Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoprotein

Blood

Volumn 96, Issue 7, 2000, Pages 2557-2561

  Guidez, F ^a   Kevin Petrie, ^a   Ford, A M ^a   Lu, H ^a   Bennett, C A ^a   MacGregor, A ^a   Hannemann, J ^a   Ito, Y ^a   Ghysdael, J ^a   Greaves, M ^a   Wiedemann, L M ^a   Zelent, A ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; HISTONE DEACETYLASE; ONCOPROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ARTICLE; CHILDHOOD LEUKEMIA; CHROMOSOME TRANSLOCATION; GENE EXPRESSION; GENE FUSION; GENE TARGETING; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; NONHUMAN; PRIORITY JOURNAL;

EID: 0034307660     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.7.2557     Document Type: Article

References (41)

1. The critical role of chromosome translocations in human leukemias
2. Molecular genetics, natural history and the demise of childhood leukaemia
3. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
4. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
5. Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
6. The TEL gene and human leukemia
7. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia
8. The t(12;21) of acute lymphoblastic leukemia resuits in a tel-AML1 gene fusion
9. TEL/AML1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic-leukemia
10. Involvement of the TEL gene in hematologic malignancy by diverse molecular genetic mechanisms
11. A new transcription factor family associated with human leukemias
12. Direct and indirect alteration of transcriptional regulation in cancer
13. The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription
14. Three distinct domains in TEL-AML1 are required for transcriptional repression of the IL-3 promoter
15. The TEL gene products: Nuclear phosphoproteins with DNA binding properties
16. The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity
17. Modulation of TEL tram scription activity by interaction with the ubiquitin-conjugating enzyme UBC9
18. TEL is a sequence-specific transcriptional repressor
19. Role of histone deacetylase complex in acute promyelocytic leukaemia
20. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia
21. Reduced retinoic acid-sensitivities of nuclear receptor co-repressor binding to PML-and PLZF-RARα underlie molecular pathogenesis and treatment of acute promyelocytic leukemia
22. Differential effects of nuclear receptor corepressor (N-CoR) expression levers on retinoic acid receptor-mediated repression support the existence of dynamically regulated corepressor complexes
23. Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of nuclear hormone receptors
24. Histone deacetylases associated with the mSin3 corepressor mediate Mad transcriptional repression
25. Phenotypic characterisation of a unique non-T, non-B acute lymphoblastic leukaemia cell line
26. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation
27. Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements
28. Intracellular leucine zipper interactions suggest c-Myc hetero-oligomerization
29. Luciferase reporter gene vectors for analysis of promoters and enhancers
30. Estrogen receptor-associated proteins: Possible mediators of hormone-induced transcription
31. Analysis of TEL proteins in human leukemias
32. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor corepressor
33. A transcriptional corepressor that interacts with nuclear hormone receptors
34. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
35. Isolation of a novel histone deacetylase reveals that crass I and class II deacetylases promote SMRT-mediated repression
36. Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein
37. Unique forms of human and mouse nuclear receptor corepressor SMRT
38. The leukemia-associated gene TEL encodes a transcription repressot which associates with SMRT and mSin3A
39. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex
40. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
41. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors