Trichostatin A-mediated regulation of gene expression and protein kinase activities: Reprogramming tumor cells for ribotoxic stress-induced apoptosis

Biological Chemistry

Volumn 381, Issue 11, 2000, Pages 1127-1132

  Eickhoff, B ^a   Germeroth, L ^a   Stahl, C ^a   Kohler, G ^a   Ruller, S ^a   Schlaak, M ^a   van der Bosch, J ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Histone deacetylase inhibitor; Kinase assay; Taqman; Tumor therapy; Western blot

Indexed keywords

ANISOMYCIN; FLAVOPIRIDOL; HEAT SHOCK PROTEIN 27; HISTONE DEACETYLASE INHIBITOR; MESSENGER RNA; PROTEIN BCL X; PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE; TRICHOSTATIN A;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DATA ANALYSIS; DEACETYLATION; DNA HYBRIDIZATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FILTER; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIFE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION; SIGNAL TRANSDUCTION; STRESS; TECHNIQUE; TUMOR CELL;

APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CASEIN KINASE II; CHAPERONIN 60; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HELIX-LOOP-HELIX MOTIFS; HISTONE DEACETYLASES; HSP72 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HT29 CELLS; HUMANS; HYDROXAMIC ACIDS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; INHIBITOR OF DIFFERENTIATION PROTEIN 2; INHIBITOR OF DIFFERENTIATION PROTEINS; NEOPLASM PROTEINS; PROTEIN KINASE C; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-ABL; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0034529731     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2000.138     Document Type: Article

References (28)

1. Direct induction of cyclin D2 by myc contributes to cell cycle progression and sequestration of p27
2. Response of human breast cancer cells to heat shock and chemotherapeutic drugs
3. Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate
4. Trichostatin A modulates expression of p21, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells
5. Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors
6. HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs
7. HSP27 inhibits cytochrome c-dependent activation of procaspase-9
8. Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells
9. Modulating IGFBP-3 expression by trichostatin A: Potential therapeutic role in the treatment of hepatocellular carcinoma
10. Escaping cell death: Survival proteins in cancer
11. Trichostatin A and herboxidiene upregulate the gene expression of low density lipoprotein receptor
12. A role for HSP27 in sensory neuron survival
13. Activation of androgen receptor function by a novel nuclear protein kinase
14. Suppression of adenovirus E1A-induced apoptosis by mutated p53 is overcome by co-expression with Id proteins
15. Coupling of cell growth control and apoptosis functions of Id proteins
16. Changes in protein kinase C isoenzyme expression associated with apoptosis in U937 myelomonocytic cells
17. Doppa induces cell death but not differentiation of U937 cells: Evidence for the involvement of PKC-beta 1 in the regulation of apoptosis
18. Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-delta
19. Sensitization of tumor cells to ribotoxic stress-induced apoptotic cell death: A new therapeutic strategy
20. Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites
21. Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor
22. The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation
23. A possible role for PKC delta in cerebellar granule cells apoptosis
24. Murine cells transfected with human Hsp27 cDNA resist TNF-induced cytotoxicity
25. Calmodulin-dependent protein kinase II mediates signal transduction in apoptosis
26. Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells
27. p300 collaborates with Sp1 and Sp3 in p21(waf1/cip1) promoter activation induced by histone deacetylase inhibitor
28. Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function