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Volumn 45, Issue 2, 2002, Pages 147-154

Modulation of inflammatory mediators and PPARγ and NFκB expression by pravastatin in response to lipoproteins in human monocytes in vitro

Author keywords

Inflammation; Lipid metabolism; PPARs; Pravastatin; Pro inflammatory molecules

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IODINE 125; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MATRIX METALLOPROTEINASE; MONOCYTE CHEMOTACTIC PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PRAVASTATIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0036445650     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2001.0922     Document Type: Article
Times cited : (161)

References (42)
  • 2
    • 0003042048 scopus 로고
    • Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits
    • Ma PT, Gil G, Sudhov TC, Bilheimer DW, Goldstein JL, Brown MS. Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits. Proc Natl Acad Sci USA 1986; 83: 8370-4.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 8370-8374
    • Ma, P.T.1    Gil, G.2    Sudhov, T.C.3    Bilheimer, D.W.4    Goldstein, J.L.5    Brown, M.S.6
  • 3
    • 0030838319 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia
    • Weber C, Erl W, Weber KS, Weber PC. HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia. J Am Coll Cardiol 1997; 30: 1212-7.
    • (1997) J Am Coll Cardiol , vol.30 , pp. 1212-1217
    • Weber, C.1    Erl, W.2    Weber, K.S.3    Weber, P.C.4
  • 5
    • 0033210904 scopus 로고    scopus 로고
    • State-of-the-art lecture. Statins and blockers of the renin-angiotensin system: Vascular protection beyond their primary mode of action
    • Faggiotto A, Paoletti R. State-of-the-art lecture. Statins and blockers of the renin-angiotensin system: Vascular protection beyond their primary mode of action. Hypertension 1999; 34: 987-96.
    • (1999) Hypertension , vol.34 , pp. 987-996
    • Faggiotto, A.1    Paoletti, R.2
  • 6
    • 0016280847 scopus 로고
    • Clofibrate reversal of platelet hypersensitivity in hyperbetalipoproteinemia
    • Carvalho AC, Colman RW, Lees RS. Clofibrate reversal of platelet hypersensitivity in hyperbetalipoproteinemia. Circulation 1974; 50: 570-4.
    • (1974) Circulation , vol.50 , pp. 570-574
    • Carvalho, A.C.1    Colman, R.W.2    Lees, R.S.3
  • 7
    • 0030069678 scopus 로고    scopus 로고
    • Is vascular smooth muscle cell proliferation beneficial?
    • Weissberg PL, Clesham GJ, Bennett MR. Is vascular smooth muscle cell proliferation beneficial? Lancet 1996; 347: 305-7.
    • (1996) Lancet , vol.347 , pp. 305-307
    • Weissberg, P.L.1    Clesham, G.J.2    Bennett, M.R.3
  • 8
    • 0031736899 scopus 로고    scopus 로고
    • Are there potential non-lipid-lowering uses of statins?
    • Wheeler DC. Are there potential non-lipid-lowering uses of statins? Drugs 1998; 56: 517-52.
    • (1998) Drugs , vol.56 , pp. 517-552
    • Wheeler, D.C.1
  • 10
    • 0026062051 scopus 로고
    • Clinical pharmacology of pravastatin, a selective inhibitor of HMG-CoA reductase
    • Pan HY. Clinical pharmacology of pravastatin, a selective inhibitor of HMG-CoA reductase. Eur J Clin Pharmacol 1991; 40: S15-18.
    • (1991) Eur J Clin Pharmacol , vol.40
    • Pan, H.Y.1
  • 11
    • 0025286202 scopus 로고
    • Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor
    • Koga T, Shimada Y, Kuroda M, Tsujita Y, Hasegawa K, Yamazaki M. Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Biochim Biophys Acta 1990; 5: 115-20.
    • (1990) Biochim Biophys Acta , vol.5 , pp. 115-120
    • Koga, T.1    Shimada, Y.2    Kuroda, M.3    Tsujita, Y.4    Hasegawa, K.5    Yamazaki, M.6
  • 12
    • 0028276448 scopus 로고
    • Toxicity of a novel HMG-CoA reductase inhibitor in the common marmoset (Callithrix jacchus)
    • Owen K, Pick CR, Libretto SE, Adams MJ. Toxicity of a novel HMG-CoA reductase inhibitor in the common marmoset (Callithrix jacchus). Hum Exp Toxicol 1994; 13: 357-68.
    • (1994) Hum Exp Toxicol , vol.13 , pp. 357-368
    • Owen, K.1    Pick, C.R.2    Libretto, S.E.3    Adams, M.J.4
  • 13
    • 0028080736 scopus 로고
    • Pravastatin inhibits cellular cholesterol synthesis and increases low density lipoprotein receptor activity in macrophages: In vitro and in vivo studies
    • Keidar S, Aviram M, Maor I, Oiknine J, Brook JG. Pravastatin inhibits cellular cholesterol synthesis and increases low density lipoprotein receptor activity in macrophages: In vitro and in vivo studies. Br J Clin Pharmacol 1994; 38: 513-9.
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 513-519
    • Keidar, S.1    Aviram, M.2    Maor, I.3    Oiknine, J.4    Brook, J.G.5
  • 14
    • 0028853846 scopus 로고
    • Reduction of serum cholesterol levels alters lesional composition of atherosclerotic plaques. Effect of pravastatin sodium on atherosclerosis in mature WHHL rabbits
    • Shiomi M, Ito T, Tsukada T, Yata T, Watanabe Y, Tsujita Y, Fukami M, Fukushige J, Hosokawa T, Tamura A. Reduction of serum cholesterol levels alters lesional composition of atherosclerotic plaques. Effect of pravastatin sodium on atherosclerosis in mature WHHL rabbits. Arterioscler Thromb Vasc Biol 1995; 15: 1938-44.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1938-1944
    • Shiomi, M.1    Ito, T.2    Tsukada, T.3    Yata, T.4    Watanabe, Y.5    Tsujita, Y.6    Fukami, M.7    Fukushige, J.8    Hosokawa, T.9    Tamura, A.10
  • 15
    • 18144435700 scopus 로고    scopus 로고
    • Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys
    • Williams JK, Sukhova GK, Herrington DM, Libby P. Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys. J Am Coll Cardiol 1998; 31: 684-91.
    • (1998) J Am Coll Cardiol , vol.31 , pp. 684-691
    • Williams, J.K.1    Sukhova, G.K.2    Herrington, D.M.3    Libby, P.4
  • 16
    • 0035916233 scopus 로고    scopus 로고
    • Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases and cell death in human carotid plaques. Implications for plaque stabilisation
    • Crisby MG, Fredriksson-Nordin G, Shah PK, Yano J, Zhu J, Nilsson J. Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases and cell death in human carotid plaques. Implications for plaque stabilisation. Circulation 2001; 103: 926-33.
    • (2001) Circulation , vol.103 , pp. 926-933
    • Crisby, M.G.1    Fredriksson-Nordin, G.2    Shah, P.K.3    Yano, J.4    Zhu, J.5    Nilsson, J.6
  • 17
    • 0033187330 scopus 로고    scopus 로고
    • Non-lipid-lowering effects of statins on atherosclerosis
    • Rosenson RS. Non-lipid-lowering effects of statins on atherosclerosis. Curr Cardiol Rep 1999; 3: 225-32.
    • (1999) Curr Cardiol Rep , vol.3 , pp. 225-232
    • Rosenson, R.S.1
  • 19
    • 0032757209 scopus 로고    scopus 로고
    • Atorvastatin reduces NF-kappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells
    • Ortego M, Bustos C, Hernandez-Presa MA, Tunon J, Diaz C, Hernandez G, Egido J. Atorvastatin reduces NF-kappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells. Atherosclerosis 1999; 147: 253-61.
    • (1999) Atherosclerosis , vol.147 , pp. 253-261
    • Ortego, M.1    Bustos, C.2    Hernandez-Presa, M.A.3    Tunon, J.4    Diaz, C.5    Hernandez, G.6    Egido, J.7
  • 20
    • 0033793133 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation
    • Chinetti G, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 2000; 49: 497-505.
    • (2000) Inflamm Res , vol.49 , pp. 497-505
    • Chinetti, G.1    Fruchart, J.C.2    Staels, B.3
  • 21
    • 0034647595 scopus 로고    scopus 로고
    • Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: Reduction of MRNA levels for interleukin-1beta, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor alpha (PPARalpha) in primary endothelial cells
    • Inoue I, Goto S, Mizotani K, Awata T, Mastunaga T, Kawai S, Nakajima T, Hokari S, Komoda T, Katayama S. Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: Reduction of MRNA levels for interleukin-1beta, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor alpha (PPARalpha) in primary endothelial cells. Life Sci 2000; 67: 863-76.
    • (2000) Life Sci , vol.67 , pp. 863-876
    • Inoue, I.1    Goto, S.2    Mizotani, K.3    Awata, T.4    Mastunaga, T.5    Kawai, S.6    Nakajima, T.7    Hokari, S.8    Komoda, T.9    Katayama, S.10
  • 22
    • 0030836051 scopus 로고    scopus 로고
    • Low density lipoprotein catabolism is enhanced by the cleaved form of alpha1-antitrypsin
    • Janciauskiene S, al Rayyes O, Floren CH, Eriksson S. Low density lipoprotein catabolism is enhanced by the cleaved form of alpha-1-antitrypsin. Scand J Clin Lab Invest 1997; 57: 325-35.
    • (1997) Scand J Clin Lab Invest , vol.57 , pp. 325-335
    • Janciauskiene, S.1    Al Rayyes, O.2    Floren, C.H.3    Eriksson, S.4
  • 23
    • 0035162723 scopus 로고    scopus 로고
    • The carboxyl-terminal fragment of alpha1-antitrypsin is present in atherosclerotic plaques and regulates inflammatory transcription factors in primary human monocytes
    • Dichtl W, Moraga F, Ares MP, Crisby M, Nilsson J, Lindgren S, Janciauskiene S. The carboxyl-terminal fragment of alpha1-antitrypsin is present in atherosclerotic plaques and regulates inflammatory transcription factors in primary human monocytes. Mol Cell Biol Res Commun 2000; 4: 50-61.
    • (2000) Mol Cell Biol Res Commun , vol.4 , pp. 50-61
    • Dichtl, W.1    Moraga, F.2    Ares, M.P.3    Crisby, M.4    Nilsson, J.5    Lindgren, S.6    Janciauskiene, S.7
  • 25
    • 0027322448 scopus 로고
    • Lipid lowering and plaque regression: New insights into prevention of plaque disruption and clinical events in coronary disease
    • Brown G, Zhao X-Q, Sacco DE. Lipid lowering and plaque regression: New insights into prevention of plaque disruption and clinical events in coronary disease. Circulation 1993; 87: 1781-91.
    • (1993) Circulation , vol.87 , pp. 1781-1791
    • Brown, G.1    Zhao, X.-Q.2    Sacco, D.E.3
  • 26
    • 0034528569 scopus 로고    scopus 로고
    • Immunomodulation: A new role for statins?
    • Palinski W. Immunomodulation: A new role for statins? Nat Med 2000; 6: 1311-2.
    • (2000) Nat Med , vol.6 , pp. 1311-1312
    • Palinski, W.1
  • 27
    • 0028853846 scopus 로고
    • Reduction of serum cholesterol levels alters lesional composition of atherosclerotic plaques. Effect of pravastatin sodium on atherosclerosis in mature WHHL rabbits
    • Shiomi M, Ito T, Tsukada T, Yata T, Watanabe Y, Tsujita Y, Fukami M, Fukushige J, Hosokawa T, Tamura A. Reduction of serum cholesterol levels alters lesional composition of atherosclerotic plaques. Effect of pravastatin sodium on atherosclerosis in mature WHHL rabbits. Arterioscler Thromb Vasc Biol 1995; 15: 1938-44.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1938-1944
    • Shiomi, M.1    Ito, T.2    Tsukada, T.3    Yata, T.4    Watanabe, Y.5    Tsujita, Y.6    Fukami, M.7    Fukushige, J.8    Hosokawa, T.9    Tamura, A.10
  • 29
    • 0033587667 scopus 로고    scopus 로고
    • Long-term effects of pravastatin on plasma concentration of C-reactive protein. The cholesterol and recurrent events (CARE) investigators
    • Ridker PM, Rifai N, Pfeffer MA, Sacks F, Braunwald E. Long-term effects of pravastatin on plasma concentration of C-reactive protein. The cholesterol and recurrent events (CARE) investigators. Circulation 1999; 100: 230-5.
    • (1999) Circulation , vol.100 , pp. 230-235
    • Ridker, P.M.1    Rifai, N.2    Pfeffer, M.A.3    Sacks, F.4    Braunwald, E.5
  • 30
    • 0034694774 scopus 로고    scopus 로고
    • Pravastatin down-regulates inflammatory mediators in human monocytes in vitro
    • Grip O, Janciauskiene S, Lindgren S. Pravastatin down-regulates inflammatory mediators in human monocytes in vitro. Eur J Pharmacol 2000; 410: 83-92.
    • (2000) Eur J Pharmacol , vol.410 , pp. 83-92
    • Grip, O.1    Janciauskiene, S.2    Lindgren, S.3
  • 31
    • 0033926330 scopus 로고    scopus 로고
    • Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production
    • Fruscella P, Romano M, Albani D, Bernasconi S, Luini W, Bruno A, Salmona M, Diomede L. Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production. Cytokine 2000; 12: 1100-3.
    • (2000) Cytokine , vol.12 , pp. 1100-1103
    • Fruscella, P.1    Romano, M.2    Albani, D.3    Bernasconi, S.4    Luini, W.5    Bruno, A.6    Salmona, M.7    Diomede, L.8
  • 32
    • 0030799043 scopus 로고    scopus 로고
    • Low density lipoprotein oxidation and its pathobiological significance
    • Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 1997; 272: 20963-6.
    • (1997) J Biol Chem , vol.272 , pp. 20963-20966
    • Steinberg, D.1
  • 33
  • 34
    • 0028080736 scopus 로고
    • Pravastatin inhibits cellular cholesterol synthesis and increases low density lipoprotein receptor activity in macrophages: In vitro and in vivo studies
    • Keidar S, Aviram M, Maor I, Oiknine J, Brook JG. Pravastatin inhibits cellular cholesterol synthesis and increases low density lipoprotein receptor activity in macrophages: In vitro and in vivo studies. Br J Clin Pharmacol 1994; 38: 513-9.
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 513-519
    • Keidar, S.1    Aviram, M.2    Maor, I.3    Oiknine, J.4    Brook, J.G.5
  • 35
    • 0032509889 scopus 로고    scopus 로고
    • Chemokines - Chemotactic cytokines that mediate inflammation
    • Luster AD. Chemokines - Chemotactic cytokines that mediate inflammation. N Engl J Med 1998; 338: 436-45.
    • (1998) N Engl J Med , vol.338 , pp. 436-445
    • Luster, A.D.1
  • 36
    • 0032134003 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    • Gu L, Okada Y, Clinton SK, Gerard C, Sukhova GK, Libby P, Rollins BJ. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell 1998; 2: 275-81.
    • (1998) Mol Cell , vol.2 , pp. 275-281
    • Gu, L.1    Okada, Y.2    Clinton, S.K.3    Gerard, C.4    Sukhova, G.K.5    Libby, P.6    Rollins, B.J.7
  • 37
    • 0033820635 scopus 로고    scopus 로고
    • Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats: Blockade of MCP-1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthesis
    • Egashira K et al.. Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats: Blockade of MCP-1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthesis. FASEB J 2000; 14: 1974-8.
    • (2000) FASEB J , vol.14 , pp. 1974-1978
    • Egashira, K.1
  • 38
    • 0033913583 scopus 로고    scopus 로고
    • Inhibition of monocyte chemotactic protein-1 synthesis by statins
    • Romano M et al. Inhibition of monocyte chemotactic protein-1 synthesis by statins. Lab Invest 2000; 80: 1095-100.
    • (2000) Lab Invest , vol.80 , pp. 1095-1100
    • Romano, M.1
  • 39
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma
    • Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 1998; 93: 229-40.
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.3    Chen, H.4    Evans, R.M.5
  • 40
    • 0021721459 scopus 로고
    • Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture
    • Heinecke JW, Rosen H, Chait A. Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture. J Clin Invest 1984; 74: 1890-4.
    • (1984) J Clin Invest , vol.74 , pp. 1890-1894
    • Heinecke, J.W.1    Rosen, H.2    Chait, A.3
  • 41
    • 0028292033 scopus 로고
    • Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions
    • Daugherty A, Dunn JL, Rateri DL, Heinecke JW. Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. J Clin Invest 1994; 94: 437-44.
    • (1994) J Clin Invest , vol.94 , pp. 437-444
    • Daugherty, A.1    Dunn, J.L.2    Rateri, D.L.3    Heinecke, J.W.4


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