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Volumn 4, Issue 1, 1997, Pages 3-13

Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia

Author keywords

Double blind multi center study; Ginkgo biloba; Primary degenerative dementia of the Alzheimer type and multi infarct dementia

Indexed keywords

GINKGO BILOBA; MARTES PENNANTI;

EID: 0002369696     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0944-7113(97)80021-9     Document Type: Article
Times cited : (39)

References (47)
  • 1
    • 0020529466 scopus 로고
    • Significance testing of many variables
    • Abt, K.: Significance testing of many variables. Neuropsychobiol. 947-51, 1983.
    • (1983) Neuropsychobiol. , vol.9 , pp. 47-51
    • Abt, K.1
  • 2
    • 0023268661 scopus 로고
    • Descriptive Data Analysis: A concept between confirmatory and exploratory data analysis
    • Abt, K.: Descriptive Data Analysis: A concept between confirmatory and exploratory data analysis. Meth. Informat. Med. 26: 77-88, 1987.
    • (1987) Meth. Informat. Med. , vol.26 , pp. 77-88
    • Abt, K.1
  • 3
    • 0025146321 scopus 로고
    • Consensus conference on the methodology of clinical trials of "Nootropics" Munich. Report of the Consensus Committee
    • Amaducci, L., Angst, J., Bech, P., Benkert, O., Bruinvels, J. et al.: Consensus conference on the methodology of clinical trials of "Nootropics" Munich. Report of the Consensus Committee. Pharmacopsychiatry 23: 171-175, 1990.
    • (1990) Pharmacopsychiatry , vol.23 , pp. 171-175
    • Amaducci, L.1    Angst, J.2    Bech, P.3    Benkert, O.4    Bruinvels, J.5
  • 5
    • 0022373567 scopus 로고
    • Hemorheological findings in patients with completed stroke and the influence of a ginkgo biloba extract
    • Anadere, I., Chmiel, H., Witte, S.: Hemorheological findings in patients with completed stroke and the influence of a ginkgo biloba extract. Clinical Hemorheology 5: 411-420, 1985.
    • (1985) Clinical Hemorheology , vol.5 , pp. 411-420
    • Anadere, I.1    Chmiel, H.2    Witte, S.3
  • 6
    • 0005576259 scopus 로고
    • Effect of ginkgo biloba extract 761 on microrheological parameters of red blood cells
    • Artmann, G., Michaelis, P., Schmid-Schönbein, H.: Effect of ginkgo biloba extract 761 on microrheological parameters of red blood cells. Clin. Hemorheol. 9: 444, 1989.
    • (1989) Clin. Hemorheol. , vol.9 , pp. 444
    • Artmann, G.1    Michaelis, P.2    Schmid-Schönbein, H.3
  • 7
    • 0025976375 scopus 로고
    • Influences of ginkgo blioba on cyclosporin A induced lipid peroxidation in human liver microsomes in comparison to vitamin E, Glutathione and N-Acetylcysteine
    • Barth, S.A., Inselmann, G., Engemann, R., Heidemann, H.T.: Influences of ginkgo blioba on cyclosporin A induced lipid peroxidation in human liver microsomes in comparison to vitamin E, Glutathione and N-Acetylcysteine. Biochemical Pharmacology 41: 1521-1526, 1991.
    • (1991) Biochemical Pharmacology , vol.41 , pp. 1521-1526
    • Barth, S.A.1    Inselmann, G.2    Engemann, R.3    Heidemann, H.T.4
  • 8
    • 0042708719 scopus 로고
    • Protective effect of an extract of ginkgo biloba and other hydroxyl radical scavengers against hypoxia
    • Tokyo July 19-24, Abstracts
    • Chatterjee, S. S., Gabard, B.: Protective effect of an extract of ginkgo biloba and other hydroxyl radical scavengers against hypoxia. Eighth International Congress of Pharmacology, Tokyo July 19-24, Abstracts, p. 483, 1981.
    • (1981) Eighth International Congress of Pharmacology , pp. 483
    • Chatterjee, S.S.1    Gabard, B.2
  • 9
    • 0007679314 scopus 로고
    • Protection of Doxorubicin toxicity by an extract of ginkgo biloba
    • Abstr. 57
    • Chatterjee, S. S., Gabard, B.: Protection of Doxorubicin toxicity by an extract of ginkgo biloba. Naunyn-Schmiedeberg's Arch. Pharm. Suppl. 319, R 15, Abstr. 57, 1982.
    • (1982) Naunyn-Schmiedeberg's Arch. Pharm. Suppl. , vol.319
    • Chatterjee, S.S.1    Gabard, B.2
  • 10
    • 0342725680 scopus 로고
    • Beltz-Test GmbH, Weinheim, 3rd edn.
    • CIPS - Collegium Internationale Psychiatriae Scalarum (eds.): Internationale Skalen für Psychiatrie. Beltz-Test GmbH, Weinheim, 3rd edn., 1986.
    • (1986) Internationale Skalen für Psychiatrie
  • 12
    • 0038438204 scopus 로고
    • Commission of the European Communities, Brussels, III/3705-91-EN. Draft 5
    • CPMP Working Parry on Efficacy of Medicinal Products: Note for guidance. Antidementia medicinal products. Commission of the European Communities, Brussels, III/3705-91-EN. Draft 5, 1992.
    • (1992) Note for Guidance. Antidementia Medicinal Products
  • 13
    • 0346417111 scopus 로고
    • Studio clinico in doppio cieco del tanakan nell' insufficienza cerebrale cronica
    • Dieli, G., LaMantia, V., Saetta, M., Costanzo, E.: Studio clinico in doppio cieco del tanakan nell' insufficienza cerebrale cronica. II Lavoro Neuropsichiatrico 68: 3-15, 1981.
    • (1981) II Lavoro Neuropsichiatrico , vol.68 , pp. 3-15
    • Dieli, G.1    LaMantia, V.2    Saetta, M.3    Costanzo, E.4
  • 14
    • 0020450885 scopus 로고
    • Kontrollierte Doppelblind-Studie zum Wirksamkeitsnachweis von Tebonin forte bei Patienten mit zerebrovaskulärer Insuffizienz
    • Eckmann, F., Schlag, H.: Kontrollierte Doppelblind-Studie zum Wirksamkeitsnachweis von Tebonin forte bei Patienten mit zerebrovaskulärer Insuffizienz (Controlled double-blind study to test the efficacy of Tebonin forte in patients with cerebrovascular insufficiency). Fortschr. Med. 100: 1474-1478, 1982.
    • (1982) Fortschr. Med. , vol.100 , pp. 1474-1478
    • Eckmann, F.1    Schlag, H.2
  • 16
    • 3843065216 scopus 로고
    • Public Health Service, Food and Drug Administration. Peripheral and Central Nervous System Drugs Advisory Panel
    • Washington, D.C., Miller Reporting Co., Inc.
    • FDA Antidementia Drug Assessment Symposium, Rockville, Md.: Department of Health and Human Services. Public Health Service, Food and Drug Administration. Peripheral and Central Nervous System Drugs Advisory Panel. Antidementia Drug Assessment Symposium, Vol. II. Washington, D.C., Miller Reporting Co., Inc., 1989.
    • (1989) Antidementia Drug Assessment Symposium , vol.2
  • 17
    • 0016823810 scopus 로고
    • "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician
    • Folstein, M. F., Folstein, S. E., McHugh, P. R.: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J. Psychiat. Res. 12: 189-198, 1975.
    • (1975) J. Psychiat. Res. , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 18
    • 0024788666 scopus 로고
    • The families of cognition enhancers
    • Fröstl, W., Maître, L.: The families of cognition enhancers. Pharmacopsychiatry 22: 54-100, 1989.
    • (1989) Pharmacopsychiatry , vol.22 , pp. 54-100
    • Fröstl, W.1    Maître, L.2
  • 19
    • 0024300219 scopus 로고
    • Hirnleistungsstörungen vaskulärer Genese. Randomisierte Doppelblindstudie zur Wirksamkeit von Ginkgo-biloba-Extrakt
    • Halama, P., Bartsch, G., Meng, G.: Hirnleistungsstörungen vaskulärer Genese. Randomisierte Doppelblindstudie zur Wirksamkeit von Ginkgo-biloba-Extrakt. (Impaired brain functions of vascular origin. Randomized double-blind study of ginkgo biloba extract.) Fortschr. Med. 106: 408-412, 1988.
    • (1988) Fortschr. Med. , vol.106 , pp. 408-412
    • Halama, P.1    Bartsch, G.2    Meng, G.3
  • 20
    • 0002047596 scopus 로고
    • Medikamentöse Beeinflussung der Hirndurchblutung
    • Heiss, W. D., Zeiler, K.: Medikamentöse Beeinflussung der Hirndurchblutung (Drug influence on cerebral circulation). Pharmakotherapie 1: 137-144, 1978.
    • (1978) Pharmakotherapie , vol.1 , pp. 137-144
    • Heiss, W.D.1    Zeiler, K.2
  • 21
    • 0024408951 scopus 로고
    • Einfluß von Ginkgo-biloba-Extrakt auf neurophysiologische und psychometrische Meßergebnisse bei Patienten mit hirnorganischem Psychosyndrom. Eine Doppelblindstudie gegen Placebo
    • Hofferberth, B.: Einfluß von Ginkgo-biloba-Extrakt auf neurophysiologische und psychometrische Meßergebnisse bei Patienten mit hirnorganischem Psychosyndrom. Eine Doppelblindstudie gegen Placebo (Influence of ginkgo biloba extract on neurophysiological and psychometric results of assessment in patients with organic psychosyndrome). Arzneim.-Forsch./Drug Res. 39: 918-922, 1989.
    • (1989) Arzneim.-Forsch./Drug Res. , vol.39 , pp. 918-922
    • Hofferberth, B.1
  • 22
    • 3843100017 scopus 로고
    • Simultanerfassung elektrophysiologischer, psychometrischer und rheologischer Parameter bei Patienten mit hirnorganischem Psychosyndrom und erhöhtem Gefäßrisiko - Eine placebokontrollierte Doppelblindstudie mit Ginkgo-biloba-Extrakt EGb 761
    • Stodtmeister, R. und Pillunat, L. E. (eds.), Enke, Stuttgart
    • Hofferberth, B.: Simultanerfassung elektrophysiologischer, psychometrischer und rheologischer Parameter bei Patienten mit hirnorganischem Psychosyndrom und erhöhtem Gefäßrisiko - Eine placebokontrollierte Doppelblindstudie mit Ginkgo-biloba-Extrakt EGb 761 (Simultaneous evaluation of electrophysiological, psychometric and rheological parameters in patients with organic psychosyndrome and increased vessel risk. A placebo-controlled double-blind study with ginkgo biloba). In: Stodtmeister, R. und Pillunat, L. E. (eds.), Mikrozirkulation in Gehirn und Sinnesorganen (Micro-circulation of brain and sensory organs). Enke, Stuttgart, 64-74, 1991.
    • (1991) Mikrozirkulation in Gehirn und Sinnesorganen (Micro-circulation of Brain and Sensory Organs) , pp. 64-74
    • Hofferberth, B.1
  • 23
    • 9244259101 scopus 로고
    • Ginkgo-biloba-Extrakt EGb 761 bei der Demenz vom Alzheimer Typ
    • Abstract N1.40
    • Ihl, R., Dierks, T., Martin, E., Frölich, L., Maurer, K.: Ginkgo-biloba-Extrakt EGb 761 bei der Demenz vom Alzheimer Typ (Ginkgo biloba extract in dementia of the Alzheimer type). 15. Donausymposium f. Psychiatrie, Abstract N1.40, 1992.
    • (1992) Donausymposium f. Psychiatrie
    • Ihl, R.1    Dierks, T.2    Martin, E.3    Frölich, L.4    Maurer, K.5
  • 24
    • 0023621357 scopus 로고
    • Extrait de Ginkgo biloba et exercises d'entrainement de la mémoire
    • Israël, L., Dell'Accio, E., Martin, G., Hugonot, R.: Extrait de Ginkgo biloba et exercises d'entrainement de la mémoire. Psychologie Médicale 19: 1431-1439, 1987.
    • (1987) Psychologie Médicale , vol.19 , pp. 1431-1439
    • Israël, L.1    Dell'accio, E.2    Martin, G.3    Hugonot, R.4
  • 26
    • 0028270519 scopus 로고
    • A 30-week randomized controlled trial of high-dose Tacrine in patients with Alzheimer's disease
    • Knapp, M.J., Knopman, D.S., Solomon, P.R., Pendlebury, W. W., Davis, C. S., Gracon, S. L: A 30-week randomized controlled trial of high-dose Tacrine in patients with Alzheimer's disease. JAMA 241: 985-991, 1994.
    • (1994) JAMA , vol.241 , pp. 985-991
    • Knapp, M.J.1    Knopman, D.S.2    Solomon, P.R.3    Pendlebury, W.W.4    Davis, C.S.5    Gracon, S.L.6
  • 27
    • 0027462537 scopus 로고
    • Factor structure and scoring of the SKT test battery
    • Kim, Y.S., Nibbelink, D.W., Overall, J.E.: Factor structure and scoring of the SKT test battery. J. Clin. Psychol. 49: 61-71, 1993.
    • (1993) J. Clin. Psychol. , vol.49 , pp. 61-71
    • Kim, Y.S.1    Nibbelink, D.W.2    Overall, J.E.3
  • 30
    • 0002067948 scopus 로고
    • Mikrozirkulation und Viskoelastizität des Vollblutes unter Ginkgo-biloba-Extrakt. Eine plazebokon-trollierte, randomisierte Doppelblind-Studie
    • Költringer, P., Eber, O., Lind, P., Langsteger, W., Wakonig, P., Klima, G., Rothlauer, W.: Mikrozirkulation und Viskoelastizität des Vollblutes unter Ginkgo-biloba-Extrakt. Eine plazebokon-trollierte, randomisierte Doppelblind-Studie (Microcirculation and viscoelasticity of whole blood under ginkgo biloba extract. A placebo-controlled, randomised double-blind study), Perfusion 1: 28-30, 1989.
    • (1989) Perfusion , vol.1 , pp. 28-30
    • Költringer, P.1    Eber, O.2    Lind, P.3    Langsteger, W.4    Wakonig, P.5    Klima, G.6    Rothlauer, W.7
  • 31
    • 0027056607 scopus 로고
    • Changes of high-affinity choline uptake in the hippocampus of old rats after long-term administration of two nootropic drugs (Tacrine and Ginkgo biloba Extract)
    • Kristofková, Z., Benesová, O., Tejkalová, H.: Changes of high-affinity choline uptake in the hippocampus of old rats after long-term administration of two nootropic drugs (Tacrine and Ginkgo biloba Extract). Dementia 3: 304-307, 1992.
    • (1992) Dementia , vol.3 , pp. 304-307
    • Kristofková, Z.1    Benesová, O.2    Tejkalová, H.3
  • 32
    • 0343889400 scopus 로고
    • Approche clinique et psychométrique en gériatrie. Méthodes d'études et choix d'une thérapeutique
    • Leroy, M., Salaün, P., Chovelon, R., Bouilloux, E.: Approche clinique et psychométrique en gériatrie. Méthodes d'études et choix d'une thérapeutique. Vie Médicale 28: 2513-2519, 1978.
    • (1978) Vie Médicale , vol.28 , pp. 2513-2519
    • Leroy, M.1    Salaün, P.2    Chovelon, R.3    Bouilloux, E.4
  • 33
    • 0003176938 scopus 로고
    • Bekanntmachung von Grundsätzen für die ordnungsgemäße Durchführung der klinischen Prüfung von Arzneimitteln vom 9. Dezember 1987
    • Ministry of Youth, Family, Women and Health: Bekanntmachung von Grundsätzen für die ordnungsgemäße Durchführung der klinischen Prüfung von Arzneimitteln vom 9. Dezember 1987 (Principles for the proper conduct of clinical studies with medicinal products). BAnz., p. 16617, 1987.
    • (1987) BAnz. , pp. 16617
  • 34
    • 0016849529 scopus 로고
    • Un nouveau stimulant circulatoire cérébral
    • Moreau, Ph.: Un nouveau stimulant circulatoire cérébral. La Nouvelle Presse Médicale 4: 2401-2402, 1975.
    • (1975) La Nouvelle Presse Médicale , vol.4 , pp. 2401-2402
    • Moreau, Ph.1
  • 38
    • 0024402557 scopus 로고
    • Superoxide anion scavenging effect and superoxide dismutase activity of Ginkgo biloba extract
    • Pincemail, J., Dupuis, M., Nasr, C., Hans, P., Haag-Berrurier, M., Anton, R., Deby, C.: Superoxide anion scavenging effect and superoxide dismutase activity of Ginkgo biloba extract. Experientia 45: 708-712, 1989.
    • (1989) Experientia , vol.45 , pp. 708-712
    • Pincemail, J.1    Dupuis, M.2    Nasr, C.3    Hans, P.4    Haag-Berrurier, M.5    Anton, R.6    Deby, C.7
  • 39
    • 0018887732 scopus 로고
    • Pathological verification of ischemic score in differentiation of dementias
    • Rosen, W.G., Terry, R.D., Fuld, P.D., Katzmann, R., Peck, A.: Pathological verification of ischemic score in differentiation of dementias. Ann. Neurol. 7: 486-488, 1980.
    • (1980) Ann. Neurol. , vol.7 , pp. 486-488
    • Rosen, W.G.1    Terry, R.D.2    Fuld, P.D.3    Katzmann, R.4    Peck, A.5
  • 40
    • 3843091261 scopus 로고
    • Evaluation of the clinical relevance and therapy sensitivity of 32 ADL - and behaviour rating scales for dementia - Part I: Posing the problem and preliminary results of an expert-rating
    • Steinwachs, K. C., Lehfeld, H., Jentzsch, J., Erzigkeit, H.: Evaluation of the clinical relevance and therapy sensitivity of 32 ADL - and behaviour rating scales for dementia - Part I: Posing the problem and preliminary results of an expert-rating. Z. Gerontopsychol. &-psychiat. 6: 241-253, 1993.
    • (1993) Z. Gerontopsychol. &-Psychiat. , vol.6 , pp. 241-253
    • Steinwachs, K.C.1    Lehfeld, H.2    Jentzsch, J.3    Erzigkeit, H.4
  • 41
    • 0022549705 scopus 로고
    • Traitement des troubles du vieillissement cérébral par l'extrait de Ginkgo biloba. Etude longitudinale multicentrique à double insu face au placebo
    • Taillandier, J., Ammar, A., Rabourdin, J. P., Ribeyre, J. P., Pichon, J., Niddam, S., Pierart, H.: Traitement des troubles du vieillissement cérébral par l'extrait de Ginkgo biloba. Etude longitudinale multicentrique à double insu face au placebo. La Presse Médicale 15: 1583-1587, 1986.
    • (1986) La Presse Médicale , vol.15 , pp. 1583-1587
    • Taillandier, J.1    Ammar, A.2    Rabourdin, J.P.3    Ribeyre, J.P.4    Pichon, J.5    Niddam, S.6    Pierart, H.7
  • 42
    • 0022922324 scopus 로고
    • Liaison des neuromédiatuers à leurs récepteurs dans le cerveau de rats
    • Taylor, J. E.: Liaison des neuromédiatuers à leurs récepteurs dans le cerveau de rats. La Presse Médicale 15: 1491-1493, 1986.
    • (1986) La Presse Médicale , vol.15 , pp. 1491-1493
    • Taylor, J.E.1
  • 43
    • 0013183615 scopus 로고
    • Quantifizierte Parameter zum Nachweis von cerebraler Durch-blutungs- Und Stoffwechselsteigerung unter Ginkgo-biloba-Therapie
    • Tea, S., Celsis, P., Clanet, M., Marc-Vergnes, J.-P., Boeters, U.: Quantifizierte Parameter zum Nachweis von cerebraler Durch-blutungs- und Stoffwechselsteigerung unter Ginkgo-biloba-Therapie (Quantified parameters for the proof of the enhancement of cerebral circulation and metabolism). Therapiewoche 37: 2655-2657, 1987.
    • (1987) Therapiewoche , vol.37 , pp. 2655-2657
    • Tea, S.1    Celsis, P.2    Clanet, M.3    Marc-Vergnes, J.-P.4    Boeters, U.5
  • 44
    • 0022560252 scopus 로고
    • Primär degenerative Demenz: Therapie mit Ginkgo-biloba-Extrakt. Placebokontrollierte Doppel-blind- Und Vergleichsstudie
    • Weitbrecht, W.-U., Jansen, W.: Primär degenerative Demenz: Therapie mit Ginkgo-biloba-Extrakt. Placebokontrollierte Doppel-blind- und Vergleichsstudie (Therapy with ginkgo biloba extract. Placebo-controlled double-blind and comparative study). Fortschr. Med. 104: 199-202, 1986.
    • (1986) Fortschr. Med. , vol.104 , pp. 199-202
    • Weitbrecht, W.-U.1    Jansen, W.2
  • 45
    • 0025962632 scopus 로고
    • Effects of an extract of Ginkgo biloba on learning and memory in mice
    • Winter, E.: Effects of an extract of Ginkgo biloba on learning and memory in mice. Pharmacol. Biochem. and Behaviour 38: 109-114, 1991.
    • (1991) Pharmacol. Biochem. and Behaviour , vol.38 , pp. 109-114
    • Winter, E.1
  • 46
    • 0022551318 scopus 로고
    • Psycho-pharmacologie clinique de l'extrait de Ginkgo biloba
    • Warburton, D. M.: Psycho-pharmacologie clinique de l'extrait de Ginkgo biloba. (Clinical psychopharmacology of Ginkgo biloba extract.) Presse Medicale 15: 1595-1604, 1986.
    • (1986) Presse Medicale , vol.15 , pp. 1595-1604
    • Warburton, D.M.1
  • 47
    • 85044686794 scopus 로고
    • Verbesserung der Hämorheologie durch Ginkgo-biloba-Extrakt. Verminderung des kardiovaskulären Risikofaktors
    • Witte, S., Anadere, I., Walitza, W: Verbesserung der Hämorheologie durch Ginkgo-biloba-Extrakt. Verminderung des kardiovaskulären Risikofaktors (Improvement of haemorheology by ginkgo biloba extract. Reduction of the cardiovascular risk factor). Fortschritte der Therapie 13: 247-250, 1992.
    • (1992) Fortschritte der Therapie , vol.13 , pp. 247-250
    • Witte, S.1    Anadere, I.2    Walitza, W.3


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