Indole amide hydroxamic acids as potent inhibitors of histone deacetylases

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 11, 2003, Pages 1897-1901

  Dai, Yujia ^a   Guo, Yan ^a   Guo, Jun ^a   Pease, Lori J ^a   Li, Junling ^a   Marcotte, Patrick A ^a   Glaser, Keith B ^a   Tapang, Paul ^a   Albert, Daniel H ^a   Richardson, Paul L ^a   Davidsen, Steven K ^a   Michaelides, Michael R ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; HYDROXAMIC ACID DERIVATIVE; INDOLAMIDE HYDROXAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER MODEL; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH;

EID: 12444313031     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00301-9     Document Type: Article

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22. 50 values for all compounds are from a single determination.
23. 50 of cell growth inhibition was determined using the procedure described by note 19 in ref 13a.