P2Y2 receptor agonist INS37217 enhances functional recovery after detachment caused by subretinal injection in normal and rds mice

Investigative Ophthalmology and Visual Science

Volumn 44, Issue 10, 2003, Pages 4505-4514

  Nour, May ^a   Quiambao, Alexander B ^b   Peterson, Ward M ^c   Al Ubaidi, Muayyad R ^a,b   Naash, Muna I ^a,b  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c Inspire Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DENUFOSOL; DNA FRAGMENT; ERYTHROMYCIN; PURINE P2Y RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

A WAVE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; ELECTRORETINOGRAM; FEMALE; GENE; HISTOLOGY; MOUSE; NICK END LABELING; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RDS GENE; RETINA CONE; RETINA DEGENERATION; RETINA DETACHMENT; RETINA ROD;

ANIMALS; DARK ADAPTATION; DEOXYCYTOSINE NUCLEOTIDES; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; ELECTRORETINOGRAPHY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IN SITU NICK-END LABELING; INJECTIONS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSPHERES; PHOTORECEPTORS, VERTEBRATE; RECEPTORS, PURINERGIC P2; RECOVERY OF FUNCTION; RETINAL DETACHMENT; RETINITIS PIGMENTOSA; URIDINE;

EID: 0141430039     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.03-0453     Document Type: Article

References (57)

1. Cook B, Lewis GP, Fisher SK, et al. Apoptotic photoreceptor degeneration in experimental retinal detachment. Invest Ophthalmol Vis Sci. 1995;36:990-996.
2. Fisher SK, Erickson PA, Lewis GP, et al. Intraretinal proliferation induced by retinal detachment. Invest Ophthalmol Vis Sci. 1991;32:1739-1748.
3. Lewis GP, Guerin CJ, Anderson DH, et al. Rapid changes in the expression of glial cell proteins caused by experimental retinal detachment. Am J Ophthalmol. 1994;118:368-376.
4. Lewis GP, Charteris DG, Sethi CS, et al. Animal models of retinal detachment and reattachment: identifying cellular events that may affect visual recovery. Eye. 2002;16:375-387.
5. Lewis GP, Fisher SK. Muller cell outgrowth after retinal detachment: association with cone photoreceptors. Invest Ophthalmol Vis Sci. 2000;41:1542-1545.
6. Lewis GP, Linberg KA, Fisher SK. Neurite outgrowth from bipolar and horizontal cells after experimental retinal detachment. Invest Ophthalmol Vis Sci. 1998;39:424-434.
7. Rex TS, Fariss RN, Lewis GP, et al. A survey of molecular expression by photoreceptors after experimental retinal detachment. Invest Ophthalmol Vis Sci. 2002;43:1234-1247.
8. Young RW, Bok D. Participation of the retinal pigment epithelium in the rod outer segment renewal process. J Cell Biol. 1969;42:392-403.
9. Bridges CD. Vitamin A and the role of the pigment epithelium during bleaching and regeneration of rhodopsin in the frog eye. Exp Eye Res. 1976;22:435-455.
10. Liou GI, Bridges CD, Fong SL, et al. Vitamin A transport between retina and pigment epithelium-an interstitial protein carrying endogenous retinol (interstitial retinol-binding protein). Vision Res. 1982;22:1457-1467.
11. Bernstein PS, Law WC, Rando RR. Isomerization of all-trans-retinoids to 11-cis-retinoids in vitro. Proc Natl Acad Sci USA. 1987;84:1849-1853.
12. Li JD, Gallemore RP, Dmitriev A, et al. Light-dependent hydration of the space surrounding photoreceptors in chick retina. Invest Ophthalmol Vis Sci. 1994;35:2700-2711.
13. Dmitriev AV, Govardovskii VI, Schwahn HN, et al. Light-induced changes of extracellular ions and volume in the isolated chick retina-pigment epithelium preparation. Vis Neurosci. 1999;16:1157-1167.
14. Burton TC. Recovery of visual acuity after retinal detachment involving the macula. Trans Am Ophthalmol Soc. 1982;80:475-497.
15. Sakai T, Calderone JB, Lewis GP, et al. Cone photoreceptor recovery after experimental detachment and reattachment: an immunocytochemical, morphological, and electrophysiological study. Invest Ophthalmol Vis Sci. 2003;44:416-425.
16. Liem AT, Keunen JE, van Meel GJ, et al. Serial foveal densitometry and visual function after retinal detachment surgery with macular involvement. Ophthalmology. 1994;101:1945-1952.
17. Kusaka S, Toshino A, Ohashi Y, et al. Long-term visual recovery after scleral buckling for macula-off retinal detachments. Jpn J Ophthalmol. 1998;42:218-222.
18. Berson EL. Retinitis pigmentosa: unfolding its mystery. Proc Natl Acad Sci USA. 1996;93:4526-4528.
19. Li T, Sandberg MA, Pawlyk BS, et al. Effect of vitamin A supplementation on rhodopsin mutants threonine-17→methionine and proline-347→serine in transgenic mice and in cell cultures. Proc Natl Acad Sci USA. 1998;95:11933-11938.
20. Frasson M, Sahel JA, Fabre M, et al. Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse. Nat Med. 1999;5:1183-1187.
21. Bok D, Yasumura D, Matthes MT, et al. Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res. 2002;74:719-735.
22. LaVail MM, Yasumura D, Matthes MT, et al. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci. 1998;39:592-602.
23. Cayouette M, Behn D, Sendtner M, et al. Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J Neurosci. 1998;18:9282-9293.
24. Cayouette M, Smith SB, Becerra SP, et al. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis. 1999;6:523-532.
25. Takahashi M, Miyoshi H, Verma IM, et al. Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol. 1999;73:7812-7816.
26. Bennett J, Zeng Y, Bajwa R, et al. Adenovirus-mediated delivery of rhodopsin-promoted bcl-2 results in a delay in photoreceptor cell death in the rd/rd mouse. Gene Ther. 1998;5:1156-1164.
27. Lewin AS, Drenser KA, Hauswirth WW, et al. Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa. Nat Med. 1998;4:967-971.
28. Acland GM, Aguirre GD, Ray J, et al. Gene therapy restores vision in a canine model of childhood blindness. Nat Genet. 2001;28:92-95.
29. Bennett J, Tanabe T, Sun D, et al. Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy. Nat Med. 1996;2:649-654.
30. Liang FQ, Aleman TS, Dejneka NS, et al. Long-term protection of retinal structure but not function using RAAV: CNTF in animal models of retinitis pigmentosa. Mol Ther. 2001;4:461-472.
31. LaVail MM, Yasumura D, Matthes MT, et al. Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy. Proc Natl Acad Sci USA. 2000;97:11488-11493.
32. Takeuchi A, Kricorian G, Yao XY, et al. The rate and source of albumin entry into saline-filled experimental retinal detachments. Invest Ophthalmol Vis Sci. 1994;35:3792-3798.
33. Lewis GP, Matsumoto B, Fisher SK. Changes in the organization and expression of cytoskeletal proteins during retinal degeneration induced by retinal detachment. Invest Ophthalmol Vis Sci. 1995;36:2404-2416.
34. Machemer R. Macular translocation. Am J Ophthalmol. 1998;125:698-700.
35. Pederson JE, MacLellan HM. Experimental retinal detachment. I. Effect of subretinal fluid composition on reabsorption rate and intraocular pressure. Arch Ophthalmol. 1982;100:1150-1154.
36. Peterson WM, Meggyesy C, Yu KF, et al. Extracellular ATP activates calcium signaling, ion, and fluid transport in retinal pigment epithelium. J Neurosci. 1997;17:2324-2337.
37. Ryan JS, Baldridge WH, Kelly MEM. Purinergic regulation of cation conductances and intracellular Ca2+ in cultured rat retinal pigment epithelial cells. J Physiol (Lond) 1999;520:745-759.
38. Meyer CH, Hotta K, Peterson WM, et al. Effect of INS37217, a P2Y(2) Receptor Agonist, on Experimental Retinal Detachment and Electroretinogram in Adult Rabbits. Invest Ophthalmol Vis Sci. 2002;43:3567-3574.
39. Maminishkis A, Jalickee S, Blaug SA, et al. The P2Y(2) receptor agonist INS37217 stimulates RPE fluid transport in vitro and retinal reattachment in rat. Invest Ophthalmol Vis Sci. 2002;43:3555-3566.
40. Cheng T, Peachey NS, Li S, et al. The effect of peripherin/rds haploinsufficiency on rod and cone photoreceptors. J Neurosci. 1997;17:8118-8128.
41. Travis GH, Brennan MB, Danielson PE, et al. Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds). Nature. 1989;338:70-73.
42. Timmers AM, Zhang H, Squitieri A, et al. Subretinal injections in rodent eyes: Effects on electrophysiology and histology of rat retina. Mol Vis. 2001;7:131-137.
43. Flannery JG, Zolotukhin S, Vaquero MI, et al. Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus. Proc Natl Acad Sci USA. 1997;94:6916-6921.
44. Hauswirth WW, LaVail MM, Flannery JG, et al. Ribozyme gene therapy for autosomal dominant retinal disease. Clin Chem Lab Med. 2000;38:147-153.
45. Miyoshi H, Takahashi M, Gage FH, et al. Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci USA. 1997;94:10319-10323.
46. Bennett J, Duan D, Engelhardt JF, et al. Real-time, noninvasive in vivo assessment of adeno-associated virus-mediated retinal transduction. Invest Ophthalmol Vis Sci. 1997;38:2857-2863.
47. Ali RR, Reichel MB, De Alwis M, et al. Adeno-associated virus gene transfer to mouse retina. Hum Gene Ther. 1998;9:81-86.
48. Zeng Y, Rosborough RC, Li Y, et al. Temporal and spatial regulation of gene expression mediated by the promoter for the human tissue inhibitor of metalloproteinases-3 (TIMP-3)-encoding gene. Dev Dyn. 1998;211:228-237.
49. Geller SF, Lewis GP, Anderson DH, et al. Use of the MIB-1 antibody for detecting proliferating cells in the retina. Invest Ophthalmol Vis Sci. 1995;36:737-744.
50. Lewis GP, Charteris DG, Sethi CS, et al. The ability of rapid retinal reattachment to stop or reverse the cellular and molecular events initiated by detachment. Invest Ophthalmol Vis Sci. 2002;43:2412-2420.
51. Hisatomi T, Sakamoto T, Goto Y, et al. Critical role of photoreceptor apoptosis in functional damage after retinal detachment. Curr Eye Res. 2002;24:161-172.
52. Kim SD, Nao-i N, Maruiwa F, et al. Electrical responses from locally detached retina and its recovery after reattachment. Ophthalmologica. 1996;210:195-199.
53. Wu WC, Lai CC, Chen SL, et al. Gene therapy for detached retina by adeno-associated virus vector expressing glial cell line-derived neurotrophic factor. Invest Ophthalmol Vis Sci. 2002;43:3480-3488.
54. Lewis GP, Linberg KA, Geller SF, et al. Effects of the neurotrophin brain-derived neurotrophic factor in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci. 1999;40:1530-1544.
55. Lewis G, Mervin K, Valter K, et al. Limiting the proliferation and reactivity of retinal Muller cells during experimental retinal detachment: the value of oxygen supplementation. Am J Ophthalmol. 1999;128:165-172.
56. Mervin K, Valter K, Maslim J, et al. Limiting photoreceptor death and deconstruction during experimental retinal detachment: the value of oxygen supplementation. Am J Ophthalmol. 1999;128:155-164.
57. Sakai T, Lewis GP, Linberg KA, et al. The ability of hyperoxia to limit the effects of experimental detachment in cone-dominated retina. Invest Ophthalmol Vis Sci. 2001;42:3264-3273.