Oral administration of dimethylarsinic acid, a main metabolite of inorganic arsenic, in mice promotes skin tumorigenesis initiated by dimethylbenz(a)anthracene with or without ultraviolet B as a promoter

Biological and Pharmaceutical Bulletin

Volumn 24, Issue 5, 2001, Pages 510-514

  Yamanaka, Kenzo ^a   Mizoi, Mutsumi ^a   Kato, Koichi ^a   Hasegawa, Akira ^a   Nakano, Masayuki ^b   Okada, Shoji ^c  

^a NIHON UNIVERSITY   (Japan)

^b National Mito Hospital   (Japan)

^c UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Dimethylarsinic acid; Dimethylbenz(a)anthracene; Inorganic arsenic; Reactive oxygen species; Skin tumor; Tumor promotion

Indexed keywords

ANTHRACENE DERIVATIVE; ARSENIC; CACODYLIC ACID; CACODYLIC ACID PEROXY RADICAL; DIMETHYBENZ[A]ANTHRACENE; DRUG METABOLITE; REACTIVE OXYGEN METABOLITE; TUMOR PROMOTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CONTROLLED STUDY; DRUG METABOLISM; EXPOSURE; HUMAN; KERATOSIS; METABOLITE; MOUSE; NONHUMAN; NUDE MOUSE; PAPILLOMA; SKIN CARCINOGENESIS; SQUAMOUS CELL CARCINOMA; TUMOR PROMOTION; ULTRAVIOLET B RADIATION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ADMINISTRATION, ORAL; ANIMALS; ARSENICALS; COCARCINOGENESIS; DEOXYGUANOSINE; FEMALE; MICE; MICE, INBRED HRS; MUTAGENS; REACTIVE OXYGEN SPECIES; SKIN NEOPLASMS; ULTRAVIOLET RAYS;

EID: 0034986099     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.24.510     Document Type: Article

References (28)

1. "Biological Monitoring of Toxic Metals"
2. Induction of lung-specific DNA damage by methylarsenics via the production of free radicals
3. Human carcinogenicity and atherogenicity induced by chronic exposure to inorganic arsenics