Dose-dependent effects on tissue distribution and metabolism of dimethylarsinic acid in the mouse after intravenous administration

Toxicology

Volumn 143, Issue 2, 2000, Pages 155-166

  Hughes, Michael F ^a   Del Razo, Luz Maria ^a   Kenyon, Elaina M ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Arsenic; Dimethylarsinic acid; Pharmacokinetics

Indexed keywords

CACODYLIC ACID; CARBON 14;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BIOTRANSFORMATION; BLOOD LEVEL; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DOSE RESPONSE; ERYTHROCYTE LEVEL; FEMALE; HALF LIFE TIME; KIDNEY; LIVER LEVEL; LUNG; METABOLISM; METABOLITE; MOUSE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RADIOACTIVITY; TISSUE DISTRIBUTION; TISSUE LEVEL; TOXICOKINETICS;

ANIMALS; AREA UNDER CURVE; ARSENIC; CACODYLIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HALF-LIFE; INJECTIONS, INTRAVENOUS; KIDNEY; LIVER; LUNG; MICE; MICE, INBRED STRAINS; ORGAN SPECIFICITY; TISSUE DISTRIBUTION;

ANIMALIA; MAMMALIA;

EID: 0033980631     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(99)00169-9     Document Type: Article

References (50)

1. Anderson L.C.D., Bruland K.W. Biogeochemistry of arsenic in natural waters: the importance of methylated species. Environ. Sci. Technol. 25:1991;420-427.
2. 74As labeled arsenite. Toxicology. 20:1981;35-44.
3. Buchet J.P., Lauwerys R., Roels H. Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate or dimethylarsinate in man. Int. Arch. Occup. Environ. Health. 48:1981;71-79.
4. Charbonneau S.M., Tam G.K.H., Bryce F., Zawidska Z., Sandi E. Metabolism of orally administered inorganic arsenic in the dog. Toxicol. Lett. 3:1979;107-113.
5. 74As) arsenic acid in the hamster. Toxicol. Lett. 5:1980;175-182.
6. Cox D. Arsine evolution-electrothermal atomic absorption method for the determination of nanogram levels of total arsenic in urine and water. J. Anal. Toxicol. 4:1980;207-211.
7. Crecelius, E.A., Bloom, N.S., Cowan, C.E., Jenne, E.A. 1986. Determination of arsenic species in Limnological samples by hydride generation atomic absorption spectroscopy. EA-4641. Project 2020-2. In: Speciation of Selenium and Arsenic in Natural Waters and Sediments. Volume 2: Arsenic Speciation. Electric Power Research Institute Ed. Palo Alto, CA, pp. 1-28.
8. Cullen W.R., Reimer K.J. Arsenic speciation in the environment. Chem. Rev. 89:1989;713-764.
9. Delnomdedieu M., Basti M.M., Otvos J.D., Thomas D.J. Reduction and binding of arsenate and dimethylarsinate by glutathione: a magnetic resonance study. Chem.-Biol. Interact. 90:1994;139-155.
10. Enterline P.E., Henderson V.L., Marsh G.M. Exposure to arsenic and respiratory cancer. Am. J. Epidemiol. 125:1987;929-938.
11. Gaines T.B. The acute toxicity of pesticides to rats. Toxicol. Appl. Pharmacol. 2:1960;88-99.
12. Gaines T.B., Linder R.E. Acute toxicity of pesticides in adult and weanling rats. Fundam. Appl. Toxicol. 7:1986;299-308.
13. Hughes M.F., Kenyon E.M. Dose-dependent effects on the disposition of monomethylarsonic acid and dimethylarsinic acid in the mouse following intravenous administration. J. Toxicol. Environ. Health. 53:1998;95-112.
14. Hughes M.F., Menache M., Thompson D.J. Dose-dependent disposition of sodium arsenate in mice following acute oral exposure. Fundam. Appl. Toxicol. 22:1994;80-89.
15. Hughes M.F., Kenyon E.M., Edwards B.C., Mitchell C.T., Thomas D.J. Strain-dependent disposition of inorganic arsenic in the mouse. Toxicology. 137:1999;95-108.
16. Hughes M.F., Thompson D.J. Subchronic dispositional and toxicological effects of arsenate administered in drinking water to mice. J. Toxicol. Environ. Health. 49:1996;177-196.
17. Judd F.W. Acute toxicity and effects of sublethal dietary exposure of monosodium methanearsonate herbicide to Peromyscus leucopus (Rodentia: Cricetidae). Bull. Environ. Contam. Toxicol. 22:1979;143-150.
18. Kaise T., Watanabe S., Itoh K. The acute toxicity of arsenobetaine. Chemosphere. 15:1985;1327-1332.
19. Kaise T., Yamauchi H., Horiguchi Y., Tani T., Watanabe S., Hirayama T., Fukui S. A comparative study on acute toxicity of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide in mice. Appl. Organometal. Chem. 3:1989;273-277.
20. Labaune J.P. Handbook of Pharmacokinetics. 1989;Wiley, New York.
21. Lee-Feldstein A. Cumulative exposure to arsenic and its relationship to respiratory cancer among copper smelter employees. J. Occup. Med. 28:1986;296-302.
22. Li W., Wanibuchi H., Salim E.I., Yamamoto S., Yoshida K., Endo G., Fukushima S. Promotion of NCI-Black-Reiter male rat bladder carcinogenesis by dimethylarsinic acid an organic arsenic compound. Cancer Lett. 134:1998;29-36.
23. Marafante E., Vahter M., Norin H., Envall J., Sandstrom M., Christakopoulos A., Ryhage R. Biotransformation of dimethylarsinic acid in mouse, hamster and man. J. Appl. Toxicol. 7:1987;111-117.
24. Murai T., Iwata H., Otoshi T., Endo G., Horiguchi S., Fukushima S. Renal lesions induced in F344/DuCrj rats by 4-weeks oral administration of dimethylarsinic acid. Toxicol. Lett. 66:1993;53-61.
25. National Research Council, 1999. Arsenic in drinking water. National Academy Press, Washington, DC.
26. Rin K., Kawaguchi K., Yamanaka K., Tezuka M., Oku N., Okada S. DNA-strand breaks induced by dimethylarsinic acid, a metabolite of inorganic arsenics, are strongly enhanced by superoxide anion radicals. Biol. Pharm. Bull. 18:1995;45-48.
27. Scott N., Hatelid K.M., MacKenzie N.E., Carter D.E. Reactions of arsenic (III) and arsenic(V) species with glutathione. Chem. Res. Toxicol. 6:1993;102-106.
28. 74As-cacodylic acid in rats after intravenous, intratracheal, or peroral administration. Environ. Health Perspect. 19:1977;151-157.
29. Stevens J.T., DiPasquale L.C., Farmer J.D. The acute inhalation toxicology of the technical grade organoarsenical herbicides, cacodylic acid and disodium methanearsonic acid: a route comparison. Bull. Environ. Contam. Toxicol. 21:1979;301-311.
30. Styblo M., Hughes M.F., Thomas D.J. Liberation and analysis of protein-bound arsenicals. J. Chromatogr. B. 677:1996;161-166.
31. 74As) in humans following oral ingestion. Toxicol. Appl. Pharmacol. 50:1979;319-322.
32. Tarrant R.F., Allard J. Arsenic levels in urine of forestry workers applying silvicides. Arch. Environ. Health. 24:1972;277-280.
33. Tezuka M., Hanioka K., Yamanaka K., Okada S. Gene damage induced in human alveolar type II (L-132) cells by exposure to dimethylarsinic acid. Biochem. Biophys. Res. Commun. 191:1993;1178-1183.
34. US EPA, 1975. Initial Scientific Review of Cacodylic Acid. U.S. Environmental Protection Agency, Office of Pesticide Programs, Criteria and Evaluation Division, Washington, DC, EPA-540/1-75-021.
35. Vahter M. Biotransformation of trivalent and pentavalent inorganic arsenics in mice and rats. Environ. Res. 25:1981;286-293.
36. Vahter M., Marafante E. Intracellular interaction and metabolic fate of arsenite and arsenate in mice and rabbits. Chem.-Biol. Interact. 47:1983;29-44.
37. 74As-dimethylarsinic acid in mice and rats. Arch. Environ. Contam. Toxicol. 13:1984;259-264.
38. Velez D., Ybanez N., Montoro R. Monomethylarsonic and dimethylarsinic acid contents in seafood products. J. Agric. Food Chem. 44:1996;859-864.
39. Wagner S.L., Weswig P. Arsenic in blood and urine of forest workers. Arch. Environ. Health. 28:1974;77-79.
40. Wanibuchi H., Yamamoto S., Chen H., Yoshida K., Endo G., Hori T., Fukushima S. Promoting effects of dimethylarsinic acid on N-butyl-N-(4-hydroxybutyl)-nitros-amine-induced urinary bladder carcinogenesis in rats. Carcinogenesis. 17:1996;2435-2439.
41. Wei M., Wanibuchi H., Yamamoto S., Li M., Fukushima S. Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats. Carcinogenesis. 20:1999;1873-1876.
42. Yamamoto S., Konishi Y., Matsuda T., Murai T., Shibata M.-A., Matsui-Yuasa I., Otani S., Kuroda K., Endo G., Fukushima S. Cancer induction by an organic arsenic compound dimethylarsinic acid (cacodylic acid) in F344/DuCrj rats after pretreatment with five carcinogens. Cancer Res. 55:1995;1271-1276.
43. Yamanaka K., Hasegawa A., Sawamura R., Okada S. DNA strand breaks in mammalian tissues induced by methylarsenics. Biol. Trace Elem. Res. 21:1989;413-417.
44. Yamanaka K., Hasegawa A., Sawamura R., Okada S. Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice. Biochem. Biophys. Res. Commun. 165:1989;43-50.
45. Yamanaka K., Hasegawa A., Sawamura R., Okada S. Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics in mice. Toxicol. Appl. Pharmacol. 108:1991;205-213.
46. Yamanaka K., Hoshino M., Okamoto M., Sawamuara R., Hasegawa A., Okada S. Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical. Biochem. Biophys. Res. Commun. 168:1990;58-64.
47. Yamanaka K., Tezuka M., Kato K., Hasegawa A., Okada S. Crosslink formation between DNA and nuclear proteins by in vivo and in vitro exposure of cells to dimethylarsinic acid. Biochem. Biophys. Res. Commun. 191:1993;1184-1191.
48. Yamanaka K., Hayashi H., Kato K., Hasegawa A., Okada S. Involvement of preferential formation of apurinic/apyrimidinic sites in dimethylarsenic-induced DNA strand breaks and DNA-protein crosslinks in cultured alveolar epithelial cells. Biochem. Biophys. Res. Commun. 207:1995;244-249.
49. Yamanaka K., Ohtsubo K., Hasegawa A., Haashi H., Ohji H., Kanisawa M., Okada S. Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice. Carcinogenesis. 17:1996;767-770.
50. Yamauchi H., Yamamura Y. Metabolism and excretion of orally administered dimethylarsinic acid in the hamster. Toxicol. Appl. Pharmacol. 74:1984;134-140.