Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level

Life Sciences

Volumn 69, Issue 20, 2001, Pages 2327-2336

  Kubota, Yoko ^a   Tanaka, Naoko ^a   Umegaki, Keizo ^b   Takenaka, Hiroyuki ^c   Mizuno, Hideya ^a   Nakamura, Kazuki ^a   Shinozuka, Kazumasa ^a   Kunitomo, Masaru ^a  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^c MicroAlgae Corporation   (Japan)

Author keywords

Ca2+ influx; Cultured endothelial cells; Endothelium dependent relaxation; Ginkgo biloba extract; Nitric oxide; Rat aorta

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; GINKGO BILOBA EXTRACT; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NORADRENALIN; QUERCETIN; THAPSIGARGIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRACELLULAR CALCIUM; MALE; NONHUMAN; RAT; THORACIC AORTA; VASCULAR RING;

ANIMALS; AORTA, THORACIC; CALCIUM; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FLUORESCENCE; GINKGO BILOBA; MALE; MICROSCOPY, CONFOCAL; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; PLANT EXTRACTS; QUERCETIN; RATS; THAPSIGARGIN; VASODILATOR AGENTS;

GINKGO BILOBA; RATTUS NORVEGICUS;

EID: 0035812865     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01303-0     Document Type: Article

References (36)

1. Ginkgo biloba
2. Effects of natural antioxdant ginkgo biloba extract (EGB 761) on myocardial ischemia-reperfusion injury
3. Lipid peroxidation in experimental spinal cord injury. Comparison of treatment with Ginkgo biloba, TRH and methylprednisolone
4. Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761)
5. The effect of intravenous infusion of Tebonin (Ginkgo biloba) on pial arteries in cats
6. Involvement of platelet-activating factor (PAF) in cerebral post-ischemic phase in Mongolian gerbils
7. Endothelium-dependent relaxations of rabbit isolated aorta produced by carbachol and by Ginkgo biloba extract
8. Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway
9. Effects of Ginkgo biloba extract (GBE) and quercetin on endothelial cells of rat aorta
10. Roken (Ginkgo biloba). Recent results in pharmacology and clinic
11. Metabolic aspects of endothelial cells cultured from rat aortae
12. The flavonoids
13. Plant Flavonoids in biology and medicine: Biochemical, pharmacological, and structure-activity relationships
14. Flavonoids as medical agents
15. Inhibition of isolated rat aorta contraction by flavonoids. Possible correlation with cyclic AMP phosphodiesterase inhibition
16. Effects of khellin on contractile responses and 45Ca2+ movements in rat isolated aorta
17. Vasodilatory action mechanisms of apigenin isolated from Apium graveolens in rat thoracic aorta
18. Vasodilator effects of quercetin in isolated rat vascular smooth muscle
19. Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships
20. Inhibitory effects of quercetin and staurosporine on phasic contractions in rat vascular smooth muscle
21. Effects of red and white wine on endothelium-dependent vasorelaxation of rat aorta and human coronary arteries
22. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta
23. Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin
24. Effects of quercetin on production and release of endothelin and cGMP from cultured endothelial cells
25. Effects of quercetin on the release of endothelin, prostacyclin and tissue plasminogen activator from human endothelial cells in culture
26. Role of endothelium in responses of vascular smooth muscle
27. Release and properties of endothelium-derived relaxing factor (EDRF) from endothelial cells in culture
28. The crucial role of physiological Ca2+ concentrations in the production of endothelial nitric oxide and the control of vascular tone
29. Quercetin stimulation of calcium release from rabbit skeletal muscle sarcoplasmic reticulum
30. Characterization by antagonists of P2-receptors mediating endothelium-dependent relaxation in the rat aorta
31. Receptors for purines and pyrimidines
32. Mechanisms controlling the production of endothelial autacoids
33. P2U receptor is linked to cytosolic Ca2+ transient and release of vasorelaxing factor in bovine endothelial cells in situ
34. Calcium entry through receptor-operated channels in bovine pulmonary artery endothelial cells
35. Voltage-activated potassium, but not calcium currents in cultured bovine aortic endothelial cells
36. Bradykinin-induced potassium current in cultured bovine aortic endothelial cells