High Doses of Multiple Antioxidant Vitamins: Essential Ingredients in Improving the Efficacy of Standard Cancer Therapy

Journal of the American College of Nutrition

Volumn 18, Issue 1, 1999, Pages 13-25

  Prasad, Kedar N ^a   Kumar, Arun ^a   Cole, William C ^a   Kochupillai, Vinod ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Diet; Differentiation; Gene regulation; Growth inhibition; Lifestyle; Vitamin supplements

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; ALPHA2B INTERFERON; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; BLEOMYCIN; CAROTENOID; CHLOROZOTOCIN; CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; FLUOROURACIL; LOMUSTINE; METHOTREXATE; MITOMYCIN C; MULTIVITAMIN; PYRIDOXINE; RETINOID; TAMOXIFEN; TIOGUANINE; VINCRISTINE; VITAMIN;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; CANCER CELL; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER THERAPY; CELL DIFFERENTIATION; DIET SUPPLEMENTATION; DIETARY FIBER; DRUG POTENCY; GENE EXPRESSION REGULATION; GROWTH INHIBITION; HUMAN; NONHUMAN; REVIEW; VITAMIN INTAKE;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANTIOXIDANTS; COMBINED MODALITY THERAPY; DIET; HUMANS; LIFE STYLE; NEOPLASMS; VITAMINS;

EID: 0032986046     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.1999.10718822     Document Type: Article

References (71)

1. Prasad KN, Cole W, Hoveland P: Cancer prevention studies: Past, present and future. Nutrition 14: 197-210, 1998.
2. Sporn MB, Roberts AB: Role of retinoids in differentiation and carcinogenesis. Cancer Res 43: 3034-3040, 1983.
3. Carter CA, Pogribny M, Davidson A, Jackson CD, McGarrity LJ, Morris SM: Effects of retinoic acid on cell differentiation and reversion towards normal in human endometrial adenocarcinoma (RL95-2) cells. Anticancer Res 16: 17-24, 1996.
4. Prasad KN, Hernandez C, Edwards-Prasad J, Nelson J, Borus T, Robinson WA: Modification of the effect of tamoxifen, cis-platin, DTIC and interferon-a2b on human melanoma cells in culture by a mixture of vitamins. Nutr Cancer 22: 233-245, 1994.
5. Prasad KN, Kumar R: Effect of individual antioxidant vitamins alone and in combination on growth and differentiation of human non-tumorigenic and tumorigenic parotid acinar cells in culture. Nutr Cancer 26: 11-19, 1996.
6. Gundimeda U, Hara S, Anderson WB, Gopalakrishna R: Retinoids inhibit the oxidation modification of protein kinase C induced by oxidant tumor promotors. Arch Biochem Biophys 300: 576-630, 1993.
7. Prasad KN, Edwards-Prasad J, Kumar S, Meyers A: Vitamins regulate gene expression and induce differentiation and growth inhibition in cancer cells. Their relevance in cancer prevention. Arch Otolaryngol Head Neck Surg 119: 1133-1140, 1993.
8. Seifter E, Rettura A, Padawar J, Levenson SM: Vitamin A and b-carotene as adjunctive therapy to tumor excision, radiation therapy and chemotherapy. In Prasad KN (ed): “Vitamins, Nutrition and Cancer.” Basel: Karger, pp 1-19, 1984.
9. Cole WC, Prasad KN: Contrasting effects of vitamins as modulators of apoptosis in cancer cells and normal cells: a review. Nutrition and Cancer 29: 97-103, 1997.
10. Meyskens FL Jr: Role of vitamin A and its derivatives in the treatment of human cancer. In Prasad KN, Santamaria L, Williams RM (eds): “Nutrients in Cancer Prevention and Treatment.” Totowa, NJ: Humana Press, pp 349-362, 1995.
11. Dreno B: Roferon-A (interferon alpha 2a) combined with Tigason (etretinate) for treatment of cutaneous T cell lymphomas. Stem Cells 11: 269-275, 1993.
12. Prasad KN, Sinha PK, Ramanujarn M, Sakamoto A: Sodium ascorbate potentiates the growth inhibitory effect of certain agents on neuroblastoma cells in culture. Proc Natl Acad Sci USA 76: 829-832, 1979.
13. Prasad KN: Modulation of the effect of tumor therapeutic agents by vitamin C. Life Sci 27: 275-280, 1980.
14. Park CH: Vitamin C in leukemia and preleukemia cell growth. Prog Clin Biol Res 259: 321-330, 1988.
15. Cohen M, Bhagavan HN: Ascorbic acid and gastrointestinal cancer. J Am Coll Nutr 14: 565-578, 1995.
16. Cameron E, Pauling L, Leibowitz B: Ascorbic acid and cancer. A review. Cancer Res 39: 663-681, 1979.
17. Creagan ET, Moertel CG, O'Fallon JR: Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. N Engl J Med 301: 687-690, 1979.
18. Chinery R, Brockman JA, Peeler MO, Shyr Y, Beauchamp D, Coffey RJ: Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAFI/CIPI via C/EBPb. Nature Medicine 3: 1233-1241, 1997.
19. Fariss MW, Fortuna MB, Everett CK, Smith JD, Trent DF, Djuric Z: The selective antiproliferative effects of a-tocopheryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compounds. Cancer Res 54: 3346-3351, 1994.
20. Prasad KN, Edwards-Prasad J: Effect of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture. Cancer Res 42: 550-555, 1982.
21. Kline K, Yu W, Zhao B: Vitamin E succinate: Mechanisms of action as tumor cell growth inhibitor. In Prasad KN, Santamaria L, Williams RM (eds): “Nutrients in Cancer Prevention and Treatment.” Totawa, NJ: Humana Press, pp 39-55, 1995.
22. Prasad KN, Edwards-Prasad J: Vitamin E and cancer prevention: Recent advances and future potentials. J Am Coll Nutr 11: 487-500, 1992.
23. Helson L, Verma M, Helson C: Vitamin E and human neuroblastoma. In Meyskan FL Jr, Prasad KN (eds): “Modulation and Mediation of Cancer Cells by Vitamins.” Basel: Karger, pp 258-265, 1983.
24. Turley JM, Ruscetti FW, Kim S, Fu T: Vitamin E succinate inhibits proliferation of BT-20 human breast cancer cells: increased binding of cyclic AMP negatively regulates E2F transactivation activity. Cancer Res 57: 2668-2675, 1997.
25. Schwartz JL: Molecular and biochemical control of tumor growth following treatment with carotenoids or tocopherols. In Prasad KN, Santamaria L, Williams RM (eds): “Nutrients in Cancer Prevention and Treatment.” Totawa, NJ: Humana Press, pp 287-316, 1995.
26. Shklar G: Inhibition and regression of experimental oral cancer by beta carotene and vitamin E: emerging concepts. In Prasad KN, Santamaria L, Williams RM (eds): “Nutrients in Cancer Prevention and Treatment.” Totowa, NJ: Humana Press, pp 317-332, 1995.
27. Carini R, Poli G, Dianzani MU, Maddix SP, Slater TF, Cheeseman KH: Comparative evaluation of the amount of the antioxidant activity of a-tocopherol, a-tocopherol polyethylene glycol 1000 succinate and a-tocopherol succinate in isolated hepatocytes and liver microsomal suspensions. Biochem Pharmacol 39: 1597-1601, 1990.
28. Prasad KN, Edwards-Prasad J, Ramanujans S, Sakamoto A: Vitamin E increases the growth-inhibitory and differentiating effects of tumor therapeutic agents on neuroblastoma cells in culture. Proc Soc Exp Biol Med 164: 158-163, 1980.
29. Ingold KU, Burton GW, Foster DO, Hughes L, Lindsay DA, Webb A: Biokinetics of and discrimination between dietary RRR-and SRR-tocopherols in the male rat. Lipids 22: 163-172, 1987.
30. Gopalakrishna R, Gundimeda U, Chen Z: Vitamin E succinate inhibits protein kinase C: Correlation with its unique inhibitory effects on cell growth and transformation. In Prasad KN, Santamaria L, Williams RM (eds): “Nutrients in Cancer Prevention and Treatment.” Totowa, NJ: Humana Press, pp 21-37, 1995.
31. Mahoney CW, Azzi A: Vitamin E inhibits protein kinase C activity. Biochem Biophys Res Commun 154: 694-697, 1988.
32. Prasad KN, Edwards-Prasad J: Expressions of some molecular cancer risk factors and their modification by vitamins. J Am Coll Nutr 9: 28-34, 1990.
33. Cole WC, Prasad KN: Heterogeneity of commercial b-carotene preparations: correlation with biological activities. In Prasad KN, Cole WC (eds): “Cancer and Nutrition” Amsterdam: IOS Press, pp 99-104, 1998.
34. Zhang LX, Cooney RV, Bertram JS: Carotenoids up-regulate connexin-43 gene expression independent of their provitamin A or antioxidant properties. Cancer Res 52: 5707-5712, 1992.
35. Garewal H: Beta-carotene and antioxidant nutrients in oral cancer prevention. In Prasad KN, Santamaria L, Williams RM (eds): “Nutrients in Cancer Prevention and Treatment.” Totawa, NJ: Human Press, pp 235-247, 1995.
36. Kennedy AR, Krinsky NI: Effects of retinoids, b-carotene and canthaxanthene on U.V. and x-ray-induced transformation of C3H10T 1/2 cells in vitro. Nutr Cancer 22: 219-232, 1994.
37. Krauhausen U, Blum U, Fortmeyer HP: Vitamin B6 responsive growth of human lung cancers in nude mice. Strahlentherapie und Onkologie 165: 562-563, 1989.
38. Tryfiates GP: Control of tumor growth by pyridoxine restriction or treatment with an anti-vitamin agent. Cancer Detect Prev 4: 159-164, 1981.
39. Kim JH, Kim SH, He SQ, Dvagovic J, Brown S: Vitamins as adjuvant to conventional cancer therapy. In Prasad KN, Santamaria L, Williams RM (eds): “Nutrients in Cancer Prevention and Treatment.” Totowa, NJ: Humana Press, pp 363-372, 1995.
40. Kim JH, Brown S, Walker E: The use of high dose vitamins as an adjunct to conventional cancer treatment. In Prasad KN, Cole WC, (eds): “Cancer and Nutrition.” Amsterdam: IOS Press, pp 205-212, 1998.
41. Sarria A, Prasad KN: DL-alpha tocopheryl succinate enhances the effect of gamma-irradiation on neuroblastoma cells in culture. Proc Soc Exp Biol Med 175: 88-92, 1984.
42. Ripoli EAP, Rawa BN, Webber MM: Vitamin E enhances the chemotherapeutic effects of adriamycin on human prostate carcinoma cells in vitro. J Urol 136: 529-531, 1986.
43. Prasad KN, Rama BN: Modification of the effect of pharmacological agents, ionizing radiation and hyperthermia on tumor cells by vitamin E. In Prasad KN (ed): “Vitamins, Nutrition and Cancer.” Basel: Karger, pp 76-104, 1984.
44. Rutz HP, Little JB: Modification of radiosensitivity and recovery from x-ray damage in vitro, by retinoic acid. Internat J Radiat Oncol Biol Phys 16: 1285-1288, 1981.
45. Teicher BA, Schwartz JL, Holden SA, Gulshan A, Northey D: In vivo modulation of several anticancer agents by b-carotene. Cancer Chemo Pharmocol 34: 235-241, 1994.
46. Gundimeda U, Hara S, Anderson WB, Gopalakrishna R: Retinoids inhibit the oxidation modification of protein kinase C induced by oxidant tumor promotors. Arch Biochem Biophys 300: 576-630, 1993.
47. Sahu SN, Prasad KN: Combined effect of adenosine 39,59-cyclic monophosphate stimulating agents, vitamin E succinate, and heat on the survival of murine B-16 melanoma cells in culture. Cancer 62: 949-953, 1988.
48. Rama BN, Prasad KN: Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture. Life Sci 34: 2089-2097, 1984.
49. Prasad KN: Butyric acid: a small fatty acid with diverse biological functions. Life Sci 27: 1351-1358, 1980.
50. Rama BN, Prasad KN: Effect of dl-alpha-tocopheryl succinate in combination with sodium butyrate and cAMP-stimulating agents on neuroblastoma cells in culture. Int J Cancer 34: 863-867, 1984.
51. Prasad KN: Differentiation of neuroblastoma cells: a useful model for neurobiology and cancer. Biol Rev 66: 431-451, 1991.
52. Hazuka MB, Edwards-Prasad J, Newman F, Kinzie JJ, Prasad KN: Beta-carotene induces morphological differentiation and decreases adenylate cyclase activity in melanoma cells in culture. J Am Coll Nutr 9: 143-149, 1990.
53. Prasad KN, Kentroti S, Edwards-Prasad J, Verndakis A, Imam M, Carvalho E, Kumar S: Modification of the expression of adenosine 39,59-cyclic monophosphate-induced differentiated functions in neuroblastoma cells by beta-carotene and d-alpha tocopheryl succinate. J Am Coll Nutr 13: 298-303, 1994.
54. Prasad KC: Induction of differentiated phenotypes in melanoma cells by a combination of an adenosine 39,59-cyclic monophosphate stimulating agent and d-a-tocopheryl succinate. Cancer Lett 116: 17-22, 1989.
55. Lippman SM, Parkinson DR, Itri LM, Kavanagh JJ, Paredes-Espinoza M, Delgadillo-Madrueno F, Paredes-Casillas P, Hong WK, Holdenev E, Krakoff I: 13-cis retinoic acid plus interferon a-2a: Highly active systemic therapy for squamous cell carcinoma of the cervix. J Natl Cancer Inst 84: 241-245, 1995.
56. Yamanaka N, Fukishima M, Koizumi K, Nishida K, Kato T, Ota K: Enhancement of DNA chain breakage by bleomycin and biological free radical producing systems. In DeDuve C and Hayashi T (eds): “Tocopherol, Oxygen and Biomembranes.” New York: North Holland, pp 59-69, 1978.
57. Myers CE, McGuire W, Young R: Adriamycin: Amelioration of toxicity by alpha-tocopherol. Cancer Treat Rep 60: 961-962, 1976.
58. Sonnevald P: Effect of alpha tocopherol on cardiotoxicity of adriamycin in the rat. Cancer Treat Rep 62: 1033-1036, 1978.
59. Van Vleet JF, Greenwood L, Ferands VJ, Rebar AH: Effect of selenium-vitamin E on adriamycin-induced cardiomyopathy in rabbits. Am J Vitam Res 39: 997-1010, 1978.
60. Wang YM, Madanat FF, Kimball JC, Gieser CA, Ali MK, Kaufman MW, Van Eys J: Effect of vitamin E against adriamycininduced toxicity in rabbits. Cancer Res 40: 1022-1027, 1980.
61. Svingen BA, Powis A, Abbel PL, Scott M: Protection against adriamycin-induced skin necrosis in the rat by dimethylsulfoxide and alpha-tocopherol. Cancer Res 41: 3395-3399, 1981.
62. Geetha A, Sankar R, Marar T, Devi CSS: Alpha tocopherol reduces doxorubicin-induced toxicity in rats-histological and biochemical evidences. Indian Physiol Pharmacol 34: 94-98, 1990.
63. Srinavasan V, Jacobs AL, Simpson SA, Weiss JF: Radioprotection by vitamin E. Effect on hepatic enzymes, delayed type hypersensitivity and post-irradiation survival in mice. In Meyskens FLJ, Prasad KN (eds): “Modulation and Mediations of Cancer Cells by Vitamins.” Basel: Karger, pp 119-131, 1983.
64. Malick MA, Roy RM, Sternberg J: Effect of vitamin E on postirradiation death in mice. Experientia 34: 1216-1217, 1978.
65. Londer HM, Myers CE: Radioprotective effects of vitamin E. (Abstract). Am J Clin Nutr 31: 705a, 1978.
66. Rostock RA, Stryker JA, Abt AB: Evaluation of high dose vitamin E as a radioprotective agent. Radiology 126: 763-765, 1980.
67. Ershoff BH, Steers CW Jr: Antioxidants and survival time of mice exposed to multiple sublethal doses of x-irradiation. Proc Soc Exp Biol Med 104: 274-276, 1960.
68. Fujita K, Shinpo K, Sato T, Niime H, Shamoto M, Hsu TC, Hong WK: Reduction of adriamycin-toxicity by ascorbate in mice and guinea pigs. Cancer Res 42: 309-316, 1982.
69. Trizna Z, Schantz SP, Lee JJ, Spitz MR, Goepfert H, et al. In Vitro protective effect of chemopreventive agents against bleomycininduced genotoxicity in lymphoblastoid cell lines and peripheral lymphocytes of head and neck cancer patients. Cancer Detect Prev 17: 575-583, 1993.
70. Fukushima S, Imaida K, Shibata M, Tamano S, Kurata Y, Shirai T: L-ascorbic acid amplification of second-stage bladder carcinogenesis promotion by NaHCO3. Cancer Res 48: 6317-6320, 1988.
71. Rao CV, Reddy BS: Modulating effect and type of dietary fat on ornithine decarboxylase tyrosine protein kinase and prostaglandins production during colon carcinogenesis. Carcinogenesis 14: 1327-1333, 1993.