Abnormalities in 5-HT2A receptor mRNA expression in frontal cortex of chronic elderly schizophrenics with varying histories of neuroleptic treatment

Journal of Neuroscience Research

Volumn 59, Issue 2, 2000, Pages 218-225

  Hernandez, Ivan ^a   Sokolov, Boris P ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

5 HT2A receptor; Frontal cortex; Neuroleptic treatment; Schizophrenia

Indexed keywords

CHLORPROMAZINE; FLUPHENAZINE; HALOPERIDOL; MESSENGER RNA; NEUROLEPTIC AGENT; PERPHENAZINE; SEROTONIN 2A RECEPTOR; THIORIDAZINE; TIOTIXENE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RNA ANALYSIS; SCHIZOPHRENIA;

AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANTIPSYCHOTIC AGENTS; BRAIN CHEMISTRY; FEMALE; FRONTAL LOBE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RNA, MESSENGER; SCHIZOPHRENIA;

EID: 0034650980     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(20000115)59:2<218::AID-JNR8>3.0.CO;2-H     Document Type: Article

References (44)

1. Abi-Dargham A, Laruelle M, Aghajanian GK, Charney D, Krystal J. 1997. The role of serotonin in the pathophysiology and treatment of schizophrenia. J Neuropsychiatry Clin Neurosci 9:1-17.
2. 2 receptors in rat cerebral cortex. J Neurochem 46:191-197.
3. Arranz MJ, Collier D, Sodhi N, Ball D, Roberts GW, Price J, Sham P, Kerwin R. 1995. Association between clozapine response and allelic variation in 5-HT2A receptor gene. Lancet 346:281-282.
4. Arranz MJ, Collier DA, Munro J, Sham P, Kirov G, Sodhi M, Roberts G, Price J, Kerwin RW. 1996. Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine. Neurosci Lett 217: 177-178.
5. 2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients. J Neural Transm 85:19-29.
6. Battaglia G, Monn JA, Schoepp DD. 1997. In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group 11 metabotropic glutamate receptor agonist LY354740 in rats. Neurosci Lett 229:161-164.
7. Bennett JP, Enna SJ, Bylund DB, Gillin JC, Wyatt RJ, Snyder SH. 1979. Neurotransmitter receptors in frontal cortex of schizophrenics. Arch Gen Psychiatry 36:927-934.
8. Breier A. 1995. Serotonin, schizophrenia and antipsychotic drug action. Schizophr Res 14:187-202.
9. 2C receptors. Mol Brain Res 48:45-52.
10. Burnet PWJ, Eastwood SL, Harrison PJ. 1996. 5-HT1A and 5-HT2A receptor mRNAs and binding sites are differentially altered in schizophrenia. Neuropsychopharmacology 15:442-455.
11. Chomczynsky P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 172:156-159.
12. Davidson M, Harvey P, Powchik P, Parella M, White L, Knobler H, Lozonczy M, Keeffe R, Katz S, Frescska E. 1995. Severity of symptoms in chronically institutionalized geriatric schizophrenic patients. Am J Psychiatry 152:197-206.
13. 2A receptors in schizophrenia. Schizophr Res 21:133-139.
14. 2 receptors and the serotonin transporter in the schizophrenic brain. Brain Res Behav Brain Res 73:169-175.
15. Erdman J, Shimron-Abarbanell D, Rietschel M, Albus M, Korner J, Bondy B, Chen K, Shih JC, Knapp M, Propping P, Notchen MM. 1996. Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. Hum Genet 97:614-619.
16. Gurevich EV, Joyce JN. 1997. Alterations in the cortical serotonergic system in schizophrenia: a postmortem study, Biol Psychiatry 42:529-545.
17. 2 receptor binding in patients with chronic schizophrenia. Psychopharmacology 112:S35-S39.
18. Hernandez I, Sokolov BP. 1997. Abnormal expression of serotonin transporter mRNA in the frontal and temporal cortex of schizophrenics. Mol Psychiatry 2:57-64.
19. Inayama Y, Yoneda H, Sakai T, Ishida T, Nonomura Y, Kono Y, Takahata R, Koh J, Sakai J, Takai A, Inada Y, Asaba H. 1996. Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia. Am J Med Genet 67:103-105.
20. Joyce JN, Shane A, Lexow N, Winokur A, Casanova MF, Kleinman JE. 1993. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 8:315-336.
21. Kouzmenko AP, Hayes WL, Pereira AM, Dean B, Burnet PW, Harrison PJ. 1997. 5-HT2A receptor polymorphism and steady state receptor expression in schizophrenia. Lancet 439:1815.
22. Laruelle M, Abi-Dargham A, Casanova MF, Toti R, Weinberg DR, Kleinman JE. 1993. Selective abnormalities of prefrontal serotonergic receptors in schizophrenia. A postmortem study. Arch Gen Psychiatry 50:810-818.
23. 18F] setoperone in neuroleptic-naïve patients and normal subjects. Am J Psychiatry 156:72-78.
24. Lidow MS, Birnbaum SG, Goldman-Rakic PS. 1995. Clozapine, haloperidol and remoxipride differentially regulate 5-HT2-serotonergic sites in the primate cerebral cortex. Shizophr Res 15:158.
25. Ma YJ, Costa ME, Ojeda SR. 1994a. Developmental expression of the genes encoding transforming growth factor alpha and its receptor in the hypothalamus of female rhesus macaques. Neuroendocrinology 60:346-359.
26. Ma YJ, Hill DF, Junier MP, Costa ME, Fedler SE, Ojeda SR. 1994b. Expression of epidermal growth factor receptor changes in the hypothalamus during the onset of female puberty. Mol Cell Neurosci 5:246-262.
27. Meltzer HY. 1991. The mechanism of action of novel antipsychotic drugs. Schizophr Bull 17:263-286.
28. 2 and increased dopamine D2 in chronic schizophrenics. Biol Psychiatry 21:1407-1414.
29. O'Dell SJ, La Hoste GJ, Widmark CB, Shapiro RM, Potkin SG, Marshall JF. 1990. Chronic treatment with clozapine or haloperidol differentially regulates dopamine and serotonin receptors in rat brain. Synapse 6:146-153.
30. Ohuoha DC, Hyde TM, Kleinman JE. 1993. The role of serotonin in schizophrenia: an overview of the nomenclature, distribution and alterations of serotonin receptors in the central nervous system. Psychopharmacology 112:S5-S15.
31. Ponte P, Ng SY, Engel J, Gunning P, Kedes L. 1984. Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of human beta-actin cDNA. Nucl Acids Res 12:1687-1996.
32. Purohit DP, Perl DP, Haroutunian V, Powchik P, Davidson D, Davis KL. 1998. Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia. A postmortem neuropathologic study of 100 cases. Arch Gen Psychiatry 55:205-211.
33. Reynolds GP, Possor M, Iversen LL. 1983. Preliminary studies of human cortical 5-HT2 receptors and their involvement in schizophrenia and neuroleptic drug action. J Neural Transm 18:273-277.
34. Saltzman AG., Morse B, Whitman MM, Ivanshchenko Y, Jaye M, Felder S. 1991. Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes. Biochem Biophys Res Commun 181:1469-1478.
35. Schramm M, Falkai P, Tepest R, Schneider-Axmann T, Przkora R, Waha A, Pietsch T, Bonte W, Bayer TA. 1999. Stability of RNA transcripts in post-mortem psychiatric brains. J Neural Transm 106: 329-335.
36. Sokolov BP. 1998. Expression of NMDA, GluR1, GluR7 and KA1 glutamate receptor mRNAs is decreased in frontal cortex of "neuroleptic-free" schizophrenics. Evidence on reversible up-regulation by typical neuroleptics. J Neurochem 71:2454-2464.
37. Spurlock G, Williams J, Daniels J, Owen M, McGuffin P. 1995. The European multi-centre study of susceptibility gene associations in schizophrenia: typing the 5HT-2R gene. Psychiatr Genet 5:S64.
38. Stanta G, Bonin S. 1998. RNA quantitative analysis from fixed and paraffin-embedded tissues: Membrane hybridization and capillary electrophoresis. BioTechniques 24:271-276.
39. Tcherepanov AA, Sokolov BP. 1997. Age related abnormalities in expression of mRNAs encoding synapsin 1A, synapsin 1B and synaptophysin in the temporal cortex of schizophrenics. J Neurosci Res 49:639-644.
40. Weinberger DR, Aloia MS, Goldberg TE, Berman KF. 1994. The frontal lobes and schizophrenia. J Neuropsychiatry Clin Neurosci 6:419-427.
41. Whitaker PM, Crow TJ, Ferrier IN. 1981. Tritiated LSD binding in frontal cortex in schizophrenia. Arch Gen Psychiatry 38:278-280.
42. Wilmot CA, Szczepanik AM. 1989. Effects of acute and chronic treatments with clozapine and haloperidol on serotonin (5-HT2) and dopamine (D2) receptors in the rat brain. Brain Res 487:288-298.
43. Yao JK, van Kammen DP, Moss HB, Sokulski DE. 1996. Decreased responsivity in platelets of drug-free patients with schizophrenia. Psychiatry Res 63:123-132.
44. Zamorano PL, Mahesh VB, Brann DW. 1996. Quantitative RT-PCR for neuroendocrine studies. Neuroendocrinology 63:397-404.