Pharmacology of nicotine and its therapeutic use in smoking cessation and neurodegenerative disorders

Pharmacology and Therapeutics

Volumn 72, Issue 1, 1996, Pages 51-81

  Balfour, David J K ^a   Fagerström, Karl O ^b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b Box 941   (Sweden)

Author keywords

Alzheimer disease; neuronal nicotinic receptors; nicotine addiction; nicotine replacement therapy; Parkinson's disease; smoking cessation

Indexed keywords

NICOTINE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; DRUG EFFICACY; DRUG TOLERANCE; DRUG WITHDRAWAL; HUMAN; INTRANASAL DRUG ADMINISTRATION; LEARNING; MEMORY; NONHUMAN; ORAL DRUG ADMINISTRATION; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; SMOKING CESSATION; TRANSDERMAL DRUG ADMINISTRATION;

ALZHEIMER DISEASE; ANIMALS; BEHAVIOR, ANIMAL; CLINICAL TRIALS; DRUG CARRIERS; HUMANS; NICOTINE; NICOTINIC AGONISTS; PARKINSON DISEASE; RECEPTORS, NICOTINIC; SMOKING CESSATION; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS;

EID: 0029955936     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(96)00099-X     Document Type: Review

References (262)

1. Abercrombie, E. B. and Jacobs, B. L. (1987) Single unit response of noradrenergic neurones in the locus coeruleus of freely moving cats 1. Acutely presented stressful and non-stressful stimuli. J. Neurosci. 7: 2837-2843.
2. American Psychiatric Association (1993) Diagnostic and Statistical Manual of Mental Disorders, DSM-IV™ 242-247 4th edn., Washington.
3. Armitage, A. K., Hall, G. H. and Morrison, C. F. (1968) Pharmacological basis of the tobacco smoking habit. Nature 271: 331-334.
4. Arneric, S. P., Sullivan, J. P., Briggs, C. A., Donnelly-Roberts, D., Anderson, D. J., Raszkiewicz, J. L., Hughes, M. L., Cadman, E. D., Adams, P., Garvey, D. S., Wasicak, J. T. and Williams, M. (1994) (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognitive-enhancing and anxiolytic activity. I. In vitro characterization. J. Pharmacol. Exp. Ther. 270: 310-318.
5. Arqueros, L., Naquira, D. and Zunino, E. (1978) Nicotine-induced release of catecholamines from rat hippocampus and striatum. Biochem. Pharmacol. 27: 2667-2674.
6. Azmitia, E. C. and Segal, M. (1979) An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179: 641-668.
7. 14C-5-hydroxytrypatmine in rat brain homogenates. Eur. J. Pharmacol. 23: 19-26.
8. Balfour, D. J. K. (1982) The effects of nicotine on brain neurotransmitter systems. Pharmacol. Ther. 15: 239-250.
9. Balfour, D. J. K. (1990a) Nicotine as the basis of the tobacco smoking habit. In: Psychotropic Drugs of Abuse, Section 130, The International Encyclopedia of Pharmacology and Therapeutics, pp. 453-481, Balfour, D. J. K. (ed.) Pergamon Press, New York.
10. Balfour, D. J. K. (1990b) A comparison of the effects of nicotine and (+)-amphetamine on rat behaviour in an unsignalled Sidman avoidance schedule. J. Pharm. Pharmacol. 42: 257-260.
11. Balfour, D. J. K. (1991) The neurochemical mechanisms underlying nicotine tolerance and dependence. In: The Biological Basis of Drug Tolerance and Dependence, pp. 121-151, Pratt, J. A. (ed.) Academic Press, London
12. Balfour, D. J. K. (1994) Neural mechanisms underlying nicotine dependence. Addiction 89: 1419-1423.
13. Balfour, D. J. K. and Benwell, M. E. M (1995) Desensitisation of the stimulatory effects of nicotine on dopamine secretion in the mesolimbic system of the rat. In: The Effects of Nicotine on Biological Systems II, pp. 211-217, Clarke, P. B. S., Quik, M., Adlkofer, F. and Thurau, K. (eds.) Birkhauser Verlag, Basel.
14. Balfour, D. J. K., Khullar, K. A. and Longden, A. (1975) Effects of nicotine on plasma corticosterone and brain amines in stressed and unstressed rats. Pharmacol. Biochem. Behav. 3: 349-354.
15. 3H-acetylcholine release from cortical slices of guinea-pig brain. Naunyn Schmeidebergs Arch. Pharmacol. 331: 293-296.
16. Benowitz, N. L. (1991) Nicotine replacement therapy during pregnancy. JAMA 266: 3174-3177.
17. Benowitz, N. L. (1993) Nicotine replacement therapy what has been accomplished - can we do better? Drugs 45: 157-170.
18. Benowitz, N. L. (1995) Smoking cessation: alternative strategies - Medical implications. Tobacco Control 4 (Suppl. 2): 44-48.
19. Benowitz, N. L., Jacob, P., III and Savanapridi, C. (1987) Determinants of nicotine intake while chewing nicotine polacrilex gum. Clin. Pharmacol. Ther. 41: 467-473.
20. Benwell, M. E. M. and Balfour, D. J. K. (1979) Effects of nicotine administration and its withdrawal on plasma corticosterone and brain 5-hydroxyindoles. Psychopharmacology 63: 7-11.
21. Benwell, M. E. M. and Balfour, D. J. K. (1982a) Effects of nicotine administration on the uptake and biosynthesis of 5-HT in rat brain synaptosomes. Eur. J. Pharmacol. 84: 71-77.
22. Benwell, M. E. M. and Balfour, D. J. K. (1982b) The effects of chronic nicotine administration on the response and adaptation to stress. Psychopharmacology 76: 160-162.
23. Benwell, M. E. M. and Balfour, D. J. K. (1985) Nicotine binding to brain tissue from drug naive and nicotine-treated rats. J. Pharm. Pharmacol. 37: 405-409.
24. Benwell, M. E. M. and Balfour, D. J. K. (1992) The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity. Br. J. Pharmacol. 105: 849-856.
25. Benwell, M. E. M., Balfour, D. J. K. and Anderson, J. M. (1988) Evidence that smoking increases the density of nicotine binding sites in human brain. J. Neurochem. 50: 1243-1247.
26. Benwell, M. E. M., Balfour, D. J. K. and Anderson, J. M. (1990) Smoking-associated changes in serotonergic systems of discrete regions of human brain. Psychopharmacology 102: 68-72.
27. Benwell, M. E. M., Balfour, D. J. K. and Lucchi, H. M. (1993) The influence of tetrodotoxin and calcium on the stimulation of mesolimbic dopamine activity evoked by systemic nicotine. Psychopharmacology 112: 467-471.
28. Benwell, M. E. M., Balfour, D. J. K. and Birrell, C. E. (1995) Desensitisation of nicotine-induced dopamine responses during constant infusion with nicotine. Br. J. Pharmacol. 114: 211-217.
29. 11C-nicotine vapor in the human airway as visualized by positron emission tomography. Clin. Pharmacol. Ther. 57: 309-317.
30. Bhagat, B. (1970) Influence of chronic administration of nicotine on the turnover and metabolism of noradrenaline in the rat brain. Psychopharmacologia (Berl.) 18: 325-332.
31. Bhat, R. V., Marks, M. J. and Collins, A. C. (1994) Effects of chronic nicotine infusion on kinetics of high-affinity nicotine binding. J. Neurochem. 62: 574-581.
32. Bittoun, R. (1991) Recurrent aphthous ulcers and nicotine. Med. J. Aust. 154: 471-472.
33. Bittoun, R. and Petrie, J. (1994) Nicotine patch combined with nicotine gum in smoking cessation. J. Smoking-Related Disord. 5: 314.
34. Bjørnson-Benson, W., Nides, M., Dolce, J., Rand, C., Lindgren, P., O'Hara, P. and Buist, A. S. (1993) Nicotine gum use in the first year of the lung health study. Addict. Behav. 18: 491-502.
35. Borsini, F., Lecci, A., Sessarego, A., Frassine, R. and Meli, A. (1989) Discovery of antidepressant activity by forced swimming test may depend upon exposure to a stressful situation. Psychopharmacology 97: 183-188.
36. Brazell, M. P., Mitchell, S. N. and Gray, J. A. (1991) Effect of acute administration of nicotine on in vivo release of noradrenaline in the hippocampus of freely moving rats: a dose-response and antagonist study. Neuropharmacology 30: 823-833.
37. Breslau, N., Kilbey, M. M. and Andreski, P. (1993) Nicotine dependence and major depression. Arch. Gen. Psychiatry 50: 31-35.
38. Brioni, J. D., O'Neil, A. B., Kim, D. J. B., Buckley, M. J., Decker, M. W. and Arneric, S. P. (1994) Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J. Pharmacol. Exp. Ther. 271: 352-361.
39. Briton, K. T., Segal, D. S., Kuczenski, R. and Hauger, R. (1992) Dissociation between in vivo hippocampal norepinephrine response and behavioral/neuroendocrine response to noise stress in rats. Brain Res. 574: 125-130.
40. Buccafusco, J. J. and Jackson, W. J. (1991) Beneficial effects of nicotine administration prior to a delayed matching-to sample task in young and aged monkeys. Neurobiol. Aging 12: 233-238.
41. Buchkremer, G., Bents, H., Minneker, E. and Opitz, K. (1988) Langfristige Effekte einer Kombination von transdermaler Nikotinzufuhr mit Verhaltenstherapie zur Raucherentwöhnung. Nervenarzt 59: 488-490.
42. Campbell, I. A., Prescott, R. J. and Tjder-Burton, S. M. (1994) Advice and support plus transdermal nicotine or placebo in hospital patients with smoking-related diseases. J. Smoking-Related Disord. 5 (Suppl. 1): 314.
43. Cervo, L. and Samanin, R. (1988) Repeated treatment with imipramine and amitriptyline reduced the immobility of rats in the swimming test by enhancing dopamine mechanisms in the nucleus accumbens. J. Pharm. Pharmacol. 40: 155-156.
44. Cervo, L., Grignaschi, G. and Samanin, R. (1990) The role of the mesolimbic dopaminergic system in the desipramine effect in the forced swimming test. Eur. J. Pharmacol. 178: 129-133.
45. Christensen, H., Maltby, N., Jorm, A. F., Creasey, H. and Brae, G. A. (1992) Cholinergic 'blockade' as a model of the cognitive deficits in Alzheimer's disease. Brain 115: 1681-1699.
46. Clarke, P. B. S. (1990) Mesolimbic dopamine activation - key to nicotine reinforcement. In: Biology of Nicotine Dependence - Ciba Foundation Symposium 152, pp. 153-168, Bock, G. and Marsh, J. (eds.) John Wiley & Sons, Chichester.
47. Clarke, P. B. S. (1992) The fall and rise of neuronal α-bungarotoxin binding sites. Trends Pharmacol. Sci. 13: 407-413.
48. Clarke, P. B. S. (1993) Nicotinic receptors in mammalian brain: localization and relation to cholinergic innervation. Prog. Brain Res. 98: 77-83.
49. Clarke, P. B. S. and Fibiger, H. C. (1990) Reinforced alternation performance is impaired by muscarinic but not by nicotinic receptor blockade in rats. Behav. Brain Res. 36: 203-207.
50. Clarke, P. B. S. and Pert, A. (1985) Autoradiographic evidence for nicotinic receptors on nigrostriatal and mesolimbic dopaminergic neurons. Brain Res. 348: 355-358.
51. 125I]-α-bungarotoxin. J. Neurosci. 5: 1307-1315.
52. Clemens, P., Baron, J. A., Coffey, D. and Reeves, A. (1995) The short-term effect of nicotine chewing gum in patients with Parkinson's disease. Psychopharmacology 117: 253-256.
53. Collins, A. C., Romm, E. and Wehner, J. M. (1990) Dissociation of the apparent relationship between nicotine tolerance and up-regulation of nicotinic receptors. Brain Res. Bull. 25: 373-379.
54. Cooper, E., Couturier, S. and Ballivet, M. (1991) Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Nature 350: 236-238.
55. Copland, A. M. and Balfour, D. J. K. (1987) The effects of diazepam on brain 5-HT and 5-HIAA in stressed and unstressed rats. Pharmacol. Biochem. Behav. 27: 619-624.
56. Corrigall, W. A. and Coen, K. M. (1989) Nicotine maintains robust self-administration in rats on a limited-access schedule. Psychopharmacology 99: 473-478.
57. Corrigall, W. A., Franklin, K. B. J., Coen, K. M. and Clarke, P. B. S. (1992) The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. Psychopharmacology 107: 285-289.
58. Corrigall, W. A., Coen, K. M. and Adamson, K. L. (1994) Self-administrated nicotine activates the mesolimbic dopamine system through the ventral tegmental area. Brain Res. 653: 278-284.
59. Costall, B., Kelly, M. E., Naylor, R. J. and Onaivi, E. S. (1989) The actions of nicotine and cocaine in a mouse model of anxiety. Pharmacol. Biochem. Behav. 33: 197-203.
60. Costall, B., Jones, B. J., Kelly, M. E., Naylor, R. J., Onaivi, E. S. and Tyers, M. B. (1990) Ondansetron inhibits a behavioural consequence of withdrawing from drugs of abuse. Pharmacol. Biochem. Behav. 36: 339-344.
61. Court, J. A. and Perry, E. K. (1991) Dementia - the neurochemical basis of putative transmitter orientated therapy. Pharmacol. Ther. 52: 423-443.
62. Court, J. A. and Perry, E. K. (1994) CNS nicotinic receptors. Possible therapeutic targets in neurodegenerative disorders. CNS Drugs 2: 216-233.
63. Daughton, D. M., Heatley, S. A., Prendergast, J. J., Causey, D. and Knowles, M. (1991) Effect of transdermal nicotine delivery as an adjunct to low-intervention smoking cessation therapy. A randomized, placebo-controlled, double-blind study. Arch. Intern. Med. 151: 749-752.
64. Dawe, S., Geroda, C., Russell, M. A. H. and Gray, J. A. (1995) Nicotine intake in smokers increases following a single dose of haloperidol. Psychopharmacology 117: 110-115.
65. Deakin, J. F. W. (1991) Distinct roles of 5-HT subsystems in panic, anxiety and depression. Biol. Psychiatry 1: 305-307.
66. Decker, M. W. and Majchrzak, M. J. (1992) Effects of systemic and intracerebroventricular administration of mecamylamine, a nicotinic cholinergic antagonist, on spatial memory in rats. Psychopharmacology 107: 530-534.
67. Decker, M. W. and Majchrzak, M. J. (1993) Effects of central nicotinic cholinergic receptor blockade produced by chlorisondamine on learning and memory. Behav. Neural Biol. 60: 163-171.
68. Decker, M. W., Majchrzak, M. J. and Anderson, D. J. (1992) Effects of nicotine on spatial memory deficits in rats with septal lesions. Brain Res. 572: 281-285.
69. Deneris, E. S., Connolly, J., Rogers, S. W. and Duvoisin, R. (1991) Pharmacological and functional diversity of neuronal nicotinic receptors. Trends Pharmacol. 12: 34-40.
70. Editorial (1991) Nicotine use after the year 2000. Lancet i: 337.
71. Edwards, J. A. and Warburton, D. M. (1984) Smoking, nicotine and electrical activity. In: Nicotine and the Tobacco Smoking Habit, Section 114, The International Encyclopedia of Pharmacology and Therapeutics, pp. 113-131, Balfour, D. J. K. (ed.) Pergamon Press, New York.
72. Elrod, K. and Buccafusco, J. J. (1991) Correlation of the amnestic effects of nicotinic antagonists with inhibition of regional brain acetylcholine synthesis in rats. J. Pharmacol. Exp. Ther. 258: 403-409.
73. Elrod, K., Buccafusco, J. J. and Jackson, W. J. (1988) Nicotine enhances delayed matching-to-sample performance by primates. Life Sci. 43: 277-287.
74. Engberg, G. and Svensson, T. H. (1980) Pharamcological analysis of a cholinergic receptor mediated regulation of brain norepinephrine neurones. J. Neural. Transm. 49: 137-150.
75. Fagerström, K. O. (1988) Efficacy of nicotine chewing gum: a review. In: Nicotine Replacement: A Critical Evaluation, pp. 109-128, Pomerleau, O. and Pomerleau, C. S. (eds.) Alan R. Liss, New York.
76. Fagerström, K. O. (1994a) Combined use of nicotine replacement products. Health Values 18: 15-20.
77. Fagerström, K. O. (1994b) Review of nicotine gum and tailoring treatment to different types of smokers. J. Smoking-Related Disord. 5 (Suppl. 1.): 179-182.
78. Fagerström, K. O. and Sachs, D. P. L. (1995) Medical management of tobacco dependence: a critical review of nicotine skin patches. Curr. Pulmonol. 16: 223-238.
79. Fagerström, K. O. and Schneider, N. G. (1989) Measuring nicotine dependence: a review of the Fagerström Tolerance Questionnaire. J. Behav. Med. 12: 159-182.
80. Fagerström, K. O., Lunell, E. and Molander, L. (1991) Continuous and intermittent transdermal delivery of nicotine: blockade of withdrawal symptoms and side effects. J. Smoking-Related Disord. 2: 173-180.
81. Fagerström, K. O., Schneider, N. G. and Lunell, E. (1993) Effectiveness of nicotine patch and nicotine gum as individual versus combined treatments for tobacco withdrawal symptoms. Psychopharmacology 111: 271-277.
82. Fagerström, K. O., Pomerleau, O., Giordani, B. and Stelson, F. (1994) Nicotine may relieve symptoms of Parkinson's disease. Psychopharmacology 116: 117-119.
83. Fagerström, K. O., Tejding, R., Westin, Å. and Lunell, E. (1996) Aiding reduction of smoking with nicotine replacement medications. A strategy for the hopeless? (Abstract B21) 2nd Annual Meeting of the Society for Research on Nicotine and Tobacco, Washington, DC.
84. Fiore, M. C., Kenford, S. L., Jorenby, D. E., Wetter, D. W., Smith, S. S. and Baker, T. B. (1994a) Two studies of the clinical effectiveness of the nicotine patch with different counseling treatments. Chest 105: 524-533.
85. Fiore, M. C., Smith, S. S., Jorenby, D. E. and Baker, T. B. (1994b) The effectiveness of the nicotine patch for smoking cessation. A Meta-analysis. JAMA 271: 1940-1947.
86. 3H]nicotine binding in human cerebral cortex: comparison between Alzheimer's disease and the normal. J. Neurochem. 47: 1948-1954.
87. Foster, N. L. Chase, T. N., Mausi, L., Brooks, R., Fedio, P., Patrones, N. J. and DiChiso, G. (1984) Cortical abnormalities in Alzheimers disease. Ann. Neurol. 16: 649-656.
88. Foulds, J., Stapleton, J., Hayward, M., Fleming, T., Feyerabend, C., Fleming, T. and Costello, J. (1993) Transdermal nicotine patches with low intensity support to aid smoking cessation in outpatients in a general hospital. Arch. Family Med. 2: 417-423.
89. Freedman, R., Weltmore, C., Stromberg, I., Leonard, S. and Olson, L. (1993) alpha-Bungarotoxin binding to hippocampal interneurons: immunochytochemical characterization and effects on growth factor expression. J. Neurosci. 13: 1965-1975.
90. Fuxe, K., Agnati, L., Eneroth, P., Gustafsson, J-A., Hokfelt, T., Lofstrom, A., Skett, B. and Skett, P. (1977) The effect of nicotine on central catecholamine neurons and gonadotrophin secretion: studies in the male rat. Med. Biol. 55: 148-157.
91. Fuxe, K., Janson, A. M., Jansson, A., Anderson, K., Eneroth, P. and Agnati, L., F. (1990) Chronic nicotine treatment increases dopamine levels and reduces dopamine utilization in substantia nigra and in surviving forebrain dopamine nerve terminal systems after a partial di-mesencephalic hemitransection. Naunyn Schmiedebergs Arch. Pharmacol. 341: 171-181.
92. Fuxe, K., Rosen, L., Lippoldt, A., Hasselrot, U., Finnman, U. B. and Agnati, L. F. (1994) Chronic continuous infusion of nicotine increases the disappearance of choline-acetyltransferase activity in the cholinergic cell bodies of the medial septal nucleus following a partial unilateral transection of the fimbriafornix. Clin. Investig. 72: 262-268.
93. Garris, P. A. and Wightman, R. M. (1994) Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex and striatum: an in vivo voltammetric study. J. Neurosci. 14: 442-450.
94. Gilbert, D. G. (1979) Paradoxical tranquilizing and emotion-reducing effects of nicotine. Psychol. Bull. 86:643-661.
95. Goldberg, S. R., Spealman, R. D. and Goldberg, D. M. (1981) Persistent behavior at high rates maintained by intravenous self-administration of nicotine. Science 214: 573-575.
96. 3H]dopamine release from synaptosomes prepared from mouse striatum. J. Neurochem. 59: 848-856.
97. 3H]dopamine release from mouse striatal synaptosomes. J. Neurochem. 62: 1390-1398.
98. Graves, A. B. and Mortimer, J. A. (1994) Does smoking reduce the risks of Parkinson's and Alzheimer's diseases? J. Smoking-Related Disord. 5 (Suppl. 1): 79-90.
99. Grunberg, N. E. and Raygada, M. (1990) Effects of nicotine on insulin: actions and implications. In: Effects of Nicotine on Biological Systems, pp. 131-142, Adlkofer, F. and Thurau, K. (ed.) Birkhauser Verlag, Basel.
100. Hagan, J. J., Jansen, J. H. M. and Broekkamp, C. L. E. (1989) Hemicholinium-3 impairs spatial learning and the deficit is reversed by cholinomimetics. Psychopharmacology 98: 347-356
101. Hall, G. H. (1970) Effects of nicotine and tobacco smoke on the electrical activity of the cerebral cortex and olfactory bulb. Br. J. Pharmacol. 38: 271-286.
102. Hall, G. H. and Turner, D. M. (1972) Effects of nicotine on the release of 3H-NA from the hypothalamus. Biochem. Pharmacol. 21: 1829-1838.
103. Harris, C. M., Emmett-Oglesby, M. W., Robinson, N. G. and Lal, H. (1986) Withdrawal from chronic nicotine substitutes partially for the interoceptive stimulus produced by pentyleneterazol (PTZ). Psychopharmacology 90: 85-89.
104. Heatherton, T. F., Kozlowski, L. T., Frecker, R. C. and Fagerström, K.O. (1991) The Fagerström test for nicotine dependence: a revision of the Fagerström Tolerance Questionnaire. Br. J. Addict. 86: 1119-1127.
105. Heishman, S. J., Taylor, R. C. and Henningfield, J. E. (1994) Nicotine and smoking: a review of effects on human performance. Exp. Clin. Psychol. 2: 345-395.
106. Henningfield, J. E. and Keenan, R. M. (1993) Nicotine delivery kinetics and abuse liability. J. Consult. Clin. Psychol. 61: 743-750.
107. Henningfield, J. E., and Stitzer, M. L. (eds.) (1991) New developments in nicotine delivery systems. Conference proceedings. Cortlandt Communications the Cortlandt Group, New York.
108. Henningfield, J. E., Stapleton, J. M., Benowitz, N. L., Grayson, R. F. and London, E. C. (1993) Higher levels of nicotine in arterial than in venous blood after cigarette smoking. Drug Alcohol Depend. 33: 23-29.
109. Herrera, N., Franco, R., Herrera, L., Partidas, A., Rolando, R. and Fagerström, K. O. (1995) Nicotine gum, 2 and 4 mg for nicotine dependence. Chest 108: 447-451.
110. Hjalmarson, A., Franzon, M., Westin, Å. and Wiklund, O. (1994) Effect of nicotine nasal spray on smoking cessation. Arch. Intern. Med. 154: 2567-2572.
111. Hodges, H., Allen, Y., Sinden, J., Lantos, P. L. and Gray, J. A. (1990) Cholinergic-rich transplants alleviate cognitive deficits in lesioned rats but exacerbate responses to cholinergic drugs. Prog. Brain Res. 82: 347-358.
112. Hughes, J. R. (1993) Pharmacotherapy for smoking cessation: unvalidated assumptions, anomalies, and suggestions for future research. J. Consult. Clin. Psychol. 61: 751-760.
113. Hughes, J. R. (1994) An algorithm for smoking cessation. Arch. Family Med. 3: 280-285.
114. Hughes, J. R., Hatsukami, D. K. and Skoog, K. P. (1986) Physical dependence on nicotine in gum: a placebo substitution trial. JAMA 255: 3277-3279.
115. Hurt, R. D., Lauger, G. G., Offord, K. P., Kottke, T. E. and Dale, L. C. (1990) Nicotine-replacement therapy with use of a transdermal nicotine patch - a randomized double-blind placebo-controlled trial. Mayo Clin. Proc. 65: 1529-1537.
116. Hurt, R. D., Dale, L. C., Fredrickson., P. A., Caldwell., C. C., Lee, G. A., Offord, K. P., Lauger, G. G., Marusic, Z., Neese, L. W. and Lundberg, T. G. (1994) Nicotine patch therapy for smoking cessation combined with physician advice and nurse follow-up. JAMA 271: 595-600.
117. Hurt, R. D., Offord, K. P., Lauger, G. G., Marusic, Z., Fagerström, K. O., Enright, P. L. and Scanlon, P. D. (1995) Cessation of long-term nicotine gum use - a prospective, randomized trial. Addiction 90: 407-413.
118. Hutchinson, R. R. and Emley, G. S. (1985) Aversive stimulation produces nicotine ingestion in squirrel monkeys. Psychol. Rec. 35: 491-502.
119. ICRF Department of Public Health and Primary Care, University of Oxford (1994) Randomised trial of nicotine patches in general practice: results at one year. Br. Med. J. 308: 1476-1477.
120. ICRF General Practice Research Group, Department of Public Health and Primary Care, University of Oxford (1993) Effectiveness of a nicotine patch in helping people stop smoking: results of a randomised trial in general practice. Br. Med. J. 306: 1304-1308.
121. Imperato, A., Mulas, A. and Di Chiara, G. (1986) Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats. Eur. J. Pharmacol. 132: 337-338.
122. Ishikawa, A. and Miyatake, T. (1993) Effects of smoking in patients with early-onset Parkinson's disease. J. Neural. Sci. 117: 28-32.
123. Janson, A. M., Hedlund, P. B., Fuxe, K. and von Euler, G. (1994) Chronic nicotine treatment counteracts dopamine D-2 receptor up-regulation induced by partial meso-encephalic hemitransection in the rat. Brain Res. 655: 25-32.
124. Jones, G. M. M., Sahakian, B. J., Levy, R., Warburton, D. M. and Gray, J. A. (1992) Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease. Psychopharmacology 108: 485-494.
125. Jorenby, D. E., Smith, S. S., Fiore, M. C., Hurt, R. D. Offord, K. P., Crohan, I. T., Hayes, J. T., Lewis, S. F. and Baker, T. B. (1995) Varying nicotine patch dose and type of counselling. JAMA 274: 1347-1352.
126. Joseph, M. H., Peters, S. L., Prior, A., Mitchell, S. N., Brazell, M. P. and Gray, J. A. (1990) Chronic nicotine administration increases tyrosine hydroxylase selectively in the rat hippocampus. Neurochem. Int. 16: 269-273.
127. Kalivas, P. W., Sorg, B. A. and Hooks, M. S. (1993) The pharmacology and neural circuitry of sensitization to psychostimulants. Behav. Pharmacol. 4: 315-334.
128. Katayama, S., Hirata, K., Tanaka, H., Yamazaki, K., Fujikane, M. and Ichimaru, Y. (1995) Efficacy of transdermal nicotine in dementia: a study using event-related potentials and a middle latency response. In: Brain Imaging of Nicotine and Tobacco Smoking, pp. 289-302, Domino, E. F. (ed.) NPP Books, Ann Arbor.
129. Kellar, K. J., Whitehouse, P. J., Martino-Barrows, A. M., Marcus, K. and Price, D. L. (1987) Muscarinic and nicotinic cholinergic binding sites in Alzheimer's disease cerebral cortex. Brain Res. 436: 62-68.
130. Killen, J. D., Fortmann, S. P., Newman, B. and Varady, A. (1990) Evaluation of a treatment approach combining nicotine gum with self-guided behavioral treatments for smoking relapse prevention. J. Consult. Clin. Psychol. 58: 85-92.
131. Kirch, D. G., Gerhardt, G. A., Shelton, R. C., Freedman, R. and Wyatt, R. J. (1987) Effect of chronic nicotine administration on monoamine and monoamine metabolite concentrations in rat brain. Clin. Neuropharmacol. 10: 376-383.
132. Kornitzer, M., Kittel, F., Dramaix, M. and Bourdoux, P. (1987) A double-blind study of 2 mg vs 4 mg nicotine-gum in an industrial setting. J. Psychosom. Res. 31: 171-176.
133. Kornitzer, M., Boutsen, M., Dramaix, M., Thijs, J. and Gustavsson, G. (1995) Combined use of nicotine patch and gum in smoking cessation: a placebo-controlled clinical trial. Prev. Med. 24: 41-47.
134. Kozak, J., Fagerström, K. O. and Säwe, U. (1995) High-dose treatment with the nicotine patch. Int. J. Smoking Cessation 4:26-28.
135. Krumpe, P., Malani, N., Adler, J., Ramoorthy, S., Asadi, S., Corwin, N., Dolan, P. and Geismar, L. (1989) Efficacy of transdermal nicotine administration as an adjunct for smoking cessation in heavily nicotine addicted smokers. Am. Rev. J. Respir. Crit. Care Med. 139: 337.
136. Ksir, C., Hakan, R. L. and Kellar, K. J. (1987) Chronic nicotine and locomotor activity: influences of exposure dose and test dose. Psychopharmacology 92: 25-29.
137. Lamberty, Y. and Gower, A. J. (1991) Cholinergic modulation of spatial learning in mice in a Morris-type water maze. Arch. Int. Pharmacodyn. Ther. 309: 5-19.
138. Lange, K. W., Wells, F. R., Jenner, P. and Marsden, C. D. (1993) Altered muscarinic and nicotinic receptor densities in cortical and subcortical regions in Parkinson's disease. J. Neurochem. 60: 197-203.
139. Lebargy, F., Benhamou, K., Morin, D., Zini, R., Bree, F., Urien, S., Branellec, A. and Lagrue, G. (1993) High affinity nicotinic receptor sites on smoker's blood polymorphonuclear cells. Eur. Respir. J. 6 (Suppl. 17): 631.
140. Lebargy, F., Benhannon, K., Morin, O., Zini, R., Urien, S., Bree, F., Bignon, J., Branellec, A. and Lagrue, G. (1996) Tobacco smoking induces expression on very high affinity nicotine binding sites on blook polymorph-nuclear cells. Am. J. Respir. Clin. Care Med., in press.
141. Leischow, S. J., Hill, A. and Otte, P. (1995) Nicotine vaporizer for smoking cessation: a placebo-controlled clinical trial. Presented at the Society of Behavioral Medicine, San Diego, March 24-25.
142. Leutje, P. J. and Patrick, J. (1991) Both α- and β-subunits contribute to agonist sensitivity of neuronal nicotinic acetylcholine receptors. J. Neurosci. 11: 837-845.
143. Levin, E. D. (1992) Nicotinic systems and cognitive function. Psychopharmacology 108: 417-431.
144. Levin, E. D., Castonguay, M. and Ellison, G. D. (1987) Effects of the nicotinic receptor blocker mecamylamine on radial-arm maze performance in rats. Behav. Neural Biol. 48: 206-212.
145. Levin, E. D., Lee, C., Rose, J. E., Reyes, A., Ellison, G., Jarvik, M. and Gritz, E. (1990) Chronic nicotine and withdrawal effects on radial-arm maze performance in rats. Behav. Neural Biol. 53: 269-276.
146. Levin, E. D., Briggs, S. J., Christopher, N. C. and Rose, J. E. (1992) Persistence of chronic nicotine-induced cognitive facilitation. Behav. Neural Biol. 58: 152-158.
147. Levin, E. D., Briggs, S. J., Christopher, N. C. and Rose, J. E. (1993) Chronic nicotinic stimulation and blockade effects on working memory. Behav. Pharmacol. 4: 179-182.
148. Levine, E. S., Litto, W. J. and Jacobs, B. L. (1990) Activity of cat locus coeruleus noradrenergic neurons during defense reaction. Brain Res. 531: 189-195.
149. Linville, D. G., Williams, S., Raszkiewicz, J. L. and Arneric, S. P. (1993) Nicotinic agonists modulate basal forebrain (BF) control of cortical cerebral blood flow in anesthetized rats. J. Pharmacol. Exp. Ther. 267: 440-448.
150. London, E. D., Ball, M. J. and Waller, S. B. (1989) Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia. Neurochem. Res. 14: 745-750.
151. Lunell, E., Molander, L., Leischow, S. J. and Fagerström, K. O. (1995) Effect of nicotine vapour inhalation on the relief of tobacco withdrawal symptoms. Eur. J. Clin. Pharmacol. 48: 345-350.
152. Malin, D., H., Lake, J. R., Newlin-Maultsby, P., Roberts, L. K., Lanier, J. G., Carter, V. A., Cunningham, J. S. and Wilson, O. B. (1992) Rodent model of nicotine abstinence syndrome. Pharmacol. Behav. 43: 779-784.
153. Malin, D. H., Lake, J. R., Carter, V. A., Cunningham, J. S., Hebert, K. M., Conrad, D. L. and Wilson, O. B. (1994) The nicotinic agonist mecamylamine precipitates nicotine abstinence syndrome in the rat. Psychopharmacology 115: 180-184.
154. Markou, A., Weiss, F., Gold, L. H., Caine, S. B. Schulteis, G. and Koob, G. F. (1993) Animal models of drug craving. Psychopharmacology 112: 163-182.
155. Marks, M. J. and Collins, A. C. (1982) Characterization of nicotine binding in mouse brain and comparison with the binding of a-bungarotoxin and quinuclidinyl benzilate. Mol. Pharmacol. 22: 554-564.
156. Marks, M. J., Burch, J. B. and Collins, A. C. (1983) Effects of chronic nicotine infusion on tolerance development and nicotinic receptors. J. Pharmacol. Exp. Ther. 226: 817-825.
157. Marks, M. J., Pauly, J. R., Gross, S. D., Deneris, E. S., Hermans-Borgmeyer, I., Heinemann, S. F. and Collins, A. C. (1992) Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J. Neurosci. 12: 2765-2784.
158. Marshall, J. and Schnieder, H. (1986) Effect of adrenaline, noradrenaline, atropine, and nicotine on some types of human tremor. J. Neurol. Neurosurg. Psychiatry 29: 214-218.
159. McGurk, S. R., Levin, E. D. and Butcher, L. L (1989a) Nicotinic-dopaminergic relationships and radial-arm maze performance in rats. Behav. Neural. Biol. 52: 78-86.
160. McGurk, S. R., Levin, E. D. and Butcher, L. L (1989b) Radial-arm maze performance in rats is impaired by a combination of nicotinic-cholinergic and D2 dopaminergic antagonist drugs. Psychopharmacology 99: 371-373.
161. Mereu, G., Yoon, K-W. P., Boi, V., Gessa, G. L., Naes, L. and Westfall, T. C. (1987) Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine. Eur. J. Pharmacol. 141: 395-399.
162. Mifsud, J-C., Hernandez, L. and Hoebel, B. G. (1989) Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis. Brain Res. 478: 365-367.
163. Mitchell, S. N. (1993) Role of the locus coeruleus in the noradrenergic response to a systemic administration of nicotine. Neuropharmacology 32: 937-949.
164. Mitchell, S. N., Brazell, M. P., Joseph, M. H., Alavijeh, M. S. and Gray, J. A. (1989) Regionally specific effects of acute and chronic nicotine on rates of catecholamine and 5-hydroxytryptamine synthesis in rat brain. Eur. J. Pharmacol. 167: 311-322.
165. Moll, H. (1926) The treatment of post-encephalitic Parkinsonism by nicotine. Br. Med. J. June 26: 1079-1081.
166. Moran, P. M. (1993) Differential effects of scopolamine and mecamylamine on working and reference memory in the rat. Pharmacol. Biochem. Behav. 45: 533-538.
167. Morens, D. M., Grandinetti, A., Reed, D., White, L. R. and Ross, G. W. (1995) Cigarette smoking and protection from Parkinson's disease: false association or etiologic clue? Neurology 45: 1041-1051.
168. Morgan, W. W. and Pfeil, K. A. (1979) Mecamylamine blockade of nicotine enhanced noradrenaline turnover in rat brain. Life Sci. 24: 417-420.
169. Morris, R. G. M., Anderson, E., Lynch, G. S. and Baudry, M. (1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319: 774-776.
170. Morrison, C. F. (1968) Modification by physostigmine of some effects of nicotine on bar-pressing behaviour of rats. Br. J. Pharmacol. 32: 28-33.
171. Morrison, C. F. (1974) Effects of nicotine and its withdrawal on the performance of rats on signalled and unsignalled avoidance schedules. Psychopharmacologia (Berl.) 38: 25-35.
172. Müller, P., Abelin, T., Ehrsam, R., Imhof, P. and Howald, H. (1990) The use of transdermal nicotine in smoking cessation. Lung 168 (Suppl.): 445-453.
173. Mulligan, S. C., Masterson, J. G., Devane, J. G. and Kelly J. G. (1990) Clinical and pharmacokinetic properties of a transdermal nicotine patch. Clin. Pharmacol. Ther. 47: 331-337.
174. Mundy, W. R. and Iwamoto, E. T. (1988) Nicotine impairs acquisition of radial maze performance in rats. Pharmacol. Biochem. Behav. 30: 119-122.
175. Murray, R., Bailey, W. C., Daniels, K., Bjornson, W. M., Kurnow, K., Connet, J. E., Nides, M. and Kiley, J. (1996) Safety of nicotine polacrilex gum used by 3,094 participants in the Lung Health Study. Chest 109: 438-445.
176. Nemeth-Coslett, R. and Henningfield, J. (1986) Effects of nicotine chewing gum on cigarette smoking and subjective and physiological effects. Clin. Pharmacol. Ther. 39: 4625-4630.
177. Newhouse, P., Sunderland, T., Tariot, P., Blumhardt, C. L., Weingartner, H., Mellow, A. and Murphy, D. L. (1988) Intravenous nicotine in Alzheimer's disease: a pilot study. Psychopharmacology 95: 171-175.
178. Nisell, M., Nomikos, G. G. and Svensson, T. H. (1994a) Infusion of nicotine in the ventral tegmental area of the nucleus accumbens of the rat differentially affects accumbal dopamine release. Pharmacol. Toxicol. 75: 348-352
179. Nisell, M., Nomikos, G. G. and Svensson, T. H. (1994b) Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area. Synapse 16: 36-44.
180. Nisenbaum, L. K., Zigmond, M. J., Sved, A. F. and Abercrombie, E. D. (1991) Prior exposure to chronic stress results in enhanced synthesis and release of hippocampal norepinephrine in response to a novel stressor. J. Neurosci. 11: 1478-1484.
181. Nordberg, A. (1993) Neuronal nicotinic receptors and their implications in ageing and neurodegenerative disorders in mammals. J. Reprod. Fert. Suppl. 46: 145-154.
182. Nordberg, A., Romanelli, L., Sundwall, A., Bianchi, C. and Beani, L. (1989) Effect of acute and subchronic nicotine treatment on cortical acetylcholine release and on nicotinic receptors in rats and guinea pigs. Br. J. Pharmacol. 98: 71-78.
183. Nordberg, A., Hartvig, P., Lilja, A., Vutanen, M., Amberla, K., Lundqvist, H., Andersson, Y., Ulin, J., Winblad, B. and Langstrom, B. (1990) Decreased uptake and binding of 11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography. J. Neural Transm. 2: 215-224.
184. Paoletti, P., Fornai, E., Maggiorelli, F., Puntoni, R., Viegi, G., Carozzi, L., Corlanto, A., Gustavsson, G., Säwe, U. and Giuntini, C. (1993) Importance of baseline cotinine plasma values in smoking cessation: results from a double-blind study with nicotine patch. Eur. Respir. J. 9: 643-651.
185. Parks, R. W., Young, C. S., Rippey, R. F., Danz, V., Vohs, C., Matthews, J. R., Collins, G. T., Zigler, S. S., Urycki, P. G., Keim, P., Kabaty, E. and Becker, R. E. (1994) Nicotinic stimulation of anterior regional cerebral glucose metabolism in Alzheimer's disease: preliminary study with transdermal patches. In: Alzheimer Disease: Therapeutic Strategies, pp. 424-427, Giacobini, E. and Bocker, R. (eds.) Birkhäuser, Boston.
186. Perry, E. K. (1986) The cholinergic hypothesis - ten years on. Br. Med. Bull. 42: 63-69.
187. Perry, E. K., Perry, R. H., Smith, C. J., Dick, D. J., Candy, J. M., Edwardson, J. A., Fairbairn, A. and Blessed, G. (1987) Nicotinic receptor abnormalities in Alzheimer's and Parkinson's diseases. J. Neurol. Neurosurg. Psychiatry 50: 806-809.
188. 3H]nicotine receptor binding in human brain: characterization and involvement in cholinergic neuropathology. Neurosci. Res. Commun. 5: 117-124.
189. Perry, E. K., Smith, C. J., Court, J. A., Perry, R. H. and Fairbairn, A. F. (1990) Cholinergic nicotinic and muscarinic receptors in dementia of Alzheimer, Parkinson and Lewy body types. J. Neural Transm. Park. Dis. Dement. Sect. 2: 149-158.
190. Peto, R., Lopez, A., Boreham, J., Thun, M. and Heath, C., Jr. (1994) Mortality from Smoking in Developed Countries, 1950-2000. Oxford University Press, Oxford.
191. Pickworth, W. B., Bunker, E. B. and Henningfield, J. E. (1994) Transdermal nicotine: reduction of smoking with minimal abuse liability. Psychopharmacology (Berl.) 115: 9-14.
192. Poincheval-Fuhrman, S. and Sara, S. J. (1993) Chronic nicotine ingestion improves radial arm maze performance in rats. Brain Res. 4: 535-539.
193. Pomerleau, C. S. and Pomerleau, O. F. (1987) The effects of a psychological stressor on cigarette smoking and subsequent behavioral and physiological responses. Psychophysiology 24: 278-285.
194. Pomerleau, O. F., Fertig, J. B. and Shanahan, S. O. (1983) Nicotine dependence in cigarette smoking: an empirically-based multivariate model. Pharmacol. Biochem. Behav. 19: 291-299.
195. Pomerleau, O. F., Collins, A. C., Shiffman, S. and Pomerleau, C. S. (1993) Why some people smoke and others do not: new perspectives. J. Consult. Clin. Psychol. 61: 723-731.
196. Pullan, R. D., Rhodes, J., Ganesh, S., Mani, V., Morris, J. S., Williams, G. T., Newcombe, R. G., Russell, M. A. H., Feyerabend, C., Thomas, G. A. O. and Säwe, U. (1994) Transdermal nicotine for active ulcerative colitis. New Engl. J. Med. 330: 811-815.
197. Puska, P., Korhonen, H. J., Vartioiaimen, E., Urjanheimo, E. L., Gur, G. and Westini, A. (1995) Is combined use of nicotine patch and gum better than gum alone in smoking cessation. Tobacco Control 4: 231-235.
198. Ramström, L. M. (1995) Consequences of tobacco dependence - A conceptual reappraisal of tobacco control policies. Presented at 37th International Congress on Alcohol and Drug Dependence, San Diego, August, 1995.
199. Rapier, C., Lunt, G. G. and Wonnacott, S. (1988) Stereoselective nicotine-induced release of dopamine from striatal synaptosomes: concentration dependence and repetitive stimulation. J. Neurochem. 50: 1123-1130.
200. 3H]dopamine release from striatal synaptosomes: pharmacological characterisation. J. Neurochem. 54: 937-945.
201. Rhodes, J. and Thomas, G. (1995) Nicotine treatment in ulcerative colitis. Current status. Drugs 49: 157-160.
202. Ribeiro, E. B., Bettiker, R. L., Bogdanov, M. and Wurtman, R. J. (1993) Effects of systemic nicotine on serotonin release in rat brain. Brain Res. 621: 311-318.
203. Richmond, R. L., Harris, K. and de Almeida Neto, A. (1994) The transdermal nicotine patch: results of a randomised placebo-controlled trial. Med. J. Aust. 161: 130-135.
204. Rinne, J. O., Myllykylä, T., Lönnberg, P. and Marjamáki, P. (1991) A postmortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease. Brain Res. 547: 167-170.
205. Robinson, S. F., Pauly, J. R., Marks, M. J. and Collins, A. C. (1994) An analysis of response to nicotine infusion using an automated radiotelemetry system. Psychopharmacology 115: 115-120.
206. Robinson, T. E. and Berridge, K. C. (1993) The neural basis of drug craving: an incentive-sensitisation theory of addiction. Brain Res. Rev. 18: 247-291.
207. Romano, C. and Goldstein, A. (1980) Stereoselective nicotine receptors in rat brain membranes. Science 210: 647-650.
208. Rose, J. E., Tashkin, D. P., Ertle, A., Zinser, M. C. and Lafer, R. (1985) Sensory blockade of smoking satisfaction. Pharmacol. Biochem. Behav. 23: 289-293.
209. Rose, J. E., Levin, E. D., Behm, F. M., Adivi, C. and Schur, C. (1990) Transdermal nicotine facilitates smoking cessation. Clin. Pharmacol. Ther. 47: 323-330.
210. 3H]acetylcholine release from mouse cerebral cortical synaptosomes. J. Neurochem. 43: 1593-1598.
211. Sachs, D. P. L. (1995) Effectiveness of the 4-mg dose of nicotine polacrilex for the initial treatment of high-dependent smokers. Arch. Intern. Med. 155: 1973-1980.
212. Sachs, D. P. L. and Benowitz, N. L. (1989) Are smokers trying to stop and smokers not trying to stop the same experimental model? In: Proceedings of the 51st Annual Scientific Meeting, Committee on Problems of Drug Dependence, Inc., NIDA Research Monograph, Harris, L. (ed.) U.S. Department of Health and Human Services, Washington, DC.
213. Sachs, D. P. L. and Fagerström, K. O. (1995) Medical management of tobacco dependence: practical office considerations. Curr. Pulmonol. 16: 239-249.
214. Sachs, D. P. L., Säwe, U. and Leischow, S. J. (1993) Effectiveness of a 16-hour transdermal nicotine patch in a medical practice setting, without intensive group counseling. Arch. Intern. Med. 153: 1881-1890.
215. Sahakian, B., Jones, G., Levy, R., Gray, J. and Warburton, D. (1989) The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer type. Br. J. Psychiatry 154: 797-800.
216. Schneider, N. G. (1992) Nicotine therapy in smoking cessation: pharmacokinetic considerations. Clin. Pharmacokinet. 23: 169-172.
217. Schneider, N. G., Olmstead, R., Mody, F. V., Doan, K., Jarvik, M. E. and Steinberg, C. (1995) Efficacy of a nicotine nasal spray in smoking cessation: a placebo-controlled, double blind trial. Addiction 90: 1671-1682.
218. Schneider, N. G., Olstead, R., Nillson, F., Mody, F. V., Franzon, M. and Doan, K. (1996) Efficacy of a nicotine inhaler in smoking cessation: a double-blind, placebo-controlled trial. Addiction 91: 1293-1306.
219. Schwartz, R. D. and Kellar, K. J. (1983) Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo. Science 220: 214-216.
220. 3H]acetylcholine recognition sites in brain by nicotinic cholinergic drugs. J. Neurochem. 45: 427-433.
221. 7 subunits: a nicotinic cation channel highly permeable to calcium. J. Neurosci. 13: 596-604.
222. Shoaib, M., Benwell, M. E. M., Akbar, M. T., Stolerman, I. P. and Balfour, D. J. K. (1994) Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists. Br. J. Pharmacol. 111: 1073-1080.
223. Silver, A. A. and Sandberg, P. R. (1993) Transdermal nicotine patch and potentiation of haloperidol in Tourette's syndrom. Lancet 342: 182.
224. Slifer, B. L. (1983) Schedule-induction of nicotine self-administration. Pharmacol. Biochem. Behav. 19: 1005-1009.
225. Smith, K. M., Mitchell, S. N. and Joseph, M. H. (1991) Effects of chronic and subchronic nicotine on tyrosine hydroxylase activity in noradrenergic and dopaminergic neurones in the rat brain. J. Neurochem. 57: 1750-1756.
226. Smith, L. A. and Lang, W. J. (1980) Changes in self-administration of nicotine by rats over a 28-day period. Pharmacol. Biochem. Behav. 13: 215-220.
227. Stapleton, J. A., Russell, M. A. H., Feyerabend, C., Wiseman, S. M., Gustavsson, G., Säwe, U. and Wiseman, D. (1995) Dose effects and predictors of outcome in a randomized trial of transdermal nicotine patches in general practice. Addiction 90: 31-42.
228. Steinbach, J. H. (1990) Mechanism of action of the nicotinic acetylcholine receptor. In: The Biology of Nicotine Dependence - Ciba Foundation Symposium 152, pp. 53-67, Bock, G. and Marsh, J. (eds.) John Wiley & Sons, Chichester.
229. Stolerman, I. P. (1990) Behavioural pharmacology of nicotine in animals. In: Nicotine Psychopharmacology: Molecular, Cellular and Behavioural Aspects, pp. 278-306, Wonnacott, S., Russell, M. A. H. and Stolerman, I. P. (eds.) Oxford University Press, Oxford.
230. Stolerman, I. P. and Shoaib, M. (1991) The neurobiology of nicotine addiction. Trends Pharmacol. 12: 467-473.
231. Sutherland, G., Stapleton, J. A., Russell, M. A. H., Jarvis, M. J., Hajek, P., Belcher, M. and Feyerabend, C. (1992) Randomised controlled trial of nasal nicotine spray in smoking cessation. Lancet 340: 324-329.
232. Svensson, T. H. and Engberg, G. (1982) Effect of nicotine on single cell activity in the noradrenergic locus coeruleus. Acta Physiol. Scand. 479: 31-34.
233. Tang, J. L., Law, M. and Wald, N. (1994) How effective is nicotine replacement therapy in helping people to stop smoking? Br. Med. J. 308: 21-26.
234. Terry, A. V. and Clarke, M. S. F. (1994) Nicotine stimulation of nerve growth factor receptor expression. Life Sci. 55: 91-98.
235. The Transdermal Nicotine Study Group (1991) Transdermal nicotine for smoking cessation. Six-month results from two multicenter controlled clinical trials. JAMA 266: 3133-3138.
236. Tønnesen, P., Fryd, V., Hansen, M., Helsted, J., Gunnersen, A. B., Forchhammer, H. and Stockner, M. (1988a) 2 and 4 mg nicotine chewing gum and group counselling in smoking cessation: an open randomized controlled trial with a 22-month follow-up. Addict. Behav. 13: 17-27.
237. Tønnesen, P., Fryd, V., Hansen, M., Helsted, J., Gunnersen, A. B., Forchhammer, H. and Stockner, M. (1988b) Effect of nicotine chewing gum in combination with group counselling on the cessation of smoking. N. Engl. J. Med. 318: 15-18.
238. Tønnesen, P., Nrregaard, J., Simonsen, K. and Säwe, U. (1991) A double-blind trial of a 16-hour transdermal nicotine patch in smoking cessation. N. Engl. J. Med. 325: 311-315.
239. Tønnesen, P., Nrregaard, J., Mikkelsen, K., Jörgensen, S. and Nilsson, F. (1993) A double-blind trial of a nicotine inhaler for smoking cessation. JAMA 269: 1268-1271.
240. United States Department of Health and Human Services (1988) Consequences of Smoking: Nicotine Addiction. U.S. Government Printing Office, Washington, DC.
241. Vaglini, F., Fascetti, F., Fornai, F., Maggio, R. and Corsini, G. U. (1994) Nicotine prevents experimental parkinsonism in rodents. Soc. Neurosci. Abstr. 20: 1465.
242. Van Duijn, C. M. and Hofman, A. (1991) Relation between nicotine intake and Alzheimer's disease. Br. Med. J. 302: 1491-1494.
243. Wada, E., Wada, K., Boulter, J., Deneris, E., Heinemann, S., Patrick, J. and Swanson, L. W. (1989) Distribution of alpha 2, alpha 3, alapha 4 and beta 2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridisation histochemical study in the rat. J. Comp. Neurol. 284: 314-335.
244. Warburton, D. M. (1992) Nicotine as a cognitive enhancer. Prog. Neuropsychopharmacol. Biol. Psychiatry 16: 181-191.
245. Warburton, D. M. and Rusted, J. M. (1993) Cholinergic control of cognitive resources. Neuropsychobiology 28: 43-46.
246. Welzl, H., Alessandri, B., Oettinger, R. and Bättig, K. (1988) The effects of long-term nicotine treatment on locomotion, exploration and memory in young and old rats. Psychopharmacology 96: 317-323.
247. Wesnes, K. and Warburton, D. M. (1984) Smoking, nicotine and human performance. In: Nicotine and the Tobacco Smoking Habit, Section 114, The International Encyclopedia of Pharmacology and Therapeutics, pp. 133-152, Balfour, D. J. K. (ed.) Pergamon Press, New York.
248. West, R. (1988) Nicotine: a dependence-producing drug. Prog. Clin. Biol. Res. 261: 237-259.
249. 3H-dopamine from rat brain slices. Neuropharmacology 13: 693-700.
250. Westman, E. C., Levin, E. D. and Rose, J. E. (1993) The nicotine patch in smoking cessation. Arch. Intern. Med. 153: 1917-1923.
251. Whitehouse, P. J., Martino, A. M., Marcus, K. A., Zweig, R. M., Singer, H. S., Price, D. L. and Kellar, K. J. (1988) Reductions in acetylcholine and nicotine binding in several degenerative diseases. Arch. Neurol. 45: 722-724.
252. Whiting, P. J. and Lindstrom, J. M. (1988) Characterization of bovine and human nicotinic acetylcholine receptors using monoclonal antibodies. J. Neurosci. 8: 3395-3404.
253. Wilson, A. L., Langley, L. K., Monley, J., Baur, T., Rottunda, S., McFalls, E., Kovesa, C. and McCarfen, J. R. (1995) Nicotine patches in Alzheimers disease: pilot study on learning, memory and safety. Pharmacol. Biochem. Behav. 51: 509-514.
254. Winders, S. E. and Grunberg, N. E. (1990) Effects of nicotine on body weight, food consumption and body composition in male rats. Life Sci. 46: 1523-1530.
255. Wise, R. A. (1990) The role of reward pathways in the development of drug dependence. In: Psychotropic Drugs of Abuse, Section 130, The International Encyclopedia of Pharmacology and Therapeutics, pp. 23-58, Balfour, D. J. K. (ed.) Pergamon Press, New York.
256. Wise, R. A. and Bozarth, M. A. (1987) A psychomotor stimulant theory of drug addiction. Psychol. Rev. 94:469-492.
257. Wonnacott, S. (1990a) Characterization of brain nicotine receptor sites. In: Nicotine Psychopharmacology: Molecular, Cellular and Behavioural Aspects, pp. 226-277, Wonnacott, S., Russell, M. A. H. and Stolerman, I. P. (eds.) Oxford University Press, Oxford.
258. Wonnacott, S. (1990b) The paradox of nicotinic acetylcholine receptor upregulation by nicotine. Trends Pharmacol. Sci. 11: 216-219.
259. Wonnacott, S., Russell, M. A. H. and Stolerman, I. P. (eds.) (1990) Nicotine Psychopharmacology: Molecular, Cellular and Behavioural Aspects. Oxford University Press, Oxford.
260. Wonnacott, S., Wilkie, G., Soliakov, L. and Whiteaker, P. (1995) Presynaptic nicotinic autoreceptors and heteroreceptors in the CNS. In: The Effects of Nicotine on Biological Systems II, pp. 87-94, Clarke, P. B. S., Quik, M., Adlkofer, F. and Thurau, K. (eds.) Birkhauser Verlag, Basel.
261. World Health Organization (1992) The ICD-10 classification of mental and behavioural disorders. Clinical descriptions and diagnostic guidelines. World Health Organization, Geneva.
262. Yoshida, K., Kato, Y. and Imura, H. (1980) Nicotine-induced release of noradrenaline from hypothalamic synaptosomes. Brain Res. 182: 361-368.