Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells

Journal of Cellular Physiology

Volumn 169, Issue 3, 1996, Pages 522-531

  Iwasaka, Chika ^a   Tanaka, Katsuhiro ^a   Abe, Mayumi ^a   Sato, Yasufumi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC FIBROBLAST GROWTH FACTOR; ANTISENSE OLIGODEOXYNUCLEOTIDE; BASIC FIBROBLAST GROWTH FACTOR; COLLAGENASE; EPIDERMAL GROWTH FACTOR; MESSENGER RNA; METALLOPROTEINASE; OLIGODEOXYNUCLEOTIDE; TRANSCRIPTION FACTOR; UROKINASE; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MICROVASCULATURE; NORMAL HUMAN; OMENTUM; PRIORITY JOURNAL; UMBILICAL VEIN;

ANIMALS; BLOOD VESSELS; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN; COLLAGENASES; DNA-BINDING PROTEINS; DRUG COMBINATIONS; ENDOTHELIUM, VASCULAR; ENZYME INDUCTION; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION; HUMANS; LAMININ; MATRIX METALLOPROTEINASE 1; MICE; OLIGONUCLEOTIDES, ANTISENSE; PROTEOGLYCANS; PROTO-ONCOGENE PROTEIN C-ETS-1; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; RNA, MESSENGER; TRANSCRIPTION FACTORS; URINARY PLASMINOGEN ACTIVATOR;

MURINAE;

EID: 0030478724     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199612)169:3<522::AID-JCP12>3.0.CO;2-7     Document Type: Article

References (50)

1. Chen, J.H. (1985) The proto-oncogene c-ets1 is preferentially expressed in lymphoid cells. Mol. Cell. Biol., 5:2993-3000.
2. Coffer, P., Jonge, M.D., Mettouchi, A., Binetruy, B., Ghysdael, J., and Kruijer, W. (1994) junB promoter regulation: Ras mediated transactivation by c-Ets-1 and c-Ets-2. Oncogene, 9:911-921.
3. Dalton, S., and Treisman, R. (1992) Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Cell, 68:597-612.
4. Fibbi, G., Ziche, M., Morbidelli, L., Magnelli, L., and Del Rosso, M. (1988) Interaction of urokinase with specific receptors stimulates mobilization of bovine adrenal capillary endothelial cells. Exp. Cell Res., 179:385-395.
5. Folkman, J., and Shing, Y. (1992) Angiogenesis. J. Biol. Chem., 267:10931-10934.
6. Ghysdael, J., Gegonne, A., Pognonec, P., Demis, D., Leprince, D., and Stehelin, D. (1986) Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic protein. Proc. Natl. Acad. Sci. U.S.A., 83:1714-1718.
7. Golub, T.R., Barker, G.F., Lovett, M., and Gilliland, D.G. (1994) Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5; 12) chromosomal translocation. Cell, 77:307-316.
8. Gross, J.L., Moscatelli, D., Jaffe, E.A., and Rifkin, D.B. (1982) Plasminogen activator and collagenase production by cultured capillary endothelial cells. J. Cell Biol., 95:974-981.
9. Gross, J.L., Moscatelli, D., and Rifkin, D.B. (1983) Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro. Proc. Natl. Acad. Sci. U.S.A., 80:2623-2627.
10. Gudewicz, P.W., and Gilboa, N. (1987) Human urokinase-type plasminogen activator stimulates chemotaxis of human neutrophils. Biochem. Biophys. Res. Commun., 147:1176-1181.
11. Gum, R., Lengyel, E., Juarez, J., Chen, J.H., Sato, H., Seiki, M., and Boyd, D. (1996) Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences. J. Biol. Chem., 271:10672-10680.
12. Gutman, A., and Wasylyk, B. (1990) The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites. EMBO J., 9:2241-2246.
13. Higashino, F., Yoshida, K., Fujinaga, Y., Kamio, K., and Fujinaga, K. (1993) Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: A new human member of the ets oncogene family. Nucl. Acid Res., 21:547-553.
14. Jorcyk, C.L., Watson, D.K., Mavrothalassitis, G.J., and Papas, T.S. (1991) The human ETS-1 gene: Genomic structure, promoter characterization and alternative splicing. Oncogene, 6:523-532.
15. Khachigian, L.M., Fries, J.W.U., Benz, M.W., Bonthron, D.T., and Collins, T. (1994) Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells. J. Biol. Chem., 269:22647-22656.
16. Kola, I., Brookes, S., Green, A.R., Garber, R., Tymms, M., Papas, T.S., and Seth, A. (1993) The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation. Proc. Natl. Acad. Sci. U.S.A., 90:7588-7592.
17. Korhonen, J., Lahtinen, I., Halmekyto, M., Alhonen, L., Janne, J., Dumont, D., and Alitalo, K (1995) Endothelial-specific gene expression directed by the tie gene promoter. Blood, 86:1828-1835.
18. Kumar, V., and Chambon, P. (1988) The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell, 55:145-156.
19. Leprince, D., Gegonne, A., Coll, J., Taisne, C.D., Schneeberger, A., Lagrou, C., and Stehelin, D. (1983) A putative second cell-derived oncogene of the avian leukaemia retrovirus E26. Nature, 306:395-397.
20. Maroulakou, I.G., Papas, T.S., and Green, J.E. (1994) Differential expression of ets-1 and ets-2 proto-oncogenes during murine embryogenesis. Oncogene, 9:1551-1565.
21. Matsuda, T., Okamura, K., Sato, Y., Morimoto, A., Ono, M., Kohno, K., and Kuwano, M. (1992) Decreased response to epidermal growth factor during cellular senescence in cultured human microvascular endothelial cells. J. Cell. Physiol., 150:510-516.
22. Morishita, K., Johnson, D.E., and Williams, L.T. (1995) A novel promoter for vascular endothelial growth factor receptor (flt-1) that confers endothelial-specific gene expression. J. Biol. Chem., 270:27948-27953.
23. Nerlov, C., Cesare, D.D., Pergola, F., Caracciolo, A., Blasi, F., Johnsen, M., and Verde, P. (1992) A regulatory element that mediates cooperation between a PEA3-AP-1 element and an AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells. EMBO J., 11:4573-4582.
24. Nunn, M.F., Seeburg, P.H., Moscovici, C., and Duesberg, P.H. (1983) Tripartite structure of the avian erythroblastosis virus E26 transforming gene. Nature, 306:391-395.
25. Odekon, L.E., Sato, Y., and Rifkin, D.E. (1992) Urokinase-type plasminogen activator mediates basic fibroblast growth factor-induced bovine endothelial cell migration independent of its proteolytic activity. J. Cell. Physiol., 150:258-263.
26. Pardanaud, L., and Dieterlen-Lievre, F. (1993) Expression of c-ETS-1 in early chick embryo mesoderm: Relationship to the hemangioblastic lineage. Cell Adhes. Commun., 1:151-160.
27. Rao, V.N., Huebner, K., Isobe, M., Ar-Rushdi, A., Croce, C.M., and Reddy, S.P. (1989) Elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. Science, 244:66-70.
28. Ray, D., Culine, S., Tavitian, A., and Moreau-Gachelin, F. (1990) The human homologue of the putative proto-oncogene Spi-1: Characterization and expression in tumors. Oncogene, 5:663-668.
29. Ray, D., Bosselut, R., Ghysdael, J., Mattei, M.G., Tavitian, A., and Moreau-Gachelin, F. (1992) Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. Mol. Cell. Biol., 12:4297-4304.
30. Reddy, E.S.P., Rao, V.N., and Papas, T.S. (1987) The erg gene: A human gene related to the ets oncogene. Proc. Natl. Acad. Sci. U.S.A., 84:6131-6135.
31. Resnati, M., Guttinger, M., Valcamonica, S., Sidenius, N., Blasi, F., and Fazioli, F. (1996) Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect. EMBO J., 15:1572-1582.
32. Roussel, M.F., Davis, J.N., Cleveland, J.L., Ghysdael, J., and Hiebert, S.W. (1994) Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F-1. Oncogene, 9:405-415.
33. Sato, Y., and Rifkin, D.B. (1988) Autocrine activities of basic fibroblast growth factor: Regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. J. Cell Biol., 107:1199-1205.
34. Sato, Y., Okamura, K., Morimoto, A., Hamanaka, R., Hamaguchi, K., Shimada, T., Ono, M., Kohno, K., Sakata, T., and Kuwano, M. (1993) Indispensable role of tissue-type plasminogen activator in growth factor-dependent tube formation of human microvascular endothelial cells in vitro. Exp. Cell Res., 204:223-229.
35. Sgouras, D.N., Athanasiou, M.A., Beal Jr., G.J., Fisher, R.J., Blair, D.G., and Mavrothalassitis, G.J. (1995) ERF: An ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. EMBO J., 14:4781-4793.
36. Shapiro, L.H. (1995) Myb and Ets proteins cooperate to transactivate an early myeloid gene. J. Biol. Chem., 270:8763-8771.
37. Takahashi, K., Sawasaki, Y., Hata, J., Mukai, K., and Goto, T. (1990) Spontaneous transformation and immortalization of human endo-thelial cells. In Vitro Cell. Dev. Biol., 25:265-274.
38. Thompson, C.B., Wang, C.-Y., Ho, I.-C., Bohjanen, P.R., Petryniak, B., June, C.H., Miesfeldt, S., Zhang, L., Nabel, G.J., Karpinski, B., and Leiden, J.M. (1992) cis-acting sequences required for inducible Interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. Mol. Cell. Biol., 12:1043-1053.
39. Tremble, P., Damsky, C.H., and Werb, Z. (1995) Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals. J. Cell Biol., 129:1707-1720.
40. Unemori, E.N., Ferrara, N., Bauer, E.A., and Amento, E.P. (1992) Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J. Cell. Physiol., 153:557-562.
41. Vandenbunder, B., Pardanaud, L., Jaffredo, T., Mirabel, M.A., and Stehelin, D. (1989) Complementary patterns of expression of c-ets-1, c-myb and c-myc in the blood-forming system of the chick embryo. Development, 106:265-274.
42. Wang, C.Y., Petryniak, B., Ho, I.C., Thompson, C.B., and Leiden, J.M. (1992) Evolutionarily conserved Ets family members display distinct DNA binding specificities. J. Exp. Med., 175:1391-1399.
43. Wasylyk, C., Gutman, A., Nicholson, R., and Wasylyk, B. (1991) The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins. EMBO J., 10:1127-1134.
44. Wasylyk, B., Hahn, S.L., and Giovane, A. (1993) The Ets family of transcription factors. Eur. J. Biochem., 211:7-18.
45. Watson, D.K., McWilliams, M.J., Lapis, P., Lautenberger, J.A., Schweinfest, C.W., and Papas, T.S. (1988) Mammalian ets-1 and ets-2 genes encode highly conserved proteins. Proc. Natl. Acad. Sci. U.S.A., 85:7862-7866.
46. Wernert, N., Raes, M.-B., Lassalle, P., Dehouck, M.-P., Gosselin, B., Vandenbunder, B., and Stehelin, D. (1992) c-ets-1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans. Am. J. Pathol., 140:119-121.
47. Wernert, N., Gilles, F., Fafeur, V., Bouali, F., Raes, M.-B., Pyke, C., Dupressoir, T., Seitz, G., Vandenbunder, B., and Stehelin, D. (1994) Stromal expression of c-Ets-1 transcription factor correlates with tumor invasion. Cancer Res., 54:5683-5688.
48. Yang, B.-S., Hauser, C.A., Henkel, G., Colman, M.S., van Beveren, C., Stacey, K.J., Hume, D.A., Maki, R.A., and Ostrowski, M.C. (1996) Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets-1 and c-Ets-2. Mol. Cell. Biol., 16:538-547.
49. Yasunaga, C., Nakashima, Y., and Sueishi, K. (1989) A role of fibrinolytic activity in angiogenesis. Quantitative assay using in vitro method. Lab. Invest., 61:698-704.
50. Zagzag, D. (1995) Angiogenic growth factors in neural embryogenesis and neoplasia. Am. J. Pathol., 146:293-309.