The P2Y2 receptor agonist INS37217 stimulates RPE fluid transport in vitro and retinal reattachment in rat

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 11, 2002, Pages 3555-3566

  Maminishkis, Arvydas ^a   Jalickee, Stephen ^a   Blaug, Sasha A ^a   Rymer, Jodi ^a   Yerxa, Benjamin R ^a   Peterson, Ward M ^a   Miller, Sheldon S ^a  

^a NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CALCIUM; DENUFOSOL; PURINE P2Y RECEPTOR; PURINERGIC RECEPTOR AFFECTING AGENT; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APICAL MEMBRANE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CATTLE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; FEMALE; FETUS; FLUID TRANSPORT; HUMAN; HUMAN CELL; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; RETINA DETACHMENT; RETINA DISEASE;

ABSORPTION; ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CATTLE; DEOXYCYTOSINE NUCLEOTIDES; ELECTROPHYSIOLOGY; HUMANS; INJECTIONS; ION TRANSPORT; MEMBRANE POTENTIALS; PIGMENT EPITHELIUM OF EYE; RATS; RATS, LONG-EVANS; RECEPTORS, PURINERGIC P2; RETINAL DETACHMENT; URIDINE; URIDINE TRIPHOSPHATE; VITREOUS BODY; WATER;

EID: 0036847575     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Ralevic V, Burnstock G. Receptors for purines and pyrimidines. Pbarmacol Rev. 1998;50:413-492.
2. Dubyak GR. Signal transduction by P2-purinergic receptors for extracellular ATP. Am J Resp Cell Mol Biol. 1991;4:295-300.
3. 2 receptor agonists: Structure, activity, and therapeutic utility. Drugs Future. 1999;24:759-769.
4. Bringmann A, Pannicke T, Moll V, et al. Upregulation of P2X receptor currents in Muller glial cells during proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2001;42:860-867.
5. Fujihara T, Murakami T, Fujita H, Nakamura M, Nakata K. Improvement of corneal barrier function by the P2Y agonist INS365 in a rat dry eye model. Invest Ophthalmol Vis Sci. 2001;42:96-100.
6. Cha SH, Hahn TW, Sekine T, Lee KH, Endou H. Purinoceptor-mediated calcium mobilization and cellular proliferation in cultured bovine corneal endothelial cells. Jpn J Pharmacol. 2000;82:181-187.
7. Wheeler-Schilling TH, Marquordt K, Kohler K, Jabs R, Guenther E. Expression of purinergic receptors in bipolar cells of the rat retina. Brain Res Mol Brain Res. 2000;76:415-418.
8. Hosoya K, Ueda H, Kim KJ, Lee VH. Nucleotide stimulation of Cl(-) secretion in the pigmented rabbit conjunctiva. J Pharmacol Exp Ther. 1999;291:53-59.
9. Merriman-Smith R, Tunstall M, Kistler J, et al. Expression profiles of P2-receptor isoforms P2Y1 and P2Y2 in the rat lens. Invest Ophthalmol Vis Sci. 1998;39:2791-2796.
10. Sullivan DM, Erb L, Anglade E, et al. Identification and characterization of P2Y2 nucleotide receptors in human retinal pigment epithelial cells. J Neurosci Res. 1997;49:43-52.
11. Shahidullah M, Wilson WS. Mobilisation of intracellular calcium by P2Y2 receptors in cultured, non-transformed bovine ciliary epithelial cells. Curr Eye Res. 1997;16:1006-1016.
12. Pederson JE. Fluid physiology of the subretinal space. In: Wilkinson CP, ed. Retina. St. Louis: Mosby; 1994:1955-1968.
13. Hughes BA, Gallemore RP, Miller SS. Transport mechanisms in the retinal pigment epithelium. In: Marmor MF, Wolfensberger TJ, eds. The Retinal Pigment Epithelium. New York: Oxford University Press; 1998:103-134.
14. Bialek S, Quong J, Yu K, Miller SS. Nonsteroidal anti-inflammatory drugs alter chloride and fluid transport in bovine retinal pigment epithelium. Am J Physiol. 1996;270:C1175-C1189.
15. Edelman JL, Miller SS. Epinephrine stimulates fluid absorption across bovine retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1991;32:3033-3040.
16. Hughes BA, Miller SS, Machen TE. Effects of cyclic AMP on fluid absorption and ion transport across frog retinal pigment epithelium: Measurements in the open-circuit state. J Gen Physiol. 1984;83:875-899.
17. Kita M, Marmor MF. Effects on retinal adhesive force in vivo of metabolically active agents in the subretinal space. Invest Ophthalmol Vis Sci. 1992;33:1883-1887.
18. Marmor MF, Maack T. Enhancement of retinal adhesion and subretinal fluid resorption by acetazolamide. Invest Ophthalmol Vis Sci. 1982;23:121-124.
19. Marmot MF, Negi A. Pharmacologic modification of subretinal fluid absorption in the rabbit eye. Arch Ophthalmol. 1986;104:1674-1677.
20. Peterson W, Meggyesy C, Yu K, Miller SS. Extracellular ATP activates calcium signaling, ion and fluid transport in retinal pigment epithelium. J Neurosci. 1997;17:2324-2337.
21. Dougherty RW, Pendergast W, Yerxa BR, et al. INS542 and INS37217: Novel P2Y2 receptor agonists with enhanced biological stability induce prolonged stimulation of tracheal mucus velocity in vivo (Abstract). J Aerosol Med. 1999;12:141.
22. Peterson WM, Venturini AE, Cowlen MS, Vezina M, Piccirilli G. Metabolism, ocular distribution, and ERG effects of INS37217, a novel P2Y2 receptor agonist, for the treatment of retinal detachment [ARVO Abstract]. Invest Ophthalmol Vis Sci. 2001;42(4): S446. Abstract nr 2408.
23. Joseph DP, Miller SS. Apical and basal membrane ion transport mechanisms in bovine retinal pigment epithelium. J Physiol (Lond). 1991;435:439-463.
24. Miller SS, Steinberg RH. Passive ionic properties of frog retinal pigment epithelium. J Membr Biol 1977;36:337-372.
25. Oakley BD, Miller SS, Steinberg RH. Effect of intracellular potassium upon the electrogenic pump of frog retinal pigment epithelium. J Membr Biol. 1978;44:281-307.
26. i in bovine retinal pigment epithelium [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1991;32(4):S671. Abstract nr 24.
27. Kenyon E, Maminishkis A, Joseph DP, Miller SS. Apical and basolateral membrane mechanisms that regulated pHi in bovine retinal pigment epithelium. Am. J. Physiol. 1997;273:C456-C472.
28. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem. 1985;260:3440-3450.
29. Daniel WW. Biostatistics: A Foundation for Analysis in the Heatlh Sciences. New York: John Wiley & Sons, Inc.; 1995.
30. Mann HB, Whitney DR. On a test of whether one of two random variables is stochastically larger than the other. Ann Math Stat. 1947;18:50-60.
31. Peterson WM, Quong JN, Blaug S, Miller SS. Evidence that cyclic-AMP dependent chloride conductance is controlled by phospholamban rather than CFTR in bovine RPE [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1997;38(4):S467. Abstract nr 2175.
32. Quinn RH, Quong JN, Miller SS. Adrenergic receptor activated ion transport in human fetal retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2001;42:255-264.
33. Teixeira M, Ferrary E, Butlen D. UTP binding and phosphoinositidase C activation in ampulla from frog semicircular canal. Am J Physiol Regul Integr Comp Physiol. 2000;279:R803-R812.
34. Chart, LN, Wang XF, Tsang LL, Chan HC. Pyrimidinoceptors-mediated activation of Ca(2+)-dependent Cl(-) conductance in mouse endometrial epithelial cells. Biochim Biophys Acta. 2000;1497:261-270.
35. Gabriel SE, Makhlina M, Martsen E, et al. Permeabilization via the P2X7 purinoreceptor reveals the presence of a Ca2+-activated Cl- conductance in the apical membrane of murine tracheal epithelial cells. J Biol Chem. 2000;275:35028-35033.
36. Clarke LL, Harline MC, Gawenis LR, et al. Extracellular UTP stimulates electrogenic bicarbonate secretion across CFTR knockout gallbladder epithelium. Am J Physiol Gastrointest Liver Physiol. 2000;279:G132-G138.
37. Miller SS, Edelman JL. Active ion transport pathways in the bovine retinal pigment epithelium. J Physiol (Lond). 1990;424:283-300.
38. - transport mechanisms in bovine pigment epithelium that could modulate subretinal space volume and composition. J Physiol (Lond). 1994;475:401-417.
39. Barnard EA, Burnstock G, Webb TE. G protein-coupled receptors for ATP and other nucleotides a new receptor family. Trends Pharmacol Sci. 1994;15:67-70.
40. Zimmermann H. Signalling via ATP in the nervous system. Trends Neurosci. 1994;17:420-426.
41. Vassort G. Adenosine 5′-triphosphate: A p2-purinergic agonist in the myocardium. Physiol Rev. 2001;81:767-806.
42. Taylor CW, Broad LM. Pharmacological analysis of intracellular Ca2+ signalling: Problems and pitfalls. Trends Pharmacol Sci. 1998;19:370-375.
43. Pozzan T, Rizzuto R, Volpe P, Meldolesi J. Molecular and cellular physiology of intracellular calcium stores. Physiol Rev. 1994;74:595-636.
44. Joseph DP, Miller SS. Alpha-1-adrenergic modulation of K and Cl transport in bovine retinal pigment epithelium J. Gen Physiol. 1992;99:263-290.
45. Edelman JL, Miller SS. Epinephrine [EP] stimulates KCI and fluid absorption across the bovine retinal pigment epithelium [RPE] [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1992;33(4):S1111. Abstract nr 2092.
46. 2+] and stimulates KCl-coupled fluid absorption across bovine retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2001;42:1921-1929.
47. Pederson JE. Fluid physiology of the subretinal space. In: Wilkinson CP, eds. Retina. St. Louis: Mosby; 2001:1870-1881.
48. Lieberman DM. Rationale for abandoning the circumferential wedge resection procedure for high myopia. J Refract Sulg. 1996;12:635-637.
49. Chihara E, Nao-IN. Transport of subretinal fluid by the retinal pigment epithelium: Studies on rhegmatogenous retinal detachment surgery without drainage of the subretinal fluid. Nippon Ganka Gakkaiz Asshi. 1984;88:1318-1323.