The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressor

Biochemical Journal

Volumn 374, Issue 1, 2003, Pages 165-173

  Nordentoft, Iver ^a   Jørgensen, Poul ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

60 kDa trans acting regulatory protein of HIV type 1 interacting protein (Tip60); E26 transforming specific transcription factor; Histone acetyltransferase; Transcription; Translocation E26 transforming specific leukaemia (TEL)

Indexed keywords

BIOCHEMISTRY; BLOOD; GENES; MUTAGENESIS; TUMORS;

TRANSCRIPTIONAL REPRESSORS;

PROTEINS;

ACYLTRANSFERASE; E26 TRANSFORMING SPECIFIC TRANSCRIPTION FACTOR; HISTONE ACETYLTRANSFERASE; HUMAN IMMUNODEFICIENCY VIRUS 1 INTERACTING PROTEIN; PROTEIN MYST; PROTEIN TIP60; PROTEIN YBF2; TRANS ACTING FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN; ZINC FINGER PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DISEASE ASSOCIATION; E26 TRANSFORMING SPECIFIC LEUKEMIA GENE; GENE; GENE FUNCTION; GENE SILENCING; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; LEUKEMIA; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ACETYLATION; ACETYLTRANSFERASES; BINDING SITES; CLONING, MOLECULAR; DNA-BINDING PROTEINS; GENE LIBRARY; HISTONE ACETYLTRANSFERASES; HIV-1; KINETICS; PLASMIDS; PROTO-ONCOGENE PROTEINS C-ETS; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE DELETION; TRANSCRIPTION, GENETIC;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA;

EID: 0042827840     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030087     Document Type: Article

References (57)

1. Golub, T. R., Barker, G. F., Lovett, M. and Gilliland, D. G. (1994) Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell (Cambridge, Mass.) 77, 307-316
2. Poirel, H., Oury, C., Carron, C., Duprez, E., Laabi, Y., Tsapis, A., Romana, S. P., Mauchauffe, M., Le Coniat, M., Berger, R. et al. (1997) The TEL gene products: nuclear phosphoproteins with DNA binding properties. Oncogene 14, 349-357
3. Wang, L. C., Kuo, F., Fujiwara, Y., Gilliland, D. G., Golub, T. R. and Orkin, S. H. (1997) Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J. 16, 4374-4383
4. Golub, T. R., Goga, A., Barker, G. F., Afar, D. E., McLaughlin, J., Bohlander, S. K., Rowley, J. D., Witte, O. N. and Gilliland, D. G. (1996) Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia. Mol. Cell. Biol. 16, 4107-4116
5. Iijima, Y., Ito, T., Oikawa, T., Eguchi, M., Eguchi-Ishimae, M., Kamada, N., Kishi, K., Asano, S., Sakaki, Y. and Sato, Y. (2000) A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation. Blood 95, 2126-2131
6. Lacronique, V., Boureux, A., Valle, V. D., Poirel, H., Quang, C. T., Mauchauffe, M., Berthou, C., Lessard, M., Berger, R., Ghysdael, J. et al. (1997) A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278, 1309-1312
7. Eguchi, M., Eguchi-Ishimae, M., Tojo, A., Morishita, K., Suzuki, K., Sato, Y., Kudoh, S., Tanaka, K., Setoyama, M., Nagamura, F. et al. (1999) Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25). Blood 93, 1355-1363
8. Andersen, M. T., Nordentoft, I., Hjalgrim, L. L., Christiansen, C. L., Jakobsen, V. D., Hjalgrim, H., Pallisgaard, N., Madsen, H. O., Christiansen, M., Ryder, L. P. et al. (2001) Characterization of t(12;21) breakpoint junctions in acute lymphoblastic leukemia. Leukemia 15, 858-859
9. Golub, T. R., Barker, G. F., Bohlander, S. K., Hiebert, S. W., Ward, D. C., Bray-Ward, P., Morgan, E., Raimondi, S. C., Rowley, J. D. and Gilliland, D. G. (1995) Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc. Natl. Acad. Sci. U.S.A. 92, 4917-4921
10. Romana, S. P., Poirel, H., Leconiat, M., Flexor, M. A., Mauchauffe, M., Jonveaux, P., Macintyre, E. A., Berger, R. and Bernard, O. A. (1995) High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia. Blood 86, 4263-4269
11. Peeters, P., Wlodarska, I., Baens, M., Criel, A., Selleslag, D., Hagemeijer, A., Van den, B. H. and Marynen, P. (1997) Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders. Cancer Res. 57, 564-569
12. Chase, A., Reiter, A., Burci, L., Cazzaniga, G., Biondi, A., Pickard, J., Roberts, I. A., Goldman, J. M. and Cross, N. C. (1999) Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12). Blood 93, 1025-1031
13. Szymczyna, B. R. and Arrowsmith, C. H. (2000) DNA binding specificity studies of four ETS proteins support an indirect read-out mechanism of protein-DNA recognition. J. Biol. Chem. 275, 28363-28370
14. Shurtleff, S. A., Buijs, A., Behm, F. G., Rubnitz, J. E., Raimondi, S. C., Hancock, M. L., Chan, G. C., Pui, C. H., Grosveld, G. and Downing, J. R. (1995) TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 9, 1985-1989
15. Cave, H., Cacheux, V., Raynaud, S., Brunie, G., Bakkus, M., Cochaux, P., Preudhomme, C., Lai, J. L., Vilmer, E. and Grandchamp, B. (1997) ETV6 is the target of chromosome 12p deletions in t(12;21) childhood acute lymphocytic leukemia. Leukemia 11, 1459-1464
16. Fenrick, R., Wang, L., Nip, J., Amann, J. M., Rooney, R. J., Walker-Daniels, J., Crawford, H. C., Hulboy, D. L., Kinch, M. S., Matrisian, L. M. et al. (2000) TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1. Mol. Cell. Biol. 20, 5828-5839
17. Van Rompaey, L., Holland, E. and Grosveld, G. (2002) TEL induces aggregation in transformed cells and induces tube formation in NIH3T3-UCLA cells. Biochem. Biophys. Res. Commun. 291, 820-828
18. Lopez, R. G., Carron, C., Oury, C., Gardellin, P., Bernard, O. and Ghysdael, J. (1999) TEL is a sequence-specific transcriptional repressor. J. Biol. Chem. 274, 30132-30138
19. Chakrabarti, S. R. and Nucifora, G. (1999) The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A. Biochem. Biophys. Res. Commun. 264, 871-877
20. Fenrick, R., Amann, J. M., Lutterbach, B., Wang, L., Westendorf, J. J., Downing, J. R. and Hiebert, S. W. (1999) Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein. Mol. Cell. Biol. 19, 6566-6574
21. Guidez, F., Petrie, K., Ford, A. M., Lu, H., Bennett, C. A., MacGregor, A., Hannemann, J., Ito, Y., Ghysdael, J., Cleaves, M. et al. (2000) Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoprotein. Blood 96, 2557-2561
22. Kamine, J., Elangovan, B., Subramanian, T., Coleman, D. and Chinnadurai, G. (1996) Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology 216, 357-366
23. Sterner, D. E. and Berger, S. L. (2000) Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev. 64, 435-459
24. Jacobson, R. H., Ladurner, A. G., King, D. S. and Tjian, R. (2000) Structure and function of a human TAFII250 double bromo domain module. Science 288, 1422-1425
25. Sewack, G. F., Ellis, T. W. and Hansen, U. (2001) Binding of TATA binding protein to a naturally positioned nucleosome is facilitated by histone acetylation. Mol. Cell. Biol. 21, 1404-1415
26. Kimura, A. and Horikoshi, M. (1998) Tip60 acetylates six lysines of a specific class in core histones in vitro. Genes Cells 3, 789-800
27. Yamamoto, T. and Horikoshi, M. (1997) Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60. J. Biol. Chem. 272, 30595-30598
28. Ikura, T., Ogryzko, V. V., Grigoriev, M., Groisman, R., Wang, J., Horikoshi, M., Scully, R., Qin, J. and Nakatani, Y. (2000) Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell (Cambridge, Mass.) 102, 463-473
29. Smith, E. R., Eisen, A., Gu, W., Sattah, M., Pannuti, A., Zhou, J., Cook, R. G., Lucchesi, J. C. and Allis, C. D. (1998) ESA1 is a histone acetyltransferase that is essential for growth in yeast. Proc. Natl. Acad. Sci. U.S.A. 95, 3561-3565
30. Kinoshita, A., Whelan, C. M., Berezovska, O. and Hyman, B. T. (2002) The γ secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. J. Biol. Chem. 277, 28530-28536
31. Legube, G., Linares, L. K., Lemercier, C., Scheffner, M., Khochbin, S. and Trouche, D. (2002) Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. EMBO J. 21, 1704-1712
32. Brady, M. E., Ozanne, D. M., Gaughan, L., Waite, I., Cook, S., Neal, D. E. and Robson, C. N. (1999) Tip60 is a nuclear hormone receptor coactivator. J. Biol. Chem. 274, 17599-17604
33. Gaughan, L., Brady, M. E., Cook, S., Neal, D. E. and Robson, C. N. (2001) Tip60 is a co-activator specific for class I nuclear hormone receptors. J. Biol. Chem. 276, 46841-46848
34. Gaughan, L., Logan, I. R., Cook, S., Neal, D. E. and Robson, C. N. (2002) Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor. J. Biol. Chem. 277, 25904-25913
35. Lyngso, C., Bouteiller, G., Damgaard, C. K., Ryom, D., Sanchez-Munoz, S., Norby, P. L., Bonven, B. J. and Jørgensen, P. (2000) Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers. J. Biol. Chem. 275, 26144-26149
36. Fields, S. and Song, O. (1989) A novel genetic system to detect protein-protein interactions. Nature (London) 340, 245-246
37. Chakrabarti, S. R., Sood, R., Ganguly, S., Bohlander, S., Shen, Z. and Nucifora, G. (1999) Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9. Proc. Natl. Acad. Sci. U.S.A. 96, 7467-7472
38. Liu, B., Liao, J., Rao, X., Kushner, S. A., Chung, C. D., Chang, D. D. and Shuai, K. (1998) Inhibition of Stat1-mediated gene activation by PIAS1. Proc. Natl. Acad. Sci. U.S.A. 95, 10626-10631
39. Imai, Y., Kimura, T., Murakami, A., Yajima, N., Sakamaki, K. and Yonehara, S. (1999) The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. Nature (London) 398, 777-785
40. Kiriakidou, M., Driscoll, D. A., Lopez-Guisa, J. M. and Strauss, III, J. F. (1997) Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. DNA Cell Biol. 16, 1289-1298
41. Li, R., Pei, H., Watson, D. K. and Papas, T. S. (2000) EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. Oncogene 19, 745-753
42. Still, I. H. and Cowell, J. K. (1998) The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13. Blood 92, 1456-1458
43. Sohal, J., Reiter, A., Goldman, J. M. and Cross, N. C. (2000) Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11-q12. Cytogenet. Cell Genet. 89, 24-28
44. Lu, K. P., Hanes, S. D. and Hunter, T. (1996) A human peptidyl-protyl isomerase essential for regulation of mitosis. Nature (London) 380, 544-547
45. Yaffe, M. B., Schutkowski, M., Shen, M., Zhou, X. Z., Stukenberg, P. T., Rahfeld, J. U., Xu, J., Kuang, J., Kirschner, M. W., Fischer, G. et al. (1997) Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science 278, 1957-1960
46. Yan, Y., Barlev, N. A., Haley, R. H., Berger, S. L. and Marmorstein, R. (2000) Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases. Mol. Cell 6, 1195-1205
47. Ford, A. M., Bennett, C. A., Price, C. M., Bruin, M. C., Van Wering, E. R. and Greaves, M. (1998) Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia. Proc. Natl. Acad. Sci. U.S.A. 95, 4584-4588
48. Bartel, F. O., Higuchi, T. and Spyropoulos, D. D. (2000) Mouse models in the study of the Ets family of transcription factors. Oncogene 19, 6443-6454
49. Hsu, T. and Schulz, R. A. (2000) Sequence and functional properties of Ets genes in the model organism Drosophila. Oncogene 19, 6409-6416
50. Maroulakou, I. G. and Bowe, D. B. (2000) Expression and function of Ets transcription factors in mammalian development: a regulatory network. Oncogene 19, 6432-6442
51. Sharrocks, A. D. (2001) The ETS-domain transcription factor family. Nat Rev. Mol. Cell Biol. 2, 827-837
52. Wasylyk, B., Hagman, J. and Gutierrez-Hartmann, A. (1998) Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway. Trends Biochem. Sci. 23, 213-216
53. Wang, L. C., Swat, W., Fujiwara, Y., Davidson, L., Visvader, J., Kuo, F., Alt, F. W., Gilliland, D. G., Golub, T. R. and Orkin, S. H. (1998) The TEL/ ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes Dev. 12, 2392-2402
54. Wang, H., Huang, Z. Q., Xia, L., Feng, Q., Erdjument-Bromage, H., Strahl, B. D., Briggs, S. D., Allis, C. D., Wong, J., Tempst, P. et al. (2001) Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science 293, 853-857
55. Garvie, C. W., Pufall, M. A., Graves, B. J. and Wolberger, C. (2002) Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships. J. Biol. Chem. 277, 45529-45536
56. Jonsen, M. D., Petersen, J. M., Xu, Q. P. and Graves, B. J. (1996) Characterization of the cooperative function of inhibitory sequences in Ets-1. Mol. Cell. Biol. 16, 2065-2073
57. 2HC zinc finger for substrate recognition. EMBO Rep. 2, 113-118