Pb2+-induced toxicity is associated with p53-independent apoptosis and enhanced by glutamate in GT1-7 neurons

Toxicology Letters

Volumn 144, Issue 2, 2003, Pages 235-246

  Loikkanen, Jarkko ^a   Chvalova, Katerina ^a   Naarala, Jonne ^a   Vähäkangas, Kirsi H ^a   Savolainen, Kai M ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

Author keywords

Caspase; Glutamate; Internucleosomal DNA fragmentation; Neuronal apoptosis; p53; Pb2+

Indexed keywords

BIOCHEMICAL MARKER; CASPASE 3; CELL PROTEIN; DNA FRAGMENT; GLUTAMIC ACID; LEAD; PROTEIN P53; CASP3 PROTEIN, MOUSE; CASPASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INDUCTION; HYPOTHALAMUS; IMMUNOBLOTTING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; NERVE CELL; TUMOR SUPPRESSOR GENE; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL SURVIVAL; CELLS, CULTURED; DNA FRAGMENTATION; GENES, P53; GLUTAMIC ACID; HYPOTHALAMUS; IMMUNOBLOTTING; LEAD; MICE; NEURONS; NUCLEOSOMES;

EID: 0043133875     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(03)00220-0     Document Type: Article

References (48)

1. Al-Modhefer A.J., Bradbury M.W., Simons T.J. Observations on the chemical nature of lead in human blood serum. Clin. Sci. 81:1991;823-829.
2. Atlante A., Calissano P., Bobba A., Giannattasio S., Marra E., Passarella S. Glutamate neurotoxicity, oxidative stress and mitochondria. FEBS Lett. 497:2001;1-5.
3. Bennett M.R. Mechanisms of p53-induced apoptosis. Biochem. Pharmacol. 58:1999;1089-1095.
4. Chandra J., Samali A., Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic. Biol. Med. 29:2000;323-333.
5. Dupois E.A., Zandbergen M.A., Peute J., Goos H.J. Evolutionary development of three gonadotropin-releasing hormone (GnRH) systems in vertebrates. Brain Res. Bull. 57:2002;413-418.
6. Earnshaw W.C., Martins L.M., Kaufmann S.H. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 68:1999;383-424.
7. Finkelstein Y., Markowitz M.E., Rosen J.F. Low-level lead-induced neurotoxicity in children: an update on central nervous system effects. Brain Res. Rev. 27:1998;168-176.
8. Fox D.A., Campbell M.L., Blocker Y.S. Functional alterations and apoptotic cell death in the retina following developmental or adult lead exposure. Neurotoxicology. 18:1997;645-664.
9. Fox D.A., He L., Poblenz A.T., Medrano C.J., Blocker Y.S., Srivastava D. Lead-induced alterations in retinal cGMP phosphodiesterase trigger calcium overload, mitochondrial dysfunction and rod photoreceptor apoptosis. Toxicol. Lett. 102-103:1998;359-361.
10. Guilarte T.R. Glutamatergic system and developmental lead neurotoxicity. Neurotoxicology. 18:1997;665-672.
11. He L., Poblenz A.T., Medrano C.J., Fox D.A. Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore. J. Biol. Chem. 275:2000;12175-12184.
12. L overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc. Natl. Acad. Sci. USA. 100:2003;1022-1027.
13. Hengartner M.O. The biochemistry of apoptosis. Nature. 407:2000;770-776.
14. Herrmann M., Lorenz H.-M., Voll R., Grünke M., Woith W., Kalden J.R. A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res. 22:1994;5506-5507.
15. 2+-induced cytotoxicity. Toxicol. Lett. 115:2000;89-98.
16. Lakkaraju A., Dubinsky J.M., Low W.C., Rahman Y.-E. Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. J. Biol. Chem. 276:2001;32000-32007.
17. Lasley S.M., Gilbert M.E. Rat hippocampal glutamate and GABA release exhibit biphasic effects as a function on chronic lead exposure level. Toxicol. Sci. 66:2002;139-147.
18. 2+ entry into cultured astroglia. Toxicol. Sci. 46:1998;90-100.
19. 2 in the mouse after intravenous injection. Neurotoxicology. 19:1998;197-207.
20. Loikkanen J.J., Naarala J., Savolainen K.M. Modification of glutamate-induced oxidative stress by lead: the role of extracellular calcium. Free Radic. Biol. Med. 24:1998;377-384.
21. Mahesh V.B., Zamorano P., De Sevilla L., Lewis D., Brann D.W. Characterization of ionotropic glutamate receptors in rat hypothalamus, pituitary and immortalized gonadotropin-releasing hormone (GnRH) neurons (GT1-7 cells). Neuroendocrinology. 69:1999;397-407.
22. Malenka R.C., Nicoll R.A. Long-term potentiation - a decade of progress? Science. 285:1999;1870-1874.
23. Martin L.J., Al-Abdulla N.A., Brambrink A.M., Kirsch J.R., Sieber F.E., Portera-Cailliau C. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis. Brain Res. Bull. 46:1998;281-309.
24. Mellon P.L., Windle J.J., Goldsmith P.C., Padula C.A., Roberts J.L., Weiner R.I. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron. 5:1990;1-10.
25. Miller F.D., Pozniak C.D., Walsh G.S. Neuronal life and death: an essential role for the p53 family. Cell Death Differ. 7:2000;880-888.
26. Morrison R.S., Kinoshita Y. The role of p53 in neuronal cell death. Cell Death Differ. 7:2000;868-879.
27. Movsesyan V.A., Yakovlev A.G., Dabaghyan E.A., Stoica B.A., Faden A.I. Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. Biochem. Biophys. Res. Commun. 299:2002;201-207.
28. Naarala J.T., Loikkanen J.J., Ruotsalainen M.H., Savolainen K.M. Lead amplifies glutamate-induced oxidative stress. Free Radic. Biol. Med. 19:1995;689-693.
29. 2+: association with deficits of LTP and spatial learning. Neurotoxicology. 22:2001;635-643.
30. ++) promotes apoptosis in newborn rat cerebellar neurons: pathological implications. J. Pharmacol. Exp. Ther. 279:1996;435-442.
31. Pipas J.M., Levine A.J. Role of T antigen interactions with p53 in tumorigenesis. Semin. Cancer Biol. 11:2001;23-30.
32. Pluquet O., Hainaut P. Genotoxic and non-genotoxic pathways of p53 induction. Cancer Lett. 174:2001;1-15.
33. Savolainen K.M., Loikkanen J., Eerikäinen S., Naarala J. Glutamate-stimulated ROS production in neuronal cultures: interactions with lead and the cholinergic system. Neurotoxicology. 19:1998;669-674.
34. Savolainen K.M., Loikkanen J., Eerikäinen S., Naarala J. Interactions of excitatory neurotransmitters and xenobiotics in excitotoxicity and oxidative stress: glutamate and lead. Toxicol. Lett. 102-103:1998;363-367.
35. Scortegagna M., Hanbauer I. The effect of lead exposure and serum deprivation on mesencephalic primary cultures. Neurotoxicology. 18:1997;331-340.
36. Serpi R., Piispala J., Järvilehto M., Vähäkangas K. Thapsigargin has similar effect on p53 protein response to benzo[a]pyrene-DNA adducts as TPA in mouse skin. Carcinogenesis. 20:1999;1755-1760.
37. Sharifi A.M., Baniasadi S., Jorjani M., Rahimi F., Bakhshayesh M. Investigation of acute lead poisoning on apoptosis in rat hippocampus in vivo. Neurosci. Lett. 329:2002;45-48.
38. Simons T.J.B. Lead-calcium interactions in cellular lead toxicity. Neurotoxicology. 14:1993;77-85.
39. Solovyan V.T., Bezvenyuk Z.A., Salminen A., Austin C.A., Courtney M.J. The role of topoisomerase II in the excision of DNA loop domains during apoptosis. J. Biol. Chem. 277:2002;21458-21467.
40. Sortino M.A., Aleppo G., Copani A., Casabona G., Nicoletti F., Ventra C., Kuhn R., Knöpfel T., Malitschek B., Canonico P.L. Immortalized hypothalamic neurons express metabotropic glutamate receptors positively coupled to cyclic AMP formation. Eur. J. Neurosci. 8:1996;2407-2415.
41. i and gonadotropin-releasing hormone secretion in immortalized hypothalamic GT1-7 neurons. Neuroendocrinology. 59:1994;309-317.
42. Talanian R.V., Quinlan C., Trautz S., Hackett M.C., Mankovich J.A., Banach D., Ghayur T., Brady K.D., Wong W.W. Substrate specificities of caspase family proteases. J. Biol. Chem. 272:1997;9677-9682.
43. Thornberry N.A., Rano T.A., Peterson E.P., Rasper D.M., Timkey T., Carcia-Calvo M., Houtzager V.M., Nordstrom P.A., Roy S., Vaillancourt J.P., Chapman K.T., Nicholson D.W. A combinatorial approach defines specificities of members of the caspase family and granzyme B. J. Biol. Chem. 272:1997;17907-17911.
44. Uberti D., Grilli M., Memo M. Contribution of NF-κB and p53 in the glutamate-induced apoptosis. Int. J. Del. Neurosci. 18:2000;447-454.
45. Urbanski H.F., Fahy M.M., Daschel M., Meshul C. N-methyl-D-aspartate receptor gene expression in the hamster hypothalamus and in immortalized luteinizing hormone-releasing hormone neurons. J. Reprod. Fertil. 100:1994;5-9.
46. Winder C. Lead, reproduction and development. Neurotoxicology. 14:1993;303-317.
47. Xiang H., Hochman D.W., Saya H., Fujiwara T., Schwartzkroin P.A., Morrison R.S. Evidence for p53-mediated modulation of neuronal viability. J. Neurosci. 16:1996;6753-6765.
48. 1-7 cells through an estrogen receptor-dependent mechanism. Neurotoxicology. 24:2003;65-73.