Adenosine receptors and phosphodiesterase inhibitors stimulate Cl - secretion in Calu-3 cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 29, Issue 3 I, 2003, Pages 410-418

  Cobb, Bryan R ^a   Fan, Lijuan ^a   Kovacs, Timea E ^a   Sorscher, Eric J ^a   Clancy, John P ^a  

^a Gregory Fleming James Cystic F ^*

Author keywords

[No Author keywords available]

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A2B RECEPTOR; ADENOSINE DEAMINASE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; ADENOSINE TRIPHOSPHATE; CHLORIDE ION; CILOSTAZOL; FLAVINE MONONUCLEOTIDE; FORSKOLIN; GLIBENCLAMIDE; HEXOKINASE; MILRINONE; MUTANT PROTEIN; PAPAVERINE; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; SILDENAFIL; THEOPHYLLINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTICLE; CELL SECRETION; CELL STIMULATION; CHLORIDE TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; EXPERIMENTAL MODEL; HEMOCONCENTRATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MONOLAYER CULTURE; RECEPTOR UPREGULATION; REGULATORY MECHANISM; SHORT CIRCUIT CURRENT; SYSTEMIC THERAPY; WILD TYPE;

ADENOSINE DEAMINASE; ANIONS; CELL LINE; CHLORINE; CYCLIC AMP; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ELECTROPHYSIOLOGY; EPITHELIUM; FORSKOLIN; GLYBURIDE; HUMANS; HYPOGLYCEMIC AGENTS; MILRINONE; MUTATION; PAPAVERINE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; RECEPTORS, PURINERGIC P1; ROLIPRAM; TETRAZOLES; TIME FACTORS;

EID: 0042831329     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2002-0247OC     Document Type: Article

References (65)

1. Anderson, M. P., H. A. Berger, D. P. Rich, R. J. Gregory, A. E. Smith, and M. J. Welsh. 1991. Nucleoside triphosphates are required to open the CFTR chloride channel. Cell 67:775-784.
2. Bear, C. E., C. Li, K. Galley, Y. Wang, E. Garami, and M Ramjeesingh. 1997. Coupling of ATP hydrolysis with channel gating by purified, reconstituted CFTR. J. Bioenerg. Biomembr. 29:465-473.
3. Cheng, S. H., D. P. Rich, J. Marshall, R. J. Gregory, M. J. Welsh, and A. E. Smith. 1991. Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel. Cell 66:1027-1036.
4. Pilewski, J. M. and R. A. Frizzell. 1999. Role of CFTR in airway disease. Physiol. Rev. 79:S215-S255.
5. Huang, P., K. Trotter, R. C. Boucher, S. L. Milgram, and M. J. Stutts. 2000. PKA holoenzyme is functionally coupled to CFTR by AKAPs. Am. J. Physiol. Cell Physiol. 278:C417-C422.
6. Smith, S. N., P. G. Middleton, S. Chadwick, A. Jaffe, K. A. Bush, S. Rolleston, R. Farley, S. J. Delaney, B. Wainwright, D. M. Geddes, and E. W. Alton. 1999. The in vivo effects of milrinone on the airways of cystic fibrosis mice and human subjects. Am. J. Respir. Cell Mol. Biol. 20:129-134.
7. Kelley, T. J., L. al-Nakkash, and M. L. Drumm. 1995. CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 13:657-664.
8. Kelley, T. J., L. Al-Nakkash, C. U. Cotton, and M. L. Drumm. 1996. Activation of endogenous ΔF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition. J. Clin. Invest. 98:513-520.
9. Grubb, B., E. Lazarowski, M. Knowles, and R. Boucher. 1993. Isobutylmethylxanthine fails to stimulate chloride secretion in cystic fibrosis airway epithelia. Am. J. Respir. Cell Mol. Biol. 8:454-460.
10. Kelley, T. J., K. Thomas, L. J. Milgram, and M. L. Drumm. 1997. In vivo activation of the cystic fibrosis transmembrane conductance regulator mutant ΔF508 in murine nasal epithelium. Proc. Natl. Acad. Sci. USA 94:2604-2608.
11. Steagall, W. K., and M. L. Drumm. 1999. Stimulation of cystic fibrosis transmembrane conductance regulator-dependent short-circuit currents across ΔF508 murine intestines. Gastroenterology 116:1379-1388.
12. Clancy, J. P., F. E. Ruiz, and E. J. Sorscher. 1999. Adenosine and its nucleotides activate wild-type and R117H CFTR through an A2B receptor-coupled pathway. Am. J. Physiol. 276:C361-C369.
13. Rubenstein, R. C., and P. L. Zeitlin. 2000. Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of ΔF508-CFTR. Am. J. Physiol. Cell Physiol. 278:C259-C267.
14. Wilschanski, M., C. Famini, H. Blau, J. Rivlin, A. Augarten, A. Avital, B. Kerem, and E. Kerem. 2000. A pilot study of the effect of gentamicin on nasal potential difference measurements in cystic fibrosis patients carrying stop mutations. Am. J. Respir. Crit. Care Med. 161:860-865.
15. Bedwell, D. M., A. Kaenjak, D. J. Benos, Z. Bebok, J. K. Bubien, J. Hong, A. Tousson, J. P. Clancy, and E. J. Sorscher. 1997. Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line. Nat. Med. 3:1280-1284.
16. Ballard, S. T., L. Trout, A. Mehta, and S. K. Inglis. 2002. Liquid secretion inhibitors reduce mucociliary transport in glandular airways. Am. J. Physiol. Lung Cell. Mol. Physiol. 283:L329-L335.
17. Ballard, S. T., L. Trout, Z. Bebok, E. J. Sorscher, and A. Crews. 1999. CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands. Am. J. Physiol. 277:L694-L699.
18. Trout, L., M. King, W. Feng, S. K. Inglis, and S. T. Ballard. 1998. Inhibition of airway liquid secretion and its effect on the physical properties of airway mucus. Am. J. Physiol. 274:L258-L263.
19. Inglis, S. K., M. R. Corboz, A. E. Taylor, and S. T. Ballard. 1997. Effect of anion transport inhibition on mucus secretion by airway submucosal glands. Am. J. Physiol. 272:L372-L377.
20. Engelhardt, J. F., J. R. Yankaskas, S. A. Ernst, Y. Yang, C. R. Marino, R. C. Boucher, J. A. Cohn, and J. M. Wilson. 1992. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat. Genet. 2:240-248.
21. Devor, D. C., A. K. Singh, L. C. Lambert, A. DeLuca, R. A. Frizzell, and R. J. Bridges. 1999. Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells. J. Gen. Physiol. 113:743-760.
22. - secretion in human airway epithelial Calu-3 cells. Toxicol. Appl. Pharmacol. 176:101-109.
23. + conductance in human airway epithelial cells. J. Pharmacol. Exp. Ther. 302:80-87.
24. +-pump activity in Calu-3 human airway cells. Biochem. Biophys. Res. Commun. 274:230-235.
25. - secretion by desensitization of beta-adrenergic receptors in calu-3 human airway cells. Biochem. Biophys. Res. Commun. 274:620-625.
26. Lofting, J., B. D. Moyer, D. Reynolds, B. E. Shmukler, S. L. Alper, and B. A. Stanton. 2000. Functional and molecular characterization of an anion exchanger in airway serous epithelial cells. Am. J. Physiol. Cell Physiol. 279:C1016-C1023.
27. - secretion. Am. J. Physiol. 266:L493-L501.
28. Cowley, E. A., and P. Linsdell. 2002. Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3. J. Physiol. 538:747-757.
29. Illek, B., A. W. Tam, H. Fischer, and T. E. Machen. 1999. Anion selectivity of apical membrane conductance of Calu 3 human airway epithelium. Pflugers Arch. 437:812-822.
30. - conductance through CFTR in human airway epithelia. Am. J. Physiol. 272:L752-L761.
31. 2. Am. J. Physiol. Lung Cell. Mol. Physiol. 282:L12-L25.
32. - conductance. Am. J. Physiol. 266:L502-L512.
33. - channels in human airway cells. Jpn. J. Physiol. 44:S199-S205.
34. - secretion via CFTR in Calu-3 airway epithelial cells. Am. J. Physiol. 275:C913-C920.
35. Smith, D. 1996. Rolipram: antidepressant used in Europe and Japan might have promise against TNF, HIV. AIDS Treat. News. 242:3-4.
36. Strohmeier, G. R., W. I. Lencer, T. W. Patapoff, L. F. Thompson, S. L. Carlson, S. J. Moe, D. K. Carnes, R. J. Mrsny, and J. L. Madara. 1997. Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia. J. Clin. Invest. 99:2588-2601.
37. Huang, P., E. R. Lazarowski, R. Tarran, S. L. Milgram, R. C. Boucher, and M. J. Stutts. 2001. Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells. Proc. Natl. Acad. Sci. USA 98:14120-14125.
38. Schwiebert, E. M. 1999. ABC transporter-facilitated ATP conductive transport. Am. J. Physiol. 276:C1-C8.
39. Schwiebert, E. M., D. J. Benos, M. E. Egan, M. J. Stutts, and W. B. Guggino. 1999. CFTR is a conductance regulator as well as a chloride channel. Physiol. Rev. 79:S145-S166.
40. Olah, M. E., and G. L. Stiles. 1992. Adenosine receptors. Annu. Rev. Physiol. 54:211-225.
41. Burnstock, G. 1978. A basis for distinguishing two types of purinergic receptors. In Cell Membrane Receptors for Drugs and Hormones: A Multidisciplinary Approach. Raven Press, New York.
42. Banderali U., E. Brochiero, S. Lindenthal, C. Raschi, S. Bogliolo, and J. Ehrenfeld. 1999. Control of apical membrane chloride permeability in the renal A6 cell line by nucleotides. J. Physiol. 519:737-751.
43. Hwang, T. H., E. M. Schwiebert, and W. B. Guggino. 1996. Apical and basolateral ATP stimulates tracheal epithelial chloride secretion via multiple purinergic receptors. Am. J. Physiol. 270:C1611-C1623.
44. Liang, B. T., and B. Haltiwanger. 1995. Adenosine A2a and A2b receptors in cultured fetal chick heart cells: high- and low-affinity coupling to stimulation of myocyte contractility and cAMP accumulation. Circ. Res. 76:242-251.
45. Brackett, L. E., and J. W. Daly. 1994. Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Biochem. Pharmacol. 47:801-814.
46. 2002. Physicians' Desk Reference: PDR, 56th ed. Medical Economics Co., Montvale, NJ.
47. Rosman, G. J., T. J. Martins, W. K. Sonnenburg, J. A. Beavo, K. Ferguson, and K. Loughney. 1997. Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3′,5′-cyclic nucleotide phosphodiesterase. Gene 191:89-95.
48. Wright, L. C., J. Seybold, A. Robichaud, I. M. Adcock, and P. J. Barnes. 1998. Phosphodiesterase expression in human epithelial cells. Am. J. Physiol. 275:L694-L700.
49. Obernolte, R., J. Ratzliff, P. A. Baecker, D. V. Daniels, P. Zuppan, K. Jarnagin, and E. R. Shelton. 1997. Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis. Biochim. Biophys. Acta 1353:287-297.
50. Soderling, S. H., S. J. Bayuga, and J. A. Beavo. 1998. Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J. Biol. Chem. 273:15553-15558.
51. McLaughlin, M. M., L. B. Cieslinski, M. Burman, T. J. Torphy, and G. P. Livi. 1993. A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain: cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA. J. Biol. Chem. 268:6470-6476.
52. Loughney, K., T. R. Hill, V. A. Florio, L. Uher, G. J. Rosman, S. L. Wolda, B. A. Jones, M. L. Howard, L. M. McAllister-Lucas, W. K. Sonnenburg, S. H. Francis, J. D. Corbin, J. A. Beavo, and K. Ferguson. 1998. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesterase. Gene 216:139-147.
53. Kotera, J., K. Fujishige, H. Akatsuka, Y. Imai, N. Yanaka, and K. Omori. 1998. Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase. J. Biol. Chem. 273:26982-26990.
54. Kotera, J., K. Fujishige, H. Michibata, K. Yuasa, A. Kubo, Y. Nakamura, and K. Omori. 2000. Characterization and effects of methyl-2-(4-aminophenyl)-1, 2-dihydro-1-oxo-7-(2-pyridinylmethoxy)-4-(3,4, 5-trimethoxyphenyl)-3-isoquinoline carboxylate sulfate (T-1032), a novel potent inhibitor of cGMP-binding cGMP-specific phosphodiesterase (PDE5). Biochem. Pharmacol. 60:1333-1341.
55. Kotera, J., K. Fujishige, and K. Omori. 2000. Immunohistochemical localization of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in rat tissues. J. Histochem. Cytochem. 48:685-693.
56. Kotera, J., N. Yanaka, K. Fujishige, Y. Imai, H. Akatsuka, T. Ishizuka, K. Kawashima, and K. Omori. 1997. Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development. Eur. J. Biochem. 249:434-442.
57. Wang, P., P. Wu, R. W. Egan, and M. M. Billah. 2000. Cloning, characterization, and tissue distribution of mouse phosphodiesterase 7A1. Biochem. Biophys. Res. Commun. 276:1271-1277.
58. Fujishige, K., J. Kotera, H. Michibata, K. Yuasa, S. Takebayashi, K. Okumura, and K. Omori. 1999. Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J. Biol. Chem. 274:18438-18445.
59. Huang, P., and M. J. Stutts. 2001. Both PDE III and PDE IV are compartmentalized with CFTR at the apical membrane of airway epithelial cells. Pediatr. Pulmonol. Suppl. 22:194
60. Kawanishi, Y., K. Kimura, A. Furukawa, T. Miyamoto, M. Tamura, A. Numata, M. Yuasa, A. Imagawa, and S. Kagawa. 1991. [The meanings of the papaverine test]. Nippon Hinyokika Gakkai Zasshi 82:961-966.
61. Shakur, Y., K. Takeda, Y. Kenan, Z. X. Yu, G. Rena, D. Brandt, M. D. Houslay, E. Degerman, V. J. Ferrans, and V. C. Manganiello. 2000. Membrane localization of cyclic nucleotide phosphodiesterase 3 (pDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulum. J. Biol. Chem. 275:38749-38761.
62. Scotland, G., M. Beard, S. Erdogan, E. Huston, F. McCallum, S. J. MacKenzie, A. H. Peden, L. Pooley, N. G. Rena, A. H. Ross, S. J. Yarwood, and M. D. Houslay. 1998. Intracellular compartmentalization of PDE4 cyclic AMP-specific phosphodiesterases. Methods 14:65-79.
63. O'Connell, J. C., J. F. McCallum, I. McPhee, J. Wakefield, E. S. Houslay, W. Wishart, G. Bolger, M. Frame, and M. D. Houslay. 1996. The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5). Biochem. J. 318:255-261.
64. Soderling, S. H., and J. A. Beavo. 2000. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr. Opin. Cell Biol. 12:174-179.
65. Kimura, Y. 1995. [Selective type III phosphodiesterase inhibitor as an anti-thrombotic agent]. Nippon Yakurigaku Zasshi 106:205-216.