humans. Psychopharmacology 104: 220-224.
38. Hernandez, I. and Sokolov, B.P. 2000. Abnormalities in 5-HT2A receptor mRNA expression in frontal cortex of chronic elderly schizophrenics with varying histories of neuroleptic treatment. J. Neurosci. Res. 59: 218-225.
39. Hodges, H., Sowinski, P., Sinden, J.D., Netto, C.A., and Fletcher, A. 1995. The selective 5-HT3 receptor antagonist, WAY 100289, enhances spatial memory in rats with ibotenate lesions of the forebrain cholinergic projection system. Psychopharmacology 117: 318-332.
40. 2 recognition sites. Brain Res. 376: 97-107.
41. 2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc. Natl. Acad. Sci. 95: 735-740.
42. Kenakin, T. 1996. The classification of seven transmembrane receptors in recombinant expression systems. Pharmacol. Rev. 48: 413-463.
43. Kobayashi, M., Ohno, M., Yamamoto, T., and Watanabe, S. 1995. Concurrent blockade of β-adrenergic and muscarinic receptors disrupts working memory but not reference memory in rats. Physiol. Behav. 58: 307-314.
44. Kronforst-Collins, M.A. and Disterhoft, J.F. 1998. Lesions of the caudal area of rabbit medial prefrontal cortex impair trace eyeblink conditioning. Neurobiol. Learn. Mem. 69: 147-162.
45. LaBar, K.S. and Disterhoft, J.F. 1998. Conditioning, awareness, and the hippocampus. Hippocampus 8: 620-626.
46. Lambe, E.K., Goldman-Rakic, P.S., and Aghajanian, G.K. 2000. Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat. Cereb. Cortex 10: 974-980.
47. Leurs, R., Smit, M.J., Alewijnse, A.E., and Timmerman, H. 1998. Agonist independent regulation of constitutively active G-protein coupled receptors. Trends Biochem. Sci. 23: 418-422.
48. 2A receptors selectively in primate brain. Neuropharmacology 37: 1147-1158.
49. Ma, T.C. and Yu, Q.H. 1993. Effect of 20 (S)-ginsenoside-Rg2 and cyproheptadine on two-way active avoidance learning and memory in rats. Arzneimittel Forschung-Drug Res. 43: 1049-1052.
50. Marchetti, E., Dumuis, A., Bockaert, J., Soumireu-Mourat, B., and Roman, F.S. 2000. Differential modulation of the 5-HT(4) receptor agonists and antagonist on rat learning and memory. Neuropharmacology 39: 2017-2027.
51. 2A receptor antagonist. Eur. J. Pharmacol. 259: 137-141.
52. Marquardt, G.M., DiStefano, V., and Ling, L.L. 1978. Pharmacological effects of (±)-, (S)-, and (R)-MDA. In Psychopharmacology of hallucinogens. (eds. R.C. Stillman and R.E. Willette), pp. 84-104. Pergamen Press, New York.
53. McEchron, M.D. and Disterhoft, J.F. 1997. Sequence of single neuron changes in CA1 hippocampus of rabbits during acquisition of trace eyeblink conditioned responses. J. Neurophysiol. 78: 1030-1044.
54. Meltzer, H.Y. 1999. The role of serotonin in antipsychotic drug action. Neuropsychopharmacology 21: 106S-115S.
55. Meneses, A. 1999. 5-HT system and cognition. Neurosci. Biobehav. Rev. 23: 1111-1125.
56. -. 2002. Tianeptine: 5-HT uptake sites and 5-HT(1-7) receptors modulate memory formation in an autoshaping Pavlovian/instrumental task. Neurosci. Biobehav. Rev. 26: 309-319.
57. Meneses, A. and Hong, E. 1994. Modification of 8-OH-DPAT effects on learning by manipulation of the assay condition. Behav. Neural Biol. 61: 29-35.
58. Milligan, G. and Bond, R.A. 1997. Inverse agonism and the regulation of receptor number. Trends Pharmacol. Sci. 18: 468-474.
59. Moser, P.C., Bergis, O.E., Jegham, S., Lochead, A., Duconseille, E., Terranova, J.P., Caille, D., Berque-Bestel, I., Lezoualc'h, F., Fischmeister, R., et al. 2002. SL65.0155, a novel 5-hydroxytryptamine(4) receptor partial agonist with potent cognition-enhancing properties. J. Pharmacol. Exp. Ther. 302: 731-741.
60. Pazos, A., Cortes, R., and Palacios, J.M. 1985. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res. 346: 231-249.
61. Phillips, R.G. and LeDoux, J.E. 1994. Lesions of the dorsal hippocampal formation interfere with background but not foreground contextual fear conditioning. Learn. Mem. 1: 34-44.
62. 3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task. Pharmacol. Biochem. Behav. 47: 95-99.
63. Port, R.L., Mikhail, A.A., and Patterson, M.M. 1985. Differential effects of hippocampectomy on classically conditioned rabbit nictitating membrane response related to interstimulus interval. Behav. Neurosci. 99: 200-208.
64. Quirion, R., Richard, J., and Dam, T.V. 1985. Evidence for the existence of serotonin type-2 receptors on cholinergic terminals in rat cortex. Brain Res. 333: 345-349.
65. Romano, A.G. 1999. Variations in CS associability and multiple unit hippocampal activity in the rabbit. Behav. Brain Res. 103: 163-173.
66. Romano, A.G. and Harvey, J.A. 1992. Drug effects on sensorimotor integration in a model system. In Drugs of abuse and neurobiology. (ed. R.R. Watson), pp. 23-37. CRC Press, Boca Raton, FL.
67. -. 1994. MDMA enhances associative and nonassociative learning in the rabbit. Pharmacol. Biochem. Behav. 47: 289-293.
68. Romano, A.G., Bormann, N.M., and Harvey, J.A. 1991. A unique enhancement of associative learning produced by methylenedioxyamphetamine. Behav. Pharmacol. 2: 225-231.
69. 2 antagonist mianserin on associative learning and performance in the rabbit. Pharmacol. Biochem. Behav. 67: 103-110.
70. Rothlin, E. 1957. Pharmacology of lysergic acid diethylamide and some of its related compounds. J. Pharm. Pharmacol. 9: 569-587.
71. Schindler, C.W. and Harvey, J.A. 1990. The use of classical conditioning procedures in behavioral pharmacology. In Contemporary research in behavioral pharmacology, drug development research. (eds. S.I. Dworkin, S.T. Higgins, and W.K. Bickel), Vol. 20, pp. 169-187. Wiley-Liss, Inc., New York.
72. Schindler, C.W., Gormezano, I., and Harvey, J.A. 1985a. Effects of morphine and LSD on the classically conditioned nictitating membrane response. Pharmacol. Biochem. Behav. 22: 41-46.
73. -. 1985b. Effects of drugs on classical conditioning. In Behavioral pharmacology: The current status. (eds. L.S. Seiden and R. Balster), pp. 55-71. Alan R. Liss, New York.
74. Sears, L.L., Andreasen, N.C., and O'Leary, D.S. 2000. Cerebellar functional abnormalities in schizophrenia are suggested by classical eyeblink conditioning. Biol. Psychiatry 48: 204-209.
75. 2 receptors in interneurons. Synapse 9: 208-218.
76. Shulgin, A.T. 1978. Psychotomimetic drugs: Structure-activity relationships. In Handbook of psychopharmacology. Vol. 11, Stimulants (eds. L.L. Iversen, S.D. Iversen, and S.H. Snyder), pp. 243-333. Plenum Press, New York.
77. Siegel, S. and Freedman, D.X. 1988. Effects of LSD-25 on classical trace conditioning. Pharmacol. Biochem. Behav. 30: 427-431.
78. Snyder, S.H., Faillace, L., and Hollister, L. 1967. 2,5-Dimethoxy-4-methylamphetamine (STP): A new hallucinogenic drug. Science 158: 669-670.
79. Solomon, P.R., Vander Schaaf, E.R., Norbe, A.C., Weisz, D.J., and Thompson, R.F. 1986. Hippocampus and trace conditioning of the rabbit's nictitating membrane response. Behav. Neurosci. 100: 729-744.
80. Steinmetz, J.E. 2000. Brain substrates of classical eyeblink conditioning: A highly localized but also distributed system. Behav. Brain Res. 110: 13-24.
81. Steinmetz, J.E., Tracy, J.A., and Green, J.T. 2001. Classical eyeblink conditioning: Clinical models and applications. Integr. Physiol. Behav. Sci. 36: 220-238.
82. Strange, P.G. 2002. Mechanisms of inverse agonism at G-protein-coupled receptors. Trends Pharmacol. Sci. 23: 89-95.
83. Tanaka, E. and North, R.A. 1993. Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex. J. Neurophysiol. 69: 1749-1757.
84. 4 receptor agonist RS17017. Psychopharmacology 135: 407-415.
85. Thompson, R.F. 1986. The neurobiology of learning and memory. Science 223: 941-947.
86. Thompson, L.T., Moskal, J.R., and Disterhoft, J.F. 1992. Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine. Nature 359: 638-641.
87. Titov, S.A., Shamakina, I.I., and Ashmarin, I.P. 1983. Effect of lysyl-vasopressin and vasotocin on a disorder of the conditioned avoidance reaction by a serotonin receptor blockader. Biulleten Eksperimentalnoi Biologii i Meditsiny 95: 31-33.
88. Vitiello, B., Martin, A., Hill, J., Mack, C., Molchan, S., Martinez, R., Murphy, D.L., and Sunderland, T. 1997. Cognitive and behavioral effects of cholinergic, dopaminergic, and serotonergic blockade in humans. Neuropsychopharmacology 16: 15-24.
89. Weible, A.P., McEchron, M.D., and Disterhoft, J.F. 2000. Cortical involvement in acquisition and extinction of trace eyeblink conditioning. Behav. Neurosci. 114: 1058-1067.
90. Weiner, D.M., Burstein, E.S., Nash, N., Croston, G.E., Currier, E.A., Vanover, K.E., Harvey, S.C., Donohue, E., Hansen, H.C., Andersson, C.M., et al. 2001. 5-Hydroxytryptamine2A receptor inverse agonists as antipsychotics. J. Pharmacol. Exp. Ther. 299: 268-276.
91. Weiss, C., Preston, A.R., Oh, M.M., Schwarz, R.D., Welty, D., and Disterhoft, J.F. 2000. The M1 muscarinic agonist CI-1017 facilitates trace eyeblink conditioning in aging rabbits and increases the excitability of CA1 pyramidal neurons. J. Neurosci. 20: 783-790.
92. Welsh, S.E., Kachelries, W.J., Romano, A.G., Simansky, K.J., and Harvey, J.A. 1998a. Effects of LSD, ritanserin, 8-OH-DPAT and lisuride on classical conditioning in the rabbit. Pharmacol. Biochem. Behav. 59: 469-475.
93. 2A/2C antagonists on associative learning in the rabbit. Psychopharmacology 137: 157-163.
94. Westphal, R.S. and Sanders-Bush, E. 1994. Reciprocal binding properties of 5-hydroxytryptamine type 2C receptor agonists and inverse agonists. Mol. Pharmacol. 46: 937-942.
95. 2A receptors in working memory. J. Neurosci. 22: 2843-2854.
96. Woodruff-Pak, D.S. 2001. Eyeblink classical conditioning differentiates normal aging from Alzheimer's disease. Integr. Physiol. Behav. Sci. 36: 87-108.
97. Yasuno, F., Suhara, T., Nakayama, T., Ichimiya, T., Okubo, Y., Takano, A., Ando, T., Inoue, M., Maeda, J., and Suzuki, K. 2003. Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory. Am. J. Psychiatry 160: 334-340.
98. Zhen, X., Du, W., Romano, A.G., Friedman, E., and Harvey, J.A. 2001. The p38 mitogen-activated protein kinase is involved in associative learning in rabbits. J. Neurosci. 21: 5513-5519.