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Volumn 30, Issue 8, 2003, Pages 448-455

Polyketide-nonribosomal peptide epothilone antitumor agents: The EpoA, B, C subunits

Author keywords

Anti tumor agent; Biosynthesis; Epothilone; Hybrid polyketide nonribosomal peptide

Indexed keywords

ANTINEOPLASTIC AGENT; EPOTHILONE A; EPOTHILONE B; EPOTHILONE C; EPOTHILONE DERIVATIVE; PACLITAXEL; POLYKETIDE; POLYKETIDE SYNTHASE; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

EID: 0141706449     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10295-003-0044-2     Document Type: Conference Paper
Times cited : (27)

References (26)
  • 2
    • 0037177229 scopus 로고    scopus 로고
    • Epothilone and paclitaxel: Unexpected differences in promoting the assembly and stabilization of yeast microtubules
    • Bode CJ, Gupta ML, Reiff EA, Suprenant KA, Georg GI, Himes RH (2002) Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubules. Biochemistry 41:3870-3874
    • (2002) Biochemistry , vol.41 , pp. 3870-3874
    • Bode, C.J.1    Gupta, M.L.2    Reiff, E.A.3    Suprenant, K.A.4    Georg, G.I.5    Himes, R.H.6
  • 4
    • 0033485280 scopus 로고    scopus 로고
    • The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases
    • Cane DE, Walsh CT (1999) The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases. Chem Biol 6: R319-R325
    • (1999) Chem Biol , vol.6
    • Cane, D.E.1    Walsh, C.T.2
  • 5
    • 0034837369 scopus 로고    scopus 로고
    • Epothilone biosynthesis: Assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit
    • Chen HW, O'Connor S, Cane DE, Walsh CT (2001) Epothilone biosynthesis: Assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. Chem Biol 8:899-912
    • (2001) Chem Biol , vol.8 , pp. 899-912
    • Chen, H.W.1    O'Connor, S.2    Cane, D.E.3    Walsh, C.T.4
  • 7
    • 0030018666 scopus 로고    scopus 로고
    • Epothilons a and b: Antifungal and cytotoxic compounds from Sorangium cellulosum (myxobacteria) - Production, physico-chemical and biological properties
    • Gerth K, Bedorf N, Hofle G, Irschik H, Reichenbach H (1996) Epothilons a and b: Antifungal and cytotoxic compounds from Sorangium cellulosum (myxobacteria) - production, physico-chemical and biological properties. J Antibiot 49:560-563
    • (1996) J Antibiot , vol.49 , pp. 560-563
    • Gerth, K.1    Bedorf, N.2    Hofle, G.3    Irschik, H.4    Reichenbach, H.5
  • 9
    • 0030758777 scopus 로고    scopus 로고
    • Paclitaxel-resistant human ovary cancer cells have mutant β-tubulins that exhibit impaired paclitaxel-driven polymerization
    • Giannakakou P, Sackett DL, Kang YK, Zhan Z, Buters JTM, Fojo T, Porunchynsky MS (1997) Paclitaxel-resistant human ovary cancer cells have mutant β-tubulins that exhibit impaired paclitaxel-driven polymerization. J Biol Chem 272:17118-17125
    • (1997) J Biol Chem , vol.272 , pp. 17118-17125
    • Giannakakou, P.1    Sackett, D.L.2    Kang, Y.K.3    Zhan, Z.4    Buters, J.T.M.5    Fojo, T.6    Porunchynsky, M.S.7
  • 10
    • 0034903353 scopus 로고    scopus 로고
    • New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: Isolation, structure elucidation, and SAR studies
    • Hardt IH, Steinmetz H, Gerth K, Sasse F, Reichenbach H, Hofle G (2001) New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: Isolation, structure elucidation, and SAR studies. J Nat Prod 64:847-856
    • (2001) J Nat Prod , vol.64 , pp. 847-856
    • Hardt, I.H.1    Steinmetz, H.2    Gerth, K.3    Sasse, F.4    Reichenbach, H.5    Hofle, G.6
  • 11
    • 0033550167 scopus 로고    scopus 로고
    • Complex target-oriented synthesis in the drug discovery process: A case history in the dEpoB series
    • Harris CR, Danishefsky SJ (1999) Complex target-oriented synthesis in the drug discovery process: a case history in the dEpoB series. J Org Chem 64:8434-8456
    • (1999) J Org Chem , vol.64 , pp. 8434-8456
    • Harris, C.R.1    Danishefsky, S.J.2
  • 13
    • 0034673927 scopus 로고    scopus 로고
    • Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum
    • Julien B, Shah S, Ziermann R, Goldman R, Katz L, Khosla C (2000) Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum. Gene 249:153-160
    • (2000) Gene , vol.249 , pp. 153-160
    • Julien, B.1    Shah, S.2    Ziermann, R.3    Goldman, R.4    Katz, L.5    Khosla, C.6
  • 14
    • 0032829915 scopus 로고    scopus 로고
    • Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis
    • Keating TA, Walsh CT (1999) Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis. Curr Opin Chem Biol 3:598-606
    • (1999) Curr Opin Chem Biol , vol.3 , pp. 598-606
    • Keating, T.A.1    Walsh, C.T.2
  • 15
    • 0033080078 scopus 로고    scopus 로고
    • How do peptide synthetases generate structural diversity?
    • Konz D, Marahiel MA (1999) How do peptide synthetases generate structural diversity? Chem Biol 6: R39-R48
    • (1999) Chem Biol , vol.6
    • Konz, D.1    Marahiel, M.A.2
  • 18
    • 0029923954 scopus 로고    scopus 로고
    • From peptide precursors to oxazole and thiazole-containing peptide antibiotics: Microcin B17 synthase
    • Li YM, Milne JC, Madison LL, Kolter R, Walsh CT (1996) From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase. Science 274:1188-1193
    • (1996) Science , vol.274 , pp. 1188-1193
    • Li, Y.M.1    Milne, J.C.2    Madison, L.L.3    Kolter, R.4    Walsh, C.T.5
  • 19
    • 0034809574 scopus 로고    scopus 로고
    • C-methyltransferase and cyclization domain activity at the intraprotein PK/NRP switch point of yersiniabactin synthetase
    • Miller DA, Walsh CT, Luo LS (2001) C-methyltransferase and cyclization domain activity at the intraprotein PK/NRP switch point of yersiniabactin synthetase. J Am Chem Soc 123:8434-8435
    • (2001) J Am Chem Soc , vol.123 , pp. 8434-8435
    • Miller, D.A.1    Walsh, C.T.2    Luo, L.S.3
  • 21
    • 0037197692 scopus 로고    scopus 로고
    • Enzymatic assembly of epothilones: The EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces
    • O'Connor SE, Chen HW, Walsh CT (2002) Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces. Biochemistry 41:5685-5694
    • (2002) Biochemistry , vol.41 , pp. 5685-5694
    • O'Connor, S.E.1    Chen, H.W.2    Walsh, C.T.3
  • 23
    • 0037174407 scopus 로고    scopus 로고
    • Utilization of alternate substrates by the first three modules of the epothilone synthetase assembly line
    • Schneider TL, Walsh CT, O'Connor SE (2002) Utilization of alternate substrates by the first three modules of the epothilone synthetase assembly line. J Am Chem Soc 124:11272-11273
    • (2002) J Am Chem Soc , vol.124 , pp. 11272-11273
    • Schneider, T.L.1    Walsh, C.T.2    O'Connor, S.E.3
  • 24
    • 0033179468 scopus 로고    scopus 로고
    • The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
    • Stachelhaus T, Mootz HD, Marahiel MA (1999) The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem Biol 6:493-505
    • (1999) Chem Biol , vol.6 , pp. 493-505
    • Stachelhaus, T.1    Mootz, H.D.2    Marahiel, M.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.