Formation of plasmid-based transfection complexes with an acid-labile cationic lipid: Characterization of in vitro and in vivo gene transfer

Pharmaceutical Research

Volumn 19, Issue 9, 2002, Pages 1292-1301

  Boomer, J A ^a   Thompson, D H ^a   Sullivan, S M ^b,c  

^a PURDUE UNIVERSITY   (United States)

^b Urigen Pharmaceuticals Inc   (United States)

^c UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

Acid sensitive lipid; Cytoplasmic delivery; Endosomal escape; Gene transfer; Transfection; Vinyl ether hydrolysis

Indexed keywords

ALCOHOL; CHLORAMPHENICOL ACETYLTRANSFERASE; DRUG CARRIER; LIPID; O (1,2 DI O (9' OCTADECENYL) GLYCEROL) 3 N (BIS 2 AMINOETHYL) CARBAMATE; O [1,2 DI O (1', 9' OCTADECADIENYL) GLYCEROL] 3 N (BIS 2 AMINOETHYL) CARBAMATE; PLASMID DNA; PLASMID VECTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CELL TYPE; COMPLEX FORMATION; CONTROLLED STUDY; DEGRADATION; DISSOCIATION; DRUG DESIGN; DRUG FORMULATION; DRUG SYNTHESIS; ENDOSOME; EVAPORATION; FETAL CALF SERUM; FLUORESCENCE; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; LUNG; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PH; PRIORITY JOURNAL;

3T3 CELLS; ACIDS; ANIMALS; CATIONS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; GENE TRANSFER TECHNIQUES; HUMANS; LIPIDS; MICE; MICE, INBRED C3H; PLASMIDS; TRANSFECTION;

EID: 0036744771     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020342523694     Document Type: Article

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