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Volumn 49, Issue 6, 2000, Pages 992-998

Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN RECEPTOR KINASE; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

EID: 0343091465     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.6.992     Document Type: Article
Times cited : (63)

References (38)
  • 2
    • 0021258643 scopus 로고
    • Correlation between muscle glycogen syntliase activity and in vivo insulin action in man
    • Bogardus C, Lillioja S, Stone K, Mott D: Correlation between muscle glycogen syntliase activity and in vivo insulin action in man. J Clin Invest 73:1185-1190, 1984
    • (1984) J Clin Invest , vol.73 , pp. 1185-1190
    • Bogardus, C.1    Lillioja, S.2    Stone, K.3    Mott, D.4
  • 3
    • 0025860114 scopus 로고
    • Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus
    • Damsbo P, Vaag A, Hother-Nielsen O, Beck-Nielsen H: Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34:239-245, 1991
    • (1991) Diabetologia , vol.34 , pp. 239-245
    • Damsbo, P.1    Vaag, A.2    Hother-Nielsen, O.3    Beck-Nielsen, H.4
  • 4
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven GM: Role of insulin resistance in human disease. Diabetes 37:1595-1607, 1988
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 5
    • 0028079621 scopus 로고
    • Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of non-insulin-dependent diabetes mellitus and obesity
    • Nolan JJ, Freidenberg G, Henry R, Reichart D, Olefsky JM: Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of non-insulin-dependent diabetes mellitus and obesity. J Clin Endocrinol Metab 78:471-477, 1994
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 471-477
    • Nolan, J.J.1    Freidenberg, G.2    Henry, R.3    Reichart, D.4    Olefsky, J.M.5
  • 6
    • 0024321216 scopus 로고
    • A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus
    • Obermaier-Kusser B, White MF, Pongratz DE, Su Z, Ermel B, Muhlbacher C, Haring HU: A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus. J Biol Chem 264:9497-9504, 1989
    • (1989) J Biol Chem , vol.264 , pp. 9497-9504
    • Obermaier-Kusser, B.1    White, M.F.2    Pongratz, D.E.3    Su, Z.4    Ermel, B.5    Muhlbacher, C.6    Haring, H.U.7
  • 7
    • 0028881784 scopus 로고
    • Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM
    • Klein HH, Vestergaard H, Kotzke G, Pedersen O: Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM. Diabetes 44:1310-1317, 1995
    • (1995) Diabetes , vol.44 , pp. 1310-1317
    • Klein, H.H.1    Vestergaard, H.2    Kotzke, G.3    Pedersen, O.4
  • 8
    • 0031057526 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
    • Bjornholm M, Kawano V, Lehtihet M, Zierath JR: Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes 46:524-527, 1997
    • (1997) Diabetes , vol.46 , pp. 524-527
    • Bjornholm, M.1    Kawano, V.2    Lehtihet, M.3    Zierath, J.R.4
  • 9
    • 0032698470 scopus 로고    scopus 로고
    • Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
    • Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kalm BB: Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest 104:733-741, 1999
    • (1999) J Clin Invest , vol.104 , pp. 733-741
    • Kim, Y.B.1    Nikoulina, S.E.2    Ciaraldi, T.P.3    Henry, R.R.4    Kalm, B.B.5
  • 10
    • 0031852665 scopus 로고    scopus 로고
    • Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects
    • Krook A, Roth RA, Jiang XJ, Zierath JR, Wallberg-Henriksson H: Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects. Diabetes 47:1281-1286, 1998
    • (1998) Diabetes , vol.47 , pp. 1281-1286
    • Krook, A.1    Roth, R.A.2    Jiang, X.J.3    Zierath, J.R.4    Wallberg-Henriksson, H.5
  • 11
    • 0032456709 scopus 로고    scopus 로고
    • Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects
    • Ferrannini E: Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocrinol Rev 19:477-490, 1998
    • (1998) Endocrinol Rev , vol.19 , pp. 477-490
    • Ferrannini, E.1
  • 12
    • 0032449219 scopus 로고    scopus 로고
    • The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity
    • Gerich JE: The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocrinol Rev 19:491-503, 1998
    • (1998) Endocrinol Rev , vol.19 , pp. 491-503
    • Gerich, J.E.1
  • 13
    • 0002872316 scopus 로고
    • Empirical risk figures for first-degree relatives of non-insulin-dependent diabetics
    • Kobberling J, Tattersall R, Eds. London, Academic
    • Kobberling J, Tillil H: Empirical risk figures for first-degree relatives of non-insulin-dependent diabetics. In The Genetics of Diabetes Mellitus. Kobberling J, Tattersall R, Eds. London, Academic, 1982, p. 202-209
    • (1982) The Genetics of Diabetes Mellitus , pp. 202-209
    • Kobberling, J.1    Tillil, H.2
  • 15
    • 0026575758 scopus 로고
    • Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus
    • Vaag A, Henriksen JE, Beck-Nielsen H: Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest 89:782-788, 1992
    • (1992) J Clin Invest , vol.89 , pp. 782-788
    • Vaag, A.1    Henriksen, J.E.2    Beck-Nielsen, H.3
  • 16
    • 0027309410 scopus 로고
    • Decreased tyrosine kinase activity in partially purified insulin receptors from muscle of young, non-obese first degree relatives of patients with type 2 (non-insulin-dependent) diabetes mellitus
    • Handberg A, Vaag A, Vinten J, Beck-Nielsen H: Decreased tyrosine kinase activity in partially purified insulin receptors from muscle of young, non-obese first degree relatives of patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 36:668-674, 1993
    • (1993) Diabetologia , vol.36 , pp. 668-674
    • Handberg, A.1    Vaag, A.2    Vinten, J.3    Beck-Nielsen, H.4
  • 17
    • 0032899013 scopus 로고    scopus 로고
    • Insulin action and secretion in healthy, glucose tolerant first degree relatives of patients with type 2 diabetes mellitus: Influence of body weight
    • Volk A, Renn W, Overkamp D, Mehnert B, Maerker E, Jacob S, Balletshofer B, Haring HU, Rett K: Insulin action and secretion in healthy, glucose tolerant first degree relatives of patients with type 2 diabetes mellitus: influence of body weight. Exp Clin Endocrinol Diabetes 107:140-147, 1999
    • (1999) Exp Clin Endocrinol Diabetes , vol.107 , pp. 140-147
    • Volk, A.1    Renn, W.2    Overkamp, D.3    Mehnert, B.4    Maerker, E.5    Jacob, S.6    Balletshofer, B.7    Haring, H.U.8    Rett, K.9
  • 18
    • 0342334698 scopus 로고
    • Isolation and characterization of human muscle cells
    • Blau HM, Webster C: Isolation and characterization of human muscle cells. Proc Natl Acad Sci U S A 78:5623-5627, 1981
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 5623-5627
    • Blau, H.M.1    Webster, C.2
  • 19
    • 0029134591 scopus 로고
    • Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects: Comparison using human skeletal muscle cell cultures
    • Henry RR, Abrams L, Nikoulina S, Ciaraldi TP: Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects: comparison using human skeletal muscle cell cultures. Diabetes 44:936-946, 1995
    • (1995) Diabetes , vol.44 , pp. 936-946
    • Henry, R.R.1    Abrams, L.2    Nikoulina, S.3    Ciaraldi, T.P.4
  • 20
    • 0026489975 scopus 로고
    • Glucose transport in human skeletal muscle cells in culture: Stimulation by insulin and metformin
    • Sarabia V, Lam L, Burdett K, Leiter LA, Klip A: Glucose transport in human skeletal muscle cells in culture: stimulation by insulin and metformin. J Clin Invest 90:1386-1395, 1992
    • (1992) J Clin Invest , vol.90 , pp. 1386-1395
    • Sarabia, V.1    Lam, L.2    Burdett, K.3    Leiter, L.A.4    Klip, A.5
  • 21
    • 0029807640 scopus 로고    scopus 로고
    • Human primary myoblast cell cultures from non-diabetic insulin resistant subjects retain defects in insulin action
    • Thompson DB, Pratley R, Ossowski V: Human primary myoblast cell cultures from non-diabetic insulin resistant subjects retain defects in insulin action. J Clin Invest 98:2346-2350, 1996
    • (1996) J Clin Invest , vol.98 , pp. 2346-2350
    • Thompson, D.B.1    Pratley, R.2    Ossowski, V.3
  • 22
    • 0033007208 scopus 로고    scopus 로고
    • Insulin receptor antophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians
    • Youngren JF, Goldfine ID, Pratley RE: Insulin receptor antophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians. Am J Physiol 276:E990-E994, 1999
    • (1999) Am J Physiol , vol.276
    • Youngren, J.F.1    Goldfine, I.D.2    Pratley, R.E.3
  • 23
    • 0032523817 scopus 로고    scopus 로고
    • Postabsorptive respiratory quotient and insulin-stimulated glucose storage rate in nondiabetic Pima Indians are related to glycogen synthase fractional activity in cultured myoblasts
    • Mott DM, Pratley RE, Bogardus C: Postabsorptive respiratory quotient and insulin-stimulated glucose storage rate in nondiabetic Pima Indians are related to glycogen synthase fractional activity in cultured myoblasts. J Clin Invest 101:2251-2256, 1998
    • (1998) J Clin Invest , vol.101 , pp. 2251-2256
    • Mott, D.M.1    Pratley, R.E.2    Bogardus, C.3
  • 24
    • 0029739976 scopus 로고    scopus 로고
    • Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects: Biochemical and molecular mechanisms
    • Henry RR, Ciaraldi TP, Abrams-Carter L, Mudaliar S, Park KS, Nikoulina SE: Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects: biochemical and molecular mechanisms. J Clinn Invest 98:1231-1236, 1996
    • (1996) J Clinn Invest , vol.98 , pp. 1231-1236
    • Henry, R.R.1    Ciaraldi, T.P.2    Abrams-Carter, L.3    Mudaliar, S.4    Park, K.S.5    Nikoulina, S.E.6
  • 25
    • 0028799952 scopus 로고
    • Glucose transport in cultured human skeletal muscle cells: Regulation by insulin and glucose in nondiabetic and non-insulin-dependent diabetes mellitus subjects
    • Ciaraldi TP, Abrams L, Nikoulina S, Mudaliar S, Henry RR: Glucose transport in cultured human skeletal muscle cells: regulation by insulin and glucose in nondiabetic and non-insulin-dependent diabetes mellitus subjects. J Clin Invest 96:2820-2827, 1995
    • (1995) J Clin Invest , vol.96 , pp. 2820-2827
    • Ciaraldi, T.P.1    Abrams, L.2    Nikoulina, S.3    Mudaliar, S.4    Henry, R.R.5
  • 26
    • 0030895726 scopus 로고    scopus 로고
    • Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for a P13-kinase mediated effect
    • Berti L, Kellerer M, Capp E, Haring HU: Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a P13-kinase mediated effect. Diabetologia 40:606-609, 1997
    • (1997) Diabetologia , vol.40 , pp. 606-609
    • Berti, L.1    Kellerer, M.2    Capp, E.3    Haring, H.U.4
  • 27
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 28
    • 0031002113 scopus 로고    scopus 로고
    • Insulin stimulation of human adipocytes activates the kinase of only a fraction of the insulin receptors
    • Klein HH, Kowalewski B, Drenckhan M, Fehm HL: Insulin stimulation of human adipocytes activates the kinase of only a fraction of the insulin receptors. Am J Physiol 272:E576-E583, 1997
    • (1997) Am J Physiol , vol.272
    • Klein, H.H.1    Kowalewski, B.2    Drenckhan, M.3    Fehm, H.L.4
  • 29
    • 0032896443 scopus 로고    scopus 로고
    • Implications of compound heterozygous insulin receptor mutations in congenital muscle fibre type disproportion myopathy for the receptor kinase activation
    • Klein HH, Muller R, Vestergaard H, Pedersen O: Implications of compound heterozygous insulin receptor mutations in congenital muscle fibre type disproportion myopathy for the receptor kinase activation. Diabetologia 42:245-249, 1999
    • (1999) Diabetologia , vol.42 , pp. 245-249
    • Klein, H.H.1    Muller, R.2    Vestergaard, H.3    Pedersen, O.4
  • 30
    • 0033564888 scopus 로고    scopus 로고
    • Microtiter well assays for protein tyrosine phosphatase activities directed against phosphorylated insulin receptor or insulin receptor substrate-1
    • Krützfeldt J, Grunweller A, Raasch W, Drenckhan M, Klein HH: Microtiter well assays for protein tyrosine phosphatase activities directed against phosphorylated insulin receptor or insulin receptor substrate-1. Anal Biochem 271:97-99, 1999
    • (1999) Anal Biochem , vol.271 , pp. 97-99
    • Krützfeldt, J.1    Grunweller, A.2    Raasch, W.3    Drenckhan, M.4    Klein, H.H.5
  • 32
    • 0014949207 scopus 로고
    • The cleavage of T4-phage
    • Laemmli UK: The cleavage of T4-phage. Nature 227:680-685, 1970
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 33
    • 0032509202 scopus 로고    scopus 로고
    • Stimulation of IRS-1-associated phosphatidylinositol 3-kinase and Akt/protein kinase B but not glucose transport by beta1-integrin signaling in rat adipocytes
    • Guilherme A, Czech MP: Stimulation of IRS-1-associated phosphatidylinositol 3-kinase and Akt/protein kinase B but not glucose transport by beta1-integrin signaling in rat adipocytes. J Biol Chem 273:33119-33122, 1998
    • (1998) J Biol Chem , vol.273 , pp. 33119-33122
    • Guilherme, A.1    Czech, M.P.2
  • 34
    • 0028147131 scopus 로고
    • Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man
    • Del Prato S, Leonetti F, Simonson DC, Sheehan P, Matsuda M, DeFronzo RA: Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia 37:1025-1035, 1994
    • (1994) Diabetologia , vol.37 , pp. 1025-1035
    • Del Prato, S.1    Leonetti, F.2    Simonson, D.C.3    Sheehan, P.4    Matsuda, M.5    DeFronzo, R.A.6
  • 35
    • 0032765395 scopus 로고    scopus 로고
    • Glucose turnover and adipose tissue lipolysis are insulin-resistant in healthy relatives of type 2 diabetes patients: Is cellular insulin resistance a secondary phenomenon?
    • Eriksson JW, Smith U, Waagstein F, Wysocki M, Jansson PA: Glucose turnover and adipose tissue lipolysis are insulin-resistant in healthy relatives of type 2 diabetes patients: is cellular insulin resistance a secondary phenomenon? Diabetes 48:1572-1578, 1999
    • (1999) Diabetes , vol.48 , pp. 1572-1578
    • Eriksson, J.W.1    Smith, U.2    Waagstein, F.3    Wysocki, M.4    Jansson, P.A.5
  • 37
    • 0030905313 scopus 로고    scopus 로고
    • Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes: Role of chronic hyperinsulinemia and hyperglycemia
    • Nikoulina SE, Ciaraldi TP, Abrams-Carter L, Mudaliar S, Park KS, Henry RR: Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes: role of chronic hyperinsulinemia and hyperglycemia. Diabetes 46:1017-1024, 1997
    • (1997) Diabetes , vol.46 , pp. 1017-1024
    • Nikoulina, S.E.1    Ciaraldi, T.P.2    Abrams-Carter, L.3    Mudaliar, S.4    Park, K.S.5    Henry, R.R.6
  • 38
    • 0025991864 scopus 로고
    • In vivo stimulation of the insulin receptor kinase in human skeletal muscle: Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies
    • Freidenberg GR, Suter SL, Henry RR, Reichart D, Olefsky JM: In vivo stimulation of the insulin receptor kinase in human skeletal muscle: correlation with insulin-stimulated glucose disposal during euglycemic clamp studies. J Clin Invest 87:2222-2229, 1991
    • (1991) J Clin Invest , vol.87 , pp. 2222-2229
    • Freidenberg, G.R.1    Suter, S.L.2    Henry, R.R.3    Reichart, D.4    Olefsky, J.M.5


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