Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: Suppression of apoptosis with concomitant cell proliferation

Cancer Research

Volumn 56, Issue 11, 1996, Pages 2506-2509

  Uhlmann, Erik J ^a   D'Sa Eipper, Cleta ^a   Subramanian, T ^a   Wagner, Andrew J ^b   Hay, Nissim ^b   Chinnadurai, G ^a  

^a S LOUIS UNIV HLTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN; PROTEIN BCL 2; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CARCINOGENESIS; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; ETIOLOGY; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; RAT; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; APOPTOSIS; BASE SEQUENCE; CELL DIVISION; CELLS, CULTURED; DNA PRIMERS; HUMANS; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0029895458     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Tsujimoto, Y., Cossman, J , Jaffe, E., and Croce, C M Involvement of the bcl-2 gene in human follicular lymphoma Science (Washington DC), 228: 1440-1443, 1985.
2. Bakhshi, A., Jensen, J. P., Goldman, P., Wright, J. J., McBride, O. W., Epstein, A. L., and Korsmeyer, S. J. Cloning of the chromosomal breakpoint of t(14,18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18 Cell, 41 899-906, 1985
3. Cleary, M L., Smith, S. D., and Sklar, J. Cloning and structural analysis of cDNAs for bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell. 47: 19-28, 1986.
4. McDonnell, T. J , Troncoso, P , Brisbay, S. M., Logothetis, C., Chung, L W , Hsieh, J T., Tu, S. M . and Campbell, M. L. Expression of the protooncogene bcl-1 in the prostate and its association with emergence of androgen-independent prostate cancer Cancer Res., 52: 6940-6944, 1992.
5. Pezzella, F., Turley, H., Kuzu, I , Tungekar, M. F., Dunnill, M. S , Pierce, C. B , Harris, A., Gatter, K C., and Mason, D Y. Bcl-2 protein in non-small-cell lung carcinoma. N Engl. J Med. 329: 690-694, 1994.
6. Lu, Q. L , Elia, G., Lucas, S., and Thomas, J. A. Bcl-2 proto-oncogene expression in Epstein-Barr-virus-associated nasopharyngeal carcinoma. Int. J. Cancer. 53: 29-35, 1993
7. Korsmeyer, S. J Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood, 80: 879-886, 1992.
8. Reed, J. C. Bcl-2 and the regulation of programmed cell death. J. Cell. Biol . 124: 1-6, 1994.
9. Hawkins, C. J., and Vaux, D. L Analysis of the role of bcl-2 in apoptosis. Immunol. Rev., 142, 127-139, 1994
10. Williams, G. T Programmed cell death: apoptosis and oncogenesis. Cell. 65: 1097-1098, 1991
11. Vaux, D L., Cory, S., and Adams, J. M. bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature (Lond.), 335: 440-442, 1988.
12. Askew, D S , Ashmun, R. A , Simmons, B. C , and Cleveland, J. L Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene, 6. 1915-1922, 1991
13. Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood T. D. Land H., Brooks, M., Waters, C M., Penn, L. Z., and Hancock, D. C. Induction of apoptosis in fibroblasts by c-myc protein. Cell, 69: 119-128, 1992
14. Wagner, A. J., Small, M. B., and Hay, N. Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2 Mol Cell. Biol., 13: 2432-2440, 1993.
15. Bissonnette, R. P., Echeverri, F., Mahboubi, A., and Green, D. R. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature (Lond ), 359: 552-554, 1992.
16. Fanidi, A , Harrington, E. A., and Evan, G I. Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature (Lond.), 359: 554-556, 1992
17. Ryan, J. J., Prochewnik, E., Gottlieb, C. A., Apel, I. J., Merino, R., Nunez, G., and Clarke, M. F. c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. Proc. Natl. Acad Sci USA. 91: 5878-5882. 1994.
18. Miyashita, T. Harigai, M. Hanada, M., and Reed, J C Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res, 54: 3131-3135. 1994.
19. Selvakumaran, M., Lin, H. K., Miyashita, T , Wang, H. G., Krajewski, S., Reed, J. C., Hoffman, B , and Liebermann, D. Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways. Oncogene, 9: 1791-1798, 1994.
20. Chiou, S. K., Rao, L., and White, E. Bcl-2 blocks p53-dependent apoptosis Mol Cell. Biol. 14: 2556-2563, 1994.
21. Subramanian, T., Boyd, J. M., and Chinnadurai, G Functional substitution identifies a cell survival promoting domain common to adenovirus E1B 19 kDa and Bcl-2 proteins. Oncogene, 11. 2404-2409, 1995.
22. Seto, M , Jaeger, U. Hockett, R. D., Graniger, W., Bennett, S., Goldman, P., and Korsmeyer, S J Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma EMBO J , 7: 123-131, 1988.
23. Fuerst, T. R., Earl, P. L , and Moss, B Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes. Mol Cell Biol., 7: 2538-2544, 1987.
24. Wagner, A. J., Kokontis, J. M., and Hay, N. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. Genes & Dev. 8: 2817-2830, 1994.
25. Boyd, J M., Malstrom, S., Subramanian, T., Venkatesh, L. K., Schaeper, U., Elangovan, B , D'Sa-Eipper, C., and Chinnadurai, G. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell, 79: 341-351, 1994
26. Oren, M. Relationship of p53 to the control of apoptotic cell death. Semin. Cancer Biol., 5: 221-227, 1994.
27. Michalovitz, D., Halevy, O., and Oren, M. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell, 62, 671-680, 1990.
28. Debbas, M , and White, E. Wild-type p53 mediates apoptosis by E1A which is inhibited by E1B. Genes & Dev., 7: 546-554, 1993.
29. Chien, C. T., Bartel, P L., Sternglanz, R., and Fields, S. The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. Proc. Natl. Acad. Sci. USA. 88: 9578-9582, 1991.
30. Wang, H-G , Miyashita, T , Takayama, S., Sato, T., Torigoe, T , Krajewski, S., Tanaka, S., Hovey, L , III, Troppmair, J., Rapp, U. R , and Reed, J C. Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. Oncogene, 9: 2751-2756, 1994.
31. Chittenden, T. Harrington, E. A., O'Connor, R., Flemington, C., Lutz, R. J., Evan, G. I., and Guild, B. C. Induction of apoptosis by the Bcl-2 homologue Bak. Nature (Lond.), 374, 733-736, 1995
32. Boyd, J M., Gallo, J. G., Elangovan, B., Houghton, A. B., Malstrom, S . Avery, B J , Ebb, R G., Subramanian, T., Chittenden, T , Lutz, R. J , and Chinnadurai, G. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival- promoting proteins Oncogene, 11, 1921-1928, 1995
33. Oltvai, Z. N., Milliman, C. K , and Korsmeyer, S. J Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death Cell, 74: 609-619, 1993
34. Haldar, S., Jena, N., and Croce, C. M. Inactivation of Bcl-2 by phosphorylation Proc. Natl. Acad. Sci. USA, 92, 4507-4511, 1995
35. Henderson, S , Huen, D., Rowe, M , Dawson, C., Johnson, G , and Rickinson, A Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2. protects human B cells from programmed cell death. Proc. Natl Acad. Sci USA, 90, 8479-8483. 1993.
36. Tarodi, B , Subramanian, T., and Chinnadurai, G. Epstein-Barr virus, BHRF1 protein protects against cell death induced by DNA-damaging agents and heterologous viral infection. Virology, 201: 404-407, 1994
37. Takayama, S., Cazals-Hatem, D. L., Kitada, S, Tanaka, S , Miyashita, T., Hovey, L. R., Huen, D , Rickinson, A , Veerapandian, P , Krajewski, S., Saito, K., and Reed. J. C. Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2oncoprotein. DNA Cell Biol , 13, 679-692, 1994
38. Theodorakis, P , D'Sa-Eipper, C., Subramanian, T . and Chinnadurai, G. L'nmasking of a proliferation-restraining activity of the anti-apoptosis protein EBV BHRF1 Oncogene, in press, 1996.
39. Sato, T., Hanada, M , Bodrug, S., Trie, S., Iwana, N., Boise, L H., Thompson, C B., Golemis, E . Fong, L., Wang, H G., and Reed, J. C. Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system Proc. Natl. Acad. Sci. USA, 91: 9238-9242, 1994.