Normal production rate of apolipoprotein B in LDL receptor-deficient mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 22, Issue 6, 2002, Pages 989-994

  Millar, John S ^a   Maugeais, Cyrille ^a   Fuki, Ilia V ^a   Rader, Daniel J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

apobec1; Familial hypercholesterolemia; Triglycerides; Triton WR1339; Very low density lipoproteins

Indexed keywords

APOLIPOPROTEIN B; APOLIPOPROTEIN B100; LOW DENSITY LIPOPROTEIN RECEPTOR; METHIONINE; TRIACYLGLYCEROL; TYLOXAPOL; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; CHOLESTEROL BLOOD LEVEL; FAMILIAL HYPERCHOLESTEROLEMIA; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SYNTHESIS; RECEPTOR BINDING; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; APOLIPOPROTEINS B; CYTIDINE DEAMINASE; ENZYME INHIBITORS; FEMALE; INJECTIONS, INTRAVENOUS; LIPASE; LIPOPROTEINS, VLDL; LIVER; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICE, MUTANT STRAINS; POLYETHYLENE GLYCOLS; RECEPTORS, LDL; RNA-BINDING PROTEINS; TRIGLYCERIDES;

EID: 0036072190     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000018304.30943.06     Document Type: Article

References (25)

1. The triple threat to nascent apolipoprotein B: Evidence for multiple, distinct degradative pathways
2. Familial hypercholesterolemia
3. The role of the LDL receptor in apolipoprotein B secretion
4. Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL
5. Simultaneous measurement of apolipoprotein B turnover in very-low- and low-density lipoproteins in familial hypercholesterolaemia
6. The metabolism of very low density and intermediate density lipoproteins in patients with familial hypercholesterolaemia
7. Apolipoprotein B metabolism in homozygous familial hypercholesterolemia
8. Lovastatin therapy in receptor negative homozygous familial hypercholesterolemia: Lack of effect on low-density lipoprotein concentrations or turnover
9. Secretion of lipoprotein from the liver of normal and Watanabe heritable hyperlipidemic rabbits
10. Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit
11. De novo production of low density lipoproteins: Fact or fancy
12. Sensitive methods to study human apolipoprotein B metabolism using stable isotope-labeled amino acids
13. Sustained hyperlipidemia induced in rabbits by means of intravenously injected surface active agents
14. Effect of Triton on lipoprotein lipase of rat plasma
15. Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglyceride and apolipoprotein B
16. Hepatic apolipoprotein E expression promotes very low density lipoprotein-apolipoprotein B production in vivo in mice
17. Markedly increased secretion of VLDL triglycerides induced by gene transfer of apolipoprotein E isoforms in apoE-deficient mice
18. Method to measure apolipoprotein B-48 and B-100 secretion rates in an individual mouse: Evidence for a very rapid turnover of VLDL and preferential removal of B-48-relative to B-100-containing lipoproteins
19. Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B-lipoproteins in a mouse with selective deficiency of brown adipose tissue, obesity and insulin resistance
20. A receptor-mediated pathway for cholesterol homeostasis
21. On the inhibition of lipoprotein lipase by Triton WR1339
22. Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339
23. The unstirred water layer as a site of control of apolipoprotein B secretion
24. Phenotype interaction of apobec-1 and CETP, LDLR, and apoE gene expression in mice: Role of apoB mRNA editing in lipoprotein phenotype expression
25. Hepatic gene transfer of the catalytic subunit of the apolipoprotein B mRNA editing enzyme results in a reduction of plasma LDL levels in normal and Watanabe heritable hyperlipidemic rabbits