Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit: Evidence for inverse agonism

Psychopharmacology

Volumn 141, Issue 2, 1999, Pages 162-168

  Harvey, J A ^a   Welsh, S E ^a   Hood, H ^a   Romano, A G ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

5 HT(2A 2C) receptor antagonists; BOL; Ketanserin; LY 53,857; MDL 11,939; Mianserin; Motor performance; Nictitating membrane; Rabbit; Ritanserin

Indexed keywords

1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; BROMOLYSERGIDE; GLEMANSERIN; KETANSERIN; MIANSERIN; RITANSERIN; SEROTONIN 2 ANTAGONIST; SEROTONIN 2 RECEPTOR; ALPHA-PHENYL-1-(2-PHENYLETHYL)-4-PIPERIDINEMETHANOL; DRUG DERIVATIVE; ERGOLINE DERIVATIVE; LYSERGIDE; PIPERIDINE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; MOTOR PERFORMANCE; NICTITATING MEMBRANE; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; RABBIT; RECEPTOR AFFINITY; REFLEX; SEROTONINERGIC SYSTEM; TACTILE STIMULATION; ANIMAL; CRANIAL NERVE; DRUG EFFECT; FEMALE; MALE; PHYSIOLOGY;

ANIMALS; CRANIAL NERVES; ERGOLINES; FEMALE; KETANSERIN; LYSERGIC ACID DIETHYLAMIDE; MALE; MIANSERIN; PIPERIDINES; RABBITS; RECEPTORS, SEROTONIN; REFLEX; RITANSERIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0032587531     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050820     Document Type: Article

References (34)

1. 2 receptors. Neuropharmacology 32: 1427-1432
2. 2C receptors reveal novel inverse agonist activity of receptor ligands. J Biol Chem 269:11687-11690
3. Barragan LA, Delhaye-Bouchaud N, Laget P (1985) Drug-induced activation of the inferior olivary nucleus in young rabbits. Differential effects of harmaline and quipazine. Neuropharmacology 24:645-654
4. Bishop GA, Ho RH (1986) Cell bodies of origin of serotonin-immunoreactive afferents to the inferior olivary complex of the rat. Brain Res 399:369-373
5. Compoint C, Buisseret-Delmas C (1988) Origin, distribution and organization of the serotoninergic innervation in the inferior olivary complex of the rat. Arch Ital Biol 126:99-110
6. Cunningham KA, Appel JB (1987) Neuropharmacological reassessment of the discriminative stimulus properties of d-lysergic acid diethylamide (LSD). Psychopharmacology 91:67-73
7. Fozard JR (1982) Mechanism of the hypotensive effect of ketanserin. J Cardiovasc Pharmacol 4:829-838
8. 2 binding sites. J Pharmacol Exp Ther 228:628-635
9. Fuller R, Snoddy H (1990) Serotonin receptor subtypes involved in the elevation of serum corticosterone concentration in rats by direct- and indirect-acting serotonin agonists. Neuroendocrinology 52:206-211
10. Glennon RA, Hauck AE (1985) Mechanistic studies on DOM as a discriminative stimulus. Pharmacol Biochem Behav 23:937-941
11. Harvey JA (1996) Serotonergic regulation of associative learning. Behav Brain Res 73:47-50
12. Harvey JA, Welsh JP (1996) Learning and performance: a critical review of the role of the cerebellum in instrumental and classical conditioning. In: Bloedel JR, Ebner TJ, Wise SP (eds) The acquisition of motor behavior in vertebrates. MIT Press, Cambridge, pp 115-141
13. Harvey JA, Gormezano I, Cool-Hauser VA, Schindler CW (1988) Effects of LSD on classical conditioning as a function of CSUCS interval: relationship to reflex facilitation. Pharmacol Biochem Behav 30:433-441
14. Jacobs BL, Fornal CA (1993) 5-HT and motor control: a hypothesis. Trends Neurosci 16:346-352
15. Kenakin T (1996) The classification of seven transmembrane receptors in recombinant expression systems. Pharmacol Rev 48:413-463
16. 2A/2C antagonist anxiolytics. II. Drug discrimination and behavioral observation studies in rats. J Pharmacol Exp Ther 282:747-759.
17. 2C receptor in Sf9 cells. Mol Pharmacol 48:150-159
18. 2-receptors: Location, pharmacological, pathological and physiological role. In: Langer S, Brunello N, Mendlewicz J (eds) Serotonin receptor subtypes: pharmacological significance and clinical implications. Karger, Basel, pp 31-43
19. Marek GJ, McMaster SE, Gormezano I, Harvey JA (1983) The role of the accessory abducens nucleus in the rabbit nictitating membrane response. Brain Res 299:215-229
20. McCall R, Aghajanian G (1980) Pharmacological characterization of serotonin receptors in the facial motor nucleus: a microiontophoretic study. Eur J Pharmacol 65:175-183
21. Romano AG, Harvey JA (1993) Enhanced learning following a single acute dose of MDA. Pharmacol. Biochem Behav 44:965-969
22. Romano AG, Harvey JA (1994) MDMA enhances associative and nonassociative learning in the rabbit. Pharmacol Biochem Behav 47:289-293
23. Romano AG, Bormann NM, Harvey JA (1991) A unique enhancement of associative learning produced by methylenedioxyamphetamine. Behav Pharmacol 2:225-231
24. 1C receptor activation by hallucinogenic drugs. Psychopharmacology 105:340-346
25. Schindler CW, Gormezano I, Harvey JA (1985) Effect of morphine and LSD on the classically conditioned nictitating membrane response. Pharmacol Biochem Behav 22:41-46
26. Schreiber R, Brocco M, Millan MJ (1994) Blockade of the discriminative stimulus effects of DOI by MDL 100,907 and the "atypical" antipsychotics, clozapine and risperidone. Eur J Pharmacol 264:99-102
27. Sugihari I, Lang EJ, Llinás R (1995) Serotonin modulation of inferior olivary oscillations and synchronicity: a multiple-electrode study in the rat cerebellum. Eur J Neurosci 7:521-534
28. 2B receptor: evidence for species differences. J Pharmacol Exp Ther 276:720-727
29. Wallis DI (1994) 5-HT receptors involved in initiation or modulation of motor patterns: opportunities for drug development. Trends Pharmacol Sci 15:288-292
30. 2A/2C antagonists on associative learning in the rabbit. Psychopharmacology 137:157-163
31. Welsh SE, Kachelries WJ, Romano AG, Simansky KJ, Harvey JA (1998b) Effects of LSD, ritanserin, 8-OH-DPAT and lisuride on classical conditioning in the rabbit. Pharmacol Biochem Behav 59:469-475
32. Westphal RS, Sanders-Bush E (1994) Reciprocal binding properties of 5-hydroxytryptamine type 2C receptor agonists and inverse agonists. Mol Pharmacol 46:937-942
33. Wiklund L, Sjolund B, Bjorklund A (1981) Morphological and functional studies on the serotonergic innervation of the inferior olive. J Physiol 77:183-186
34. Yamamoto T, Walker EA, Woods JH (1991) Agonist and antagonist properties of serotonergic compounds in pigeons trained to discriminate either quipazine or 1-5-hydroxytryptophan. J Pharmacol Exp Ther 258:999-1007