Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors

Journal of Physiology

Volumn 522, Issue 3, 2000, Pages 349-355

  Selyanko, A A ^a   Hadley, J K ^a   Wood, I C ^a,c   Abogadie, F C ^a   Jentsch, T J ^b   Brown, D A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF HAMBURG   (Germany)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCARINIC M1 RECEPTOR; OXOTREMORINE; POTASSIUM CHANNEL; PROTEIN SUBUNIT; DELAYED RECTIFIER POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; POTASSIUM CHANNEL KCNQ4;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; SECOND MESSENGER; CELL ATTACHED PATCH CLAMP; CHO CELL LINE; PERFORATED PATCH CLAMP; POTASSIUM CURRENT; PROTEIN EXPRESSION;

EID: 0034142060     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2000.t01-2-00349.x     Document Type: Article

References (28)

1. Ks cardiac potassium current. Nature 384, 78-80.
2. 2+ current and M current in rat sympathetic neurons. Proceedings of the National Academy of Sciences of the USA 89, 9544-9548.
3. BIERVERT, C., SCHROEDER, B. C., KUBISCH, C., BERKOVIC, S. F., PROPPING, P., JENTSCH, T. & STEINLEIN, O. K. (1998). A potassium channel mutation in neonatal human epilepsy. Science 279, 403-406.
4. BROWN, D. A. (1988). M-currents. In Ion Channels, vol. 1, ed. NARAHASHI, T., pp. 55-94. Plenum Publishing, New York.
5. CHARLIER, C., SINGH, N. A., RYAN, S. G., LEWIS, T. B., REUS, B. E., LEACH, R. J. & LEPPERT, M. (1998). A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nature Genetics 18, 53-55.
6. + channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias. EMBO Journal 16, 5472-5479.
7. + current in guinea pig sino-atrial node is not mediated by muscarinic receptors. Molecular Pharmacology 47, 1248-1254.
8. HALEY, J. E., ABOGADIE, F. C., DELMAS, P., DAYRELL, M., VALLIS, Y., MILLIGAN, G., CAULFIELD, M. P., BROWN, D. A. & BUCKLEY, N. J. (1998). The α subunit of Gq contributes to muscarinic inhibition of the M-type potassium current in sympathetic neurons. Journal of Neuroscience 18, 4521-4531.
9. HAMILTON, S. E., LOOSE, M. D., QI, M., LEVEY, A. I., HILLE, B., MCKNIGHT, G. S., IDZERDA, R. L. & NATHANSON, N. M. (1997). Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Proceedings of the National Academy of Sciences of the USA 94, 13311-13316.
10. + current in mammalian heart involves G proteins. American Journal of Physiology 257, H818-823.
11. HORN, R. & MARTY, A. (1988). Muscarinic activation of ionic currents measured by a new whole-cell recording method. Journal of General Physiology 92, 145-159.
12. KUBISCH, C., SCHROEDER, B. C., FRIEDRICH, T., LUTJOHANN, B., EL-AMRAOUI, A., MARLIN, S., PETIT, C. & JENTSCH, T. J. (1999). KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 96, 437-446.
13. + current due to a novel mutation in KCNQ2 causes neonatal convulsions. Annals of Neurology 46, 305-312.
14. K,n contributes to maturation of mouse outer hair cells. Journal of Physiology 520, 653-660.
15. MARRION, N. V. (1997). Control of M-current. Annual Review of Physiology 59, 483-504.
16. 1-subtype. British Journal of Pharmacology 98, 557-573.
17. q. Biochemical Journal 289, 125-131.
18. RAE, J., COOPER, K., GATES, P. & WATSKY, M. (1991). Low access resistance perforated patch recordings using amphotericin B. Journal of Neuroscience Methods 37, 15-26.
19. SANGUINETTI, M. C. (1999). Dysfunction of delayed rectifier potassium channels in an inherited cardiac arrhythmia. Annals of New York Academy of Sciences 868, 406-413.
20. SANGUINETTI, M. C., CURRAN, M. E., ZOU, A., SHEN, J., SPECTOR, P.S., ATKINSON, D. L. & KEATING, M. T. (1996). Coassembly of KvLQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 384, 80-83.
21. SELYANKO, A. A. & BROWN, D. A. (1999). M-channel gating and simulation. Biophysical Journal 77, 701-713.
22. + channel subunit, erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell. Journal of Neuroscience 19, 7742-7756.
23. SELYANKO, A. A., ROBBINS, J. & BROWN, D. A. (1995). Putative M-type potassium channels in neuroblastoma-glioma hybrid cells: inhibition by muscarine and bradykinin. Receptors and Channels 3, 147-159.
24. SELYANKO, A. A., STANSFELD, C. E. & BROWN, D. A. (1992). Closure of potassium M-channels by muscarinic acetylcholine-receptor stimulants requires a diffusible messenger. Proceedings of the Royal Society B 250, 119-125.
25. SINGH, N. A., CHARLIER, C., STAUFFER, D., DUPONT, B. R., LEACH, R. J., MELIS, R., RONEN, G. M., BJERRE, I., QUATTLEBAUM, T., MURPHY, J. V., MCHARG, M. L., GAGNON, D., ROSALES, T., PEIFFER, A., ANDERSON, V. E. & LEPPERT, M. (1998). A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nature Genetics 18, 25-29.
26. WANG, H.-S., PAN, Z., BROWN, B. S., WYMORE, R. S., COHEN, I. S., DIXON, J. E. & MCKINNON, D. (1998). KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282, 1890-1893.
27. YANG, W.-P., LEVESQUE, P. C., LITTLE, W. A., CONDOR, M. L., SHALABY, F. Y. & BLANAR, M. A. (1997). KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proceedings of the National Academy of Sciences of the USA 94, 4017-4021.
28. YAZAWA, K. & KAMEYAMA, M. (1990). Mechanism of receptor-mediated modulation of the delayed outward potassium current in guinea-pig ventricular myocytes. Journal of Physiology 421, 135-150.