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Volumn 2, Issue 6, 2003, Pages 332-338

Atherosclerosis: Anti-inflammatory and immunomodulatory activities of statins

Author keywords

Atherosclerosis; Cholesterol lowering; Immunomodulation; Inflammation; Statins

Indexed keywords

CD11 ANTIGEN; CD40 ANTIGEN; COLLAGEN; CYCLIN DEPENDENT KINASE INHIBITOR; DIMETHYLALLYLTRANSFERASE; FARNESYL DIPHOSPHATE; GAMMA INTERFERON; GELATINASE B; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; LOW DENSITY LIPOPROTEIN RECEPTOR; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEVALONIC ACID; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PADGEM PROTEIN; PROTEIN P27; RAS PROTEIN; RHO FACTOR; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0141750424     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1568-9972(03)00049-1     Document Type: Review
Times cited : (99)

References (40)
  • 1
    • 0035936802 scopus 로고    scopus 로고
    • Atherosclerosis: The road ahead
    • Glass C.K., Witztum J.L. Atherosclerosis: the road ahead. Cell. 104:2001;503-516.
    • (2001) Cell , vol.104 , pp. 503-516
    • Glass, C.K.1    Witztum, J.L.2
  • 2
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis: An inflammatory disease
    • Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 340:1999;115-126.
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 3
    • 0034116663 scopus 로고    scopus 로고
    • Changing concepts of atherogenesis
    • Libby P. Changing concepts of atherogenesis. J Intern Med. 247:2000;349-358.
    • (2000) J Intern Med , vol.247 , pp. 349-358
    • Libby, P.1
  • 4
  • 5
    • 0033984125 scopus 로고    scopus 로고
    • The evolving role of statins in the management of atherosclerosis
    • Vaughan C.J., Gotto A.M., Basson C.T. The evolving role of statins in the management of atherosclerosis. J Am Coll Cardiol. 35:2000;1-10.
    • (2000) J Am Coll Cardiol , vol.35 , pp. 1-10
    • Vaughan, C.J.1    Gotto, A.M.2    Basson, C.T.3
  • 6
    • 0035572718 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
    • Takemoto M., Liao J.K. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arterioscler Thromb Vasc Biol. 21:2001;1712-1719.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1712-1719
    • Takemoto, M.1    Liao, J.K.2
  • 7
    • 0031032831 scopus 로고    scopus 로고
    • Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month
    • O'Driscoll G., Green D., Taylor R.R. Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation. 95:1997;1126-1131.
    • (1997) Circulation , vol.95 , pp. 1126-1131
    • O'Driscoll, G.1    Green, D.2    Taylor, R.R.3
  • 8
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • Laufs U., La Fata V., Plutzky J., Liao J.K. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation. 97:1998;1129-1135.
    • (1998) Circulation , vol.97 , pp. 1129-1135
    • Laufs, U.1    La Fata, V.2    Plutzky, J.3    Liao, J.K.4
  • 9
    • 0035192759 scopus 로고    scopus 로고
    • Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits
    • Rikitake Y., Kawashima S., Takeshita S., Yamashita T., Azumi H., Yasuhara M., et al. Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits. Atherosclerosis. 154:2001;87-96.
    • (2001) Atherosclerosis , vol.154 , pp. 87-96
    • Rikitake, Y.1    Kawashima, S.2    Takeshita, S.3    Yamashita, T.4    Azumi, H.5    Yasuhara, M.6
  • 10
    • 0031451344 scopus 로고    scopus 로고
    • Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase
    • Laufs U., Fata V.L., Liao J.K. Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase. J Biol Chem. 272:1997;31725-31729.
    • (1997) J Biol Chem , vol.272 , pp. 31725-31729
    • Laufs, U.1    Fata, V.L.2    Liao, J.K.3
  • 11
    • 0034113014 scopus 로고    scopus 로고
    • Direct effects of statins on cells primarily involved in atherosclerosis
    • Chen H., Ikeda U., Shimpo M., Shimada K. Direct effects of statins on cells primarily involved in atherosclerosis. Hypertens Res. 23:2000;187-192.
    • (2000) Hypertens Res , vol.23 , pp. 187-192
    • Chen, H.1    Ikeda, U.2    Shimpo, M.3    Shimada, K.4
  • 12
    • 0033549204 scopus 로고    scopus 로고
    • Statins and monocytes
    • Ikeda U., Shimada K. Statins and monocytes. Lancet. 353:1999;2070.
    • (1999) Lancet , vol.353 , pp. 2070
    • Ikeda, U.1    Shimada, K.2
  • 13
    • 0036445650 scopus 로고    scopus 로고
    • Modulation of inflammatory mediators and pparα and nfκb expression by pravastatin in response to lipoproteins in human monocytes in vitro
    • Zelvyte I., Dominaitiene R., Crisby M., Janciauskiene S. Modulation of inflammatory mediators and pparα and nfκb expression by pravastatin in response to lipoproteins in human monocytes in vitro. Pharmacol Res. 45:2002;147-154.
    • (2002) Pharmacol Res , vol.45 , pp. 147-154
    • Zelvyte, I.1    Dominaitiene, R.2    Crisby, M.3    Janciauskiene, S.4
  • 14
    • 0030838319 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia
    • Weber C., Erl W., Weber K.S., Weber P.C. HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia. J Am Coll Cardiol. 30:1997;1212-1217.
    • (1997) J Am Coll Cardiol , vol.30 , pp. 1212-1217
    • Weber, C.1    Erl, W.2    Weber, K.S.3    Weber, P.C.4
  • 15
    • 0034948339 scopus 로고    scopus 로고
    • Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
    • Weitz-Schmidt G., Welzenbach K., Brinkmann V., Kamata T., Kallen J., Bruns C., et al. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med. 7:2001;687-692.
    • (2001) Nat Med , vol.7 , pp. 687-692
    • Weitz-Schmidt, G.1    Welzenbach, K.2    Brinkmann, V.3    Kamata, T.4    Kallen, J.5    Bruns, C.6
  • 16
    • 0030292168 scopus 로고    scopus 로고
    • Inhibitory effect of fluvastatin, an HMG-CoA reductase inhibitor, on the expression of adhesion molecules on human monocyte cell line
    • Niwa S., Totsuka T., Hayashi S. Inhibitory effect of fluvastatin, an HMG-CoA reductase inhibitor, on the expression of adhesion molecules on human monocyte cell line. Int J Immunopharmacol. 18:1996;669-675.
    • (1996) Int J Immunopharmacol , vol.18 , pp. 669-675
    • Niwa, S.1    Totsuka, T.2    Hayashi, S.3
  • 17
    • 0034753831 scopus 로고    scopus 로고
    • A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: The role of mevalonic acid
    • Stalker T.J., Lefer A.M., Scalia R. A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br J Pharmacol. 133:2001;406-412.
    • (2001) Br J Pharmacol , vol.133 , pp. 406-412
    • Stalker, T.J.1    Lefer, A.M.2    Scalia, R.3
  • 19
    • 0035162266 scopus 로고    scopus 로고
    • Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering
    • Sparrow C.P., Burton C.A., Hernandez M., Mundt S., Hassing H., Patel S., et al. Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering. Arterioscler Thromb Vasc Biol. 21:2001;15-121.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 15-121
    • Sparrow, C.P.1    Burton, C.A.2    Hernandez, M.3    Mundt, S.4    Hassing, H.5    Patel, S.6
  • 21
    • 0030826180 scopus 로고    scopus 로고
    • Simvastatin reduces graft vessel disease and mortality after heart transplantation: A four-year randomized trial
    • Wenke K., Meiser B., Thiery J., Nagel D., von Scheidt W., Steinbeck G., et al. Simvastatin reduces graft vessel disease and mortality after heart transplantation: a four-year randomized trial. Circulation. 96:1997;1398-1402.
    • (1997) Circulation , vol.96 , pp. 1398-1402
    • Wenke, K.1    Meiser, B.2    Thiery, J.3    Nagel, D.4    Von Scheidt, W.5    Steinbeck, G.6
  • 22
    • 0035064073 scopus 로고    scopus 로고
    • The bare lymphocyte syndrome and the regulation of MHC expression
    • Reith W., Mach B. The bare lymphocyte syndrome and the regulation of MHC expression. Annu Rev Immunol. 19:2001;331-373.
    • (2001) Annu Rev Immunol , vol.19 , pp. 331-373
    • Reith, W.1    Mach, B.2
  • 23
    • 0030949011 scopus 로고    scopus 로고
    • Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA
    • Muhlethaler-Mottet A., Otten L.A., Steimle V., Mach B. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J. 16:1997;2851-2860.
    • (1997) EMBO J , vol.16 , pp. 2851-2860
    • Muhlethaler-Mottet, A.1    Otten, L.A.2    Steimle, V.3    Mach, B.4
  • 24
    • 0034533147 scopus 로고    scopus 로고
    • Statins as a newly recognized type of immunomodulator
    • Kwak B., Mulhaupt F., Myit S., Mach F. Statins as a newly recognized type of immunomodulator. Nat Med. 6:2000;1399-1402.
    • (2000) Nat Med , vol.6 , pp. 1399-1402
    • Kwak, B.1    Mulhaupt, F.2    Myit, S.3    Mach, F.4
  • 25
    • 0035102526 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin inhibits IFN-gamma induced MHC class II expression in human vascular endothelial cells
    • Kwak B., Mulhaupt F., Veillard N., Pelli G., Mach F. The HMG-CoA reductase inhibitor simvastatin inhibits IFN-gamma induced MHC class II expression in human vascular endothelial cells. Swiss Med Wkly. 131:2001;41-46.
    • (2001) Swiss Med Wkly , vol.131 , pp. 41-46
    • Kwak, B.1    Mulhaupt, F.2    Veillard, N.3    Pelli, G.4    Mach, F.5
  • 26
    • 0035872757 scopus 로고    scopus 로고
    • Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors
    • Sadeghi M.M., Tiglio A., Sadigh K., O'Donnell L., Collinge M., Pardi R., et al. Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors. Transplantation. 71:2001;1262-1268.
    • (2001) Transplantation , vol.71 , pp. 1262-1268
    • Sadeghi, M.M.1    Tiglio, A.2    Sadigh, K.3    O'Donnell, L.4    Collinge, M.5    Pardi, R.6
  • 27
    • 15644376974 scopus 로고    scopus 로고
    • Pharmacological control of the mevalonate pathway: Effect on arterial smooth muscle cell proliferation
    • Raiteri M., Arnaboldi L., McGeady P., Gelb M.H., Verri D., Tagliabue C., et al. Pharmacological control of the mevalonate pathway: effect on arterial smooth muscle cell proliferation. J Pharmacol Exp Ther. 281:1997;1144-1153.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 1144-1153
    • Raiteri, M.1    Arnaboldi, L.2    McGeady, P.3    Gelb, M.H.4    Verri, D.5    Tagliabue, C.6
  • 28
    • 0027537289 scopus 로고
    • HMG CoA reductase inhibitors. In vivo effects on carotid intimal thickening in normocholesterolemic rabbits
    • Soma M.R., Donetti E., Parolini C., Mazzini G., Ferrari C., Fumagalli R., et al. HMG CoA reductase inhibitors. In vivo effects on carotid intimal thickening in normocholesterolemic rabbits. Arterioscler Thromb. 13:1993;571-578.
    • (1993) Arterioscler Thromb , vol.13 , pp. 571-578
    • Soma, M.R.1    Donetti, E.2    Parolini, C.3    Mazzini, G.4    Ferrari, C.5    Fumagalli, R.6
  • 29
    • 0033618378 scopus 로고    scopus 로고
    • 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase-induced downregulation of p27(Kip1)
    • Laufs U., Marra D., Node K., Liao J.K. 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase-induced downregulation of p27(Kip1). J Biol Chem. 274:1999;21 926-21 931.
    • (1999) J Biol Chem , vol.274 , pp. 21926-21931
    • Laufs, U.1    Marra, D.2    Node, K.3    Liao, J.K.4
  • 30
    • 0031814992 scopus 로고    scopus 로고
    • Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells
    • Stark W.W. Jr, Blaskovich M.A., Johnson B.A., Qian Y., Vasudevan A., Pitt B., et al. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells. Am J Physiol. 275:1998;L55-L63.
    • (1998) Am J Physiol , vol.275
    • Stark W.W., Jr.1    Blaskovich, M.A.2    Johnson, B.A.3    Qian, Y.4    Vasudevan, A.5    Pitt, B.6
  • 31
    • 0032494101 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture
    • Guijarro C., Blanco-Colio L.M., Ortego M., Alonso C., Ortiz A., Plaza J.J., et al. 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. Circ Res. 83:1998;490-500.
    • (1998) Circ Res , vol.83 , pp. 490-500
    • Guijarro, C.1    Blanco-Colio, L.M.2    Ortego, M.3    Alonso, C.4    Ortiz, A.5    Plaza, J.J.6
  • 32
    • 0031213519 scopus 로고    scopus 로고
    • Proapoptotic effect of atorvastatin on stimulated rabbit smooth muscle cells
    • Baetta R., Donetti E., Comparato C., Calore M., Rossi A., Teruzzi C., et al. Proapoptotic effect of atorvastatin on stimulated rabbit smooth muscle cells. Pharmacol Res. 36:1997;115-121.
    • (1997) Pharmacol Res , vol.36 , pp. 115-121
    • Baetta, R.1    Donetti, E.2    Comparato, C.3    Calore, M.4    Rossi, A.5    Teruzzi, C.6
  • 33
    • 0035902456 scopus 로고    scopus 로고
    • Current concepts of the pathogenesis of the acute coronary syndromes
    • Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation. 104:2001;365-372.
    • (2001) Circulation , vol.104 , pp. 365-372
    • Libby, P.1
  • 34
    • 0035895319 scopus 로고    scopus 로고
    • An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro
    • Aikawa M., Rabkin E., Sugiyama S., Voglic S.J., Fukumoto Y., Furukawa Y., et al. An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation. 103:2001;276-283.
    • (2001) Circulation , vol.103 , pp. 276-283
    • Aikawa, M.1    Rabkin, E.2    Sugiyama, S.3    Voglic, S.J.4    Fukumoto, Y.5    Furukawa, Y.6
  • 35
    • 0035916305 scopus 로고    scopus 로고
    • Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits
    • Fukumoto Y., Libby P., Rabkin E., Hill C.C., Enomoto M., Hirouchi Y., et al. Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits. Circulation. 103:2001;993-999.
    • (2001) Circulation , vol.103 , pp. 993-999
    • Fukumoto, Y.1    Libby, P.2    Rabkin, E.3    Hill, C.C.4    Enomoto, M.5    Hirouchi, Y.6
  • 36
    • 0035916233 scopus 로고    scopus 로고
    • Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: Implications for plaque stabilization
    • Crisby M., Nordin-Fredriksson G., Shah P.K., Yano J., Zhu J., Nilsson J. Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization. Circulation. 103:2001;926-933.
    • (2001) Circulation , vol.103 , pp. 926-933
    • Crisby, M.1    Nordin-Fredriksson, G.2    Shah, P.K.3    Yano, J.4    Zhu, J.5    Nilsson, J.6
  • 39
    • 0025026740 scopus 로고
    • Platelet reactivity and arachidonic acid metabolism in type II hyperlipoproteinaemia and its modification by cholesterol-lowering agents
    • Schror K. Platelet reactivity and arachidonic acid metabolism in type II hyperlipoproteinaemia and its modification by cholesterol-lowering agents. Eicosanoids. 3:1990;67-73.
    • (1990) Eicosanoids , vol.3 , pp. 67-73
    • Schror, K.1
  • 40
    • 0033966049 scopus 로고    scopus 로고
    • HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells
    • Bourcier T., Libby P. HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells. Arterioscler Thromb Vasc Biol. 20:2000;556-562.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 556-562
    • Bourcier, T.1    Libby, P.2


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