-
2
-
-
0037134442
-
Lack of evidence for the involvement of the phosphoinositide 3-kinase/ Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension
-
Alvarez-Tejado M, Alfranca A, Aragones J, Vara A, Landazuri MO, del Peso L. (2002) Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J Biol Chem.; 277: 13508-17.
-
(2002)
J Biol Chem
, vol.277
, pp. 13508-13517
-
-
Alvarez-Tejado, M.1
Alfranca, A.2
Aragones, J.3
Vara, A.4
Landazuri, M.O.5
Del Peso, L.6
-
3
-
-
0037177867
-
Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription
-
Arsham AM, Plas DR, Thompson CB, Simon MC. (2002) Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem.; 277: 15162-70.
-
(2002)
J Biol Chem
, vol.277
, pp. 15162-15170
-
-
Arsham, A.M.1
Plas, D.R.2
Thompson, C.B.3
Simon, M.C.4
-
4
-
-
0034668187
-
Signaling angiogenesis via p42/p44 MAP kinase and hypoxia
-
Berra E, Milanini J, Richard DE, Le Gall M, Vinals F, Gothie E, Roux D, Pages G, Pouyssegur J. (2000) Signaling angiogenesis via p42/p44 MAP kinase and hypoxia. Biochem Pharmacol.; 60: 1171-8.
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 1171-1178
-
-
Berra, E.1
Milanini, J.2
Richard, D.E.3
Le Gall, M.4
Vinals, F.5
Gothie, E.6
Roux, D.7
Pages, G.8
Pouyssegur, J.9
-
5
-
-
0035477438
-
Effects of ras and von Hippel-Lindau. (VHL) gene mutations on hypoxia-inducible factor (HIF)-1α HIF-2α and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway
-
Blancher C, Moore JW, Robertson N, Harris AL. (2001) Effects of ras and von Hippel-Lindau. (VHL) gene mutations on hypoxia-inducible factor (HIF)-1α HIF-2α and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway. Cancer Res.; 61: 7349-55.
-
(2001)
Cancer Res
, vol.61
, pp. 7349-7355
-
-
Blancher, C.1
Moore, J.W.2
Robertson, N.3
Harris, A.L.4
-
7
-
-
0035980110
-
2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells
-
2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells. J Biol Chem.; 276: 32663-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 32663-32669
-
-
Brouet, A.1
Sonveaux, P.2
Dessy, C.3
Balligand, J.L.4
Feron, O.5
-
8
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick RK, McKnight SL. (2001) A conserved family of prolyl-4-hydroxylases that modify HIF. Science.; 294: 1337-40.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
9
-
-
0025008449
-
Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells
-
Busse R, Mulsch A. (1990) Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells. FEBS Lett.; 275: 87-90.
-
(1990)
FEBS Lett
, vol.275
, pp. 87-90
-
-
Busse, R.1
Mulsch, A.2
-
10
-
-
0034076189
-
Mechanisms of angiogenesis and arteriogenesis
-
Carmeliet P. (2000) Mechanisms of angiogenesis and arteriogenesis. Nat Med.; 6: 389-95.
-
(2000)
Nat Med
, vol.6
, pp. 389-395
-
-
Carmeliet, P.1
-
12
-
-
0030865655
-
Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells
-
Chin K, Kurashima Y, Ogura T, Tajiri H, Yoshida S, Esumi H. (1997) Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells. Oncogene.; 15: 437-42.
-
(1997)
Oncogene
, vol.15
, pp. 437-442
-
-
Chin, K.1
Kurashima, Y.2
Ogura, T.3
Tajiri, H.4
Yoshida, S.5
Esumi, H.6
-
13
-
-
0034682783
-
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
-
Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. (2000) Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem.; 275: 25733-41.
-
(2000)
J Biol Chem
, vol.275
, pp. 25733-25741
-
-
Cockman, M.E.1
Masson, N.2
Mole, D.R.3
Jaakkola, P.4
Chang, G.W.5
Clifford, S.C.6
Maher, E.R.7
Pugh, C.W.8
Ratcliffe, P.J.9
Maxwell, P.H.10
-
14
-
-
0033542476
-
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
-
Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature.; 399: 601-5.
-
(1999)
Nature
, vol.399
, pp. 601-605
-
-
Dimmeler, S.1
Fleming, I.2
Fisslthaler, B.3
Hermann, C.4
Busse, R.5
Zeiher, A.M.6
-
15
-
-
0343851651
-
Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells
-
Dulak J, Jozkowicz A, Dembinska-Kiec A, Guevara I, Zdzienicka A, Zmudzinska-Grochot D, Florek I, Wojtowicz A, Szuba A, Cooke JP. (2000) Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol.; 20: 659-66.
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 659-666
-
-
Dulak, J.1
Jozkowicz, A.2
Dembinska-Kiec, A.3
Guevara, I.4
Zdzienicka, A.5
Zmudzinska-Grochot, D.6
Florek, I.7
Wojtowicz, A.8
Szuba, A.9
Cooke, J.P.10
-
16
-
-
0036090780
-
Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells
-
Dulak J, Jozkowicz A, Foresti R, Kasza A, Frick M, Huk I, Green CJ, Pachinger O, Weidinger F, Motterlini R. (2002) Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells. Antioxid Redox Signal.; 4: 229-40.
-
(2002)
Antioxid Redox Signal
, vol.4
, pp. 229-240
-
-
Dulak, J.1
Jozkowicz, A.2
Foresti, R.3
Kasza, A.4
Frick, M.5
Huk, I.6
Green, C.J.7
Pachinger, O.8
Weidinger, F.9
Motterlini, R.10
-
17
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell.; 107: 43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
Tian, Y.M.11
Masson, N.12
Hamilton, D.L.13
Jaakkola, P.14
Barstead, R.15
Hodgkin, J.16
Maxwell, P.H.17
Pugh, C.W.18
Schofield, C.J.19
Ratcliffe, P.J.20
more..
-
18
-
-
0033566693
-
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
-
Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, Semenza GL. (1999) Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res.; 59: 3915-8.
-
(1999)
Cancer Res
, vol.59
, pp. 3915-3918
-
-
Feldser, D.1
Agani, F.2
Iyer, N.V.3
Pak, B.4
Ferreira, G.5
Semenza, G.L.6
-
19
-
-
0033525718
-
VEGF induces nuclear translocation of Flk-1/KDR endothelial nitric oxide synthase and caveolin-1 in vascular endothelial cells
-
Feng Y, Venema VJ, Venema RC, Tsai N, Caldwell RB. (1999) VEGF induces nuclear translocation of Flk-1/KDR endothelial nitric oxide synthase and caveolin-1 in vascular endothelial cells. Biochem Biophys Res Commun.; 256: 192-7.
-
(1999)
Biochem Biophys Res Commun
, vol.256
, pp. 192-197
-
-
Feng, Y.1
Venema, V.J.2
Venema, R.C.3
Tsai, N.4
Caldwell, R.B.5
-
20
-
-
0019195506
-
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
-
Furchgott RF, Zawadzki JV. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature.; 288: 373-6.
-
(1980)
Nature
, vol.288
, pp. 373-376
-
-
Furchgott, R.F.1
Zawadzki, J.V.2
-
21
-
-
0036899189
-
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: Role of PI3K PKC and PLC pathways
-
Gelinas DS, Bernatchez PN, Rollin S, Bazan NG, Sirois MG. (2002) Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K PKC and PLC pathways. Br J Pharmacol.; 137: 1021-30.
-
(2002)
Br J Pharmacol
, vol.137
, pp. 1021-1030
-
-
Gelinas, D.S.1
Bernatchez, P.N.2
Rollin, S.3
Bazan, N.G.4
Sirois, M.G.5
-
22
-
-
0032515047
-
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
-
Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N. (1998) Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem.; 273: 30336-43.
-
(1998)
J Biol Chem
, vol.273
, pp. 30336-30343
-
-
Gerber, H.P.1
McMurtrey, A.2
Kowalski, J.3
Yan, M.4
Keyt, B.A.5
Dixit, V.6
Ferrara, N.7
-
23
-
-
0018311634
-
Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide nitroprusside and a carcinogenic nitrosoamine
-
Gruetter CA, Barry BK, McNamara DB, Gruetter DY, Kadowitz PJ, Ignarro L. (1979) Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide nitroprusside and a carcinogenic nitrosoamine. J Cyclic Nucleotide Res.; 5: 211-24.
-
(1979)
J Cyclic Nucleotide Res
, vol.5
, pp. 211-224
-
-
Gruetter, C.A.1
Barry, B.K.2
McNamara, D.B.3
Gruetter, D.Y.4
Kadowitz, P.J.5
Ignarro, L.6
-
24
-
-
0033609922
-
Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src
-
He H, Venema VJ, Gu X, Venema RC, Marrero MB, Caldwell RB. (1999) Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src. J Biol Chem.; 274: 25130-5.
-
(1999)
J Biol Chem
, vol.274
, pp. 25130-25135
-
-
He, H.1
Venema, V.J.2
Gu, X.3
Venema, R.C.4
Marrero, M.B.5
Caldwell, R.B.6
-
26
-
-
0033605676
-
Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling
-
Huang LE, Willmore WG, Gu J, Goldberg MA, Bunn HF. (1999) Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J Biol Chem.; 274: 9038-44.
-
(1999)
J Biol Chem
, vol.274
, pp. 9038-9044
-
-
Huang, L.E.1
Willmore, W.G.2
Gu, J.3
Goldberg, M.A.4
Bunn, H.F.5
-
27
-
-
0026551016
-
Haem-dependent activation of cytosolic guanylate cyclase by nitric oxide: A widespread signal transduction mechanism
-
Ignarro LJ. (1992) Haem-dependent activation of cytosolic guanylate cyclase by nitric oxide: a widespread signal transduction mechanism. Biochem Soc Trans.; 20: 465-9.
-
(1992)
Biochem Soc Trans
, vol.20
, pp. 465-469
-
-
Ignarro, L.J.1
-
28
-
-
0001123777
-
Physiology and pathophysiology of nitric oxide
-
Ignarro LJ. (1996) Physiology and pathophysiology of nitric oxide. Kidney Int Suppl.; 55: S2-5.
-
(1996)
Kidney Int Suppl
, vol.55
-
-
Ignarro, L.J.1
-
29
-
-
0029117223
-
Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells
-
Ikeda E, Achen MG, Breier G, Risau W. (1995) Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem.; 270: 19761-6.
-
(1995)
J Biol Chem
, vol.270
, pp. 19761-19766
-
-
Ikeda, E.1
Achen, M.G.2
Breier, G.3
Risau, W.4
-
30
-
-
0033525830
-
Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway
-
Kallio PJ, Wilson WJ, O'Brien S, Makino Y, Poellinger L. (1999) Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway. J Biol Chem.; 274: 6519-25.
-
(1999)
J Biol Chem
, vol.274
, pp. 6519-6525
-
-
Kallio, P.J.1
Wilson, W.J.2
O'Brien, S.3
Makino, Y.4
Poellinger, L.5
-
31
-
-
0036382929
-
Effects of nitric oxide donors on vascular endothelial growth factor gene induction
-
Kimura H, Ogura T, Kurashima Y, Weisz A, Esumi H. (2002) Effects of nitric oxide donors on vascular endothelial growth factor gene induction. Biochem Biophys Res Commun.; 296: 976-82.
-
(2002)
Biochem Biophys Res Commun
, vol.296
, pp. 976-982
-
-
Kimura, H.1
Ogura, T.2
Kurashima, Y.3
Weisz, A.4
Esumi, H.5
-
32
-
-
0033975850
-
Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
-
Kimura H, Weisz A, Kurashima Y, Hashimoto K, Ogura T, D'Acquisto F, Addeo R, Makuuchi M, Esumi H. (2000) Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood.; 95: 189-97.
-
(2000)
Blood
, vol.95
, pp. 189-197
-
-
Kimura, H.1
Weisz, A.2
Kurashima, Y.3
Hashimoto, K.4
Ogura, T.5
D'Acquisto, F.6
Addeo, R.7
Makuuchi, M.8
Esumi, H.9
-
33
-
-
0035910429
-
Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide
-
Kimura H, Weisz A, Ogura T, Hitomi Y, Kurashima Y, Hashimoto K, D'Acquisto F, Makuuchi M, Esumi H. (2001) Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J Biol Chem.; 276: 2292-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 2292-2298
-
-
Kimura, H.1
Weisz, A.2
Ogura, T.3
Hitomi, Y.4
Kurashima, Y.5
Hashimoto, K.6
D'Acquisto, F.7
Makuuchi, M.8
Esumi, H.9
-
34
-
-
0030265393
-
Vascular endothelial growth factor and its receptors
-
Klagsbrun M, D'Amore PA. (1996) Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev.; 7: 259-70.
-
(1996)
Cytokine Growth Factor Rev
, vol.7
, pp. 259-270
-
-
Klagsbrun, M.1
D'Amore, P.A.2
-
35
-
-
0028349156
-
Nitric oxide synthases in mammals
-
Knowles RG, Moncada S. (1994) Nitric oxide synthases in mammals. Biochem J.; 298: 249-58.
-
(1994)
Biochem J
, vol.298
, pp. 249-258
-
-
Knowles, R.G.1
Moncada, S.2
-
36
-
-
0031028157
-
Effects of hypoxia on growth factor expression in the rat kidney in vivo
-
Kramer BK, Bucher M, Sandner P, Ittner KP, Riegger GA, Ritthaler T, Kurtz A. (1997) Effects of hypoxia on growth factor expression in the rat kidney in vivo. Kidney Int.; 51: 444-7.
-
(1997)
Kidney Int
, vol.51
, pp. 444-447
-
-
Kramer, B.K.1
Bucher, M.2
Sandner, P.3
Ittner, K.P.4
Riegger, G.A.5
Ritthaler, T.6
Kurtz, A.7
-
37
-
-
0032573554
-
VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2. (KDR)
-
Kroll J, Waltenberger J. (1998) VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2. (KDR). Biochem Biophys Res Commun.; 252: 743-6.
-
(1998)
Biochem Biophys Res Commun
, vol.252
, pp. 743-746
-
-
Kroll, J.1
Waltenberger, J.2
-
38
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. (2001) HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol.; 21: 3995-4004.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
39
-
-
0030044039
-
Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
-
Levy AP, Levy NS, Goldberg MA. (1996) Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem.; 271: 2746-53.
-
(1996)
J Biol Chem
, vol.271
, pp. 2746-2753
-
-
Levy, A.P.1
Levy, N.S.2
Goldberg, M.A.3
-
40
-
-
0032511014
-
Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer
-
Liu Y, Christou H, Morita T, Laughner E, Semenza GL, Kourembanas S. (1998) Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer. J Biol Chem. ; 273: 15257-62.
-
(1998)
J Biol Chem
, vol.273
, pp. 15257-15262
-
-
Liu, Y.1
Christou, H.2
Morita, T.3
Laughner, E.4
Semenza, G.L.5
Kourembanas, S.6
-
41
-
-
0032431037
-
Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors
-
Marti HH, Risau W. (1998) Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors. Proc Natl Acad Sci U S A.; 95: 15809-14.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 15809-15814
-
-
Marti, H.H.1
Risau, W.2
-
42
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature.; 399: 271-5.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
43
-
-
0028651863
-
Nitric oxide/cyclic GMP-mediated signal transduction
-
Mayer B. (1994) Nitric oxide/cyclic GMP-mediated signal transduction. Ann N Y Acad Sci.; 733: 357-64.
-
(1994)
Ann N Y Acad Sci
, vol.733
, pp. 357-364
-
-
Mayer, B.1
-
44
-
-
0037124173
-
The use of dioxygen by HIF prolyl hydroxylase (PHD1)
-
McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. (2002) The use of dioxygen by HIF prolyl hydroxylase (PHD1). Bioorg Med Chem Lett.; 12: 1547-50.
-
(2002)
Bioorg Med Chem Lett
, vol.12
, pp. 1547-1550
-
-
McNeill, L.A.1
Hewitson, K.S.2
Gleadle, J.M.3
Horsfall, L.E.4
Oldham, N.J.5
Maxwell, P.H.6
Pugh, C.W.7
Ratcliffe, P.J.8
Schofield, C.J.9
-
45
-
-
0032102292
-
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia
-
Murohara T, Asahara T, Silver M, Bauters C, Masuda H, Kalka C, Kearney M, Chen D, Symes JF, Fishman MC, Huang PL, Isner JM. (1998) Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest.; 101: 2567-78.
-
(1998)
J Clin Invest
, vol.101
, pp. 2567-2578
-
-
Murohara, T.1
Asahara, T.2
Silver, M.3
Bauters, C.4
Masuda, H.5
Kalka, C.6
Kearney, M.7
Chen, D.8
Symes, J.F.9
Fishman, M.C.10
Huang, P.L.11
Isner, J.M.12
-
46
-
-
2642597076
-
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
-
Papapetropoulos A, Garcia-Cardena G, Madri JA, Sessa WC. (1997) Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest.; 100: 3131-9.
-
(1997)
J Clin Invest
, vol.100
, pp. 3131-3139
-
-
Papapetropoulos, A.1
Garcia-Cardena, G.2
Madri, J.A.3
Sessa, W.C.4
-
47
-
-
0032512822
-
Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase 1/2 activation in postcapillary endothelium
-
Parenti A, Morbidelli L, Cui XL, Douglas JG, Hood JD, Granger HJ, Ledda F, Ziche M. (1998) Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase 1/2 activation in postcapillary endothelium. J Biol Chem.; 273: 4220-6.
-
(1998)
J Biol Chem
, vol.273
, pp. 4220-4226
-
-
Parenti, A.1
Morbidelli, L.2
Cui, X.L.3
Douglas, J.G.4
Hood, J.D.5
Granger, H.J.6
Ledda, F.7
Ziche, M.8
-
48
-
-
0032725554
-
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha. (HIF-1α) and enhance the transcriptional activity of HIF-1
-
Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J. (1999) p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha. (HIF-1α) and enhance the transcriptional activity of HIF-1. J Biol Chem. ; 274: 32631-7.
-
(1999)
J Biol Chem
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothie, E.3
Roux, D.4
Pouyssegur, J.5
-
49
-
-
18444380862
-
Expression of hypoxia-inducible factor-1α and -2α in hypoxic and ischemic rat kidneys
-
Rosenberger C, Mandriota S, Jurgensen JS, Wiesener MS, Horstrup JH, Frei U, Ratcliffe PJ, Maxwell PH, Bachmann S, Eckardt KU. (2002) Expression of hypoxia-inducible factor-1α and -2α in hypoxic and ischemic rat kidneys. J Am Soc Nephrol.; 13: 1721-32.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 1721-1732
-
-
Rosenberger, C.1
Mandriota, S.2
Jurgensen, J.S.3
Wiesener, M.S.4
Horstrup, J.H.5
Frei, U.6
Ratcliffe, P.J.7
Maxwell, P.H.8
Bachmann, S.9
Eckardt, K.U.10
-
50
-
-
0030961006
-
Hypoxia-inducible factor 1α. (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda S, Caro J. (1997) Hypoxia-inducible factor 1α. (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem.; 272: 22642-7.
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
51
-
-
0035864361
-
Accumulation of HIF-1α under the influence of nitric oxide
-
Sandau KB, Fandrey J, Brune B. (2001) Accumulation of HIF-1α under the influence of nitric oxide. Blood.; 97: 1009-15.
-
(2001)
Blood
, vol.97
, pp. 1009-1015
-
-
Sandau, K.B.1
Fandrey, J.2
Brune, B.3
-
52
-
-
0034638623
-
Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway
-
Sandau KB, Faus HG, Brune B. (2000) Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway. Biochem Biophys Res Commun.; 278: 263-7.
-
(2000)
Biochem Biophys Res Commun
, vol.278
, pp. 263-267
-
-
Sandau, K.B.1
Faus, H.G.2
Brune, B.3
-
54
-
-
8044253996
-
Structural and functional analysis of hypoxiainducible factor 1
-
Semenza GL, Agani F, Booth G, Forsythe J, Iyer N, Jiang BH, Leung S, Roe R, Wiener C, Yu A. (1997) Structural and functional analysis of hypoxiainducible factor 1. Kidney Int.; 51: 553-5.
-
(1997)
Kidney Int
, vol.51
, pp. 553-555
-
-
Semenza, G.L.1
Agani, F.2
Booth, G.3
Forsythe, J.4
Iyer, N.5
Jiang, B.H.6
Leung, S.7
Roe, R.8
Wiener, C.9
Yu, A.10
-
55
-
-
0032730327
-
Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway
-
Shen BQ, Lee DY, Zioncheck TF. (1999) Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway. J Biol Chem.; 274: 33057-63.
-
(1999)
J Biol Chem
, vol.274
, pp. 33057-33063
-
-
Shen, B.Q.1
Lee, D.Y.2
Zioncheck, T.F.3
-
56
-
-
0035860246
-
MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF
-
Sodhi A, Montaner S, Miyazaki H, Gutkind JS. (2001) MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF. Biochem Biophys Res Commun.; 287: 292-300.
-
(2001)
Biochem Biophys Res Commun
, vol.287
, pp. 292-300
-
-
Sodhi, A.1
Montaner, S.2
Miyazaki, H.3
Gutkind, J.S.4
-
57
-
-
0032560504
-
Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia
-
Sogawa K, Numayama-Tsuruta K, Ema M, Abe M, Abe H, Fujii-Kuriyama Y. (1998) Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia Proc Natl Acad Sci U S A.; 95: 7368-73.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 7368-7373
-
-
Sogawa, K.1
Numayama-Tsuruta, K.2
Ema, M.3
Abe, M.4
Abe, H.5
Fujii-Kuriyama, Y.6
-
58
-
-
0037070223
-
Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway
-
Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Burgel T. (2002) Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway. FEBS Lett.; 512: 157-62.
-
(2002)
FEBS Lett
, vol.512
, pp. 157-162
-
-
Stiehl, D.P.1
Jelkmann, W.2
Wenger, R.H.3
Hellwig-Burgel, T.4
-
59
-
-
0034663894
-
Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein
-
Tanimoto K, Makino Y, Pereira T, Poellinger L. (2000) Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein. EMBO J.; 19: 4298-309.
-
(2000)
EMBO J
, vol.19
, pp. 4298-4309
-
-
Tanimoto, K.1
Makino, Y.2
Pereira, T.3
Poellinger, L.4
-
60
-
-
0033538057
-
The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling
-
Thakker GD, Hajjar DP, Muller WA, Rosengart TK. (1999) The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling. J Biol Chem.; 274: 10002-7.
-
(1999)
J Biol Chem
, vol.274
, pp. 10002-10007
-
-
Thakker, G.D.1
Hajjar, D.P.2
Muller, W.A.3
Rosengart, T.K.4
-
61
-
-
0037127297
-
Rapid transactivation of the vascular endothelial growth factor receptor KDR/Flk-1 by the bradykinin B2 receptor contributes to endothelial nitric-oxide synthase activation in cardiac capillary endothelial cells
-
Thuringer D, Maulon L, Frelin C. (2002) Rapid transactivation of the vascular endothelial growth factor receptor KDR/Flk-1 by the bradykinin B2 receptor contributes to endothelial nitric-oxide synthase activation in cardiac capillary endothelial cells. J Biol Chem.; 277: 2028-32.
-
(2002)
J Biol Chem
, vol.277
, pp. 2028-2032
-
-
Thuringer, D.1
Maulon, L.2
Frelin, C.3
-
62
-
-
0030745193
-
Reciprocal relation between VEGF and NO in the regulation of endothelial integrity
-
Tsurumi Y, Murohara T, Krasinski K, Chen D, Witzenbichler B, Kearney M, Couffinhal T, Isner JM. (1997) Reciprocal relation between VEGF and NO in the regulation of endothelial integrity. Nat Med.; 3: 879-86.
-
(1997)
Nat Med
, vol.3
, pp. 879-886
-
-
Tsurumi, Y.1
Murohara, T.2
Krasinski, K.3
Chen, D.4
Witzenbichler, B.5
Kearney, M.6
Couffinhal, T.7
Isner, J.M.8
-
63
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang GL, Semenza GL. (1995) Purification and characterization of hypoxia-inducible factor 1. J Biol Chem.; 270: 1230-7.
-
(1995)
J Biol Chem
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
64
-
-
0032171420
-
Chemical biology of nitric oxide: Insights into regulatory cytotoxic and cytoprotective mechanisms of nitric oxide
-
Wink DA, Mitchell JB. (1998) Chemical biology of nitric oxide: Insights into regulatory cytotoxic and cytoprotective mechanisms of nitric oxide. Free Radical Biol Med.; 25: 434-56.
-
(1998)
Free Radical Biol Med
, vol.25
, pp. 434-456
-
-
Wink, D.A.1
Mitchell, J.B.2
-
65
-
-
0032987731
-
Role of phospholipase C protein kinase C and calcium in VEGF-induced venular hyperpermeability
-
Wu HM, Yuan Y, Zawieja DC, Tinsley J, Granger HJ. (1999) Role of phospholipase C protein kinase C and calcium in VEGF-induced venular hyperpermeability. Am J Physiol.; 276: H535-42.
-
(1999)
Am J Physiol
, vol.276
-
-
Wu, H.M.1
Yuan, Y.2
Zawieja, D.C.3
Tinsley, J.4
Granger, H.J.5
-
66
-
-
2642709170
-
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C its isoforms and endothelial cell growth
-
Xia P, Aiello LP, Ishii H, Jiang ZY, Park DJ, Robinson GS, Takagi H, Newsome WP, Jirousek MR, King GL. (1996) Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C its isoforms and endothelial cell growth. J Clin Invest.; 98: 2018-26.
-
(1996)
J Clin Invest
, vol.98
, pp. 2018-2026
-
-
Xia, P.1
Aiello, L.P.2
Ishii, H.3
Jiang, Z.Y.4
Park, D.J.5
Robinson, G.S.6
Takagi, H.7
Newsome, W.P.8
Jirousek, M.R.9
King, G.L.10
-
67
-
-
0032169214
-
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT
-
Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, Cohen B. (1998) Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT. EMBO J.; 17: 5085-94.
-
(1998)
EMBO J
, vol.17
, pp. 5085-5094
-
-
Zelzer, E.1
Levy, Y.2
Kahana, C.3
Shilo, B.Z.4
Rubinstein, M.5
Cohen, B.6
-
68
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL. (2000) Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res.; 60: 1541-5.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
Simons, J.W.7
Semenza, G.L.8
-
69
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ. (2000) Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev.; 14: 391-6.
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
Gottschalk, A.R.7
Ryan, H.E.8
Johnson, R.S.9
Jefferson, A.B.10
Stokoe, D.11
Giaccia, A.J.12
|