Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats

International Journal for Vitamin and Nutrition Research

Volumn 69, Issue 5, 1999, Pages 341-347

  Shin, Yong Won ^d   Bok, Song Hae ^d   Jeong, Tae Sook ^a   Bae, Ki Hwan ^b   Jeoung, Nam Ho ^d   Choi, Myung Sook ^c   Lee, Sung Heui ^d   Park, Yong Bok ^d  

^a Korea Institute of Science and Technology   (South Korea)

^b Chungnam National University   (South Korea)

^c Kyungpook National University   (South Korea)

^d Kyungpook National University ^*

Author keywords

ACAT; Cholesterol lowering effect; HMG CoA reductase; Naringin

Indexed keywords

ANIMALIA; CITRUS;

EID: 0033199150     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831.69.5.341     Document Type: Article

References (45)

1. Wald, N. J. and Law, M. R. (1995) Serum Cholesterol and Ischaemic Heart Disease. Atherosclerosis 118 (Suppl), S1-S5.
2. Alberts, A. W., Chen, J., Kuron, G., Hunt, V., Huff, J., Hoffman, C., Rothrock, J., Lopez, M., Joshua, H., Harris, E., Patchett, A., Monaghan, R., Currie, S., Stapley, E., Albers-Schonberg, G., Hensens, O., Hirshfield, J., Hoogsteen, K., Liesch, J. and Springer, J. (1980) Mevinolin; A Highly Potent Competitive Inhibitor of Hydroxymethylglutaryl-Coenzyme A Reductase and a Cholesterol-lowering Agent. Proc. Natl. Acad. Sci. 77, 3957-3961.
3. Amin, D., Gustafson, S. K., Weinacht, J. M., Cornell, S. A., Neuenschwander, K., Scotese, A. C., Regan, J. R. and Perrone, M. H. (1993) RG 12561 (Dalvastatin): A Novel Synthetic Inhibitor of HMG-CoA Reductase and Cholesterol-lowering Agent. Pharmacology 46, 13-22.
4. Alberts, A. W. (1988) Discovery, Biochemistry and Biology of Lovastatin. Am. J. Cardiol. 62, 10J-15J.
5. Fujioka, T., Nara, F., Tsujita, Y., Fukushige, J., Masaharu, F. and Kuroda, M. (1995) The Mechanism of Lack of Hypocholesterolemic Effects of Pravastatin Sodium, a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, in Rats. Biochimica et Biophysica Acta 1254, 7-12.
6. Lovastatin study groups I through IV (1993) Lovastatin 5-year Safety and Efficacy Study. Arch. Intern. Med. 153, 1079-1087.
7. Brown, M. S., Ho, Y. K. and Goldslein, J. L. (1980) The Cholesteryl Ester Cycle in Macrophage Foam Cells. Continual Hydrolysis and Re-esterification of Cytoplasmic Cholesteryl Esters. J. Biol. Chem. 255, 9344-9352.
8. Kannel, W. B., Casteri, W. P., Gondon, T. and McNamara, P. M. (1971) Serum Cholesterol, Lipoproteins, and the Risk of Coronary Heart Disease: the Framingham Study. Ann. Intern. Med. 74, 1-12.
9. Frick, M. H., Elso, O. and Haapa, K. et al (1987) Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-aged Men with Dyslipidemia: Safety of Treatment Changes in Risk Factors, and Incidence of Coronary Heart Disease. N. Engl. J. Med. 317, 1237-1245.
10. Helgerud, P., Sarem, K. and Norum, K. R. (1981) Acyl-CoA: Cholesterol Acyltransferase in Human Small Intestine: Its Activity and Some Properties of the Enzyme Reaction. J. Lipid Res. 22, 271-277.
11. Suckling, K. E. and Stange, E. F. (1985) Role of Acyl-CoA: Cholesterol Acyltransferase in Cellular Cholesterol Metabolism. J. Lipid Res. 26, 647-671.
12. Hertog, M. G. L., Feskens, E. J. M., Hollman, P. C. H., Katan, M. B. and Kromhout, D. (1993) Dietarey antioxidant flavonoids and risk of coronary heart diseases: the Zutphen elderly study. Lancet 342, 1007-1011.
13. Hertog, M. G. L., Kromhout, D., Aravanis, C., Blackbum, H., Buzina, R. Fidanza, F. and Giampaoli, S. (1995) Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Intern. Med. 155, 381-386.
14. Knekt, P., Jarvine, R., Reunanen, A. and Maatela, J. (1996) Flavonoid intake and coronary mortality in Finland: a cohort study. Brit. Med. L. 312, 478-481.
15. American Institute of Nutrition (1977) Report of the American Institute of Nutrition. Ad Hoc Committee on Standards for Nutritional Studies. J. Nutr. 107, 1340-1348.
16. American Institute of Nutrition (1980) Report of Ad Hoc Committee on Standards for Nutritional Studies. J. Nutr. 110, 1726.
17. Allain, C. C., Poon, L. S. and Chan, C. S. G. et al (1974) Enzymatic Determination of Total Serum Cholesterol. Clin. Chem. 20, 470-475.
18. Warnick, R. G. and Albers, J. J. (1978) A Comprehensive Evaluation of the Heparin-manganease Precipitation Procedure for Estimating High Density Lipoprotein Cholesterol. J. Lipid Res. 19, 65-76.
19. McGowan, M. W., Artiss, J. D., Strandbergh, D. R. and Zak, B. (1983) A Peroxidase-coupled Method for the Colorimetric Determination of Serum Triglycerides. Clin. Chem. 29, 538-542.
20. Folch, J., Lees, M. and Sloan-Stanley, G. H. (1956) A Simple Method for Isolation and Purification of Total Lipids from Animal Tissues. J. Biol. Chem. 226, 497-509.
21. Omodeo, S., Marchesini, S., Fishman, P. H. and Berra, B. (1984) A Sensitive Enzymatic Assay for Determination of Cholesterol in Lipid Extract. Analytical Biochemistry 142, 347-350.
22. Czubayko, F., Beumers, B., Lammsfuss, S., Lütjohann, D. and von Bergmann, K. (1991) A Simplified Micro-method for Quantification of Fecal Excretion of Neutral and Acidic Sterols for Outpatient Studies in Humans. J. Lipid Res. 32, 1861-1867.
23. Hulcher, F. H. and Oleson, W. H. (1973) Simplified Spectrophotometric Assay for Microsomal 3-Hydroxy-3-Methylglutaryl CoA Reductase by Measurement of Coenzyme A. J. Lipid Res. 14, 625-631.
24. Bradford, M. M. (1976) A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-dye Binding. Anal. Biochem. 72, 248-254.
25. Shapiro, D. J., Nordstrom, J. L.; Mitschelen, J. J., Rodwell, V. W. and Schimke, R. T. (1974) Micro Assay for 3-Hydroxy-3-Methylglutaryl-CoA Reductase in Rat Liver and in L-cell Fibroblasts. Biochim. Biophy. Acta 370, 369-377.
26. Erickson, S. K., Schrewsbery, M. A., Brooks, C. and Meyer, D. J. (1980) Rat Liver Acyl-Coenzy me A: Cholesterol Acyltransferase: Its Regulation in vivo and Some of Properties in vitro. J. Lipid Res, 21, 93-941.
27. Gillies, P. J., Rathgeb, K. A. and Robinson, C. S. (1986) Regulation of Acyl-CoA:Cholesterol Acyltransferase Activity in Normal and Atherosclerotic Rabbit Aortas: Role of a Cholesterol Substrate Pool. Experimental and Molecular Pathology 44, 320-339.
28. Cook, N. C. and Samman, S. (1996) Flavonoids-chemistry, metabolism, cardiopropective effects, and dietary sources. J. Nutr. Biochem. 7, 66-76.
29. Middleton, E. and Kadaswami, C. (1993) The impact of plant flavonoids on mammalian biology: Implication for immunity, inflammation and cancer. In: The Flavonoids: Advances in Research Since 1986. (J. B. Harborne, ed.) pp. 619-652, Chapman and Hall, London, UK.
30. Endo, A. (1992) The Discovery and Development of HMG-CoA Reductase Inhibitors. J. Lipid Res. 33, 1569-1582.
31. Fears, R., Richards, D. H. and Ferres, H. (1980) The Effect of Compactin, a Potent Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme. A Reductase activity, on Cholesterogenesis and Serum Cholesterol Levels in Rats and Chicks. Atherosclerosis 35, 439-449.
32. Endo, A., Tsujia, Y., Kuroda, M. and Tanzawa, K. (1979) Effects of ML-236B on Cholesterol Metabolism in Mice and Rats: Lack of Hypocholesterolemic Activity in Normal Animals. Biochim. Biophys. Acta. 575, 266-276.
33. Ma, P. T. S., Gil, G., Sudhog, T. C., Bilheimer, D. W., Goldstein, J. L. and Brown, M. S. (1986) Mevinolin, and Inhibitor of Cholesterol Synthesis, Induces mRNA for Low Density Lipoprotein Receptor in Livers of Hamsters and Rabbits. Proc. Natl. Acad. Sci USA, 83, 8370-8374.
34. Tall, A. R. (1993) Plasma cholesteryl ester transfer protein. J. Lipid Res. 34, 1255-1274.
35. Shand, J. H. and West, D. W. (1995) The Effects of Simvastatin and Cholestyramine, Alone and in Combination, on Hepatic Cholesterol Metabolism in the Male Rate. Lipids, 30, 917-926.
36. Krause, B. R., Anderson, M., Bisgaier, C. L., Bocan, T., Bousley, R., DeHart, P., Essenburg, A., Hamelehle, K., Homan, R., Kieft, K., McNally, W., Stanfield, R. and Newton, R. S. (1993) In vivo Evidence that the Lipid-Regulating Activity of the ACAT Inhibitor CI-976 in Rat is due to Inhibition of Both Intestinal and Liver ACAT. J. Lipid Res. 34, 279-294.
37. Van Heek, M., France, C. F., Compton, D. S., McLeod, R. L., Yumibe, N. P., Alton, K. B., Sybertz, E. J. and Davis, H. R. Jr. (1997) In vivo Metabolism-Based Discovery of a Potent Cholesterol Absorption Inhibitor, SCH 58235, in the Rat and Rhesus Monkey through the Identification of the Active Metabolites of SCH 48461. The Journal of Pharmacology and Experimental Therapeutics (JPET) 283, 157-163.
38. Schnitzler-Polokoff, R., Compton, D., Boykow, G., Harry, D. and Robert, B. (1991) Effects of Acyl-CoA:Cholesterol O-Acyltransferase Inhibition of Cholesterol Absorption and Plasma Lipoprotein Composition in Hamsters. Comp. Biochem. Physiol. 99, 665-670.
39. Largis, E. F., Wang, C. H., DeVries, V. G. and Schaffer, S. A. (1989) CL 277082: a Novel Inhibitor of ACAT-Catalysed Cholesterol Esterification and Cholesterol Absorption. J. Lipid Res. 30, 681-690.
40. Williams, R. J., McCarthy, A. D. and Sutherland, C. D. (1989) Esterification and Absorption of Cholesterol: in vitro and in vivo Observations in the Rat. Biochim. Biophys. Acta 1003, 213-216.
41. Marezetta, C. A., Savoy, Y. E., Freeman, A. M., Long, C. A., Pettini, J. L., Hagar, R. E., Inskeep, P. B., Davis, K., Stucchi, A. F., Nicolosi, R. J. and Hamanaka, E. S. (1994) Pharmacological Properties of a Novel ACAT Inhibitor (CP-113,818) in Cholesterol-Fed Rats, Hamsters, Rabbits, and Monkeys. J. Lipid Res. 35, 1829-1838.
42. Harris, W. S., Dujovne, C. A., von Bergmann, K., Neal, J., Akester, J., Windsor, S. L., Greene, D. and Look, Z. (1990) Effects of the ACAT Inhibitor CL 277,082 on Cholesterol Metabolism in Humans. Clin. Pharmacol.Ther. 48, 189-194.
43. Bjorkhem, I. (1985) Mechanism of Bile Acid Biosynthesis in Mammalian Liver. In: New comprehensive Biochemistry, (Danielsson, H. and Sjovall, J., eds.), pp. 231-278, Amsterdam: Elsevier Scientific Publishing Co.
44. Field, F. J., Cooper, A. D. and Erickson, S. K. (1982) Regulation of Rabbit Intestinal Acyl Coenzyme A: Cholesterol Acyltransferase In Vivo and In Vitro. Gasteroenterology 83, 873-880.
45. Carr, T. P., Parks, J. S. and Rudel, L. L. (1992) Hepatic ACAT Activity in African Green Monkeys in Highly Correlated to Plasma LDL Cholesteryl Enrichment and Coronary Artery Atherosclerosis. Arterioscler. Thromb. 12, 1274-1283.