메뉴 건너뛰기




Volumn 17, Issue 3, 2003, Pages 445-467

Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects - Experiences from relatives and twin studies

Author keywords

Glucose intolerance; Glycogen synthase; Insulin deficiency; Insulin resistance; Intrauterine malnutrition; Obesity; Twins; Type 2 diabetes

Indexed keywords

ACYL COENZYME A; FATTY ACID; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE; INSULIN; INSULIN RECEPTOR KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; TRIACYLGLYCEROL; GASTROINTESTINAL HORMONE;

EID: 0141678155     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-690X(03)00041-1     Document Type: Review
Times cited : (72)

References (84)
  • 1
    • 0028091753 scopus 로고
    • Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus
    • Beck-Nielsen H & Groop LC. Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus. Journal of Clinical Investigation 1994; 94: 1714-1721.
    • (1994) Journal of Clinical Investigation , vol.94 , pp. 1714-1721
    • Beck-Nielsen, H.1    Groop, L.C.2
  • 2
    • 0141523874 scopus 로고    scopus 로고
    • Obesity in type 2 diabetes mellitus
    • In LeRoith D, Taylor SI & Olefsky JM (eds); Philadelphia: Lippincott Williams & Wilkins
    • Beck-Nielsen H & Hother-Nielsen O. Obesity in type 2 diabetes mellitus. In LeRoith D, Taylor SI & Olefsky JM (eds) Diabetes Mellitus. A Fundamental and Clinical Text. Philadelphia: Lippincott Williams & Wilkins, 2000, pp. 567-575.
    • (2000) Diabetes Mellitus. A Fundamental and Clinical Text , pp. 567-575
    • Beck-Nielsen, H.1    Hother-Nielsen, O.2
  • 3
    • 0026008824 scopus 로고
    • Fetal and infant growth and impaired glucose tolerance at age 64
    • Hales CN, Barker DJ, Clark PM et al. Fetal and infant growth and impaired glucose tolerance at age 64. British Medical Journal 1991; 303: 1019-1022.
    • (1991) British Medical Journal , vol.303 , pp. 1019-1022
    • Hales, C.N.1    Barker, D.J.2    Clark, P.M.3
  • 4
    • 0002629878 scopus 로고
    • Hereditary factors elucidated by twin studies
    • In Neel JV, et al. (eds); Washington, DC: Department of Health, Education and Welfare
    • Harvald B & Hauge M. Hereditary factors elucidated by twin studies. In Neel JV, et al. (eds) Genetics and the Epidemiology of Chronic Diseases. Washington, DC: Department of Health, Education and Welfare, 1965, pp. 61-76.
    • (1965) Genetics and the Epidemiology of Chronic Diseases , pp. 61-76
    • Harvald, B.1    Hauge, M.2
  • 5
    • 0032953097 scopus 로고    scopus 로고
    • Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance - A population-based twin study
    • Poulsen P, Kyvik KO, Vaag A & Beck-Nielsen H. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance - A population-based twin study. Diabetologia 1999; 42: 139-145.
    • (1999) Diabetologia , vol.42 , pp. 139-145
    • Poulsen, P.1    Kyvik, K.O.2    Vaag, A.3    Beck-Nielsen, H.4
  • 7
    • 0015524118 scopus 로고
    • Diabetes in identical twins
    • Tattersall RB & Pyke DA. Diabetes in identical twins. Lancet 1972; ii: 1120-1125.
    • (1972) Lancet , vol.2 , pp. 1120-1125
    • Tattersall, R.B.1    Pyke, D.A.2
  • 8
    • 0023781470 scopus 로고
    • Diabetes mellitus in twins: A cooperative study in Japan
    • Commmittee on diabetic twins JDS, Diabetes mellitus in twins: A cooperative study in Japan. Diabetes Research Clinical Practice 1988; 5: 271-280.
    • (1988) Diabetes Research Clinical Practice , vol.5 , pp. 271-280
  • 9
    • 0023201498 scopus 로고
    • Concordance for type 2 (non-insulin-dependent) diabetis mellitus in male twins
    • Newman B, SELBY JV, King MC et al. Concordance for type 2 (non-insulin-dependent) diabetis mellitus in male twins. Diabetologia 1987; 30: 763-768.
    • (1987) Diabetologia , vol.30 , pp. 763-768
    • Newman, B.1    Selby, J.V.2    King, M.C.3
  • 11
    • 0026641354 scopus 로고
    • Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland
    • Kaprio J, Tuomilehto J, Koskenvuo M et al. Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia 1992; 35: 1060-1067.
    • (1992) Diabetologia , vol.35 , pp. 1060-1067
    • Kaprio, J.1    Tuomilehto, J.2    Koskenvuo, M.3
  • 12
    • 0023201498 scopus 로고
    • Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins
    • Newman B, Selby JV, King MC et al. Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins. Diabetologia 1987; 30: 763-768.
    • (1987) Diabetologia , vol.30 , pp. 763-768
    • Newman, B.1    Selby, J.V.2    King, M.C.3
  • 14
    • 0035004489 scopus 로고    scopus 로고
    • Genetic versus environmental aetiology of the metabolic syndrome among male and female twins
    • Poulsen P, Vaag A, Kyvik K & Beck-Nielsen H. Genetic versus environmental aetiology of the metabolic syndrome among male and female twins. Diabetologia 2001; 44: 537-543.
    • (2001) Diabetologia , vol.44 , pp. 537-543
    • Poulsen, P.1    Vaag, A.2    Kyvik, K.3    Beck-Nielsen, H.4
  • 15
    • 0031019562 scopus 로고    scopus 로고
    • Genetic and environmental architecture of the features of the insulin-resistance syndrome
    • Hong Y, Pedersen NL, Brismar K & De Faire U. Genetic and environmental architecture of the features of the insulin-resistance syndrome. American Journal of Human Genetics 1997; 60: 143-152.
    • (1997) American Journal of Human Genetics , vol.60 , pp. 143-152
    • Hong, Y.1    Pedersen, N.L.2    Brismar, K.3    De Faire, U.4
  • 16
    • 0030063437 scopus 로고    scopus 로고
    • Genetic and environmental influences on insulin levels and the insulin resistance syndrome: An analysis of women twins
    • Mayer EJ, Newman B, Austin MA et al. Genetic and environmental influences on insulin levels and the insulin resistance syndrome: An analysis of women twins. American Journal of Epidemiology 1996; 143: 323-332.
    • (1996) American Journal of Epidemiology , vol.143 , pp. 323-332
    • Mayer, E.J.1    Newman, B.2    Austin, M.A.3
  • 19
    • 0028448486 scopus 로고
    • Genetic and environmental correlations between obesity and body fat distribution in adult male twins
    • Cardon LR, Carmelli D, Fabsitz RR & Reed T. Genetic and environmental correlations between obesity and body fat distribution in adult male twins. Human Biology 1994; 66: 465-479.
    • (1994) Human Biology , vol.66 , pp. 465-479
    • Cardon, L.R.1    Carmelli, D.2    Fabsitz, R.R.3    Reed, T.4
  • 20
    • 0030980023 scopus 로고    scopus 로고
    • Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs
    • Poulsen P, Vaag AA, Kyvik KO et al. Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs. Diabetologia 1997; 40: 439-446.
    • (1997) Diabetologia , vol.40 , pp. 439-446
    • Poulsen, P.1    Vaag, A.A.2    Kyvik, K.O.3
  • 21
    • 0027531047 scopus 로고
    • Fetal growth and impaired glucose tolerance in men and women
    • Phipps K, Barker DJ, Hales CN et al. Fetal growth and impaired glucose tolerance in men and women. Diabetologia 1993; 36: 225-228.
    • (1993) Diabetologia , vol.36 , pp. 225-228
    • Phipps, K.1    Barker, D.J.2    Hales, C.N.3
  • 22
    • 0028337091 scopus 로고
    • Fetal growth and insulin secretion in adult life
    • Phillips DI, Hirst S, Clark PM et al. Fetal growth and insulin secretion in adult life. Diabetologia 1994; 37: 592-596.
    • (1994) Diabetologia , vol.37 , pp. 592-596
    • Phillips, D.I.1    Hirst, S.2    Clark, P.M.3
  • 23
    • 0027418055 scopus 로고
    • Twin studies in medical research: Can they tell us whether diseases are genetically determined?
    • Phillips DI. Twin studies in medical research: Can they tell us whether diseases are genetically determined? Lancet 1993; 341: 1008-1009.
    • (1993) Lancet , vol.341 , pp. 1008-1009
    • Phillips, D.I.1
  • 25
    • 0008421647 scopus 로고
    • The fetal and neonatal development of twins
    • Naeye RL. The fetal and neonatal development of twins. Pediatrics 1964; 33: 546-549.
    • (1964) Pediatrics , vol.33 , pp. 546-549
    • Naeye, R.L.1
  • 26
    • 0027925766 scopus 로고
    • Twin studies in medical research
    • McDonald AM. Twin studies in medical research. Lancet 1993; 341: 1419.
    • (1993) Lancet , vol.341 , pp. 1419
    • McDonald, A.M.1
  • 27
    • 0033578176 scopus 로고    scopus 로고
    • Does zygosity influence the metabolic profile of twins? A population based cross sectional study
    • Poulsen P, Vaag A & Beck-Nielsen H. Does zygosity influence the metabolic profile of twins? A population based cross sectional study. British Medical Journal 1999; 319: 151-154.
    • (1999) British Medical Journal , vol.319 , pp. 151-154
    • Poulsen, P.1    Vaag, A.2    Beck-Nielsen, H.3
  • 28
    • 0036460038 scopus 로고    scopus 로고
    • Age-dependent impact of zygosity and birth weight on insulin secretion and insulin action in twins
    • Poulsen P, Levin K, Beck-Nielsen H & Vaag A. Age-dependent impact of zygosity and birth weight on insulin secretion and insulin action in twins. Diabetologia 2002; 45: 1649-1657.
    • (2002) Diabetologia , vol.45 , pp. 1649-1657
    • Poulsen, P.1    Levin, K.2    Beck-Nielsen, H.3    Vaag, A.4
  • 29
    • 0032748846 scopus 로고    scopus 로고
    • The Trp64Arg mutation of the adrenergic beta-3 receptor gene impairs insulin secretion: A twin study
    • Christiansen C, Poulsen P & Beck-Nielsen H. The Trp64Arg mutation of the adrenergic beta-3 receptor gene impairs insulin secretion: A twin study. Diabetic Medicine 1999; 16: 835-840.
    • (1999) Diabetic Medicine , vol.16 , pp. 835-840
    • Christiansen, C.1    Poulsen, P.2    Beck-Nielsen, H.3
  • 30
    • 0033747184 scopus 로고    scopus 로고
    • Impact of the Xba1-polymorphism of the human muscle glycogen synthase gene on parameters of the insulin resistance syndrome in a Danish twin population
    • Fenger M, Poulsen P, Beck-Nielsen H & Vaag A. Impact of the Xba 1-polymorphism of the human muscle glycogen synthase gene on parameters of the insulin resistance syndrome in a Danish twin population. Diabetic Medicine 2000; 17: 735-740.
    • (2000) Diabetic Medicine , vol.17 , pp. 735-740
    • Fenger, M.1    Poulsen, P.2    Beck-Nielsen, H.3    Vaag, A.4
  • 31
    • 0036170465 scopus 로고    scopus 로고
    • The influence of the polymorphism in apolipoprotein B codon 2488 on insulin and lipid levels in a Danish twin population
    • Bentzen J, Poulsen P, Vaag A et al. The influence of the polymorphism in apolipoprotein B codon 2488 on insulin and lipid levels in a Danish twin population. Diabetic Medicine 2002; 19: 12-18.
    • (2002) Diabetic Medicine , vol.19 , pp. 12-18
    • Bentzen, J.1    Poulsen, P.2    Vaag, A.3
  • 32
    • 0037221208 scopus 로고    scopus 로고
    • Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: Thrifty genotype, thrifty phenotype, or both?
    • Poulsen P, Andersen G, Fenger M et al. Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: Thrifty genotype, thrifty phenotype, or both? Diabetes 2003; 52: 194-198.
    • (2003) Diabetes , vol.52 , pp. 194-198
    • Poulsen, P.1    Andersen, G.2    Fenger, M.3
  • 34
    • 0141746998 scopus 로고    scopus 로고
    • What have metabolic studies in healthy relatives taught us about the pathogenesis of type 2 diabetes?
    • In Walker M et al. (eds)
    • Nyholm B, Oestergaard T, Vaag A & Schmitz O. What have metabolic studies in healthy relatives taught us about the pathogenesis of type 2 diabetes? In Walker M et al. (eds) The Diabetes Annual, 2000.
    • (2000) The Diabetes Annual
    • Nyholm, B.1    Oestergaard, T.2    Vaag, A.3    Schmitz, O.4
  • 35
    • 0022632852 scopus 로고
    • Insulin resistance: A common feature of diabetes mellitus
    • (editorial)
    • Kahn CR. Insulin resistance: A common feature of diabetes mellitus (editorial). New England Journal of Medicine 1986; 315: 252-2354.
    • (1986) New England Journal of Medicine , vol.315 , pp. 252-254
    • Kahn, C.R.1
  • 36
    • 0026575758 scopus 로고
    • Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus
    • Vaag A, Heriksen JE & Beck-Nielsen H. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. Journal of Clinical Investigation 1992; 89: 782-788.
    • (1992) Journal of Clinical Investigation , vol.89 , pp. 782-788
    • Vaag, A.1    Heriksen, J.E.2    Beck-Nielsen, H.3
  • 37
    • 0028837903 scopus 로고
    • Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus
    • Vaag A, Henriksen JE, Madsbad S et al. Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus. Journal of Clinical Investigation 1995; 95: 690-698.
    • (1995) Journal of Clinical Investigation , vol.95 , pp. 690-698
    • Vaag, A.1    Henriksen, J.E.2    Madsbad, S.3
  • 38
    • 0029791119 scopus 로고    scopus 로고
    • Intracellular glucose and fat metabolism in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM): Acquired versus genetic metabolic defects?
    • Vaag A, Alford F & Beck-Nielsen H. Intracellular glucose and fat metabolism in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM): Acquired versus genetic metabolic defects? Diabetic Medicine 1996; 13: 806-815.
    • (1996) Diabetic Medicine , vol.13 , pp. 806-815
    • Vaag, A.1    Alford, F.2    Beck-Nielsen, H.3
  • 39
    • 0029022819 scopus 로고
    • Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative
    • Pimenta W, Korytkowski M, Mitrakou A et al. Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. Journal of the American Medical Association 1995; 273: 1855-1861.
    • (1995) Journal of the American Medical Association , vol.273 , pp. 1855-1861
    • Pimenta, W.1    Korytkowski, M.2    Mitrakou, A.3
  • 40
    • 0025854490 scopus 로고
    • Importance of maternal history of non-insulin dependent diabetic patients
    • Alcolado JC & Alcolado R. Importance of maternal history of non-insulin dependent diabetic patients. British Medical Journal 1991; 302: 1178-1180.
    • (1991) British Medical Journal , vol.302 , pp. 1178-1180
    • Alcolado, J.C.1    Alcolado, R.2
  • 41
    • 9844258892 scopus 로고    scopus 로고
    • Multiple metabolic abnormalities in normal glucose tolerance relatives of NIDDM families
    • Humphriss DB, Stewart MW, Berrish TS et al. Multiple metabolic abnormalities in normal glucose tolerance relatives of NIDDM families. Diabetologia 1997; 40: 1185-1190.
    • (1997) Diabetologia , vol.40 , pp. 1185-1190
    • Humphriss, D.B.1    Stewart, M.W.2    Berrish, T.S.3
  • 42
    • 0030009002 scopus 로고    scopus 로고
    • Metabolic abnormalities in offspring of NIDDM patients with a family history of diabetes mellitus
    • Migdalis IN, Zachariadis D, Kalogeropoulou K et al. Metabolic abnormalities in offspring of NIDDM patients with a family history of diabetes mellitus. Diabetic Medicine 1996; 13: 434-440.
    • (1996) Diabetic Medicine , vol.13 , pp. 434-440
    • Migdalis, I.N.1    Zachariadis, D.2    Kalogeropoulou, K.3
  • 43
    • 0030941820 scopus 로고    scopus 로고
    • Metabolic defects in lean nondiabetic offspring of NIDDM parents: A cross-sectional study
    • Perseghin G, Ghosh S, Gerow K & Shulman GI. Metabolic defects in lean nondiabetic offspring of NIDDM parents: A cross-sectional study. Diabetes 1997; 46: 1001-1009.
    • (1997) Diabetes , vol.46 , pp. 1001-1009
    • Perseghin, G.1    Ghosh, S.2    Gerow, K.3    Shulman, G.I.4
  • 44
    • 0034839167 scopus 로고    scopus 로고
    • Metabolic impact of a family history of type 2 diabetes. Results from a European multicentre study (EGIR)
    • Vaag A, Lehtovirta M, Thye-Ronn P & Groop L. Metabolic impact of a family history of type 2 diabetes. Results from a European multicentre study (EGIR). Diabetic Medicine 2001; 18: 533-540.
    • (2001) Diabetic Medicine , vol.18 , pp. 533-540
    • Vaag, A.1    Lehtovirta, M.2    Thye-Ronn, P.3    Groop, L.4
  • 45
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nature Genetics 2000; 26: 76-80.
    • (2000) Nature Genetics , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 46
    • 17944362462 scopus 로고    scopus 로고
    • Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant caucasians
    • Ek J, Andersen G, Urhammer SA et al. Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant caucasians. Diabetologia 2001; 44: 1170-1176.
    • (2001) Diabetologia , vol.44 , pp. 1170-1176
    • Ek, J.1    Andersen, G.2    Urhammer, S.A.3
  • 47
    • 0035676129 scopus 로고    scopus 로고
    • Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-I) and relationships of identified amino acid polymorphisms to type II diabetes mellitus
    • Ek J, Andersen G, Urhammer SA et al. Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-I) and relationships of identified amino acid polymorphisms to type II diabetes mellitus. Diabetologia 2001; 44: 2220-2226.
    • (2001) Diabetologia , vol.44 , pp. 2220-2226
    • Ek, J.1    Andersen, G.2    Urhammer, S.A.3
  • 48
    • 0027930399 scopus 로고
    • Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM
    • Bjorbaek C, Echwald SM, Hubricht P et al. Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM. Diabetes 1994; 43: 976-983.
    • (1994) Diabetes , vol.43 , pp. 976-983
    • Bjorbaek, C.1    Echwald, S.M.2    Hubricht, P.3
  • 49
    • 0027367546 scopus 로고
    • Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus
    • Almind K, Bjorbaek C, Vestergaard H et al. Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. Lancet 1993; 342: 828-832.
    • (1993) Lancet , vol.342 , pp. 828-832
    • Almind, K.1    Bjorbaek, C.2    Vestergaard, H.3
  • 50
    • 0024348996 scopus 로고
    • Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus
    • Eriksson J, Franssila-Kallunki A, Ekstrand A et al. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. New England Journal of Medicine 1989; 321: 337-343.
    • (1989) New England Journal of Medicine , vol.321 , pp. 337-343
    • Eriksson, J.1    Franssila-Kallunki, A.2    Ekstrand, A.3
  • 51
    • 0026636946 scopus 로고
    • Impaired activation of glycogen synthase in people at increased risk for developing NIDDM
    • Schalin-Jantti C, Harkonen M & Groop LC. Impaired activation of glycogen synthase in people at increased risk for developing NIDDM. Diabetes 1992; 41: 598-604.
    • (1992) Diabetes , vol.41 , pp. 598-604
    • Schalin-Jantti, C.1    Harkonen, M.2    Groop, L.C.3
  • 52
    • 0029739976 scopus 로고    scopus 로고
    • Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms
    • Henry RR, Ciaraldi TP, Abrams-Carter L et al. Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms. Journal of Clinical Investigation 1996; 98: 1231-1236.
    • (1996) Journal of Clinical Investigation , vol.98 , pp. 1231-1236
    • Henry, R.R.1    Ciaraldi, T.P.2    Abrams-Carter, L.3
  • 53
    • 0027457357 scopus 로고
    • Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects. Evidence for an abnormality specific to glucose metabolism
    • Wells AM, Sutcliffe IC, Johnson AB & Taylor R. Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects. Evidence for an abnormality specific to glucose metabolism. Diabetes 1993; 42: 583-589.
    • (1993) Diabetes , vol.42 , pp. 583-589
    • Wells, A.M.1    Sutcliffe, I.C.2    Johnson, A.B.3    Taylor, R.4
  • 54
    • 0036224284 scopus 로고    scopus 로고
    • The diabetic phenotype is conserved in myotubes established from diabetic subjects: Evidence for primary defects in glucose transport and glycogen synthase activity
    • Gaster M, Petersen I, Hojlund K et al. The diabetic phenotype is conserved in myotubes established from diabetic subjects: Evidence for primary defects in glucose transport and glycogen synthase activity. Diabetes 2002; 51: 921-927.
    • (2002) Diabetes , vol.51 , pp. 921-927
    • Gaster, M.1    Petersen, I.2    Hojlund, K.3
  • 55
    • 0038321327 scopus 로고    scopus 로고
    • Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes
    • in press
    • Hojlund K, Staehr P & Hansen BF. Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes. Diabetes 2003; in press.
    • (2003) Diabetes
    • Hojlund, K.1    Staehr, P.2    Hansen, B.F.3
  • 56
    • 0028809238 scopus 로고
    • Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus
    • Rothman DL, Magnusson I, Cline G et al. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proceedings of the National Academy of Sciences of the USA 1995; 92: 983-987.
    • (1995) Proceedings of the National Academy of Sciences of the USA , vol.92 , pp. 983-987
    • Rothman, D.L.1    Magnusson, I.2    Cline, G.3
  • 57
    • 0029890918 scopus 로고    scopus 로고
    • NMR studies of muscle glycogen synthesis in insulin-resistant offspring of parents with non-insulin-dependent diabetes mellitus immediately after glycogen-depleting exercise
    • Price TB, Perseghin G, Duleba A et al. NMR studies of muscle glycogen synthesis in insulin-resistant offspring of parents with non-insulin-dependent diabetes mellitus immediately after glycogen-depleting exercise. Proceedings of the National Academy of Sciences of the USA 1996; 93: 5329-5334.
    • (1996) Proceedings of the National Academy of Sciences of the USA , vol.93 , pp. 5329-5334
    • Price, T.B.1    Perseghin, G.2    Duleba, A.3
  • 58
    • 0029849462 scopus 로고    scopus 로고
    • Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects
    • Perseghin G, Price TB, Petersen KF et al. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. New England Journal of Medicine 1996; 335: 1357-1362.
    • (1996) New England Journal of Medicine , vol.335 , pp. 1357-1362
    • Perseghin, G.1    Price, T.B.2    Petersen, K.F.3
  • 59
    • 0036594230 scopus 로고    scopus 로고
    • Insulin signalling in human skeletal muscle of subjects with or without type II-diabetes and first degree relatives of patients with the disease
    • Meyer MM, Levin K, Grimmsmann T et al. Insulin signalling in human skeletal muscle of subjects with or without type II-diabetes and first degree relatives of patients with the disease. Diabetologia 2002; 45: 813-822.
    • (2002) Diabetologia , vol.45 , pp. 813-822
    • Meyer, M.M.1    Levin, K.2    Grimmsmann, T.3
  • 60
    • 0035653508 scopus 로고    scopus 로고
    • Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients (corrected)
    • Storgaard H, Song XM, Jensen CB et al. Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients (corrected). Diabetes 2001; 50: 2770-2778.
    • (2001) Diabetes , vol.50 , pp. 2770-2778
    • Storgaard, H.1    Song, X.M.2    Jensen, C.B.3
  • 61
    • 0014116149 scopus 로고
    • Diminished insulin response to hyperglycemia in prediabetes and diabetes
    • Colwell JA & Lein A. Diminished insulin response to hyperglycemia in prediabetes and diabetes. Diabetes 1967; 16: 560-565.
    • (1967) Diabetes , vol.16 , pp. 560-565
    • Colwell, J.A.1    Lein, A.2
  • 62
    • 0014223380 scopus 로고
    • Diminished serum insulin response to glucose in genetic prediabetic males with normal glucose tolerance
    • Soeldner JS, Gleason RE, Williams RF et al. Diminished serum insulin response to glucose in genetic prediabetic males with normal glucose tolerance. Diabetes 1968; 17: 17-26.
    • (1968) Diabetes , vol.17 , pp. 17-26
    • Soeldner, J.S.1    Gleason, R.E.2    Williams, R.F.3
  • 63
    • 0029832366 scopus 로고    scopus 로고
    • Beta-cell dysfunction in first-degree relatives of patients with non-insulin-dependent diabetes mellitus
    • Fernandez-Castaner M, Biarnes J, Camps I et al. Beta-cell dysfunction in first-degree relatives of patients with non-insulin-dependent diabetes mellitus. Diabetic Medicine 1996; 13: 953-959.
    • (1996) Diabetic Medicine , vol.13 , pp. 953-959
    • Fernandez-Castaner, M.1    Biarnes, J.2    Camps, I.3
  • 64
    • 0030955017 scopus 로고    scopus 로고
    • Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM
    • Schmitz O, Porksen N, Nyholm B et al. Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM. American Journal of Physiology 1997; 272: E218-E226.
    • (1997) American Journal of Physiology , vol.272
    • Schmitz, O.1    Porksen, N.2    Nyholm, B.3
  • 65
    • 0028181010 scopus 로고
    • Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: The role of skeletal muscle glucose uptake and hepatic glucose production in the development of hyperglycaemia. A critical comment
    • Beck-Nielsen H, Hother-Nielsen O, Vaag A & Alford F. Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: The role of skeletal muscle glucose uptake and hepatic glucose production in the development of hyperglycaemia. A critical comment. Diabetologia 1994; 37: 217-221.
    • (1994) Diabetologia , vol.37 , pp. 217-221
    • Beck-Nielsen, H.1    Hother-Nielsen, O.2    Vaag, A.3    Alford, F.4
  • 66
    • 0141523873 scopus 로고
    • Sur les possibilités d'un traitement du diabetes par l'incretine
    • La Barre J. Sur les possibilités d'un traitement du diabetes par l'incretine. Bulletin Academie Royale de Medecine Belge 1932; 12: 620-634.
    • (1932) Bulletin Academie Royale de Medecine Belge , vol.12 , pp. 620-634
    • La Barre, J.1
  • 67
    • 0026659679 scopus 로고
    • Glucagon-like peptide-1, a new hormone of the entero-insular axis
    • Orskov C. Glucagon-like peptide-1, a new hormone of the entero-insular axis. Diabetologia 1992; 35: 701-711.
    • (1992) Diabetologia , vol.35 , pp. 701-711
    • Orskov, C.1
  • 68
    • 0035675446 scopus 로고    scopus 로고
    • Proliferation conditions for human satellite cells. The fractional content of satellite cells
    • Gaster M, Beck-Nielsen H & Schroder HD. Proliferation conditions for human satellite cells. The fractional content of satellite cells. APMIS 2001; 109: 726-734.
    • (2001) APMIS , vol.109 , pp. 726-734
    • Gaster, M.1    Beck-Nielsen, H.2    Schroder, H.D.3
  • 70
    • 0029134591 scopus 로고
    • Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures
    • Henry RR, Abrams L, Nikoulina S & Ciaraldi TP. Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures. Diabetes 1995; 44: 936-946.
    • (1995) Diabetes , vol.44 , pp. 936-946
    • Henry, R.R.1    Abrams, L.2    Nikoulina, S.3    Ciaraldi, T.P.4
  • 71
    • 0035969561 scopus 로고    scopus 로고
    • The basal kinetic parameters of glycogen synthase in human myotube cultures are not affected by chronic high insulin exposure
    • Gaster M, Schroder HD, Handberg A & Beck-Nielsen H. The basal kinetic parameters of glycogen synthase in human myotube cultures are not affected by chronic high insulin exposure. Biochimica et Biophysica Acta 2001; 1537: 211-221.
    • (2001) Biochimica et Biophysica Acta , vol.1537 , pp. 211-221
    • Gaster, M.1    Schroder, H.D.2    Handberg, A.3    Beck-Nielsen, H.4
  • 72
    • 0343091465 scopus 로고    scopus 로고
    • Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity
    • Krutzfeldt J, Kausch C, Volk A et al. Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity. Diabetes 2000; 49: 992-998.
    • (2000) Diabetes , vol.49 , pp. 992-998
    • Krutzfeldt, J.1    Kausch, C.2    Volk, A.3
  • 73
    • 0036227755 scopus 로고    scopus 로고
    • Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3prime; kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance
    • Vollenweider P, Menard B & Nicod P. Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3prime; kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance. Diabetes 2002; 51: 1052-1059.
    • (2002) Diabetes , vol.51 , pp. 1052-1059
    • Vollenweider, P.1    Menard, B.2    Nicod, P.3
  • 74
    • 0029807640 scopus 로고    scopus 로고
    • Human primary myoblast cell cultures from non-diabetic insulin resistant subjects retain defects in insulin action
    • Thompson DB, Pratley R & Ossowski V. Human primary myoblast cell cultures from non-diabetic insulin resistant subjects retain defects in insulin action. Journal of Clinical Investigation 1996; 98: 2346-2350.
    • (1996) Journal of Clinical Investigation , vol.98 , pp. 2346-2350
    • Thompson, D.B.1    Pratley, R.2    Ossowski, V.3
  • 75
    • 0026772772 scopus 로고
    • Type 2 (non-insulin-dependent) diabetes mellitus: The thrifty phenotype hypothesis
    • Hales CN & Barker DJP. Type 2 (non-insulin-dependent) diabetes mellitus: The thrifty phenotype hypothesis. Diabetologia 1992; 35: 595-601.
    • (1992) Diabetologia , vol.35 , pp. 595-601
    • Hales, C.N.1    Barker, D.J.P.2
  • 76
    • 0036227764 scopus 로고    scopus 로고
    • Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight
    • Jensen CB, Storgaard H, Dela F et al. Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight. Diabetes 2002; 51: 1271-1280.
    • (2002) Diabetes , vol.51 , pp. 1271-1280
    • Jensen, C.B.1    Storgaard, H.2    Dela, F.3
  • 77
    • 0027976431 scopus 로고
    • Thinness at birth and insulin resistance in adult life
    • Phillips DI, Barker DJ, Hales CN et al. Thinness at birth and insulin resistance in adult life. Diabetologia 1994; 37: 150-154.
    • (1994) Diabetologia , vol.37 , pp. 150-154
    • Phillips, D.I.1    Barker, D.J.2    Hales, C.N.3
  • 78
    • 0026002683 scopus 로고
    • Effects of fat on insulin-stimulated carbohydrate metabolism in normal men
    • Boden G, Jadali F, White J et al. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. Journal of Clinical Investigation 1991; 88: 960-966.
    • (1991) Journal of Clinical Investigation , vol.88 , pp. 960-966
    • Boden, G.1    Jadali, F.2    White, J.3
  • 79
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • Lewis GF, Carpentier A, Adeli K & Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocrine Reviews 2002; 23: 201-229.
    • (2002) Endocrine Reviews , vol.23 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 80
    • 0034076660 scopus 로고    scopus 로고
    • Fuel selection in human skeletal muscle in insulin resistance: A reexamination
    • Kelly DE & Mandarino LJ. Fuel selection in human skeletal muscle in insulin resistance: A reexamination. Diabetes 2000; 49: 677-683.
    • (2000) Diabetes , vol.49 , pp. 677-683
    • Kelly, D.E.1    Mandarino, L.J.2
  • 81
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN & Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; i: 785-789.
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 82
    • 0025860114 scopus 로고
    • Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus
    • Damsbo P, Vaag A, Hother-Nielsen O & Beck-Nielsen H. Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1991; 34: 239-245.
    • (1991) Diabetologia , vol.34 , pp. 239-245
    • Damsbo, P.1    Vaag, A.2    Hother-Nielsen, O.3    Beck-Nielsen, H.4
  • 83
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI. Cellular mechanisms of insulin resistance. Journal of Clinical Investigation 2000; 106: 171-176.
    • (2000) Journal of Clinical Investigation , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 84
    • 85047681686 scopus 로고    scopus 로고
    • Hepatic steatosis, insulin resistance, and adipose tissue disorders
    • Garg A & Misra A. Hepatic steatosis, insulin resistance, and adipose tissue disorders. Journal of Clinical Endocrinology and Metabolism 2002; 87: 3019-3022.
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , pp. 3019-3022
    • Garg, A.1    Misra, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.