Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C α activity

Oncogene

Volumn 20, Issue 57, 2001, Pages 8258-8269

  Le, Xiao Feng ^a   Marcelli, Marco ^b   McWatters, Amanda ^a   Nan, Bicheng ^b   Mills, Gordon B ^a   O’brian, Catherine A ^a   Bast, Robert C ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; Bcl 2; Caspase 7; HER2; Heregulin; Protein kinase C

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 9; NEU DIFFERENTIATION FACTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C LAMBDA; PROTEIN KINASE C TAU; PROTEIN KINASE C ZETA; RECOMBINANT HEREGULIN BETA1; RO 318425; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

APOPTOSIS; BREAST NEOPLASMS; CASPASE 7; CASPASES; CELL DIVISION; DOWN-REGULATION; DRUG SYNERGISM; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; GENES, ERBB-2; HUMANS; ISOENZYMES; MODELS, BIOLOGICAL; NEUREGULIN-1; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSFECTION; TUMOR CELLS, CULTURED;

ADENOVIRIDAE;

EID: 0035857113     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1205039     Document Type: Article

References (62)