The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity

Biochemistry

Volumn 35, Issue 45, 1996, Pages 14276-14280

  Barski, Oleg A ^a   Gabbay, Kenneth H ^a   Bohren, Kurt M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE REDUCTASE;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALDEHYDE REDUCTASE; ARGININE; BINDING SITES; DICARBOXYLIC ACIDS; ENZYME INHIBITORS; HUMANS; ISOELECTRIC POINT; KINETICS; MUTAGENESIS, SITE-DIRECTED; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 0029846857     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9619740     Document Type: Article

References (23)

1. Barski, O. A., Gabbay, K. H., Grimshaw, C. E., & Bohren, K. M. (1995) Biochemistry 34, 11264-11275.
2. Bohren, K. M., Bullock, B., Wermuth, B., & Gabbay, K. H. (1989) J. Biol. Chem. 264, 9547-9551.
3. Bohren, K. M., Page, J. L., Shankar, R., Henry, S. P., & Gabbay, K. H. (1991) J. Biol. Chem. 266, 24031-24037.
4. Bohren, K. M., Grimshaw, C. E., & Gabbay, K. H. (1992) J. Biol. Chem. 267, 20965-20970.
5. Bohren, K. M., Grimshaw, C. E., Lai, C.-J., Harrison, D. H., Ringe, D., Petsko, G. A., & Gabbay, K. H. (1994) Biochemistry 33, 2021-2032.
6. Branlant, G. (1982a) Eur. J. Biochem. 121, 407-411.
7. Branlant, G. (1982b) Eur. J. Biochem. 129, 99-104.
8. Branlant, G., & Biellmann, J.-F. (1980) Eur. J. Biochem. 105, 611-621.
9. Branlant, G., Tritsch, D., & Biellmann, J.-F. (1981) Eur. J. Biochem. 116, 505-512.
10. Bruce, N. C., Willey, D. L., Coulson, A. F. W., & Jeffery, J. (1994) Biochem. J. 299, 805-811.
11. Ehrig, T., Bohren, K. M., Prendergast, F. G., & Gabbay, K. H. (1994) Biochemistry 33, 7157-7165.
12. El-Kabbani, O., Green, N. C., Flynn, T. G., & DeLucas, L. J. (1994) Acta Crystallogr. D50, 859-868.
13. El-Kabbani, O., Judge, K., Ginell, S. L., Myles, D. A. A., Delucas, L. J., & Flynn, T. G. (1995) Nat. Struct. Biol. 2, 687-692.
14. Genetics Computer Group (1994) Program Manual for the Wisconsin Package, Version 8, September 1994, 575 Science Dr., Madison, WI 53711.
15. Harrison, D. H., Bohren, K. M., Ringe, D., Petsko, G. A., & Gabbay, K. H. (1994) Biochemistry 33, 2011-2020.
16. Menger, F. M. (1992) Biochemistry 31, 5368-5373.
17. Rondeau, J.-M., Tete-Fâvier, F., Podjarny, A., Reyman, J.-M., Barth, P., Biellmann, J.-F., & Moras, D. (1992) Nature 355, 469-472.
18. Sadowski, J., & Gasteiger, J. (1993) Chem. Rev. 93, 2567-2581.
19. Stinson, R. A., & Holbrook, J. J. (1973) Biochem. J. 131, 719-728.
20. Tarle, I., Borhani, D. W., Wilson, D. K., Quiocho, F. A., & Petrash, J. M. (1993) J. Biol Chem. 268, 25687-25693.
21. Wermuth, B. (1985) in Enzymology of Carbonyl Metabolism 2: Aldehyde Dehydrogenase, Aldo/Keto Reductase, and Alcohol Dehydrogenase, pp 209-230, Alan R. Liss, Inc., New York.
22. Wilson, D. K., Bohren, K. M., Gabbay, K. H., & Quiocho, F. A. (1992) Science 257, 81-84.
23. Wilson, D. K., Tarle, I., Petrash, J. M., & Quiocho, F. A. (1993) Proc. Natl. Acad. Sci . U.S.A. 90, 9847-9851.