The antioxidant conundrum in cancer

Cancer Research

Volumn 63, Issue 15, 2003, Pages 4295-4298

  Seifried, Harold E ^a   McDonald, Sharon S ^b   Anderson, Darrell E ^b   Greenwald, Peter ^a   Milner, John A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Scientific Consulting Group Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CELL DNA; CELL PROTEIN; GLUTATHIONE TRANSFERASE; LYCOPENE; MULTIVITAMIN; NICOTINIC ACID; PROSTAGLANDIN F2; PROTEIN P53; SELENIUM; SELENIUM DERIVATIVE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UBIDECARENONE; ZINC;

AEROBIC METABOLISM; ANTINEOPLASTIC ACTIVITY; BLEEDING; CANCER CHEMOTHERAPY; CANCER PREVENTION; CANCER RADIOTHERAPY; CANCER RISK; DIARRHEA; DIET SUPPLEMENTATION; DNA DAMAGE; DNA DETERMINATION; DNA STRAND BREAKAGE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EMOTIONAL DISORDER; EXCISION REPAIR; FATIGUE; GASTROINTESTINAL SYMPTOM; GENE EXPRESSION; GENETIC VARIABILITY; GONAD DYSFUNCTION; HEALTH STATUS; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; MASTALGIA; MUSCLE CRAMP; MUSCLE WEAKNESS; NAUSEA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; RISK ASSESSMENT; VISUAL IMPAIRMENT;

ANTIOXIDANTS; DIETARY SUPPLEMENTS; HUMANS; NEOPLASMS; REACTIVE OXYGEN SPECIES;

EID: 0043127120     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (50)

1. National Academy of Sciences, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids: A Report of the Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and on Interpretation and Use of Dietary Reference Intakes, and the Standing Committee on Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine, p. 17. Washington, DC: National Academy Press, 2000.
2. Schwartz, J. L. The dual roles of nutrients as antioxidants and prooxidants: their effects on tumor cell growth. J. Nutr., 126: 1221S-1227S, 1996.
3. Krinsky, N. I. Carotenoids as antioxidants. Nutrition, 17: 815-817, 2001.
4. Palozza, P. Prooxidant actions of carotenoids in biologic systems. Nutr. Rev., 56: 257-265, 1998.
5. Black, H. S. Pro-oxidant and anti-oxidant mechanism(s) of BHT and β-carotene in photocarcinogenesis. Front. Biosci., 7: d1044-d1055, 2002.
6. Lopaczynski, W., and Zeisel, S. H. Antioxidants, programmed cell death, and cancer. Nutr. Res., 21: 295-307, 2001.
7. Castro, L., and Freeman, B. A. Reactive oxygen species in human health and disease. Nutrition, 17: 161-165, 2001.
8. McCord, J. M. The evolution of free radicals and oxidative stress. Am. J. Med., 108: 652-659, 2000.
9. Heim, K. E., Tagliaferro, A. R., and Bobilya, D. J. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J. Nutr. Biochem., 13: 572-584, 2002.
10. IARC Working Group on the Evaluation of Cancer Preventive Agents. IARC Handbooks of Cancer Prevention: Carotenoids, Vol. 2, pp, 1-326. Lyon, France, IARC, 1998.
11. Bianchini, F., and Vainio, H. Allium vegetables and organosulfur compounds: do they help prevent cancer? Environ. Health Perspect., 109: 893-902, 2001.
12. Halvorsen, B. L., Holte, K., Myhrstad, M. C. W., Barikmo, I., Hvattum, E., Remberg, S. F., Wold, A-B., Haffner, K., Baugerød, H., Andersen, L. F., Moskaug, J. Ø., Jacobs, D. R., Jr., and Blomhoff, R. A systematic screening of total antioxidants in dietary plants. J. Nutr., 132: 461-471, 2002.
13. Goldman, I. L., Kader, A. A., and Heintz, C. Influence of production, handling, and storage on phytonutrient content of foods. Nutr. Rev., 57: S46-S52, 1999.
14. Bendich, A., and Machlin, L. J., Safety of oral intake of vitamin E. Am. J. Clin. Nutr., 48: 612-619, 1988.
15. Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and Interpretation and Uses of Dietary Reference Intakes and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine, Vitamin E. In: Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids, pp. 251-253. Washington, DC: National Academy Press, 2000.
16. Fairfield, K. M., and Fletcher, R. H. Vitamins for chronic disease prevention in adults: scientific review. J. Am. Med. Assoc., 287: 3116-3126, 2002.
17. Raich, P. C., Lu, J., Thompson, H. J., and Combs, G. F., Jr. Selenium in cancer prevention: clinical issues and implications. Cancer Investig., 19: 540-553, 2001.
18. Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and Interpretation and Uses of Dietary Reference Intakes and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine, Selenium. In: Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids, pp. 311-313. Washington, DC: National Academy Press, 2000.
19. Jiang, Q., Christen, S., Shigenaga, M. K., and Ames, B. N. γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am. J. Clin. Nutr., 74: 714-722, 2001.
20. Giovanucci, E. Tomatoes, tomato-based products, lycopene and cancer: review of the epidemiologic literature. J. Natl. Cancer Inst. (Bethesda), 91: 317-331, 1999.
21. Kim, D. J., Takasuka, N., Kim, J. M., Sekine, K., Ota, T., Asamoto, M., Murakoshi, M., Nishino, H., Nir, Z., and Tsuda, H. Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH. Cancer Lett., 120: 15-22, 1997.
22. Re, R., Fraser, P. D., Long, M., Bramley, P. M., and Rice-Evans, C. Isomerization of lycopene in the gastric milleu. Biochem. Biophys. Res. Commun., 281: 576-581, 2001.
23. Frei, B., and McCall, M. R. Antioxidant vitamins: evidence from biomarkers in humans. Bibl. Nutr. Dieta, 55: 46-67, 2001.
24. Halliwell, B. Why and how should we measure oxidative DNA damage in nutritional studies? How far have we come? Am. J. Clin. Nutr., 72: 1082-1087, 2000.
25. Helbock, H. J., Beckman, K. B., Shigenaga, M. K., Walter, P. B., Woodall, A. A., Yeo, H. C., and Ames, B. N. DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc. Natl. Acad. Sci. USA, 95: 288-293, 1998.
26. Cadet, J., Douki, T., Frelon, S., Sauvaigo, S., Pouget, J. P., and Ravanat, J. L. Assessment of oxidative base damage to isolated and cellular DNA by HPLC-MS/MS measurement. Free Radic. Biol. Med., 33: 441-449, 2002.
27. Ravanat, J. L., Douki, T., Duez, P., Gremaud, E., Herbert, K., Hofer, T., Lasserre, L., Saint-Pierre, C., Favier, A., and Cadet, J. Cellular background level of 8-oxo-7,8-dihydro-2′-deoxyguanosine: an isotope based method to evaluate artefactual oxidation of DNA during its extraction and subsequent work-up. Carcinogenesis (Lond.), 23: 1911-1918, 2002.
28. Stadtman, E. Introduction to serial reviews on oxidatively modified proteins in aging and disease. Free Radic. Biol. Med., 32: 789, 2002.
29. Loft, S., and Poulsen, H. E. Antioxidant intervention studies related to DNA damage, DNA repair and gene expression. Free Radic. Res., 33: S67-S83, 2000.
30. Forsberg, L., de Faire, U., and Morgenstern, R. Oxidative stress, human genetic variation, and disease. Arch. Biochem. Biophys., 389: 84-93, 2001.
31. van Gils, C. H., Bostick, R. M., Stern, M. C., and Taylor, J. A. Differences in base excision repair capacity may modulate the effect of dietary antioxidant intake on prostate cancer risk: an example of polymorphisms in the XRCCI gene. Cancer Epidemiol. Biomark. Prev., 11: 1279-1284, 2002.
32. Zhang, H. J., Tao, Y., Oberley, T. D., and Oberley, L. W. Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype. Cancer Res., 59: 6276-6283, 1999.
33. Plymate, S. R., Haugk, K. H., Sprenger, C. C., Nelson, P. S., Tennant, M. K., Zhang, Y., Oberley, L. W., Zhong, W., Drivdahl, R., and Oberley, T. D. Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1. Oncogene, 22: 1024-1034, 2003.
34. Zhao, Y., Oberley, T. D., Chaiswing, L., Lin, S., Epstein, C., Huang, T., and St. Clair, D. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model Oncogene, 21: 3836-3846, 2002.
35. Woodson, K., Stewart, C., Barrett, M., Bhat, N. K., Virtamo, J., Taylor, P. R., and Albanes, D. Effect of vitamin intervention on the relationship between GSTM1, smoking, and lung cancer risk among male smokers. Cancer. Epidemiol. Biomark. Prev., 8: 965-970, 1999.
36. Brigelius-Flohé, R., Kelly, F. J., Salonen, J. T., Neuzil, J., Zingg, J-M., and Azzi, A. The European perspective on vitamin E: current knowledge and future research. Am. J. Clin. Nutr., 76: 703-716, 2002.
37. Kline, K., Yu, W., and Sanders, B. G. Vitamin E: mechanisms of action as tumor cell growth inhibitors. J. Nutr., 131: 161S-163S, 2001.
38. Calfee-Mason, K. G., Spear, B. T., and Glauert, H. P. Vitamin E inhibits hepatic NF-κB activation in rats administered the hepatic tumor promoter, phenobarbital. J. Nutr., 132: 3178-3185, 2002.
39. Seo, Y. R., Kelley, M. R., and Smith, M. L. Selenomethionine regulation of p53 by a ref1-dependent redox mechanism. Proc. Natl. Acad. Sci. USA, 99: 14548-14553, 2002.
40. Shen, C-L., Song, W., and Pence, B. C. Interactions of selenium compounds with other antioxidants in DNA damage and apoptosis in human normal keratinocytes. Cancer Epidemiol. Biomark. Prev., 10: 385-390, 2001.
41. Menter, D. G., Sabichi, A. L., and Lippman, S. M. Selenium effects on prostate cell growth. Cancer Epidemiol. Biomark. Prev., 9: 1171-1182, 2000.
42. Stewart, M. S., Spallhotz, J. E., Neldner, K. H., and Pence, B. H. Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis. Free Radic. Biol. Med., 26: 42-48, 1999.
43. Prasad, K. N., Cole, W. C., Kumar, B., and Prasad, K. C. Scientific rationale for using high-dose multiple micronutrients as an adjunct to standard and experimental cancer therapies. J. Am. Coll. Nutr., 20: 450S-463S, 2001.
44. Prasad, K. N., Kumar, A., Kochupillai, V., and Cole, W. C. High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy. J. Am. Coll. Nutr., 18: 13-25, 1999.
45. Lamson, D. W., and Brignall, M. S. Antioxidants in cancer therapy; their actions and interactions with oncologic therapies. Altern. Med. Rev., 4: 304-329, 1999.
46. Prasad, K. N., Cole, W. C., Kumar, B., and Prasad, K. C. Pros and cons of antioxidant use during radiation therapy. Cancer Treat. Rev., 28: 79-91, 2002.
47. Conklin, K. A. Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects. Nutr. Cancer, 37: 1-18, 2000.
48. Richardson, M. A., Sanders, T., Palmer, J. L., Greisinger, A., and Singletary, S. E. Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology. J. Clin. Oncol., 18: 2505-2514, 2000.
49. Burstein, H. J., Gelber, S., Guadagnoli, E., and Weeks, J. C. Use of alternative medicine by women with early-stage breast cancer. N. Engl. J. Med., 340: 1733-1739, 1999.
50. Lesperance, M. L., Olivotto, I. A., Forde, N., Zhao, Y., Speers, C., Foster, H., Tsao, M., MacPherson, N., and Hoffer, A. Mega-dose vitamins and minerals in the treatment of non-metastatic breast cancer: an historical cohort study. Breast Cancer Res. Treat., 76: 137-143, 2002.