Activation of endogenous ΔF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition

Journal of Clinical Investigation

Volumn 98, Issue 2, 1996, Pages 513-520

  Kelley, Thomas J ^a   Al Nakkash, Layla ^a   Cotton, Calvin U ^b   Drumm, Mitchell L ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cyclic AMP; cystic fibrosis; epithelium; ion channels; protein kinases

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHLORIDE; CHLORIDE CHANNEL; CHLORINE 36; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PROTEIN KINASE INHIBITOR; TRANSMEMBRANE CONDUCTANCE REGULATOR; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID; ADENOSINE 3',5' PHOSPHOROTHIOATE; ADENOSINE-3',5'-CYCLIC PHOSPHOROTHIOATE; ANTISENSE OLIGONUCLEOTIDE; CALCIUM; CFTR PROTEIN, HUMAN; DRUG DERIVATIVE; EGTAZIC ACID; ENZYME INHIBITOR; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; ISOBUTYLMETHYLXANTHINE; ISOPRENALINE; MILRINONE; NUCLEOTIDE; OLIGODEOXYRIBONUCLEOTIDE; PYRIDONE DERIVATIVE; SALBUTAMOL;

ARTICLE; CHLORIDE TRANSPORT; CONTROLLED STUDY; CYSTIC FIBROSIS; ENZYME INHIBITION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUMAN TISSUE; MUTATION; PRIORITY JOURNAL; CELL LINE; CELL MEMBRANE POTENTIAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; EPITHELIUM; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY;

1-METHYL-3-ISOBUTYLXANTHINE; ADRENERGIC BETA-AGONISTS; ALBUTEROL; BASE SEQUENCE; CALCIUM; CELL LINE; CHLORIDES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DRUG SYNERGISM; EGTAZIC ACID; ENZYME INHIBITORS; EPITHELIUM; HUMANS; ISOPROTERENOL; KINETICS; MEMBRANE POTENTIALS; MILRINONE; MOLECULAR SEQUENCE DATA; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHODIESTERASE INHIBITORS; PYRIDONES; THIONUCLEOTIDES;

EID: 0029665963     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118819     Document Type: Article

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