Proapoptotic effect of atorvastatin on stimulated rabbit smooth muscle cells

Pharmacological Research

Volumn 36, Issue 2, 1997, Pages 115-121

  Baetta, Roberta ^a   Donetti, Elena ^a   Comparato, Carmen ^a   Calore, Monica ^a   Rossi, Alessandra ^a   Teruzzi, Chiara ^a   Paoletti, Rodolfo ^a   Fumagalli, Remo ^a   Soma, Maurizio R ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Apoptosis; Atherosclerosis; Atorvastatin; HMGCoA reductase inhibitors; Smooth muscle cells

Indexed keywords

ATORVASTATIN; DNA; DNA NUCLEOTIDYLEXOTRANSFERASE; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID; PRAVASTATIN; SIMVASTATIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CAROTID ARTERY; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOFLUOROMETRY; MALE; METAPHASE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0031213519     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1997.0211     Document Type: Article

References (27)

1. 1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362: 801-9.
2. 2. Raines EW, Ross R. Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis. Br Heart J 1993; 69: S30-7.
3. 3. Soma MR, Paoletti R. Resume of the future of cardiovascular disease - prevention and the role of lipid regulation. Cardiovasc Risk Factors 1996; 6: 262-8.
4. 4. Isner JM, Kearney M, Bortman S, Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation 1995; 91: 2703-11.
5. 5. Han DKM, Haudenschild CC, Hong MK, Tinkle BT, Leon MB, Liau G. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model. Am J Pathol 1995; 147: 267-77.
6. 6. Bennett MR, Evan GI, Schwartz SM. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest 1995; 95: 2266-74.
7. 7. Cho A, Courtman D, Langille L. Apoptosis (programmed cell death) in arteries of the neonatal lamb. Circ Res 1995; 76: 168-75.
8. 8. Kockx MM, Cambier BA, Bortier HE, De Meyer GR, Declercq SC, Van Cauwelaert PA, Bultinck J. Foam cell replication and smooth muscle cell apoptosis in human saphenous vein grafts. Histopathology 1994; 25: 365-71.
9. 9. Geng Y-J, Libby P. Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1beta-converting enzyme. Am J Pathol 1995; 147: 251-66.
10. 10. Soma MR, Donetti E, Parolini C, Mazzini G, Ferrari C, Fumagalli R, Paoletti R. HMG CoA reductase inhibitors: in vivo effects on carotid intimal thickening in normocholesterolemic rabbits. Arterioscl Thromb 1993; 13: 571-8.
11. 11. Soma MR, Parolini C, Donetti E, Fumagalli R, Paoletti R. Inhibition of isoprenoid biosynthesis and arterial smooth muscle cell proliferation. J Cardiovasc Phamacol 1995; 25: S20-4.
12. 12. Soma MR, Baetta R, de Renzis MR, Mazzini G, Davegna C, Magrassi L, Butti G, Pezzotta S, Paoletti R, Fumagalli R. In vivo enhanced antitumor activity of carmustine [N,N′-Bis(2-chloroethyl)-N-nitrosourea] by simvastatin. Cancer Res 1995; 55: 597-602.
13. 13. Perez-Sala D, Collado-Escobar D, Mollinedo F. Intracellular alkalinization suppresses Lovastatin-induced Apoptosis in HL-60 cells trough the inactivaction of a pH-dependent endonuclease. J Biol Chem 1995; 270: 6235-42.
14. 14. Bansal N, Houle AG, Melnykovgch G. Comparison of dexamethasone and lovastatin (mevinolin) as growth inhibitors in cultures of T-cell derived human acute leukemia lines (CEM). Leukemia Res 1989; 13: 875-882.
15. 15. Jones KJ, Couldwell WT, Hinton DR, Su Y, He S, Anker L, Law RE. Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells. Biochem Biophys Res Commun 1994; 205: 1681-7.
16. 16. Ross R. The smooth mucle cells. II. Growth of smooth muscle cells in culture and formation of elòastic fibers. J Cell Biol 1971; 50: 172-86.
17. 17. Corsini A, Mazzotti M, Raiteri M, Soma MR, Gabbiani G, Fumagalli R, Paoletti R. Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. Atherosclerosis 1993; 101: 117-25.
18. 18. Kita T, Brown MS, Goldstein JL. Feedback regulation of HMGCoA reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. J Clin Invest 1980; 66: 1094-100.
19. 19. Ian Freshney R: Trypan Blue Dye exclusion method. In: Ian Freshney R, ed. Culture of Animal Cells. A Manual of Basic Technique. New York: ARL, 1986: pp. 208-9.
20. 20. Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 1990; 343: 425-30.
21. 21. Osborne JA, Lento PH, Siegfried MR, Stahl GL, Fusman B, Lefer AM. Cardiovascular effects of acute hypercholesterolemia in rabbits. Reversal with lovastatin treatment. J Clin Invest 1989; 83: 465-73.
22. 22. Gellman J, Ezekowitz MD, Sarembock IJ, Azrin MA, Nochomowitz LE, Lerner E, Haudenschild CC. Effect of lovastatin on intimal hyperplasia after balloon angioplasty. A study in an atherosclerotic hypercholesterolemic rabbit. J Am Coll Cardiol 1991; 17: 251-9.
23. 23. Zhu BQ, Sievers RE, Sun YP, Isenberg WM, Parmley WW. Effect of lovastatin on suppression and regression of atherosclerosis in lipid-fed rabbits. J Cardiovasc Pharmacol 1992; 19: 246-55.
24. 24. Azarin MA. Effect of lovastatin on intimal hyperplasia after balloon angioplasty: a study in an atherosclerotic hypercholesterolemic rabbit. J Am Coll Cardiol 1991; 17: 251-9.
25. 25. Davidson MH, Stein EA, Dujovne C, Hunninghake DB, Weiss SR, Knopp RH, Illingworth DR, Mitchell B, Melino MR, Zupkis RW, Dobrinska MR, Amin RD, Tobert JA. The efficacy and six-week tolerability of simvastatin 80 and 160 mg/day. Am J Cardiol 1997; 79: 38-42.
26. 26. Thibault A, Samid D, Tompkins AC, Figg WD, Cooper MR, Hohl RJ, Trepel J, Liang B, Patronas N, Venzon DJ, Reed E, Myers CE. Phase I study of lovastatin, an inhibitors of the mevalonate pathway, in patients with cancer. Clin Cancer Res 1996; 2: 483-91.
27. 27. Soma MR, Pagliarini P, Butti G, Paoletti R, Paoletti P, Fumagalli R. Simvastatin, an inhibitor of cholesterol biosynthesis, shows synergistic effect with N,N′-Bis(2-chloroethyl)-N-nitrosourea and beta interferon on human glioma cells. Cancer Res 1992; 52: 4348-55.