Has basic research contributed to chronic pain treatment?

Acta Anaesthesiologica Scandinavica

Volumn 45, Issue 9, 2001, Pages 1128-1135

  Jensen, T S ^a   Gottrup, H ^a   Kasch, H ^a   Nikolajsen, L ^a   Terkelsen, A J ^a   Witting, N ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Alternative treatment; Chronic pain; Clinical translation; Hyperexcitability; Mechanism based classification; New treatments

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; AMANTADINE; ANTIDEPRESSANT AGENT; BACLOFEN; CAPSAICIN; CARBAMAZEPINE; CLONIDINE; CYCLOOXYGENASE 2 INHIBITOR; DEXTROMETHORPHAN; GABAPENTIN; KETAMINE; LAMOTRIGINE; LEVODOPA; LIDOCAINE; MEMANTINE; MEXILETINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; OPIATE AGONIST; OXCARBAZEPINE; PHENTOLAMINE; PHENYTOIN; SEROTONIN UPTAKE INHIBITOR; TRAMADOL; TRICYCLIC ANTIDEPRESSANT AGENT; VALPROIC ACID;

ALGORITHM; CHRONIC PAIN; DRUG INDICATION; HUMAN; MEDICAL RESEARCH; NERVE EXCITABILITY; NOCICEPTION; NOCICEPTIVE STIMULATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

ANIMALS; CHRONIC DISEASE; HUMANS; PAIN;

EID: 0034771359     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.2001.450913.x     Document Type: Review

References (45)

1. The neurobiology of pain
2. Neuronal plasticity: Increasing the gain m pain
3. Pain: Molecular mechanisms
4. Opioid receptors: From genes to mice
5. Peripheral and central hyperexcitability: Differential signs and symptoms in persistent pain
6. Concepts of pain mechanisms: The contribution of functional imaging of the human brain
7. Management of chronic pain
8. H(+)-gated cation channels
9. Silent glutamatergic synapses and long-term facilitation in spinal dorsal horn neurones
10. Neural basis of persistent pain: Sensory specialization, sensory modulation, and neuronal plasticity
11. Sodium channels as molecular targets in pain
12. ATP (P2X) receptors and pain
13. Mechanisms of neuropathic pain
14. Painful neuropathy: Altered central processing, maintained dynamically by peripheral input
15. The relationship between sensory thresholds and mechanical hyperalgesia in nerve injury
16. Psychophysical examination of patients following operation for cancer mammae
17. Painful neuropathies
18. The effect of differential and complete nerve block on experimental muscle pain in humans
19. Local and referred pain induced by intradermal and intramuscular capsaicin
20. Stimulus-response functions in areas with experimentally induced referred muscle pain - A psychophysical study
21. Evidence of qualitatively altered nociception in patients with fibromyalgia
22. Qualitative altered nociception in chronic myofascial pain
23. Pain thresholds and tenderness in neck and head following acute whiplash injury: A prospective study
24. Modern concepts of pain and hyperalgesia: Beyond the polymodal C-nociceptor
25. Efficacy of pharmacological treatments of neuropathic pain: An update and effect related to mechanism of drug action
26. Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients
27. Pre-emptive analgesia in postamputation pain: An update
28. The prevention of postoperative pain
29. Prevention of chronicity
30. Do preemptive treatments provide better pain control
31. Phantom limb pain: An update
32. Neuronal plasticity and pre-emptive analgesia: Implications for the management of post-operative pain
33. Randomised trial of epidural bupivacaine and morphine in prevention of stump and phantom pain in lower-limb amputation
34. Neuropathic pain
35. The number needed to treat: A clinically useful measure of treatment effect
36. Efficacy of pharmacological treatments of neuropathic pain: An update and effect related to mechanism of drug action
37. Pharmacological treatment of pain in neuropathies
38. The attentional control of pain: Methodological and theoretical concerns
39. Central nervous system mechanisms of pain modulation
40. Neurotransmitters in nociceptive modulatory circuits
41. Central pharmacology of nociceptive transmission
42. Factors that determine the magnitude and presence of placebo analgesia
43. Neuronal activity in medullary dorsal horn of awake monkeys trained in a thermal discrimination task. III. Task related responses and their functional role