Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest

Cancer Research

Volumn 59, Issue 24, 1999, Pages 6145-6152

  Moasser, Mark M ^a,b   Srethapakdi, Mary ^b,c   Sachar, Komal S ^b   Kraker, Alan J ^d   Rosen, Neal ^a,b  

^a Department of Medicine ^*  (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c Laboratory of Molecular Biology and Biochemistry   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (2,6 DICHLOROPHENYL) 8 METHYL 2 (3 METHYLTHIOANILINO) 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; CYCLIN A; CYCLIN B; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME CONDENSATION; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROPHASE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; GENES, SRC; HUMANS; MITOSIS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-YES; PYRIDONES; PYRIMIDINES; SRC-FAMILY KINASES; TUMOR CELLS, CULTURED;

EID: 0033572412     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Parsons, J. T., and Parsons, S. J. Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways. Curr. Opin. Cell Biol., 9: 187-192, 1997.
2. Erpel, T., and Courtneidge, S. A. Src family protein tyrosine kinases and cellular signal transduction pathways. Curr. Opin. Cell Biol., 7: 176-182, 1995.
3. Stehelin, D., Varmus, H. E., Bishop, J. M., and Vogt, P. K. DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature (Lond.), 260: 170-173, 1976.
4. Collett, M. S., Brugge, J. S., and Erikson, R. L. Characterization of a normal avian cell protein related 10 the avian sarcoma virus transforming gene product. Cell, 15: 1363-1369, 1978.
5. Brickell, P. M. The p60c-src family of protein-tyrosine kinases: structure, regulation, and function. Crit. Rev. Oncog., 3: 401-446, 1992.
6. Courtneidge, S. A. Protein tyrosine kinases, with emphasis on the Src family. Semin. Cancer Biol., 5: 239-246, 1994.
7. Muthuswamy, S. K., and Muller, W. J. Activation of the Src family of tyrosine kinases in mammary tumorigenesis. Adv. Cancer Res., 64: 111-123, 1994.
8. Irby, R. B. M., and Fujita, D. J. J. Activating SRC mutation in a subset of advanced human colon cancers. Nat. Genet., 21: 187-190, 1999.
9. Guy, C. T., Webster, M. A., Schaller, M., Parsons, T. J., Cardiff, R. D., and Muller, W. J. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc. Natl. Acad. Sci. USA, 89: 10578-10582, 1992.
10. Guy, C. T., Muthuswamy, S. K., Cardiff, R. D., Soriano, P., and Muller, W. J. Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev., 8: 23-32, 1994.
11. Muthuswamy, S. K., Siegel, P. M., Dankort, D. L., Webster, M. A., and Muller, W. J. Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity. Mol. Cell. Biol., 14: 735-743, 1994.
12. Roche, S., Koegl, M., Barone, M. V., Roussel, M. F., and Courtneidge, S. A. DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases. Mol. Cell. Biol., 15, 1102-1109, 1995.
13. Twamley-Stein, G. M., Pepperkok, R., Ansorge, W., and Courtneidge, S. A. The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells. Proc. Natl. Acad. Sci. USA, 90: 7696-7700, 1993.
14. Li, S., Couet, J., and Lisanti, M. P. Src tyrosine kinases, Gα subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J. Biol. Chem., 271: 29182-29190, 1996.
15. Chackalaparampil, I., and Shalloway, D. Altered phosphorylation and activation of pp60c-src during fibroblast mitosis. Cell, 52: 801-810, 1988.
16. David-Pfeuty, T., and Nouvian-Dooghe, Y. Immunolocalization of the cellular src protein in interphase and mitotic NIH c-src overexpresser cells, J. Cell Biol., 111: 3097-3116, 1990.
17. Shenoy, S., Choi, J. K., Bagrodia, S., Copeland, T. D., Maller, J. L., and Shalloway, D. Purified maturation promoting factor phosphorylates pp60c-src at the sites phosphorylated during fibroblast mitosis. Cell, 57: 763-774, 1989.
18. 2 for fibroblast cell division. Science (Washington DC), 269: 1567-1569, 1995.
19. Lowell, C. A., and Soriano, P. Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Genes Dev., 10: 1845-1857, 1996.
20. Taylor, S. J., and Shalloway, D. An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis. Nature (Lond.), 368: 867-871, 1994.
21. Fumagalli, S., Totty, N. F., Hsuan, J. J., and Courtneidge, S. A. A target for Src in mitosis. Nature (Lond.), 368: 871-874, 1994.
22. 2/M-phase subpopulations in mammalian cell nuclei using side scatter and DNA content measurements. Cytometry, 11: 813-821, 1990.
23. Hunter, T. A tale of two srcs: mutatis mutandis. Cell, 49: 1-4, 1987.
24. Osusky, M., Taylor, S. J., and Shalloway, D. Autophosphorylation of purified c-Src at its primary negative regulation site. J. Biol. Chem., 270, 25729-25732, 1995.
25. Superti-Furga, G., and Courtneidge, S. A. Structure-function relationships in Src family and related protein tyrosine kinases. BioEssays, 17: 321-330, 1995.
26. Cooper, J. A., and Howell, B. The when and how of src regulation. Cell, 73: 1051-1054, 1993.
27. c-src. Mol. Cell. Biol., 8: 4541-4546, 1999.
28. cdc2-associated protein kinase. Cell, 57: 775-786, 1989.
29. Stover, D. R., Liebetanz, J., and Lydon, N. B. Cdc2-mediated modulation of pp60c-src activity. J. Biol. Chem., 269: 26885-26889, 1994.
30. Shenoy, S., Chackalaparampil, I., Bagrodia, S., Lin, P. H., and Shalloway, D. Role of p34cdc2-mediated phosphorylations in two-step activation of pp60c-src during mitosis. Proc. Natl. Acad. Sci. USA. 89: 7237-7241, 1992.
31. Ohsato, Y., Nada, S., Okada, M., and Nakagawa, H. Mitotic activation of c-Src is suppressed by Csk. Jpn. J. Cancer Res., 85: 1023-1028, 1994.
32. -/- mutant mice. Genes Dev., 11: 2835-2844, 1997.
33. Lin, J., Tao, J., Dyer, R. B., Herzog, N. K., and Justement, L. B. Kinase-independent potentiation of B cell antigen receptor-mediated signal transduction by the protein tyrosine kinase Src. J. Immunol., 159: 4823-4833, 1997.
34. Abu-Amer, Y., Ross, F. P., Schlesinger, P., Tondravi, M. M., and Teitelbaum, S. L. Substrate recognition by osleoclast precursors induces C-src/microtubule association. J. Cell Biol., 137: 247-258, 1997.
35. Matten, W. T., Aubry, M., West, J., and Maness, P. F. Tubulin is phosphorylated at tyrosine by pp60c-src in nerve growth cone membranes. J. Cell Biol., 111: 1959-1970, 1990.
36. Maa, M. C., Leu, T. H., McCarley, D. J., Schatzman, R. C., and Parsons, S. J. Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers. Proc. Natl. Acad. Sci. USA, 92: 6981-6985, 1995.
37. Stukenberg, P. T., Lustig, K. D., McGarry, T. J., King, R. W., Kuang, J., and Kirschner, M. W. Systematic identification of mitotic phosphoproteins. Curr. Biol., 7: 338-348, 1997.
38. King, R. W., Jackson, P. K., and Kirschner, M. W. Mitosis in transition. Cell, 79: 563-571, 1994.
39. Rudd, C. E., Janssen, O., Prasad, K. V. S., Raab, M., DaSilva, A., Telfer, J. C., and Yamamoto, M. Src-related protein tyrosine kinases and their surface receptors. Biochim. Biophys. Acta, 1155: 239-266, 1993.
40. Maness, P. F., Beggs, H. E., Klinz, S. G., and Morse, W. R. Selective neural cell adhesion molecule signaling by Src family tyrosine kinases and tyrosine phosphatases. Perspect. Dev. Neurobiol., 4: 169-181, 1996.
41. Rahimi, N., Hung, W., Tremblay, E., Saulnier, R., and Elliolt, B. c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells. J. Biol. Chem., 273: 33714-33721, 1998.
42. Hall, C. L., Lange, L. A., Prober, D. A., Zhang, S., and Turley, E. A. pp60(c-src) is required for cell locomotion regulated by the hyaluronan receptor RHAMM. Oncogene, 13: 2213-2224, 1996.
43. Chaturvedi, P., Reddy, M. V., and Reddy, E. P. Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation. Oncogene, 16: 1749-1758, 1998.
44. Arbet-Engels, C., Tartare-Deckert, S., and Eckhart, W. C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor. J. Biol. Chem., 274: 5422-5428, 1999.
45. Rahimi, N., Hung, W., Tremblay, E., Saulnier, R., and Elliott, B. c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells. J. Biol. Chem., 273: 33714-33721, 1998.
46. Marchetti, D., Parikh, N., Sudol, M., and Gallick, G. E. Stimulation of the protein tyrosine kinase c-Yes but not c-Src by neurotrophins in human brain-metastatic melanoma cells. Oncogene, 16: 3253-3260, 1998.
47. Luttrell, D. K., Lee, A., Lansing, T. J., Crosby, R. M., Jung, K. D., Willard, D., Luther, M., Rodriguez, M., Berman, J., and Gilmer, T. M. Involvement of pp60c-src with two major signaling pathways in human breast cancer. Proc. Natl. Acad. Sci. USA, 91: 83-87, 1994.
48. Muthuswamy, S. K., and Muller, W. J. Activation of Src family kinases in Neuinduced mammary tumors correlates with their association with distinct sets of tyrosine phosphorylated proteins in vivo. Oncogene, 11: 1801-1810, 1995.
49. Stover, D. R., Becker, M., Leibetanz, J., and Lydon, N. B. Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and p85α. J. Biol. Chem., 270: 15591-15597, 1995.