Teratogen-Induced Activation of the Mitochondrial Apoptotic Pathway in the Yolk Sac of Day 9 Mouse Embryos

Birth Defects Research Part A - Clinical and Molecular Teratology

Volumn 67, Issue 2, 2003, Pages 98-107

  Soleman, Donna ^a   Cornel, Leanne ^a   Little, Sally A ^a   Mirkes, Philip E ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROPEROXYCYCLOPHOSPHAMIDE; CASPASE; CASPASE 3; CYTOCHROME C; DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 2; PROCASPASE 3; PROCASPASE 9; STAUROSPORINE; TERATOGENIC AGENT; UNCLASSIFIED DRUG; CASP3 PROTEIN, MOUSE; CYCLOPHOSPHAMIDE; DRUG DERIVATIVE; FETOPROTEIN; PERFOSFAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; ENZYME ACTIVITY; FEMALE; HYPERTHERMIA; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; MITOCHONDRION; MOUSE; NEUROEPITHELIUM; NONHUMAN; PRIORITY JOURNAL; TERATOGENESIS; YOLK SAC; ANIMAL; ANTIBODY SPECIFICITY; COMPARATIVE STUDY; DRUG EFFECT; DRUG RESISTANCE; ENZYME ACTIVATION; FETUS HEART; GESTATIONAL AGE; HEAD; HEAT; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CYCLOPHOSPHAMIDE; DRUG RESISTANCE; ENZYME ACTIVATION; FEMALE; FETAL HEART; FETAL PROTEINS; GESTATIONAL AGE; HEAD; HEAT; MICE; MITOCHONDRIA; ORGAN CULTURE TECHNIQUES; ORGAN SPECIFICITY; PREGNANCY; STAUROSPORINE; TERATOGENS; YOLK SAC;

EID: 0141889511     PISSN: 15420752     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdra.10005     Document Type: Article

References (49)

1. Adams JM, Corey S. 1998. The Bcl-2 protein family: arbiters of cell survival. Science 281:1322-1325.
2. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J. 1996. Human ICE/CED-3 protease nomenclature. Cell 87:171.
3. Antonsson B, Martinou J-C. 2000. The Bcl-2 protein family. Exp Cell Res 256:50-57.
4. Berk M, Desai SY, Heyman HC, Colmenares C. 1997. Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial patterning, and skeletal muscle development. Genes Dev 11:2029-2039.
5. Cecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P. 1998. Apaf1 (CED-4 homologue) regulates programmed cell death in mammalian development. Cell 94:727-737.
6. Chang HY, Yang X. 2000. Proteases for cell suicide: functions and regulation of caspases. Microbiol Mol Biol Rev 64:821-846.
7. Datta SP, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. 1997. Phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
8. Dunty WC, Chen S-Y, Zucker RM, Dehart DB, Sulik KK. 2001. Selective vulnerability of embryonic cell populations to ethanol-induced apoptosis: Implications for alcohol-related birth defects and neurodevelopmental disorder. Alcohol Clin Exp Res 25:1523-1535.
9. Ellis HM, Horvitz HR. 1986. Genetic control of programmed cell death in the nematode C. elegans. Cell 75:817-829.
10. Faleiro L, Kobayashi R, Feamhead H, Lazebnik Y. 1997. Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells. EMBO J 16:2271-2281.
11. Freeman SJ. 1990. Functions of extraembryonic membranes. In: Copp AJ, Cockroft DL, editors. Postimplantation mammalian embryos: a practical approach. New York: IRL Press. p 249-265.
12. Gao X, Blackburn MR, Knudsen TB. 1994. Activation of apoptosis in early mouse embryos by 2-deoxyadenosine exposure. Teratology 49:1-12.
13. Glucksman A. 1951. Cell deaths in normal vertebrate ontogeny. Biol Rev 26:59-86.
14. Honarpour N, Gilbert SL, Lahn BT, Wang X, Herz J. 2001. Apaf1 deficiency and neural tube defects are found in fog mice. Proc Natl Acad Sci USA 98:9683-9687.
15. Jacobson MD, Weil M, Raff MC. 1997. Programmed cell death in animal development. Cell 88:347-354.
16. Jurgensmeirer JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC. 1998. Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA 95:4997-5002.
17. Kharbanda S, Pandey P, Schofield L, Israels S, Roncinske R, Yoshida K, Bharti A, Yuan ZM, Saxena S, Weichselbaum R, Nalin C, Kufe D. 1997. Role for Bcl-xL as an inhibitor of cytosolic cytochrome c accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci USA 94:6939-6942.
18. Kim CN, Wang X, Huang Y, lbrado AM, Liu L, Fang G, Bhalla K. 1997. Overexpression of Bcl-X(L) inhibits Ara-c-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res 57:3115-3120.
19. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. 1997. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136.
20. Knudsen TB. 1997. Cell death. In: Kavlock RJ, Daston GP, editors. Drug toxicity in embryonic development, vol. 124/I. New York: Springer. p 211-244.
21. Korsmeyer SJ. 1999. BCL-2 gene family and the regulation of programmed cell death. Cancer Res 59(Suppl):1693S-1700S.
22. Kuan C-Y, Yang DD, Roy DRS, Davis RJ, Rakic P, Flavell RA. 1999. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during brain development. Neuron 22:667-676.
23. Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell RA. 1996. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:368-372.
24. Kuida K. 2000. Caspase-9. Int J Biochem Cell Biol 32:121-124.
25. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
26. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. 1997a. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease. Cell 91:479-489.
27. Li H, Bergeron L, Cryns V, Pasternack MS, Zhu H, Shi L, Greenberg A, Yuan J. 1997b. Activation of caspase-2 in apoptosis. J Biol Chem 272:21010-21017.
28. Mirkes PE. 1985a. Cyclophosphamide teratogenesis: a review. Teratogen Carcinogen Mutagen 5:75-88.
29. Mirkes PE. 1985b. Effects of acute exposures to elevated temperatures on rat embryo growth and development in vitro. Teratology 32:259-266.
30. Mirkes PE, Ellison A, Little SA. 1991. Resistance of rat embryonic heart cells to the cytotoxic effects of cyclophosphamide does not involve aldehyde dehydrogenase-mediated metabolism. Teratology 43:307-318.
31. Mirkes PE, Little SA. 1998. Teratogen-induced cell death in postimplantation mouse embryos: differential tissue sensitivity and hallmarks of apoptosis. Cell Death Diff 5:592-600.
32. Mirkes PE, Little SA. 2000. Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. Toxicol Appl Pharmacol 162:197-206.
33. Mirkes PE. 2002. 2001 Warkany lecture: to die or not to die, the role of apoptosis in normal and abnormal mammalian development. Teratology 65:228-239.
34. New DAT. 1978. Whole embryo culture and the study of mammalian embryos during organogenesis. Biol Rev 53:81-122.
35. Reed JC. 1998. Bcl-2 family proteins. Oncogene 17:3225-3236.
36. Saunders JW Jr, Gasseling MT. 1962. Cellular death in morphogenesis of the avian wing. Dev Biol 5:147-178.
37. Scheid MP, Woodgett JR. 2001. PKB/AKT: Functional Insights from genetic models. Nat Rev Mol Cell Biol 2:760-768.
38. Schendel SL, Montal M, Reed JC. 1998. Bcl-2 family proteins as ion-channels. Cell Death Diff 5:372-380.
39. Scott WJ. 1977. Cell death and reduced proliferative rate. In: Wilson JG, Fraser FC, editors. Handbook of teratology, vol. 2. New York: Plenum. p 81-98.
40. Srinivasan A, Roth KA, Sayers RO, Shindler KS, Wong AM, Fritz LC, Tomaselli KJ. 1998. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system. Cell Death Diff 5:1004-1016.
41. Strasser A, O'Connor L, Dixit VM. 2000. Apoptosis signaling. Ann Rev Biochem 69:217-245.
42. Stroh C, Schulze-Osthoff K. 1998. Death by a thousand cuts: An ever-increasing list of caspase substrates. Cell Death Diff 5:997-1000.
43. Sulik KK, Cook CS, Webster WS. 1988. Teratogens and craniofacial malformations: relationships to cell death. Development 103(Suppl): 213-232.
44. Thayer JM, Mirkes PE. 1995. Programmed cell death and N-acetoxy-2-acetylaminofluorene-induced apoptosis in the rat embryo. Teratology 51:418-429.
45. Umpierre CC, Little SA, Mirkes PE. 2001. Co-localization of active caspase-3 and DNA fragmentation (TUNEL) in normal and hyperthermia-induced abnormal mouse development. Teratology 63:134-143.
46. Wolter KG, Hsu Y-T, Smith C L, Nechushtan A, Xi XG, Youle RJ. 1997. Movement of Bax from cytosol to mitochondria during apoptosis. J Cel Biol 139:1281-1292.
47. Xue D, Horvitz HR. 1995. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 377:248-251.
48. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng T-I, Jones DP, Wang X. 1997. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275:1129-1132.
49. Zha JP, Harada H, Yang E, Jockel J, Korsmeyer SJ. 1996. Serine phosphorylation of death agonist bad in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87:619-628.