A concise review of the toxicity and carcinogenicity of dimethylarsinic acid

Toxicology

Volumn 160, Issue 1-3, 2001, Pages 227-236

  Kenyon, E M ^a   Hughes, M F ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Arsenic; Cancer; Dimethylarsinic acid

Indexed keywords

CACODYLIC ACID; PEROXY RADICAL; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER CARCINOMA; CARCINOGENICITY; CONTROLLED STUDY; CYTOTOXICITY; DIET; DNA STRAND BREAKAGE; DOSE RESPONSE; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; LIVER CARCINOMA; LONG TERM EXPOSURE; LUNG ALVEOLUS CELL; LUNG TOXICITY; LUNG TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; THYROID CARCINOMA; TUMOR PROMOTION;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; CACODYLIC ACID; CARCINOGENICITY TESTS; CARCINOGENS; COCARCINOGENESIS; DNA; DRUG SYNERGISM; EMBRYONIC AND FETAL DEVELOPMENT; HERBICIDES; HUMANS; MICE; MUTAGENS; RATS; REPRODUCTION;

ANIMALIA; RODENTIA;

EID: 0035819871     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00458-3     Document Type: Article

References (52)

1. Effects of dietary dimethylarsinic acid on the urine and urothelium of rats
2. Molecular aspects of arsenic stress
3. Dimethylarsinic acid treatment alters six different rat biochemical parameters: Relevance to arsenic carcinogenesis
4. Acute promyelocytic leukemia: Cellular and molecular basis of differentiation and apoptosis
5. The role of urinary physiology and chemistry in bladder carcinogenesis
6. Urinary bladder carcinogenesis
7. Evalutation of cell proliferative activity in the rat urinary bladder after feeding high doses of cacodylic acid
8. Metabolites of arsenic induced tetraploids and mitotic arrest in cultured cells
9. Dimethylarsinic acid induces tetraploids in Chinese hamster cells
10. Roles of urinary sodium ion concentration and pH in promotion by ascorbic acid of urinary bladder carcinogenesis
11. Developmental and reproductive toxicity of inorganic arsenic: Animal studies and human concerns
12. Evaluation of arsenic metabolites for prenatal effects in the hamster
13. Dose-dependent effects on tissue distribution and metabolism of dimethylarsinic acid in the mouse after intravenous administration
14. Dose-dependent effects on the disposition of monomethylarsonic acid and dimethylarsinic acid in the mouse after intravenous administration
15. The acute toxicity of arsenobetaine
16. A comparative study on acute toxicity of methyl arsonic acid, dimethylarsinic acid and trimethylarsine oxide in mice
17. DNA damage induced in cultured human alveolar (L-132) cells by exposure to dimethylarsinic acid
18. Promotion of NCI-Black-Reiter male rat bladder carcinogenesis by dimethylarsinic acid an organic arsenic compound
19. Biotransformation of dimethylarsinic acid in mouse, hamster and man
20. Methylated arsenic(III) species react directly with DNA and are potential proximate or ultimate genotoxic forms of arsenic
21. Relative genotoxic potency of arsenic and its methylated metabolites
22. Renal lesions induced in F344/DuCrj rats by 4-weeks oral administration of dimethylarsinic acid
23. Dimethylarsinic acid causes apoptosis in HL-60 cells via interaction with glutathione
24. Induction of chromosomal aberrations in cultured human fibroblasts by inorganic and organic arsenic compounds and the different roles of glutathione in such induction
25. DNA-strand breaks induced by dimethylarsinic acid, a metabolite of inorganic arsenics, are strongly enhanced by superoxide anion radicals
26. The teratogenic potential of cacodylic acid in the rat and mouse
27. Disposition of 14C and/or 74As-cacodylic acid in rats after intravenous, intratracheal, or peroral administration
28. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells
29. Gene damage induced in human alveolar type II (L-132) cells by exposure to dimethylarsinic acid
30. Intracellular interaction and metabolic fate of arsenite and arsenate in mice and rabbits
31. Tissue distribution and retention of 74As-dimethylarsinic acid in mice and rats
32. Chronic carcinogenicity assessment of cacodylic acid
33. Promoting effects of dimethylarsinic acid on N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in rats
34. Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats
35. Arsenic-induced axial skeletal (dysraphic) disorders
36. Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens
37. DNA strand breaks in mammalian tissues induced by methylarsenics
38. Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice
39. Mutagenicity of dimethylated metabolites of inorganic arsenics
40. Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical
41. Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice
42. Crosslink formation between DNA and nuclear proteins by in vivo and in vitro exposure of cells to dimethylarsinic acid
43. Involvement of preferential formation of apurinic/apyrimidinic sites in dimethylarsenic-induced DNA strand breaks and DNA-protein crosslinks in cultured alveolar epithelial cells
44. Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice
45. DNA single-strand breaks in L-132 cells resulting from inhibition of repair polymerization shortly after exposure to dimethylarsinic acid
46. The role of orally administered dimethylarsinic acid, a main metabolite of inorganic arsenics, in the promotion and progression of UVB-induced skin tumorigenesis in hairless mice
47. Metabolism and excretion of orally administered dimethylarsinic acid in the hamster
48. Metabolism and excretion of orally administered methylarsonic acid in the hamster
49. The urinary excretion of arsenic metabolites after a single oral administration of dimethylarsinic acid to rats