Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue

Chemical Research in Toxicology

Volumn 13, Issue 11, 2000, Pages 1181-1186

  Sampayo Reyes, A ^a   Zakharyan, R A ^a   Healy, S M ^a   Aposhian, H V ^a  

^a University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC; ARSENIC ACID DERIVATIVE; ARSENIC TRIOXIDE; METHANEARSONIC ACID; OXIDOREDUCTASE;

ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CONCENTRATION RESPONSE; ENZYME ACTIVITY; ENZYME SPECIFICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; SYRIAN HAMSTER; TISSUE DISTRIBUTION;

ANIMALS; ARSENATES; ARSENICALS; BRAIN; CRICETINAE; LIVER; MALE; MESOCRICETUS; OXIDOREDUCTASES; TISSUE DISTRIBUTION; URINARY BLADDER;

ANIMALIA; CRICETINAE; MAMMALIA; MESOCRICETUS AURATUS;

EID: 0033712061     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000154s     Document Type: Article

References (43)

1. Biochemical toxicology of arsenic
2. Enzymatic reduction of arsenic compounds in mammalian systems: Reduction of arsenate to arsenite by human liver arsenate reductase
3. Enzymatic methylation of arsenic compounds: Assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver
4. Study of inorganic arsenic methylation by rat liver in vitro: Relevance for the interpretation of observations in man
5. Mono- and dimethylation of arsenic in rat liver cytosol in vitro
6. Enzymatic methylation of arsenic compounds VI. Characterization of hamster liver arsenite and methylarsonic acid methyltransferase activities in vitro
7. Enzymatic reduction of arsenic compounds in mammalian systems: The rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase
8. Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMA(III)) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes
9. Changes in the chemical speciation of arsenic following ingestion by man
10. Biotransformation of dimethylarsinic acid in mouse, hamster and man
11. Metabolism and excretion of orally administered arsenic trioxide in the hamster
12. Urinary excretion of arsenic metabolites after long-term oral administration of various arsenic compounds to rats
13. Methylation and demethylation of dimethylarsinic acid in rats following chronic oral exposure
14. Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice
15. Genotoxicity of arsenic and its methylated metabolites
16. Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenic, strongly promotes tumorigenesis initiated by 4-nitroquinoline-1-oxide in the lungs of mice
17. Promoting effects of dimethylarsine acid on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in rats
18. Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens
19. Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats
20. Monomethylarsonous acid (MMAh(III)) is more toxic than arsenite in Chang human hepatocytes
21. The metabolism of methylarsine oxide and sulfide
22. Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols
23. Relative genotoxic potency of arsenic and its methylated metabolites
24. The reaction of methylarsenicals with thiols: Some biological implications
25. Comparative in vitro methylation of trivalent and pentavalent arsenicals
26. DMPS-arsenic challenge test: II. Modulation of arsenic species, including monomethylarsonous acid (MMA(III)), excreted in human urine
27. Occurrence of monomethyarsonous acid in urine of humans exposed to inorganic arsenic
28. Determination of monomethylarsonous acid (MMA(III)), a key arsenic methylation intermediate, in human urine
29. 74As-labeled arsenate and arsenite for use in biological experiments
30. Speciation of arsenic in natural waters by solvent extraction and hydride generation atomic absorption spectrometry
31. The separation of dimethylarsinic acid, methylarsonous acid, methylarsonic acid, arsenate and dimethylarsinous acid on the Hamilton PRP-X100 anion-exchange column
32. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
33. 74As
34. Effects of glutathione depletion on the acute nephrotoxic potential of arsenite and on arsenic metabolism in hamsters
35. Methylarsenicals and arsinothiols are potent inhibitors of mouse liver thioredoxin reductase
36. Short-column liquid chromatography with hydride generation atomic fluorescence detection for the speciation of arsenic
37. Biliary and urinary excretion of inorganic arsenic: Monomethylarsonous acid as a major biliary metabolite in rats
38. Metabolism of subcutaneous administered indium arsenide in the hamster
39. Inorganic and methylated arsenic compounds induce cell death in murine macrophages via different mechanisms