Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry

EMBO Journal

Volumn 22, Issue 20, 2003, Pages 5459-5470

  Janumyan, Yelena M ^a   Sansam, Courtney G ^a   Chattopadhyay, Anuja ^a   Cheng, Ningli ^a   Soucie, Erinn L ^b   Penn, Linda Z ^b   Andrews, David ^c   Knudson, C Michael ^a   Yang, Elizabeth ^a,d  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d MCMASTER UNIVERSITY   (Canada)

Author keywords

Apoptosis; BAD; Bcl 2; Bcl XL; Cell cycle

Indexed keywords

ESTROGEN RECEPTOR; PROTEIN BCL 2; PROTEIN BCL XL; PYRONINE;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL SURVIVAL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; RAT; SARCOPLASMIC RETICULUM; T LYMPHOCYTE ACTIVATION; TUMOR MODEL;

ANIMALIA;

EID: 0142073728     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg533     Document Type: Article

References (35)

1. Asoh, S., Ohtsu, T. and Ohta, S. (2000) The super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL. J. Biol. Chem., 275, 37240-37245.
2. Borner, C., Martinou, I., Mattmann, C., Irmler, M., Schaerer, E., Martinou, J.C. and Tschopp, J. (1994) The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis. J. Cell Biol., 126, 1059-1068.
3. Brady, H.J., Gil-Gomez, G., Kirberg, J. and Berns, A.J. (1996) Bax alpha perturbs T cell development and affects cell cycle entry of T cells. EMBO J., 15, 6991-7001.
4. 1 arrest. Oncogene, 20, 4507-4518.
5. Cheng, E.H., Levine, B., Boise, L.H., Thompson, C.B. and Hardwick, J.M. (1996) Bax-independent inhibition of apoptosis by Bcl-XL. Nature, 379, 554-556.
6. Cheng, E.H., Kirsch, D.G., Clem, R.J., Ravi, R., Kastan, M.B., Bedi, A., Ueno, K. and Hardwick, J.M. (1997) Conversion of Bcl-2 to a Bax-like death effector by caspases. Science, 278, 1966-1968.
7. Darzynkiewicz, Z. (1994) Simultaneous analysis of cellular RNA and DNA content. Methods Cell Biol., 41, 401-420.
8. de La Coste, A., Mignon, A., Fabre, M., Gilbert, E., Porteu, A., Van Dyke, T., Kahn, A. and Perret, C. (1999) Paradoxical inhibition of c-myc-induced carcinogenesis by Bcl-2 in transgenic mice. Cancer Res., 59, 5017-5022.
9. Fang, G., Chang, B.S., Kim, C.N., Perkins, C., Thompson, C.B. and Bhalla, K.N. (1998) "Loop" domain is necessary for taxol-induced mobility shift and phosphorylation of Bcl-2 as well as for inhibiting taxol-induced cytosolic accumulation of cytochrome c and apoptosis. Cancer Res., 58, 3202-3208.
10. Furth, P.A., Bar-Peled, U., Li, M., Lewis, A., Laucirica, R., Jager, R., Weiher, H. and Russell, R.G. (1999) Loss of anti-mitotic effects of Bcl-2 with retention of anti-apoptotic activity during tumor progression in a mouse model. Oncogene, 18, 6589-6596.
11. 1 cyclin-dependent kinases. Oncogene, 21, 7765-7775.
12. 1 cell-cycle progression by oncogenes and tumor suppressor genes. Curr. Opin. Genet. Dev., 12, 47-52.
13. Huang, D.C., O'Reilly, L.A., Strasser, A. and Cory, S. (1997) The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry. EMBO J., 16, 4628-4638.
14. Huang, D.C., Adams, J.M. and Cory, S. (1998) The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. EMBO J., 17, 1029-1039.
15. Kelekar, A., Chang, B.S., Harlan, J.E., Fesik, S.W. and Thompson, C.B. (1997) Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. Mol. Cell. Biol., 17, 7040-7046.
16. Lee, S.T., Hoeflich, K.P., Wasfy, G.W., Woodgett, J.R., Leber, B., Andrews, D.W., Hedley, D.W. and Penn, L.Z. (1999) Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts. Oncogene, 18, 3520-3528.
17. Lind, E.F., Wayne, J., Wang, Q.Z., Staeva, T., Stolzer, A. and Petrie, H.T. (1999) Bcl-2-induced changes in E2F regulatory complexes reveal the potential for integrated cell cycle and cell death functions. J. Immunol., 162, 5374-5379.
18. Linette, G.P., Li, Y., Roth, K. and Korsmeyer, S.J. (1996) Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation. Proc. Natl Acad. Sci. USA, 93, 9545-9552.
19. Mazel, S., Burtrum, D. and Petrie, H.T. (1996) Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death. J. Exp. Med., 183, 2219-2226.
20. Murphy, K.L., Kittrell, F.S., Gay, J.P., Jager, R., Medina, D. and Rosen, J.M. (1999) Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice. Oncogene, 18, 6597-6604.
21. Nguyen, M., Branton, P.E., Walton, P.A., Oltvai, Z.N., Korsmeyer, S.J. and Shore, G.C. (1994) Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus. J. Biol. Chem., 269, 16521-16524.
22. O'Reilly, L.A., Huang, D.C. and Strasser, A. (1996) The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J., 15, 6979-6990.
23. Plas, D.R. and Thompson, C.B. (2002) Cell metabolism in the regulation of programmed cell death. Trends Endocrinol. Metab., 13, 75-78.
24. Plas, D.R., Talapatra, S., Edinger, A.L., Rathmell, J.C. and Thompson, C.B. (2001) Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J. Biol. Chem., 276, 12041-12048.
25. Polymenis, M. and Schmidt, E.V. (1999) Coordination of cell growth with cell division. Curr. Opin. Genet. Dev., 9, 76-80.
26. Srivastava, R.K., Mi, Q.S., Hardwick, J.M. and Longo, D.L. (1999) Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis. Proc. Natl Acad. Sci. USA, 96, 3775-3780.
27. Stocker, H. and Hafen, E. (2000) Genetic control of cell size. Curr. Opin. Genet. Dev., 10, 529-535.
28. Uhlmann, E.J., D'Sa-Eipper, C., Subramanian, T., Wagner, A.J., Hay, N. and Chinnadurai, G. (1996) Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: suppression of apoptosis with concomitant cell proliferation. Cancer Res., 56, 2506-2509.
29. Vail, M.E., Pierce, R.H. and Fausto, N. (2001) Bcl-2 delays and alters hepatic carcinogenesis induced by transforming growth factor alpha. Cancer Res., 61, 594-601.
30. Vail, M.E., Chaisson, M.L., Thompson, J. and Fausto, N. (2002) Bcl-2 expression delays hepatocyte cell cycle progression during liver regeneration. Oncogene, 21, 1548-1555.
31. Vairo, G., Innes, K.M. and Adams, J.M. (1996) Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival. Oncogene, 13, 1511-1519.
32. Kip1, pRB relative p130 and altered E2F regulation. Mol. Cell. Biol., 20, 4745-4753.
33. Vander Heiden, M.G., Chandel, N.S., Schumacker, P.T. and Thompson, C.B. (1999) Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol. Cell, 3, 159-167.
34. Yang, E., Zha, J., Jockel, J., Boise, L.H., Thompson, C.B. and Korsmeyer, S.J. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell, 80, 285-291.
35. Zhu, W., Cowie, A., Wasfy, G.W., Penn, L.Z., Leber, B. and Andrews, D.W. (1996) Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. EMBO J., 15, 4130-4141.