Potentiation of tumor necrosis factor-induced NF-κB activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of IκBα

Molecular and Cellular Biology

Volumn 23, Issue 17, 2003, Pages 6200-6209

  Adam, Emmanuelle ^a   Quivy, Vincent ^a   Bex, Françoise ^a   Chariot, Alain ^b   Collette, Yves ^c   Vanhulle, Caroline ^a   Schoonbroodt, Sonia ^b   Goffin, Véronique ^a   Nguyên, Thi Liên Anh ^a   Gloire, Geoffrey ^b   Carrard, Géraldine ^d   Friguet, Bertrand ^d   De Launoit, Yvan ^a,e   Burny, Arsène ^a   Bours, Vincent ^b   Piette, Jacques ^b   Van Lint, Carine ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c INSERM   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e INSTITUT DE BIOLOGIE DE LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEIN SUBUNIT; RIBONUCLEASE; TRICHOSTATIN A; TUMOR NECROSIS FACTOR;

ACETYLATION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN LOCALIZATION; TRANSACTIVATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; BUTYRIC ACID; CYSTEINE ENDOPEPTIDASES; CYTOPLASM; ENZYME INHIBITORS; HELA CELLS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; LEUPEPTINS; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIENZYME COMPLEXES; NF-KAPPA B; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0042971647     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.17.6200-6209.2003     Document Type: Article

References (53)

1. Aoudjit, F., N. Brochu, B. Belanger, C. Stratowa, J. Hiscott, and M. Audette. 1997. Heterodimeric retinoic acid receptor-β and retinoid X receptor-α complexes stimulate expression of the intercellular adhesion molecule-1 gene. Cell Growth Differ. 8:335-342.
2. Arenzana-Seisdedos, F., P. Turpin, M. Rodriguez, D. Thomas, R. T. Hay, J. L. Virelizier, and C. Dargemont. 1997. Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm. J. Cell Sci. 110:369-378.
3. Ashburner, B. P., S. D. Westerheide, and A. S. Baldwin, Jr. 2001. The p65 (RelA) subunit of NF-KB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol. Cell. Biol. 21:7065-7077.
4. Baldwin, A. S., Jr. 2001. Series introduction: the transcription factor NF-κB and human disease. J. Clin. Investig. 107:3-6.
5. Ben Neriah, Y. 2002. Regulatory functions of ubiquitination in the immune system. Nat. Immunol. 3:20-26.
6. Bordonaro, M., J. M. Mariadason, F. Aslam, B. G. Heerdt, and L. H. Augenlicht. 1999. Butyrate-induced apoptotic cascade in colonic carcinoma cells: modulation of the β-catenin-Tcf pathway and concordance with effects of sulindac and trichostatin A but not curcumin. Cell Growth Differ. 10:713-720.
7. Boyes, J., P. Byfield, Y. Nakatani, and V. Ogryzko. 1998. Regulation of activity of the transcription factor GATA-1 by acetylation. Nature 396:594-598.
8. Bulteau, A., I. Petropoulos, and B. Friguet. 2000. Age-related alterations of proteasome structure and function in aging epidermis. Exp. Gerontol. 35:767-777.
9. Calomme, C., T.-L. Nguyen, Y. de Launoit, V. Kiermer, L. Droogmans, A. Burny, and C. Van Lint. 2002. Upstream stimulatory factors binding to an E box motif in the R region of the bovine leukemia virus long terminal repeat stimulates viral gene expression. J. Biol. Chem. 277:8775-8789.
10. Chen, H., M. Tini, and R. M. Evans. 2001. HATs on and beyond chromatin. Curr. Opin. Cell Biol. 13:218-224.
11. Chen, L., W. Fischle, E. Verdin, and W. C. Greene. 2001. Duration of nuclear NF-κB action regulated by reversible acetylation. Science 293:1653-1657.
12. Chen, L., Y. Mu, and W. C. Greene. 2002. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-κB. EMBO J. 21:6539-6548.
13. Dai, R.-M., E. Chen, D. L. Longo, C. M. Gorbea, and C.-C. H. Li. 1998. Involvement of valosin-containing protein, an ATPase co-purified with IκBα and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IκBα. J. Biol. Chem. 273:3562-3573.
14. de Launoit, Y., M. Audette, H. Pelczar, S. Plaza, S., and J. L. Baert, 1998. The transcription of the intercellular adhesion molecule-1 is regulated by Ets transcription factors. Oncogene 16:2065-2073.
15. Duckett, C. S., N. D. Perkins, T. F. Kowalik, R. M. Schmid, E. S. Huang, A. S. Baldwin, Jr., and G. J. Nabel. 1993. Dimerization of NF-κB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an IκB (MAD-3). Mol. Cell. Biol. 13:1315-1322.
16. Eickhoff, B., L. Germeroth, C. Stahl, G. Köhler, S. Rüller, M. Schlaak, and J. van der Bosch. 2000. Trichostatin A-mediated regulation of gene expression and protein kinase activities: reprogramming tumor cells for ribotoxic stress-induced apoptosis. Biol. Chem. 381:1127-1132.
17. El Kharroubi, A., G. Piras, R. Zensen, and M. A. Martin. 1998. Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. Mol. Cell. Biol. 18:2535-2544.
18. Gerritsen, M. E., A. J. Williams, A. S. Neish, S. Moore, Y. Shi, and T. Collins. 1997. CREB-binding protein/p300 are transcriptional coactivators of p65. Proc. Natl. Acad. Sci. USA 94:2927-2932.
19. Ghosh, S., and M. Karin, 2002. Missing pieces in the NF-κB puzzle. Cell 109:S82-S96.
20. Giuliano, M., M. Lauricelia, G. Calvaruso, M. Carabillo, S. Emanuele, R. Vento, and G. Tesoriere, 1999. The apoptotic effects and synergistic interaction of sodium butyrate and MG132 in human retinoblastoma Y79 cells. Cancer Res. 59:5586-5595.
21. Gu, W., and R. G. Roeder. 1997. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90:595-606.
22. Ichiyama, T., K. Okada, J. M. Lipton, T. Matsubara, T. Hayashi, and S. Furukawa. 2000. Sodium valproate inhibits production of TNF-α and IL-6 and activation of NF-κB. Brain Res. 857:246-251.
23. Israel, A. 2000. The IKK complex: an integrator of all signals that activate NF-kappaB? Trends Cell Biol. 10:129-133.
24. Ito, K., P. J. Barnes, and I. M. Adcock. 2000. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin 1β-induced histone H4 acetylation on lysines 8 and 12. Mol. Cell. Biol. 20:6891-6903.
25. Jaffray, E., K. M. Wood, and R. Hay, 1995. Domain organization of IκBα and sites of interaction with NF-κB p65. Mol. Cell. Biol. 15:2166-2172.
26. Karin, M., and Y. Ben Neriah. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18:621-663.
27. Kiernan, R., V. Brès, R. W. M. Ng, M.-P. Coudart, S. El Messaoudi, C. Sardet, D.-Y. Jin, S. Emiliani, and M. Benkirane. 2003. Post-activation turn-off of NF-κB-dependent transcription is regulated by acetylation of p65. J. Biol. Chem. 278:2758-2766.
28. Lee, S. K., J. H. Kim, Y. C. Lee, J. Cheong, and J. W. Lee. 2000. Silencing mediator of retinoic acid and thyroid hormone receptors as a novel transcriptional corepressor molecule of activating protein 1, nuclear factor-κB, and serum response factor. J. Biol. Chem. 275:12470-12474.
29. Merika, M., A. J. Williams, G. Chen, T. Collins, and D. Thanos. 1998. Recruitment of CBP/p300 by the IFN-β enhanceosome is required for synergistic activation of transcription. Mol. Cell 1:277-287.
30. Munshi, N., M. Merika, J. Yie, K. Senger, G. Chen, and D. Thanos. 1998. Acetylation of HMG I(Y) by CBP turns off IFN-β expression by disrupting the enhanceosome. Mol. Cell 2:457-4467.
31. Na, S. Y., S. K. Lee, S. J. Han, H. S. Choi, S. Y. Im, and J. W. Lee. 1998. Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor κB-mediated transactivations. J. Biol. Chem. 273:10831-10834.
32. Osborn, L., S. Kunkel, and G. J. Nabel. 1989. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor κ B. Proc. Natl. Acad. Sci. USA 86:2336-2340.
33. Ott, M., J. L. Lovett, L. Mueller, and E. Verdin. 1998. Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-κB factors. J. Immunol. 160:2872-2880.
34. Perkins, N. D., L. K. Felzien, J. C. Betts, K. Leung, D. H. Beach, and G. J. Nabel. 1997. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275:523-527.
35. Rodriguez, M. S., J. Thompson, R. T. Hay, and C. Dargemont. 1999. Nuclear retention of IκB protects it from signal-induced degradation and inhibits nuclear factor κB transcriptional activation. J. Biol. Chem. 274:9108-9115.
36. Saccani, S., S. Pantano, and G. Natoli. 2001. Two waves of nuclear factor κB recruitment to target promoters. J. Exp. Med. 193:1351-1359.
37. Saccani, S., S. Pantano, and G. Natoli. 2002. p38-dependent marking of inflammatory genes for increased NF-κB recruitment. Nat. Immunol. 3:69-75.
38. Sakurai, H., H. Chiba, H. Miyoshi, T. Sugita, and W. Toriumi. 1999. IκB kinase phosphorylates NF-κB p65 subunit on serine 536 in the transactivation domain J. Biol. Chem. 274:30353-30356.
39. Schoonbroodt, S., V. Ferreira, M. Best-Belpomme, J. R. Boelaert, S. Legrand-Poels, M. Korner, and J. Piette. 2000. Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of IκB alpha in NF-κB activation by an oxidative stress. J. Immunol. 164:4292-4300.
40. Seigneurin-Berny, D., A. Verdel, S. Curtet, C. Lemercier, J. Garin, S. Rousseaux, and S. Khochbin, 2001. Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. Mol. Cell. Biol. 21:8035-8044.
41. Sheppard, K. A., D. W. Rose, Z. K. Haque, R. Kurokawa, E. McInerney, S. Westin, D. Thanos, M. G. Rosenfeld, C. K. Glass, and T. Collins, 1999. Transcriptional activation by NF-κB requires multiple coactivators. Mol. Cell. Biol. 19:6367-6378.
42. Spencer, T. E., G. Jenster, M. M. Burein, C. D. Allis, J. Zhou, C. A. Mizzen, N. J. McKenna, S. A. Onate, S. Y. Tsai, M. J. Tsai, and B. W. O'Malley. 1997. Steroid receptor coactivator 1 is a histone acetyltransferase. Nature 389:194-198.
43. Spiegelman, V. S., T. J. Slaga, M. Pagano, T. Minamoto, Z. Ronai, and S. Y. Fuchs. 2000. Wnt/β-catenin signaling induces the expression and activity of βTRCP ubiquitin ligase receptor. Mol. Cell 5:877-882.
44. Spiegelman, V. S., P. Stavropoulos, E. Latres, M. Pagano, Z. Ronai, T. J. Slaga, and S. Y. Fuchs. 2001. Induction of β-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-κB. J. Biol. Chem. 276:27152-27158.
45. Turpin, P., R. H. Hay, and C. Dargemont. 1999. Characterization of IκBα nuclear import pathway. J. Biol. Chem. 274:6804-6812.
46. Vanden Berghe, W., K. De Bosscher, E. Boone, S. Plaisance, and G. Haegeman. 1999. The nuclear factor-κB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin 6 gene promoter. J. Biol. Chem. 274:32091-32098.
47. Van Lint, C., S. Emiliani, M. Ott, and E. Verdin. 1996. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J. 15:1112-1120.
48. Vermeulen, L., G. De Wilde, S. Notebaert, W. Vanden Berghe, and G. Haegeman. 2002. Regulation of the transcriptional activity of the nuclear factor-κB p65 subunit. Biochem. Pharmacol. 64:963-970.
49. West, M. J., A. D. Lowe, and J. Karn. 2001. Activation of human immuno-deficiency virus transcription in T cells revisited: NF-κB p65 stimulates transcriptional elongation. J. Virol. 75:8524-8537.
50. Yin, L., G. Laevsky, and C. Giardina. 2001. Butyrate suppression of colonocyte NF-κB activation and cellular proteasome activity. J. Biol. Chem. 276:44641-44646.
51. Zhong, H., H. SuYang, H. Erdjument-Bromage, P. Tempst, and S. Ghosh. 1997. The transcriptional activity of NF-κB is regulated by the IκB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell 89:413-424.
52. Zhong, H., R. E. Voll, and S. Ghosh. 1998. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1:661-671.
53. Zhong, H., M. J. May, E. Jimi, and S. Ghosh. 2002. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol. Cell 9:625-636.