Disturbances of the blood-brain barrier without expression of amyloid precursor protein-containing neuritic clusters or neuronal loss during late stages of thiamine deficiency in guinea pigs

Developmental Neuroscience

Volumn 20, Issue 4-5, 1998, Pages 454-461

  Calingasan, Noel Y ^a   Park, Larry C H ^a   Gandy, Samuel E ^b   Gibson, Gary E ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Blood brain barrier; Oxidative damage; Thiamine deficiency

Indexed keywords

AMYLOID PRECURSOR PROTEIN; FERRITIN; IMMUNOGLOBULIN G; IRON; NITRIC OXIDE; PYRITHIAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; BLOOD BRAIN BARRIER; BRAIN REGION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRAVASATION; GUINEA PIG; IMMUNOREACTIVITY; MALE; MICROVASCULATURE; NERVE DEGENERATION; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; THIAMINE DEFICIENCY;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; BRAIN; CELL COUNT; FERRITINS; GUINEA PIGS; HISTOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IRON; MALE; NADPH DEHYDROGENASE; NEURITES; NEURONS; THIAMINE DEFICIENCY;

EID: 0031788434     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017343     Document Type: Conference Paper

References (40)

1. Gibson GE, Sheu K-FR, Baker AC, Carlson KC, Harding B, Perrino P: Reduced activities of thiamine-dependent enzymes in brains and peripheral tissues of Alzheimer patients. Arch Neurol 1988;45:836-840.
2. Mastrogiacomo F, Bergeron C, Kish SJ: Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. J Neurochem 1993;61:2007-2014.
3. Sheu K-FR, Cooper AJL, Koike K, Koike M, Lindsay JG, Blass JP: Abnormality of the α-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease. Ann Neurol 1994;35:312-318.
4. Witt ED: Neuroanatomical consequences of thiamine deficiency: A comparative analysis. Alcohol 1985;2:201-221.
5. Barclay LL, Gibson GE, Blass JP: Impairment of behavior and acetylcholine metabolism in thiamine deficiency. J Pharmacol Exp Ther 1981;217:537-543.
6. Langlais PJ, Savage LM: Thiamine deficiency in rats produces cognitive and memory deficits on spatial tasks that correlate with tissue loss in diencephalon, cortex and white matter. Behav Brain Res 1997;68:75-89.
7. Calingasan NY, Baker H, Sheu K-FR, Gibson GE: Blood-brain barrier abnormalities in vulnerable brain regions during thiamine deficiency. Exp Neurol 1995;134:64-72.
8. Harata N, Iwasaki Y: Evidence for early blood-brain barrier breakdown in experimental thiamine deficiency in the mouse. Metab Brain Dis 1995;10:159-174.
9. Calingasan NY, Gandy SE, Baker H, Sheu K-FR, Kim K-S, Wisniewski HM, Gibson GE: Accumulation of amyloid precursor protein-like immunoreactivity in rat brain in response to thiamine deficiency. Brain Res 1995;677: 50-60.
10. Calingasan NY, Gandy SE, Baker H, Sheu K-FR, Smith JD, Lamb BT, Gearhart JD; Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS, Gibson GE: Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. Am J Pathol 1996;149: 1063-1071.
11. Johnstone EM, Chaney MO, Norris FH, Pascual R, Little SP: Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis. Mol Brain Res 1991;10:299-305.
12. De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K, Dotti CG: Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. EMBO J 1995;14:4932-4938.
13. Otvos LJ, Szendrei GI, Lee VM, Mantsch HH: Human and rodent Alzheimer's beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents. Eur J Biochem 1993;211:249-257.
14. Perusini G: Histologische und histopathologische Arbeiten über die Grosshirnrinde; in Nissl F (ed). Jena, Fischer, 1910, vol 3, pp 297-458.
15. Calingasan NY, Park LCH, Trifiletti RR, Gandy SE, Gibson GE: Induction of nitric oxide and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism. Am J Pathol 1998;153:599-610.
16. Schmidt-Kastner R, Meller D, Bellander B-M, Stromberg I, Olson L, Ingvar M: A one-step immunohistochemical method for detection of blood-brain barrier disturbances for immunoglobulins in lesioned rat brain with special reference to false positive labelling in immunohistochemistry. J Neurosci Methods 1993;46: 121-132.
17. Matsumoto T, Nakane M, Pollock JS; Kuk JE, Forstermann U: A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase activity is only seen after exposure of the tissue to fixative. Neurosci Lett 1993;155: 61-64.
18. Hsu S, Raine L, Fanger H: Use of avidin-biotin-peroxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981;29:577-580.
19. Bhasin R, Van Nostrand W, Saitoh T, Donets M, Barnes E, Quitschke W, Goldgaber D: Expression of active secreted forms of human amyloid β-protein precursor by recombinant baculovirus-infected cells. Proc Natl Acad Sci USA 1991;88:10307-10311.
20. Buxbaum JD, Gandy SE, Cicchetti P, Ehrlich ME, Czernik AJ, Fracasso PJ, Ramabhadran T, Unterbeck AJ, Greengard P: Processing of Alzheimer β/A4-amyloid precursor protein: Modulation by agents that regulate protein phosphorylation. Proc Natl Acad Sci USA 1990;87:6003-6006.
21. Caporaso GL, Gandy SE, Buxbaum JD, Greengard P: Chloroquine inhibits intracellular degradation but not secretion of Alzheimer β/A4 amyloid precursor protein. Proc Natl Acad Sci USA 1992;89:2252-2256.
22. Gandy SE, Bhasin R, Ramabhadran TV, Koo EH, Price DL, Goldgaber D, Greengard P: Alzheimer β/A4 amyloid precursor protein: Evidence for putative amyloidogenic fragment. J Neurochem 1992;58:383-386.
23. Nordstedt C, Gandy SE, Alafuzoff I, Caporaso GL, Iverfeldt K, Grebb JA, Winblad B, Greengard P: Alzheimer β/A4 amyloid precursor protein in human brain: Aging-associated increases in holoprotein and in a proteolytic fragment. Proc Natl Acad Sci USA 1991;88:8910-8914.
24. Suzuki T, Nairn AC, Gandy SE, Greengard P: Phosphorylation of Alzheimer amyloid precursor protein by protein kinase. Neuroscience 1992;48:755-761.
25. Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB: Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 1992;359: 322-325.
26. Hill JM, Switzer RC: The regional distribution and cellular localization of iron in the rat brain. Neuroscience 1984;11:595-603.
27. Kondo Y, Ogawa N, Asanuma M, Ota Z, Mori A: Regional differences in late-onset iron deposition, ferritin, transferrin, astrocyte proliferation, and microglial activation after transient forebrain ischemia in rat brain. J Cereb Blood Flow Metab 1995;15:216-226.
28. Leigh PN, Connick JH, Stone TW: Distribution of NADPH-diaphorase positive cells in the rat brain. Comp Biochem Physiol 1990;97: 259-264.
29. Vincent SR, Kimura H: Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 1992;46:755-784.
30. Ouimet CC, Baerwald KD, Gandy SE, Greengard P: Immunocytochemical localization of amyloid precursor protein in rat brain. J Comp Neurol 1994;348:244-260.
31. Qi Y, Jamindar TM, Dawson G: Hypoxia alters iron homeostasis and induces ferritin synthesis in oligodendrocytes. J Neurochem 1995;64:2458-2464.
32. Phillips SC, Cragg BG: Blood-brain barrier dysfunction in thiamine-deficient, alcohol-treated rats. Acta Neuropathol 1984;62:235-241.
33. La Selva M, Beltramo E, Pagnozzi F, Bena E, Molinatti PA, Molinatti GM, Porta M: Thiamine corrects delayed replication and decreases production of lactate and advanced glycation end-products in bovine retinal and human umbilical vein endothelial cells cultured under high glucose conditions. Diabetologia 1996;39:1263-1268.
34. Romero IA, Rist RJ, Aleshaiker A, Abbott NJ: Metabolic and permeability changes caused by thiamine deficiency in immortalized rat brain microvessel endothelial cells. Brain Res 1997; 756:133-140.
35. Langlais PJ, Anderson G, Gui SX, Bondy SC: Increased cerebral free radical production during thiamine deficiency. Metab Brain Dis 1997;12:137-143.
36. Todd KG, Butterworth RF: Evidence that oxidative stress plays a role in neuronal cell death due to thiamine deficiency. J Neurochem 1997: 69:S136A.
37. Mannering GJ: Vitamin requirements of guinea pig. Vitam Horm 1949;7:201-221.
38. Ghosh MK, Chattopadhyay DJ, Chatterjee IB: Vitamin C prevents oxidative damage. Free Radic Res 1996;25:173-179.
39. Cadenas S, Rojas C, Perez-Campo R, Lopez-Torres M, Barja G: Effect of dietary vitamin C and catalase inhibition of antioxidants and molecular markers of oxidative damage in guinea pigs. Free Radic Res 1994;21:109-118.
40. Chakraborty S, Nandi A, Mukhopadhyay M, Mukhopadhyay CK, Chatterjee IB: Ascorbate protects guinea pig tissues against lipid peroxidation. Free Radic Biol Med 1994;16:417-426.