The decrease of PKCα is associated with hepatic apoptosis at early and late phases of polymicrobial sepsis

Shock

Volumn 15, Issue 2, 2001, Pages 130-134

  Jao, Hsiao Ching ^a   Yang, Rei Cheng ^a   Hsu, Hseng Kuang ^a   Hsu, Chin ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Bax; Bcl 2; Bcl xL; Hepatocytes; PARP; PKC

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; BAX PROTEIN, RAT; BCL2L1 PROTEIN, RAT; DNA FRAGMENT; ISOENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ONCOPROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN KINASE C; PROTEIN KINASE C ALPHA;

ANIMAL; APOPTOSIS; ARTICLE; CELL MEMBRANE; DRUG EFFECT; EVALUATION; GENETICS; LIVER; LIVER CELL; MALE; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; RAT; SEPSIS; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CELL MEMBRANE; DNA FRAGMENTATION; HEPATOCYTES; ISOENZYMES; LIVER; MALE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS;

EID: 0035258832     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200115020-00009     Document Type: Article

References (28)

1. Blobe GC, Stribling S, Obeid LM, HannunYA: Protein kinase C isozymes: regulation and function. Cancer Surv 27:213-248, 1996.
2. Keenan C, Tompson S, Knox K, Pears C: Protein kinase C-α is essential for Ramos-BL B cell survival. Cell Immunol 196:104-109, 1999.
3. Sanchez V, Lucas M, Sanz A, Goberna R: Decreased protein kinase C activity is associated with programmed cell death (apoptosis) in freshly isolated rat hepatocytes. Biosci Rep 12:199-205, 1992.
4. Hsu C, Jao HC, Yang SL, Hsu HK, Liu MS: Inactivation of protein kinase C in rat liver during late hypoglycemic phase of sepsis. Mol Cell Biochem 181:181-189, 1998.
5. Stravitz RT, Rao YP, Vlahcevic ZR, Gurley EC, Javis WD, Hylemon PB: Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase. Am J Physiol 271:G293-G303, 1996.
6. Leirdal M, Sioud M: Ribozyme inhibition of the protein kinase Cα triggers apoptosis in glioma cells. Br J Cancer 80(10): 1558-1564, 1999.
7. Blackburn RV, Galoforo SS, Berns CM, Motwani NM, Corry PM, Lee YJ: Differential induction of cell death in human glioma cell lines by sodium nitroprusside. Cancer 82(6): 1137-1145, 1998.
8. Kroemer G: The protooncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3:614-620, 1997.
9. Ito T, Deng X, CarrB, May WS: Bcl-2 phosphorylation required for anti-apoptosis function. J Biol Chem 272:11671-11673, 1997.
10. Ruvolo PP, Deng X, Carr BK, May WS: A functional role for mitochondrial protein kinase Cα in Bcl-2 phosphorylation and suppression of apoptosis. J Biol Chem 273:25436-25442, 1998.
11. Leszczynski D, Zhao Y, Luokkamaki M, Foegh ML: Apoptosis of vascular smooth muscle cell: protein kinase C and oncoprotein Bcl-2 are involved in regulation of apoptosis in non-transformed rat vascular smooth muscle cells. Am J Pathol 145:1265-1270, 1994.
12. Meßmer UK, Brune B: Attenuation of P53 expression and Bax down-regulation during phorbol ester mediated inhibition of apoptosis. Br J Pharmacol 121:625-634, 1997.
13. Wichterman KA, Baue AE, Chaudry IH: Sepsis and septic shock: a review of laboratory models and a proposal. J Surg Res 29:189-201, 1980.
14. Klaunig JE, Goldblatt PJ, Hinton DE, Lipsky MM, Chacko J, and Trump BF: Mouse liver cell culture: I. Hepatocyte isolation. In Vitro 17(10):913-925, 1981.
15. Wise BC. Raynor RL, Kuo JF: Phospholipid-sensitive Ca2+-dependent protein kinase from heart: I. Purification and general properties. J Biol Chem 257:8481-8488, 1982.
16. Way DK, Cook PP, Webster C, Parker PJ: Effect of phorbol esters on protein kinase C-α. J Biol Chem 267(7):4799-4805, 1992.
17. Arber N, Han EKH, Sgambato A, Piazza GA, Delohery TM, Begemann M, Weghorst CM, Kim NH, Pamukcu R, Ahnen DJ, Reed JC, Weinstein JB: A k-ras oncogen increases resistance to sulindac-induced apoptosis in rat enterocytes. Gastroenterology 113:1892-1900, 1997.
18. Kepple-Hafkemeyer A, Brinkmann U, Pastan I: Role of caspase in immunotoxin-induced apoptosis of cancer cells. Biochemistry 37:16934-16942, 1998.
19. Homburg CHE, de Haas M, von dem Borne AEGKR, Verhoeven AJ, Reutelingsperger CPM, Roos D: Human neutrophils lose their surface FcαRIII and acquire annexin V binding sites during apoptosis in vitro. Blood 85(2):532-540, 1995.
20. Baxter GT, Miller DL, Kuo RC, Wada HG, Owicki JC: PKCα is involved in granulocyte-macrophage colony-stimulating factor signal transduction: evidence from microphysiometry and antisense oligonucleotide experiments. Biochemistry 31:10950-10954, 1992.
21. Wang P, Chaudry IH: Mechanism of hepatocellular dysfunction during hyperdynamic sepsis. Am J Physiol 270:R927-R938, 1996.
22. Wang JH, Redmond HP, Watson RWG, Bouchier-Hayes D: Role of lipopolysaccharide and tumor necrosis factor-a in induction of hepatocyte necrosis. Am J Physiol 269:G297-G304, 1995.
23. Hiramatsu M, Hotchkiss RS, Karl IE, Buchman TG: Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway. Shock 7(4):246-253, 1997.
24. Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE: Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med 25(8):1298-1307, 1997.
25. Ayara A, Evans TA, Chaudry IH: Does hepatocellular injury in sepsis involve apoptosis? J Surg Res 76:165-173, 1998.
26. Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM, Buchman TG, Karl IE: Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27(7): 1230-1248, 1999.
27. Benedetti A, Jezequel AM, Orlandi F: Preferential distribution of apoptotic bodies in acinar zone 3 of normal human and rat liver. J Hepatol 7:319-324, 1988.
28. Rinaudo MS, Su K, Falk LA, Haldar S, Mufson RA: Human interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cells. Blood 86(1):80-88, 1995.