The effect of peripherin/rds haploinsufficiency on rod and cone photoreceptors

Journal of Neuroscience

Volumn 17, Issue 21, 1997, Pages 8118-8128

  Cheng, Tong ^a   Peachey, Neal S ^b,c   Li, Shihong ^a   Goto, Yoshinobu ^b,c,e   Cao, Yun ^a   Naash, Muna I ^a,d  

^a UNIVERSITY OF ILLINOIS   (United States)

^b HINES VA HOSPITAL   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

^d University of Illinois Chicago   (United States)

^e KYUSHU UNIVERSITY   (Japan)

Author keywords

Electroretinograms; Outer segment; Peripherin rds; Photoreceptors; Retinal degeneration

Indexed keywords

PERIPHERIN; RHODOPSIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN ANALYSIS; RETINA CONE; RETINA DEGENERATION; RETINA ROD; RETINA ROD OUTER SEGMENT;

EID: 0030831115     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-21-08118.1997     Document Type: Article

References (14)

1. Al-Ubaidi MR, Pittler SJ, Champagne MS, Triantafyllos JT, McGinnis JF, Baehr W (1990) Mouse opsin: gene structure and molecular basis of multiple transcripts. J Biol Chem 265:20563-20569.
2. Arikawa K, Molday LL, Molday RS, Williams DS (1992) Localization of peripherin/rds in the disk membranes of cone and rod photoreceptors: relationship to disk membrane morphogenesis and retinal degeneration. J Cell Biol 116:659-667.
3. Birch DG, Kedzierski W, Nusinowitz S, Anderson JL, Travis GH (1995) Rod photoreceptor function in transgenic mice expressing mutant rds/peripherin. ARVO abstracts. Invest Ophthalmol Vis Sci 35:S641.
4. Birch DG, Travis GH, Locke KG, Hood DC (1997) Rod ERGs in mice and humans with putative null mutations in the RDS gene. In: Vision science and its applications, Vol 1, 1997 OSA technical digest series, pp 262-265. Washington, DC: Optical Society of America.
5. Bowes C, Li T, Danciger M, Baxter LC, Applebury ML, Farber DB (1990) Retinal degeneration in rd mouse is caused by a defect in the β subunit of rod cGMP-phosphodiesterase. Nature 347:677-680.
6. Breton ME, Schueller AW, Lamb TD, Pugh Jr EN (1994) Analysis of ERG a-wave amplification and kinetics in terms of the G-protein cascade of phototransduction. Invest Ophthalmol Vis Sci 35:295-309.
7. Cantera R, von Schantz M, Chader GJ, Ehinger B, Sanyal S, van Veen T (1990) Postnatal development of photoreceptor-specific proteins in mice with hereditary retinal degeneration. Exp Biol 48:305-312.
8. Carter-Dawson LD, LaVail MM (1979) Rods and cones in the mouse retina. I. Structural analysis using light and electron microscopy. J Comp Neurol 188:245-262.
9. Carter-Dawson LD, LaVail MM, Sidman RL (1978) Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci 17:489-498.
10. Cheng T, Al-Ubaidi MR, Naash MI (1997) Structural and developmental analysis of the mouse peripherin/rds gene. Somat Cell Mol Genet 23:165-183.
11. Chiu MI, Nathans J (1994) A sequence upstream of the mouse blue visual pigment gene directs blue cone-specific transgene expression in mouse retinas. Vis Neurosci 11:773-780.
12. Eckmiller MS (1997) Morphogenesis and renewal of cone outer segments. Prog Ret Eye Res 16:401-441.
13. Farrar GJ, Kenna P, Jordan SA, Kumar-Singh R, Humphries MM, Sharp EM, Shells DM, Humphries P (1991) A three-base-pair deletion in the peripherin-RDS gene in one form of retinitis pigmentosa. Nature 354:478-480.
14. Fishman GA, Stone E, Gilbert LD, Vandenburgh K, Sheffield VC, Heckenlively JR (1994) Clinical features of a previously undescribed codon 216 (proline to serine) mutation in the peripherin/retinal degeneration slow gene in autosomal dominant retinitis pigmentosa. Ophthalmology 101:1409-1421.