Antioxidant vitamins: Evidence from biomarkers in humans

Forum of Nutrition

Volumn 55, Issue , 2001, Pages 46-67

  Frei, Balz ^a   McCall, Mark R ^a  

^a OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BIOLOGICAL MARKER; PROTEIN; REACTIVE OXYGEN METABOLITE;

ARTERIOSCLEROSIS; DNA DAMAGE; HUMAN; LIPID METABOLISM; LIPID PEROXIDATION; METABOLISM; NEOPLASM; NUTRITIONAL REQUIREMENT; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHYSIOLOGY; REVIEW; SMOKING;

ANTIOXIDANTS; ARTERIOSCLEROSIS; ASCORBIC ACID; BIOLOGICAL MARKERS; DNA DAMAGE; HUMANS; LIPID METABOLISM; LIPID PEROXIDATION; NEOPLASMS; NUTRITIONAL REQUIREMENTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEINS; REACTIVE OXYGEN SPECIES; SMOKING; VITAMIN E;

EID: 56749183608     PISSN: 16600347     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (76)

1. Halliwell B, Chirico S: Lipid peroxidation: Its mechanism, measurement, and significance. Am J Clin Nutr 1993;57:715S-725S.
2. Loft S, Poulsen HE: Cancer risk and oxidative DNA damage in man. J Mol Med 1996;74:297-312.
3. Stahl W, Sies H: Antioxidant defense: Vitamins E and C and carotenoids. Diabetes 1997;46:S14-S18.
4. Bowen PE, Mobarhan S: Evidence from cancer intervention and biomarker studies and the development of biochemical markers. Am J Clin Nutr 1995;62:1403S-1409S.
5. Keaney JF Jr, Frei B: Antioxidant protection of low-density lipoprotein and its role in the prevention of atherosclerotic vascular disease; in Frei B (ed): Natural Antioxidants in Human Health and Disease. New York, Academic Press, 1994, chapt 11, pp 303-351.
6. Esterbauer H, Ramos P: Chemistry and pathophysiology of oxidation of LDL. Rev Physiol Biochem Pharmacol 1995;127:31-64.
7. Esterbauer H: Estimation of peroxidative damage. A critical review. Pathol Biol 1996;44:25-28.
8. Janero DR: Malondialdehyde and thiobarbituric acid reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 1990;9:515-540.
9. Harats D, Ben-Naim M, Dabach Y, Hollander G, Havivi E, Stein O, Stein Y: Effect of vitamin C and E supplementation on susceptibility of plasma lipoproteins to peroxidation induced by acute smoking. Atherosclerosis 1990;85:47-54.
10. Brown KM, Morrice PC, Duthie GG: Vitamin E supplementation suppresses indexes of lipid peroxidation and platelet counts in blood of smokers and nonsmokers but plasma lipoprotein concentrations remain unchanged. Am J Clin Nutr 1994;60:383-387.
11. Cadenas S, Rojas C, Méndez J, Herrero A, Barja G: Vitamin E decreases urine lipid peroxidation products in young healthy human volunteers under normal conditions. Pharmacol Toxicol 1996;79:247-253.
12. Mol MJTM, de Rijke YB, Demacker PNM, Stalenhoef AFH: Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: Effects of vitamin E treatment. Atherosclerosis 1997;129:169-176.
13. Wen Y, Cooke T, Feely J: The effect of pharmacological supplementation with vitamin C on lowdensity lipoprotein oxidation. Br J Clin Pharmacol 1997;44:94-97.
14. O'Brien KD, Alpers CE, Hokanson JE, Wang S, Chait A: Oxidation-specific epitopes in human coronary atherosclerosis are not limited to oxidized low-density lipoprotein. Circulation 1996;94:1216-1225.
15. 2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 1990;87:9383-9387.
16. FitzGerald GA, Tigges J, Barry P, Lawson JA: Markers of platelet activation and oxidant stress in atherothrombotic disease. Thromb Haemost 1997;78:280-284.
17. 2-isoprostane receptors on rat vascular smooth muscle cells. Am J Physiol 1993;264:1619-1624.
18. 2α excretion in man. J Pharmacol Exp Ther 1995;275:94-100.
19. 2α generation during coronary reperfusion. A potential quantitative marker of oxidant stress in vivo. Circulation 1997;95:2492-2499.
20. 2α . J Biol Chem 1995;270:9800-9808.
21. 2-isoprostane formation. Br J Pharmacol 1996;118:1285-1293.
22. Reilly M, Delanty N, Lawson JA, FitzGerald GA: Modulation of oxidant stress in vivo in chronic cigarette smokers. Circulation 1996;94:19-25.
23. Kneepkens CMF, Lepage G, Roy CC: The potential of the hydrocarbon breath test as a measure of lipid peroxidation. Free Radic Biol Med 1994;17:127-160.
24. Springfield JR, Levitt MD: Pitfalls in the use of breath pentane measurements to assess lipid peroxidation. J Lipid Res 1994;35:1497-1504.
25. Hoshino E, Shariff R, Van Gossum A, Allard JP, Pichard C, Kurian R, Jeejeebhoy KN: Vitamin E suppresses increased lipid peroxidation in cigarette smokers. J Parenter Enter Nutr 1990;14:300-305.
26. Gottlieb K, Zarling EJ, Mobarhan S, Bowen P, Sugerman S: β-Carotene decreases markers of lipid peroxidation in healthy volunteers. Nutr Cancer 1993;19:207-212.
27. Allard JP, Royall D, Kurian R, Muggli R, Jeejeebhoy KN: Effects of β-carotene supplementation on lipid perioxidation in humans. Am J Clin Nutr 1994;59:884-890.
28. Do BKQ, Garewal HS, Clements NC Jr, Peng YM, Habib MP: Exhaled ethane and antioxidant vitamin supplements in active smokers. Chest 1996;100:159-164.
29. Haberland ME, Fong D, Cheng L: Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits. Science 1988;241:215-218.
30. Daugherty A, Zweifel BS, Sobel BE, Schonfeld G: Isolation of low density lipoprotein from atherosclerotic vascular tissue of Watanabe heritable hyperlipidemic rabbits. Arteriosclerosis 1988;8:768-777.
31. Ylä-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, Witztum JL, Steinberg D: Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest 1989;84:1086-1095.
32. Kita T, Nagano Y, Yokode M, Ishii K, Kume N, Ooshima A, Yoshida H, Kawai C: Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. Proc Natl Acad Sci USA 1987;84:5928-5931.
33. Carew TE, Schwenke DC, Steinberg D: Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: Evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci USA 1987;84:7725-7729.
34. Björkhem I, Henriksson-Freyschuss A, Breuer O, Diczfalusy U, Berglund L, Henriksson P: The antioxidant butylated hydroxytoluene protects against atherosclerosis. Arterioscler Thromb 1991;11:15-22.
35. Quinn MT, Parthasarathy S, Fong LG, Steinberg D: Oxidatively modified low density lipoproteins: A potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA 1987;84:2995-2998.
36. Steinbrecher UP, Parthasarathy S, Leake DS,Witztum JL, Steinberg D: Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci USA 1984;81:3883-3887.
37. 2 activity in endothelial cell-induced modification of low density lipoprotein. Proc Natl Acad Sci USA 1985;82:3000-3004.
38. McDowell IFW, Brennan GM, McEneny J, Young IS, Nicholls DP, McVeigh GE, Bruce I, Trimble ER, Johnston GD: The effect of probucol and vitamin E treatment on the oxidation of low-density lipoprotein and forearm vascular responses in humans. Eur J Clin Invest 1994;24:759-765.
39. Suzukawa M, Ishikawa T, Yoshida H, Nakamura H: Effect of in-vivo supplementation with low-dose vitamin E on susceptibility of low-density lipoprotein and high-density lipoprotein to oxidative modification. J Am Coll Nutr 1995;14:46-52.
40. Mol MJTM, de Rijke YB, Demacker PNM, Stalenhoef AFH: Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: Effect of vitamin E treatment. Atherosclerosis 1997;129:169-176.
41. Jialal I, Fuller CJ, Huet BA: The effect of α-tocopherol supplementation on LDL oxidation. A doseresponse study. Arterioscler Thromb Vasc Biol 1995;15:190-197.
42. Princen HMG, van Duyvenvoorde W, Buytenhek R, van der Laarse A, van Poppel G, Leuven JAG, van Hinsbergh VWM: Supplementation with low doses of vitamin E protects LDL from lipid peroxidation in men and women. Arterioscler Thromb Vasc Biol 1995;15:325-333.
43. Simons LA, Von Konigsmark M, Balasubramaniam S: What dose of vitamin E is required to reduce susceptibility of LDL to oxidation? Aust NZ J Med 1996;26:496-503.
44. Reaven PD, Ferguson E, Navab M, Powell FL: Susceptibility of human LDL to oxidative modification. Effects of variations in β-carotene concentration and oxygen tension. Arterioscler Thromb 1994;14:1162-1169.
45. Gaziano JM, Hatta A, Flynn M, Johnson EJ, Krinsky NI, Ridker PM, Hennekens CH, Frei B: Supplementation with β-carotene in vivo and in vitro does not inhibit low density lipoprotein oxidation. Atherosclerosis 1995;112:187-195.
46. Fuller CJ, Grundy SM, Norkus EP, Jialal I: Effect of ascorbate supplementation on low density lipoprotein oxidation in smokers. Atherosclerosis 1996;119:139-150.
47. Wen Y, Cooke T, Feely J: The effect of pharmacological supplementation with vitamin C on lowdensity lipoprotein oxidation. Br J Clin Pharmacol 1997;44:94-97.
48. Nyyssonen K, Porkkala E, Salonen R, Korpela H, Salonen JT: Increase in oxidation resistance of atherogenic serum lipoproteins following antioxidant supplementation: A randomized double-blind placebo-controlled clinical trial. Eur J Clin Nutr 1994;48:633-642.
49. Gilligan DM, Sack MN, Guetta V, Casino PR, Quyyumi AA, Rader DJ, Panza JA, Cannon RO III: Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia. J Am Coll Cardiol 1994;24:1611-1617.
50. Abbey M, Noakes M, Nestel PJ: Dietary supplementation with orange and carot juice in cigarette smokers lowers oxidation products in copper-oxidized low-density lipoproteins. J Am Diet Assoc 1995;95:671-675.
51. Mosca L, Rubenfire M, Mandel C, Rock C, Tarshis T, Tsai A, Pearson T: Antioxidant nutrient supplementation reduces the susceptibility of low density lipoprotein to oxidation in patients with coronary artery disease. J Am Coll Cardiol 1997;30:392-399.
52. Bowry VW, Stocker R: Tocopherol-mediated peroxidation. The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein. J Am Chem Soc 1993;115:6029-6040.
53. Thomas SR, Neuzil J, Mohr D, Stocker R: Coantioxidants make α-tocopherol an efficient antoxidant for low-density lipoprotein. Am J Clin Nutr 1995;62:1357S-1364S.
54. Dean RT, Fu S, Stocker R, Davies MJ: Biochemistry and pathology of radical-mediated protein oxidation. Biochem J 1997;324:1-18.
55. Berlett BS, Stadtman ER: Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 1997;272:20313-20316.
56. Hazen SL, Crowley JR, Mueller DM, Heinecke JW: Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attomole sensitivity: A sensitive and specific marker for myeloperoxidase-catalyzed chlorination at sites of inflammation. Free Radic Biol Med 1997;23:909-916.
57. Huggins TG, Wells-Knecht MC, Detorie NA, Baynes JW, Thorpe SR: Formation of o-tyrosine and dityrosine in proteins during radiolytic and metal-catalyzed oxidation. J Biol Chem 1993;268:12341-12347.
58. Wells-Knecht MC, Lyons TJ, McCance DR, Thorpe SR, Baynes JW: Age-dependent increase in ortho-tyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes. Evidence against a generalized increase in oxidative stress in diabetes. J Clin Invest 1997;100:839-846.
59. Vlassara H:Recent progress in advanced glycation end products and diabetic complications. Diabetes 1997;46:S19-S25.
60. Sell DR, Monnier VM: Structure elucidation of a senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process. J Biol Chem 1989;264:21597-21602.
61. ε-(Carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins. Biochem J 1997;324:565-570.
62. Nagaraj RH, Shipanova IN, Faust FM: Protein cross-linking by the Maillard reaction. J Biol Chem 1996;271:19338-19345.
63. ε-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions. J Biol Chem 1996;271:9982-9986.
64. Requena JR, Ahmed MU, Fountain AW, Degenhardt TP, Reddy S, Perez C, Lyons TJ, Jenkins AJ, Baynes JW, Thorpe SR: Carboxymethylethanolamine, a biomarker of phospholipid modification during the Maillard reaction in vivo. J Biol Chem 1997;272:17473-17479.
65. Lindahl T: Instability and decay of the primary structure of DNA. Nature 1993;362:709-715.
66. Gerster H: Intermediate cancer biomarkers and their use in beta-carotene studies in humans. Int J Vitam Nutr Res 1996;66:3-18.
67. Ravanat JL, Turesky RJ, Gremaud E, Trudel LJ, Stadler RH: Determination of 8-oxoguanine in DNA by gas chromatography-mass spectrometry and HPLC-electrochemical detection: Overestimation of the background level of the oxidized base by the gas chromatography-mass spectrometry assay. Chem Res Toxicol 1995;8:1039-1045.
68. Collins AR, Dusinska M, Gedik CM, Stetina R: Oxidative damage to DNA: Do we have a reliable biomarker? Environ Health Perspect 1996;104:465-469.
69. Singh NP, McCoy MT, Tice RR, Schneider EL: A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184-191.
70. Fraga CG, Motchnik PA, Shigenaga MK, Helbock HJ, Jacob RA, Ames BN: Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci USA 1991;88:11003-11006.
71. Fraga CG, Motchnik PA, Wyrobek AJ, Rempel DM, Ames BN: Smoking and low antioxidant levels increase oxidative damage to sperm DNA. Mut Res 1996;351:199-203.
72. Duthie SJ, Ma A, Ross MA, Collins AR: Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res 1996;56:1291-1295.
73. Witt EH, Reznick AZ, Viguie CA, Starke-Reed P, Packer L: Exercise, oxidative damage and effects of antioxidant manipulation. J Nutr 1992;122:766-773.
74. Loft S, Vistisen K, Ewertz M, Tjønneland A, Overvad K, Poulsen HE: Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: Influence of smoking, gender and body mass index. Carcinogenesis 1992;13:2241-2247.
75. Van Poppel G, Poulsen H, Loft S, Verhagen H: No influence of beta-carotene on oxidative DNA damage in male smokers. J Nat Cancer Inst 1995;87:310-311.
76. Priemé H, Loft S, Nyyssönen K, Salonen JT, Poulsen HE: No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion in smokers. Am J Clin Nutr 1997;65:503-507.