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Volumn 13, Issue 9, 1996, Pages 806-815

Intracellular glucose and fat metabolism in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM): Acquired versus genetic metabolic defects?

Author keywords

Discordant twins; Glucose fatty acid cycle; Insulin resistance; Muscle glycogen synthase; Non insulin dependent diabetes

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; GLUCOSE METABOLISM; GLYCOGEN MUSCLE LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID METABOLISM; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; TWIN DISCORDANCE;

EID: 0029791119     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9136(199609)13:9<806::AID-DIA179>3.0.CO;2-5     Document Type: Article
Times cited : (21)

References (36)
  • 1
    • 0026572747 scopus 로고
    • Pathogenesis of Type 2 (non-insulin dependent) diabetes mellitus: A balanced overview
    • DeFronzo RA. Pathogenesis of Type 2 (non-insulin dependent) diabetes mellitus: A balanced overview. Diabetologia 1992; 35: 389-397.
    • (1992) Diabetologia , vol.35 , pp. 389-397
    • DeFronzo, R.A.1
  • 3
    • 0025052076 scopus 로고
    • Insulin insensitivity in offspring of parents with type 2 diabetes mellitus
    • Ho LT, Chang ZY, Wang JT, Li SH, Liu YF, Chen YD, et al. Insulin insensitivity in offspring of parents with type 2 diabetes mellitus. Diabet Med 1990; 7: 31-34.
    • (1990) Diabet Med , vol.7 , pp. 31-34
    • Ho, L.T.1    Chang, Z.Y.2    Wang, J.T.3    Li, S.H.4    Liu, Y.F.5    Chen, Y.D.6
  • 4
    • 0024334374 scopus 로고
    • Insulin resistance and hypertriglyceridemia in nondiabetic relatives of patients with noninsulin-dependent diabetes mellitus
    • Laws A, Stefanick ML, Reaven GM. Insulin resistance and hypertriglyceridemia in nondiabetic relatives of patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1989; 69: 343-347.
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 343-347
    • Laws, A.1    Stefanick, M.L.2    Reaven, G.M.3
  • 5
    • 0026636946 scopus 로고
    • Impaired activation of glycogen synthase in people at increased risk for developing NIDDM
    • Schalin Jantti C, Harkonen M, Groop LC. Impaired activation of glycogen synthase in people at increased risk for developing NIDDM. Diabetes 1992; 41: 598-604.
    • (1992) Diabetes , vol.41 , pp. 598-604
    • Schalin Jantti, C.1    Harkonen, M.2    Groop, L.C.3
  • 6
    • 0026575758 scopus 로고
    • Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus
    • Vaag A, Henriksen JE, Beck Nielsen H. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1992; 89: 782-788.
    • (1992) J Clin Invest , vol.89 , pp. 782-788
    • Vaag, A.1    Henriksen, J.E.2    Beck Nielsen, H.3
  • 7
    • 0028837903 scopus 로고
    • Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for NIDDM
    • Vaag A, Henriksen JE, Madsbad S, Holm N, Beck-Nielsen H. Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for NIDDM. J Clin Invest 1995; 95: 690-698.
    • (1995) J Clin Invest , vol.95 , pp. 690-698
    • Vaag, A.1    Henriksen, J.E.2    Madsbad, S.3    Holm, N.4    Beck-Nielsen, H.5
  • 8
    • 0019762341 scopus 로고
    • The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization
    • DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 1981; 30: 1000-1007.
    • (1981) Diabetes , vol.30 , pp. 1000-1007
    • DeFronzo, R.A.1    Jacot, E.2    Jequier, E.3    Maeder, E.4    Wahren, J.5    Felber, J.P.6
  • 9
    • 0025860114 scopus 로고
    • Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus
    • Damsbo P, Vaag A, Hother Nielsen O, Beck Nielsen H. Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1991; 34: 239-245.
    • (1991) Diabetologia , vol.34 , pp. 239-245
    • Damsbo, P.1    Vaag, A.2    Hother Nielsen, O.3    Beck Nielsen, H.4
  • 10
    • 0025098765 scopus 로고
    • Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
    • Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med 1990; 322: 223-228.
    • (1990) N Engl J Med , vol.322 , pp. 223-228
    • Shulman, G.I.1    Rothman, D.L.2    Jue, T.3    Stein, P.4    DeFronzo, R.A.5    Shulman, R.G.6
  • 12
    • 0026539663 scopus 로고
    • The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents
    • Gulli G, Ferrannini E, Stern M, Haffner S, DeFronzo RA. The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes 1992; 41: 1575-1586.
    • (1992) Diabetes , vol.41 , pp. 1575-1586
    • Gulli, G.1    Ferrannini, E.2    Stern, M.3    Haffner, S.4    DeFronzo, R.A.5
  • 13
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; 1: 785-789.
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 14
    • 0023618126 scopus 로고
    • Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes
    • Felber JP, Ferrannini E, Golay A, Meyer HU, Theibaud D, Curchod B, et al. Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes. Diabetes 1987; 36: 1341-1350.
    • (1987) Diabetes , vol.36 , pp. 1341-1350
    • Felber, J.P.1    Ferrannini, E.2    Golay, A.3    Meyer, H.U.4    Theibaud, D.5    Curchod, B.6
  • 15
    • 0024392514 scopus 로고
    • Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance
    • Groop LC, Bonadonna RC, DelPrato S, Ratheiser K, Zyck K, Ferrannini E, et al. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest 1989; 84: 205-213.
    • (1989) J Clin Invest , vol.84 , pp. 205-213
    • Groop, L.C.1    Bonadonna, R.C.2    DelPrato, S.3    Ratheiser, K.4    Zyck, K.5    Ferrannini, E.6
  • 16
    • 0028819524 scopus 로고
    • Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycamia of NIDDM
    • Vaag A, Alford F, Henriksen FL, Christopher M, Beck-Nielsen H. Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycamia of NIDDM. Diabetologia 1995; 38: 326-336.
    • (1995) Diabetologia , vol.38 , pp. 326-336
    • Vaag, A.1    Alford, F.2    Henriksen, F.L.3    Christopher, M.4    Beck-Nielsen, H.5
  • 17
    • 0025949378 scopus 로고
    • Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus
    • Vaag A, Skott P, Damsbo P, Gall MA, Richter EA, Beck Nielsen H. Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1991; 88: 1282-1290.
    • (1991) J Clin Invest , vol.88 , pp. 1282-1290
    • Vaag, A.1    Skott, P.2    Damsbo, P.3    Gall, M.A.4    Richter, E.A.5    Beck Nielsen, H.6
  • 18
    • 0027218865 scopus 로고
    • Interaction between glucose and free fatty acid metabolism in human skeletal muscle
    • Kelley DE, Mokan M, Simoneau JA, Mandarino LJ. Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 1993; 92: 91-98.
    • (1993) J Clin Invest , vol.92 , pp. 91-98
    • Kelley, D.E.1    Mokan, M.2    Simoneau, J.A.3    Mandarino, L.J.4
  • 19
    • 0028809238 scopus 로고
    • Decreased muscle glucose transport/phosphorylation is an early detect in the pathogenesis of non-insulin-dependent diabetes mellitus
    • Rothman DL, Magnusson I, Cline G, Gerard D, Kahn CR, Shulman RG, et al. Decreased muscle glucose transport/phosphorylation is an early detect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 1995; 92: 983-987.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 983-987
    • Rothman, D.L.1    Magnusson, I.2    Cline, G.3    Gerard, D.4    Kahn, C.R.5    Shulman, R.G.6
  • 21
    • 0027500242 scopus 로고
    • Characterization of cellular defects of insulin action in Type 2 (non-insulin-dependent) diabetes mellitus
    • Del Prato S, Bonadonna RC, Bonora E, Gulli G, Solini A, Shank M, et al. Characterization of cellular defects of insulin action in Type 2 (non-insulin-dependent) diabetes mellitus. Journal of Clinical Investigation 1993; 91(2): 484-494.
    • (1993) Journal of Clinical Investigation , vol.91 , Issue.2 , pp. 484-494
    • Del Prato, S.1    Bonadonna, R.C.2    Bonora, E.3    Gulli, G.4    Solini, A.5    Shank, M.6
  • 23
    • 0003721372 scopus 로고
    • Technical Report Series 727, Geneva: World Health Organization
    • WHO Study Group. Diabetes Mellitus. Technical Report Series 727, Geneva: World Health Organization, 1985.
    • (1985) Diabetes Mellitus
  • 24
    • 0000648085 scopus 로고
    • Influence of glucose loading and of injected insulin on hepatic glucose output
    • Steele R. Influence of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 1959; 82: 420-430.
    • (1959) Ann NY Acad Sci , vol.82 , pp. 420-430
    • Steele, R.1
  • 25
    • 0023508465 scopus 로고
    • Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism
    • Mandarino LJ, Wright KS, Verity LS, Nichols J, Bell JM, Kolterman OG, et al. Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism. J Clin Invest 1987; 80: 655-663.
    • (1987) J Clin Invest , vol.80 , pp. 655-663
    • Mandarino, L.J.1    Wright, K.S.2    Verity, L.S.3    Nichols, J.4    Bell, J.M.5    Kolterman, O.G.6
  • 26
    • 0014428937 scopus 로고
    • A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose
    • Thomas JA, Schlender KK, Larner J. A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose. Anal Biochem 1968; 25: 486-499.
    • (1968) Anal Biochem , vol.25 , pp. 486-499
    • Thomas, J.A.1    Schlender, K.K.2    Larner, J.3
  • 27
    • 0028947949 scopus 로고
    • The fourth musketeer - From Alexandra Dumas to Claude Bernard
    • Reaven GM. The fourth musketeer - from Alexandra Dumas to Claude Bernard. Diabetologia 1995; 38: 3-13.
    • (1995) Diabetologia , vol.38 , pp. 3-13
    • Reaven, G.M.1
  • 28
    • 0029087640 scopus 로고
    • Relationships of generalized and regional adiposity to insulin sensitivity in men
    • Abate N, Garg A, Peshock RM, Stray-Gundersen J, Grundy SM. Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 1995; 96: 88-98.
    • (1995) J Clin Invest , vol.96 , pp. 88-98
    • Abate, N.1    Garg, A.2    Peshock, R.M.3    Stray-Gundersen, J.4    Grundy, S.M.5
  • 29
    • 0020576146 scopus 로고
    • Calculation of substrate oxidation rates in vivo from gaseous exchange
    • Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 1983; 55: 628-634.
    • (1983) J Appl Physiol , vol.55 , pp. 628-634
    • Frayn, K.N.1
  • 30
    • 0028091753 scopus 로고
    • Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus
    • Beck-Nielsen H, Groop L. Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus. J Clin Invest 1994; 94: 1714-1721.
    • (1994) J Clin Invest , vol.94 , pp. 1714-1721
    • Beck-Nielsen, H.1    Groop, L.2
  • 31
    • 0027457357 scopus 로고
    • Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects. Evidence for an abnormality specific to glucose metabolism
    • Wells AM, Sutcliffe IC, Johnson AB, Taylor R. Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects. Evidence for an abnormality specific to glucose metabolism. Diabetes 1993; 42: 583-589.
    • (1993) Diabetes , vol.42 , pp. 583-589
    • Wells, A.M.1    Sutcliffe, I.C.2    Johnson, A.B.3    Taylor, R.4
  • 32
    • 0027511164 scopus 로고
    • Assocation between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus
    • Groop LC, Kankuri M, Schalin Jantti C, Ekstrand A, Nikula Ijas P, Widen E, et al. Assocation between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. N Engl J Med 1993; 328: 10-14.
    • (1993) N Engl J Med , vol.328 , pp. 10-14
    • Groop, L.C.1    Kankuri, M.2    Schalin Jantti, C.3    Ekstrand, A.4    Nikula Ijas, P.5    Widen, E.6
  • 33
    • 0026651566 scopus 로고
    • In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: Effects of diet treatment
    • Bak JF, Moller N, Schmitz O, Saaek A, Pedersen O. In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: effects of diet treatment. Diabetologia 1992; 35: 777-784.
    • (1992) Diabetologia , vol.35 , pp. 777-784
    • Bak, J.F.1    Moller, N.2    Schmitz, O.3    Saaek, A.4    Pedersen, O.5
  • 34
    • 0025315749 scopus 로고
    • Effects of intensive dietary treatment on insulin-stimulated skeletal muscle glycogen synthase activation and insulin secretion in newly presenting type 2 diabetic patients
    • Johnson AB, Argyraki M, Thow JC, Broughton D, Jones IR, Taylor R. Effects of intensive dietary treatment on insulin-stimulated skeletal muscle glycogen synthase activation and insulin secretion in newly presenting type 2 diabetic patients. Diabetic Med 1990; 7: 420-428.
    • (1990) Diabetic Med , vol.7 , pp. 420-428
    • Johnson, A.B.1    Argyraki, M.2    Thow, J.C.3    Broughton, D.4    Jones, I.R.5    Taylor, R.6
  • 36
    • 0026002683 scopus 로고
    • Effects of fat on insulin-stimulated carbohydrate metabolism in normal men
    • Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, et al. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 1991; 88: 960-966.
    • (1991) J Clin Invest , vol.88 , pp. 960-966
    • Boden, G.1    Jadali, F.2    White, J.3    Liang, Y.4    Mozzoli, M.5    Chen, X.6


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