메뉴 건너뛰기




Volumn 8, Issue 4, 2003, Pages 200-206

Molecular diagnosis of tumor angiogenesis and anti-angiogenic cancer therapy

Author keywords

Angiogenesis; Angiopoietin; Antiangiogenesis; VEGF

Indexed keywords

2 METHOXYESTRADIOL; 2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 5 AMINO 1 [3,5 DICHLORO 4 (4 CHLOROBENZOYL)BENZYL] 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; AE 941; ALPHA INTERFERON; ANGIOGENESIS INHIBITOR; ANGIOPOIETIN; BEVACIZUMAB; CELECOXIB; CILENGITIDE; CYCLOOXYGENASE 2 INHIBITOR; DALTEPARIN; ENZASTAURIN; GEFITINIB; HALOFUGINONE; IMATINIB; INTERLEUKIN 12; ISOFLAVONE DERIVATIVE; LENALIDOMIDE; LOW MOLECULAR WEIGHT HEPARIN; MATRIX METALLOPROTEINASE INHIBITOR; MEDIMMUNL; MONOCLONAL ANTIBODY LM 609; PROTEIN KINASE C INHIBITOR; REBIMASTAT; ROFECOXIB; SURAMIN; THALIDOMIDE DERIVATIVE; TUMOR MARKER; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN ANTIBODY;

EID: 0141680285     PISSN: 13419625     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10147-003-0342-8     Document Type: Review
Times cited : (52)

References (58)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285:1182-1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 2
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W (1997) Mechanisms of angiogenesis. Nature 386:671-674
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 3
    • 0035160312 scopus 로고    scopus 로고
    • Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    • Lyden D, Hattori K, Dias S, et al. (2001) Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 7:1194-1201
    • (2001) Nat Med , vol.7 , pp. 1194-1201
    • Lyden, D.1    Hattori, K.2    Dias, S.3
  • 4
    • 0037434561 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
    • Hill JM, Zalos G, Halcox JP, et al. (2003) Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 348:593-600
    • (2003) N Engl J Med , vol.348 , pp. 593-600
    • Hill, J.M.1    Zalos, G.2    Halcox, J.P.3
  • 5
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353-364
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 6
    • 0032707249 scopus 로고    scopus 로고
    • A requirement for neuropilin-1 in embryonic vessel formation
    • Kawasaki T, Kitsukawa T, Bekku Y, et al. (1999) A requirement for neuropilin-1 in embryonic vessel formation. Development 126:4895-4902
    • (1999) Development , vol.126 , pp. 4895-4902
    • Kawasaki, T.1    Kitsukawa, T.2    Bekku, Y.3
  • 7
    • 0036803751 scopus 로고    scopus 로고
    • Abnormal lymphatic vessel development in neuropilin 2 mutant mice
    • Yuan L, Moyon D, Pardanaud L, et al. (2002) Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development 129:4797-4806
    • (2002) Development , vol.129 , pp. 4797-4806
    • Yuan, L.1    Moyon, D.2    Pardanaud, L.3
  • 8
    • 0035003384 scopus 로고    scopus 로고
    • Structure and function of VEGF/VEGF-receptor system involved in angiogenesis
    • Shibuya M (2001) Structure and function of VEGF/VEGF-receptor system involved in angiogenesis. Cell Struct Funct 26:25-35
    • (2001) Cell Struct Funct , vol.26 , pp. 25-35
    • Shibuya, M.1
  • 9
    • 0030460424 scopus 로고    scopus 로고
    • Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    • Davis S, Aldrich TH, Jones PF, et al. (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87:1161-1169
    • (1996) Cell , vol.87 , pp. 1161-1169
    • Davis, S.1    Aldrich, T.H.2    Jones, P.F.3
  • 10
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • Maisonpierre PC, Suri C, Jones PF, et al. (1997) Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277:55-60
    • (1997) Science , vol.277 , pp. 55-60
    • Maisonpierre, P.C.1    Suri, C.2    Jones, P.F.3
  • 11
    • 13044292625 scopus 로고    scopus 로고
    • Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans
    • Valenzuela DM, Griffiths JA, Rojas J, et al. (1999) Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc Natl Acad Sci USA 96:1904-1909
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1904-1909
    • Valenzuela, D.M.1    Griffiths, J.A.2    Rojas, J.3
  • 12
    • 0030851764 scopus 로고    scopus 로고
    • Signaling vascular morphogenesis and maintenance
    • Hanahan D (1997) Signaling vascular morphogenesis and maintenance. Science 277:48-50
    • (1997) Science , vol.277 , pp. 48-50
    • Hanahan, D.1
  • 13
    • 0032547764 scopus 로고    scopus 로고
    • Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia
    • Mandriota SJ, Pepper MS (1998) Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Circ Res 83:852-859
    • (1998) Circ Res , vol.83 , pp. 852-859
    • Mandriota, S.J.1    Pepper, M.S.2
  • 14
    • 0035745001 scopus 로고    scopus 로고
    • cDNA microarray analysis of the gene expression profile of VEGF-activated human umbilical vein endothelial cells
    • Abe M, Sato Y (2001) cDNA microarray analysis of the gene expression profile of VEGF-activated human umbilical vein endothelial cells. Angiogenesis 4:289-298
    • (2001) Angiogenesis , vol.4 , pp. 289-298
    • Abe, M.1    Sato, Y.2
  • 15
    • 0036223819 scopus 로고    scopus 로고
    • Stable expression of angiopoietin-1 and other markers by cultured pericytes: Phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo
    • Sundberg C, Kowanetz M, Brown LF, et al. (2002) Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo. Lab Invest 82:387-401
    • (2002) Lab Invest , vol.82 , pp. 387-401
    • Sundberg, C.1    Kowanetz, M.2    Brown, L.F.3
  • 16
    • 0030448814 scopus 로고    scopus 로고
    • Blood vessel formation: What is its molecular basis?
    • Folkman J, D'Amore PA (1996) Blood vessel formation: what is its molecular basis? Cell 87:1153-1155
    • (1996) Cell , vol.87 , pp. 1153-1155
    • Folkman, J.1    D'Amore, P.A.2
  • 17
    • 0033863589 scopus 로고    scopus 로고
    • Molecular mechanism of angiogenesis transcription factors and their therapeutic relevance
    • Sato Y (2000) Molecular mechanism of angiogenesis transcription factors and their therapeutic relevance. Pharmacol Ther 87:51-60
    • (2000) Pharmacol Ther , vol.87 , pp. 51-60
    • Sato, Y.1
  • 18
    • 0030478724 scopus 로고    scopus 로고
    • Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells
    • Iwasaka C, Tanaka K, Abe M, et al. (1996) Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells. J Cell Physiol 169:522-531
    • (1996) J Cell Physiol , vol.169 , pp. 522-531
    • Iwasaka, C.1    Tanaka, K.2    Abe, M.3
  • 19
    • 0034690028 scopus 로고    scopus 로고
    • Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells
    • Kanno S, Oda N, Abe M, et al. (2000) Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells. Oncogene 19:2138-2146
    • (2000) Oncogene , vol.19 , pp. 2138-2146
    • Kanno, S.1    Oda, N.2    Abe, M.3
  • 20
    • 0035941117 scopus 로고    scopus 로고
    • Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1
    • Oikawa M, Abe M, Kurosawa H, et al. (2001) Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1. Biochem Biophys Res Commun 289:39-43
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 39-43
    • Oikawa, M.1    Abe, M.2    Kurosawa, H.3
  • 21
    • 0033949087 scopus 로고    scopus 로고
    • Angiogenesis inhibition by transdominant mutant Ets-1
    • Nakano T, Abe M, Tanaka K, et al. (2000) Angiogenesis inhibition by transdominant mutant Ets-1. J Cell Physiol 184:255-262
    • (2000) J Cell Physiol , vol.184 , pp. 255-262
    • Nakano, T.1    Abe, M.2    Tanaka, K.3
  • 22
    • 0032921704 scopus 로고    scopus 로고
    • ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin β3
    • Oda N, Abe M, Sato Y (1999) ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin β3. J Cell Physiol 178:121-132
    • (1999) J Cell Physiol , vol.178 , pp. 121-132
    • Oda, N.1    Abe, M.2    Sato, Y.3
  • 23
    • 0035943514 scopus 로고    scopus 로고
    • Neurophilin-1 is a downstream target of transcription factor Ets-1 in human umbilical vein endothelial cells
    • Teruyama K, Abe M, Nakano T, et al. (2001) Neurophilin-1 is a downstream target of transcription factor Ets-1 in human umbilical vein endothelial cells. FEBS Lett 504:1-4
    • (2001) FEBS Lett , vol.504 , pp. 1-4
    • Teruyama, K.1    Abe, M.2    Nakano, T.3
  • 24
    • 0141590017 scopus 로고    scopus 로고
    • The ETS family of transcription factors
    • Hoying JB (ed). BIOS Scientific, Oxford
    • Sato Y (2003) The ETS family of transcription factors. In: Hoying JB (ed) Genetics of angiogenesis. BIOS Scientific, Oxford, pp 55-68
    • (2003) Genetics of Angiogenesis , pp. 55-68
    • Sato, Y.1
  • 25
    • 0032493368 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
    • Huang LE, Gu J, Schau M, et al. (1998) Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 95:7987-7992
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7987-7992
    • Huang, L.E.1    Gu, J.2    Schau, M.3
  • 26
    • 0035903468 scopus 로고    scopus 로고
    • Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
    • Masson N, Willam C, Maxwell PH, et al. (2001) Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation. EMBO J 20:5197-5206
    • (2001) EMBO J , vol.20 , pp. 5197-5206
    • Masson, N.1    Willam, C.2    Maxwell, P.H.3
  • 27
    • 18444368709 scopus 로고    scopus 로고
    • Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
    • Hon WC, Wilson MI, Harlos K, et al. (2002) Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL. Nature 417:975-978
    • (2002) Nature , vol.417 , pp. 975-978
    • Hon, W.C.1    Wilson, M.I.2    Harlos, K.3
  • 28
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, Wiesener MS, Chang GW, et al. (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 29
    • 0033954247 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
    • Ravi R, Mookerjee B, Bhujwalla ZM, et al. (2000) Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α. Genes Dev 14:34-44
    • (2000) Genes Dev , vol.14 , pp. 34-44
    • Ravi, R.1    Mookerjee, B.2    Bhujwalla, Z.M.3
  • 30
    • 0034050050 scopus 로고    scopus 로고
    • Loss of PTEN facilitates HIF-1-mediated gene expression
    • Zundel W, Schindler C, Haas-Kogan D, et al. (2000) Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 14:391-396
    • (2000) Genes Dev , vol.14 , pp. 391-396
    • Zundel, W.1    Schindler, C.2    Haas-Kogan, D.3
  • 31
    • 0028060380 scopus 로고
    • Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
    • Dameron KM, Volpert OV, Tainsky MA, et al. (1994) Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265:1582-1584
    • (1994) Science , vol.265 , pp. 1582-1584
    • Dameron, K.M.1    Volpert, O.V.2    Tainsky, M.A.3
  • 32
    • 9844261161 scopus 로고    scopus 로고
    • A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis
    • Nishimori H, Shiratsuchi T, Urano T, et al. (1997) A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis. Oncogene 15:2145-2150
    • (1997) Oncogene , vol.15 , pp. 2145-2150
    • Nishimori, H.1    Shiratsuchi, T.2    Urano, T.3
  • 33
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to antiangiogenic therapy
    • Yu JL, Rak JW, Coomber BL, et al. (2002) Effect of p53 status on tumor response to antiangiogenic therapy. Science 295:1526-1528
    • (2002) Science , vol.295 , pp. 1526-1528
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3
  • 34
    • 0036124520 scopus 로고    scopus 로고
    • Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    • Morikawa S, Baluk P, Kaidoh T, et al. (2002) Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol 160:985-1000
    • (2002) Am J Pathol , vol.160 , pp. 985-1000
    • Morikawa, S.1    Baluk, P.2    Kaidoh, T.3
  • 35
    • 0032939205 scopus 로고    scopus 로고
    • Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma
    • Tanaka S, Mori M, Sakamoto Y, et al. (1999) Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. J Clin Invest 103:341-345
    • (1999) J Clin Invest , vol.103 , pp. 341-345
    • Tanaka, S.1    Mori, M.2    Sakamoto, Y.3
  • 36
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash J, Maisonpierre PC, Compton D, et al. (1999) Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284:1994-1998
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1    Maisonpierre, P.C.2    Compton, D.3
  • 37
    • 0035866389 scopus 로고    scopus 로고
    • The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer
    • Ahmad SA, Liu W, Jung YD, et al. (2001) The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer. Cancer Res 61:1255-1259
    • (2001) Cancer Res , vol.61 , pp. 1255-1259
    • Ahmad, S.A.1    Liu, W.2    Jung, Y.D.3
  • 38
    • 0036112626 scopus 로고    scopus 로고
    • Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth
    • Hawighorst T, Skobe M, Streit M, et al. (2002) Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am J Pathol 160:1381-1392
    • (2002) Am J Pathol , vol.160 , pp. 1381-1392
    • Hawighorst, T.1    Skobe, M.2    Streit, M.3
  • 39
    • 0022490269 scopus 로고
    • A monoclonal antibody reacting with endothelial cells of budding vessels in tumors and inflammatory tissues, and non-reactive with normal adult tissues
    • Hagemeier HH, Vollmer E, Goerdt S, et al. (1986) A monoclonal antibody reacting with endothelial cells of budding vessels in tumors and inflammatory tissues, and non-reactive with normal adult tissues. Int J Cancer 38:481-488
    • (1986) Int J Cancer , vol.38 , pp. 481-488
    • Hagemeier, H.H.1    Vollmer, E.2    Goerdt, S.3
  • 40
    • 0026469991 scopus 로고
    • Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer
    • Rettig WJ, Garin-Chesa P, Healey JH, et al. (1992) Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. Proc Natl Acad Sci USA 89:10832-10836
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10832-10836
    • Rettig, W.J.1    Garin-Chesa, P.2    Healey, J.H.3
  • 41
    • 0029611184 scopus 로고
    • Up-regulation of endoglin on vascular endothelial cells in human solid tumors: Implications for diagnosis and therapy
    • Burrows FJ, Derbyshire EJ, Tazzari PL, et al. (1995) Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy. Clin Cancer Res 1:1623-1634
    • (1995) Clin Cancer Res , vol.1 , pp. 1623-1634
    • Burrows, F.J.1    Derbyshire, E.J.2    Tazzari, P.L.3
  • 42
    • 0034060755 scopus 로고    scopus 로고
    • Imaging of tumour neovasculature by targeting the TGF-β binding receptor endoglin
    • Bredow S, Lewin M, Hofmann B, et al. (2000) Imaging of tumour neovasculature by targeting the TGF-β binding receptor endoglin. Eur J Cancer 36:675-681
    • (2000) Eur J Cancer , vol.36 , pp. 675-681
    • Bredow, S.1    Lewin, M.2    Hofmann, B.3
  • 43
    • 0034027107 scopus 로고    scopus 로고
    • Endoglin is a suitable target for efficient imaging of solid tumors: In vivo evidence in a canine mammary carcinoma model
    • Fonsatti E, Jekunen AP, Kairemo KJ, et al. (2000) Endoglin is a suitable target for efficient imaging of solid tumors: in vivo evidence in a canine mammary carcinoma model. Clin Cancer Res 6:2037-2043
    • (2000) Clin Cancer Res , vol.6 , pp. 2037-2043
    • Fonsatti, E.1    Jekunen, A.P.2    Kairemo, K.J.3
  • 44
    • 0034682892 scopus 로고    scopus 로고
    • Genes expressed in human tumor endothelium
    • St Croix B, Rago C, Velculescu V, et al. (2000) Genes expressed in human tumor endothelium. Science 289:1197-1202
    • (2000) Science , vol.289 , pp. 1197-1202
    • St Croix, B.1    Rago, C.2    Velculescu, V.3
  • 45
    • 0035884593 scopus 로고    scopus 로고
    • Cell surface tumor endothelial markers are conserved in mice and humans
    • Carson-Walter EB, Watkins DN, Nanda A, et al. (2001) Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res 61:6649-6655
    • (2001) Cancer Res , vol.61 , pp. 6649-6655
    • Carson-Walter, E.B.1    Watkins, D.N.2    Nanda, A.3
  • 46
    • 0036527585 scopus 로고    scopus 로고
    • Molecular mechanisms of lymphangiogenesis in health and disease
    • Alitalo K, Carmeliet P (2002) Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 1:219-227
    • (2002) Cancer Cell , vol.1 , pp. 219-227
    • Alitalo, K.1    Carmeliet, P.2
  • 47
    • 17744390184 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
    • Mandriota SJ, Jussila L, Jeltsch M, et al. (2001) Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J 20:672-862
    • (2001) EMBO J , vol.20 , pp. 672-862
    • Mandriota, S.J.1    Jussila, L.2    Jeltsch, M.3
  • 48
    • 0035122537 scopus 로고    scopus 로고
    • Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
    • Skobe M, Hawighorst T, Jackson DG, et al. (2001) Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 7:192-198
    • (2001) Nat Med , vol.7 , pp. 192-198
    • Skobe, M.1    Hawighorst, T.2    Jackson, D.G.3
  • 49
    • 0037024472 scopus 로고    scopus 로고
    • Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
    • He Y, Kozaki K, Karpanen T, et al. (2002) Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 94:819-825
    • (2002) J Natl Cancer Inst , vol.94 , pp. 819-825
    • He, Y.1    Kozaki, K.2    Karpanen, T.3
  • 50
    • 0035431418 scopus 로고    scopus 로고
    • Clinical trials referral resource: Current clinical trials of the anti-VEGF monoclonal antibody bevacizumab
    • Chen HX, Gore-Langton RE, Cheson BD (2001) Clinical trials referral resource: current clinical trials of the anti-VEGF monoclonal antibody bevacizumab. Oncology (Huntingt) 15:1017, 1020, 1023-1026
    • (2001) Oncology (Huntingt) , vol.15 , pp. 1017
    • Chen, H.X.1    Gore-Langton, R.E.2    Cheson, B.D.3
  • 52
    • 12244277954 scopus 로고    scopus 로고
    • Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent
    • Mendel DB, Laird AD, Smolich BD, et al. (2000) Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent. Anticancer Drug Des 15:29-41
    • (2000) Anticancer Drug Des , vol.15 , pp. 29-41
    • Mendel, D.B.1    Laird, A.D.2    Smolich, B.D.3
  • 53
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    • Wood JM, Bold G, Buchdunger E, et al. (2000) PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 60:2178-2189
    • (2000) Cancer Res , vol.60 , pp. 2178-2189
    • Wood, J.M.1    Bold, G.2    Buchdunger, E.3
  • 54
    • 0033883776 scopus 로고    scopus 로고
    • SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors
    • Laird AD, Vajkoczy P, Shawver LK, et al. (2000) SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res 60:4152-4160
    • (2000) Cancer Res , vol.60 , pp. 4152-4160
    • Laird, A.D.1    Vajkoczy, P.2    Shawver, L.K.3
  • 55
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge SR, Ogilvie DJ, Dukes M, et al. (2002) ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 62:4645-4655
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 56
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N, et al. (2002) VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 99:11393-11398
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 57
    • 0035527306 scopus 로고    scopus 로고
    • AE-941 (Neovastat): A novel multifunctional antiangiogenic compound
    • Gingras D, Batist G, Beliveau R (2001) AE-941 (Neovastat): a novel multifunctional antiangiogenic compound. Expert Rev Anticancer Ther 1:341-347
    • (2001) Expert Rev Anticancer Ther , vol.1 , pp. 341-347
    • Gingras, D.1    Batist, G.2    Beliveau, R.3
  • 58
    • 0035207897 scopus 로고    scopus 로고
    • Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials
    • Falardeau P, Champagne P, Poyet P, et al. (2001) Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials. Semin Oncol 28:620-625
    • (2001) Semin Oncol , vol.28 , pp. 620-625
    • Falardeau, P.1    Champagne, P.2    Poyet, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.